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4

Pancreas

Table 4.7 Differentiating pancreatic cancer from focal pancreatitis

 

 

Pancreatic cancer

Focal pancreatitis

 

Tumor lesion

 

 

 

Texture

Homogeneous to finely mottled

Lobulated, spotted

 

 

irregular

 

 

Delineation

Polycyclic

Well defined

 

Color-flow duplex

No intrinsic vascularization, infil-

Normal or marked vascularization

 

scanning

trating growth

 

Fig. 4.39 Hypoechoic structure within the pancreatic head

Contrast-enhanced

Hypoenhancement

Similar to the residual parenchyma

and the uncinate process corresponding to a ventral

anlage (in pancreatic lipomatosis).

ultrasound

 

 

 

Residual organ

 

 

 

Contour

Smooth

Undulating

 

Parenchyma

Homogeneous to finely mottled

Inhomogeneous, coarsely mottled

 

Pancreatic duct

Smooth

Irregular

 

Calcifications

(+)

+++

 

Pseudocysts

(+)

+++

 

Isoechoic Lesion

 

 

 

Diffuse Pancreatic Change

Pancreas

Hypoechoic Lesion

 

 

 

Focal Changes

 

 

 

Anechoic Lesion

 

 

 

Isoechoic Lesion

 

 

 

Hyperechoic Lesion

 

 

 

Irregular (Complex Structured) Lesion

 

 

 

Dilatation of the Pancreatic Duct

 

 

 

Pancreatic Cancer

Malignant Lymphoma

Focal Pancreatitis

Pancreas Divisum

Annular Pancreas

Pancreatic Cancer

If the texture of the pancreas is hypoechoic, as evidenced in slim young patients, the texture of pancreatic cancer will be isoechoic and can only be differentiated by its bulging contour and any secondary signs. Cancers of the pancreatic tail and uncinate process are also hard to detect, and at that only in the special planes of the oblique/transverse epigastric views: on the right for the head and on the left for the tail of the pancreas. The obstructed pancreatic duct may be a leading sign (Fig. 4.40).

Fig. 4.40 Malignant tumor (TU) of the pancreatic head: texture isoechoic to the rest of the pancreas (PA).

a Transverse scan.

b Longitudinal scan. AO = aorta, WS = vertebral column, AMS = superior mesenteric artery, CF = venous confluence, DUO = duodenum, A = antrum, DP = pancreatic duct.

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Malignant Lymphoma

Malignant lymphoma may also be isoechoic with the pancreas, although its characteristic texture is visualized as markedly hypoechoic (Fig. 4.9a, Fig. 4.36).

Focal Pancreatitis

While in most cases acute focal pancreatitis appears hypoechoic, chronic focal pancreatitis may be isoechoic with the surrounding pancreatic tissue, and therefore can only be differentiated by focal enlargement and a more macronodular texture. A special form of focal pancreatitis (mainly of the head) is a chronic autoimmune pancreatitis, often characterized by a pancreatic head (or tail12) mass or also by a diffuse pancreatitis. There is a lack of pseudocysts or calculi; the diagnosis is made by antibodies, biopsy, and trial of cortisone therapy (Fig. 4.41, Fig. 4.17b).

Fig. 4.41 Segmental pancreatitis of the head (cursors, P), isoechoic texture.

a Transverse scan.

b Longitudinal scan: Obstruction of the dilated common bile duct (DCH) and cystic duct. DUO = duodenum, WS = vertebral column, AO = aorta, AMS = mesenteric superior artery, VC = vena cava, VP = portal vein, LI LL = left liver lobe, CF = venous confluence.

PancreasDivisum

Pancreas divisum is characterized by a strikingly enlarged head of the pancreas with normal texture, segmental ductal dilatation in the pancreatic body, and the demonstration of two distinct ductal systems in the pancreatic head (Fig. 4.43, Fig. 4.44).

Congenital Anomaly—Pancreas Divisum

During embryological development, the smaller, originally ventral anlage and the larger dorsal anlage fuse. The ventral anlage constitutes the inferior parts of the head and uncinate process of the pancreas, as well as the main pancreatic duct, while from the dorsal anlage emanate the remainder of the pancreatic head, the entire body and tail, and the anlage for the accessory duct of Santorini. The latter may sometimes persist after fusion and drain the pancreatic juice to the minor papilla, or it may resolve and drain into the main pancreatic duct to the papilla of Vater.

Fusion anomalies (complete or incomplete pancreas divisum) are quite common. The accessory duct of Santorini will drain most of the pancreatic juice via the minor papilla, while the main pancreatic duct (of Wirsung) drains part of the pancreatic head and the uncinate process and displays either no (complete pancreas divisum) or only a thin (incomplete pancreas divisum) communication with the main duct (Fig. 4.42). The relative stenosis upstream of the minor papilla may cause recurrent episodes of pancreatitis.

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Focal Changes

Fig. 4.42 Schematic drawing of complete and incomplete pancreas divisum.

Fig. 4.43 Enlarged head of pancreas.

a Impressing the posterior wall of the gallbladder (arrow).

b Impressing the vena cava. CT study suspected malignancy. Ultrasound diagnosis: probably pancreas divisum. ERCP: pancreas divisum.

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Pancreas

Annular pancreas is another example of an isoechoic focal lesion with changes in size and shape; only in rare instances is it completely annular. In most patients it is completely or incompletely annular around the pancreatic head, which envelops the descending duodenum and may result in stenosis.

In ultrasonography there is definite compression of the descending duodenum by the enlarged head of the pancreas, which is missing its usual border with the duodenum and extends further to the right, posterior and lateral to the duodenum (Fig. 4.45).13

b Pancreatic tissue (P) unusually far to the right; the

c Transverse epigastric

view. The pancreas continues

descending duodenum (D) is stenosed by the formation

rather strikingly to the

right (arrows) posterior to the

of the pancreas. A = antrum, BD = duodenal bulb, GB =

dilated (prestenotic) duodenum (BD). VL = splenic vein.

gallbladder, U = uncinate process, VC = vena cava, AO =

 

 

aorta.

 

 

Fig. 4.44 Pancreas divisum, recurrent pancreatitis.

aLongitudinal ultrasound view demonstrating two pancreatic ducts (arrows). The ventral duct is seen to possess

anarrow communication with the main pancreatic duct (DP); the larger posterior duct is the accessory duct of Santorini. VC = vena cava.

b ERCP through the papilla of Vater, with visualization of the CBD and rudiments of the main pancreatic duct (see also 4.1 l).

Fig. 4.45 Annular pancreas.

a Pathology specimen (from Riede and Werner13).

d Hypotonic duodenogram: stenosis of the descending duodenum.

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Hyperechoic Lesion

 

 

 

Diffuse Pancreatic Change

Pancreas

Hypoechoic Lesion

 

 

 

Focal Changes

 

 

 

Anechoic Lesion

 

 

 

Isoechoic Lesion

 

 

 

Hyperechoic Lesion

 

 

 

Irregular (Complex Structured) Lesion

 

 

 

Dilatation of the Pancreatic Duct

 

 

 

Calcification/Intraductal Calculus

Calcified Splenic Artery

Microcalcification, Fat Necrosis

Intraductal Gas/Stent

Focal Fatty Infiltration

Calcification/Intraductal Calculus

The most striking, and in addition pathogno-

calculi)

and the branching ductules (“paren-

change of the wave velocity, from phase alter-

monic, criteria for chronic pancreatitis are cal-

chymal

calcification”). They appear

as inten-

ation or Doppler shifting, and may also be

cification and intraductal calculi. They consist

sively hyperechoic structures with

posterior

caused by mechanical pulses leading to mini-

of calcium carbonate precipitates and are lo-

shadowing; the “twinkling artifact” is used as

mal movements of the calculi (Figs. 4.46, 4.47;

cated in the main pancreatic duct (intraductal

a diagnostic sign. This probably results from a

see also Fig. 4.66b).

4

Focal Changes

Fig. 4. 46 Chronic calcifying pancreatitis. a Ductal stones.

Fig. 4.47a–c Chronic calcifying pancreatitis.

a Brightness picture: coarse diffuse echogenic structure with multiple posterior shadowing and summation shadowing. VL = splenic vein; AMS = superior mesenteric vein; AO = aorta.

b Multiple parenchymal calcification, partly with shadowing. WS = vertebral column, AO = aorta, AMS = superior mesenteric artery, VC = vena cava, VRS = left renal vein.

b Color Doppler “twinkling artifact” with confetti phenomenon. VP = portal vein; VC = vena cava.

c Calcifications, stones in the pancreatic duct, atrophy.

c Trans-splenic section. Calcification (arrows) in the tail of the pancreas, shadowing (S). MI = spleen.

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4

Pancreas

Fig. 4.48

a Echogenic calcified mottling (arrows): calcified splenic artery. VL = splenic vein; P = pancreas.

b Hyperechoic reflection with shadowing (S) overlapping the pancreas: calcified splenic artery.

Microcalcification, Fat Necrosis

Microcalcification can be found in chronic pancreatitis, in pancreatic cancer, and as sclerosis in arterial walls. Fat necrosis as part of acute pancreatitis will appear as focal echogenic peripancreatic mottling/bands (Figs. 4.6, 4.49, 4.50).

Fig. 4.49 Echogenic microcalcification with shadowing (S) in pancreatic cancer; cut-off of the pancreatic duct (DP).

Fig. 4.50 Microcalcification and macrocalcification (arrows, shadowing S) in advanced pancreatic cancer (T).

Intraductal Gas/Stent

After endoscopic intervention at the papilla or pancreatic duct, gas (after papillotomy) or stents in the pancreatic or intrapancreatic CBD may be evidenced as echogenic foreign

bodies within the duct (Figs. 4.51, 4.52, 4.53). Usually their differential diagnosis becomes self-evident from the patient’s history.

Fig. 4.51 Gas in the pancreatic duct in duodenal diverticulum: hyperechoic band.

Fig. 4.52 Echogenic stent in the pancreatic duct (arrow; DP). P = pancreas; VL = splenic vein; AO = aorta.

Fig. 4.53 Diffuse pancreatic cancer in the head/body of the pancreas (P) (calipers 20 mm); CBD stent (arrows) in place. AO = aorta.

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