- •ICU Protocols
- •Preface
- •Acknowledgments
- •Contents
- •Contributors
- •1: Airway Management
- •Suggested Reading
- •2: Acute Respiratory Failure
- •Suggested Reading
- •Suggested Reading
- •Website
- •4: Basic Mechanical Ventilation
- •Suggested Reading
- •Suggested Reading
- •Websites
- •Suggested Reading
- •Websites
- •7: Weaning
- •Suggested Reading
- •8: Massive Hemoptysis
- •Suggested Reading
- •9: Pulmonary Thromboembolism
- •Suggested Reading
- •Suggested Reading
- •Websites
- •11: Ventilator-Associated Pneumonia
- •Suggested Readings
- •12: Pleural Diseases
- •Suggested Reading
- •Websites
- •13: Sleep-Disordered Breathing
- •Suggested Reading
- •Websites
- •14: Oxygen Therapy
- •Suggested Reading
- •15: Pulse Oximetry and Capnography
- •Conclusion
- •Suggested Reading
- •Websites
- •16: Hemodynamic Monitoring
- •Suggested Reading
- •Websites
- •17: Echocardiography
- •Suggested Readings
- •Websites
- •Suggested Reading
- •Websites
- •19: Cardiorespiratory Arrest
- •Suggested Reading
- •Websites
- •20: Cardiogenic Shock
- •Suggested Reading
- •21: Acute Heart Failure
- •Suggested Reading
- •22: Cardiac Arrhythmias
- •Suggested Reading
- •Website
- •23: Acute Coronary Syndromes
- •Suggested Reading
- •Website
- •Suggested Reading
- •25: Aortic Dissection
- •Suggested Reading
- •26: Cerebrovascular Accident
- •Suggested Reading
- •Websites
- •27: Subarachnoid Hemorrhage
- •Suggested Reading
- •Websites
- •28: Status Epilepticus
- •Suggested Reading
- •29: Acute Flaccid Paralysis
- •Suggested Readings
- •30: Coma
- •Suggested Reading
- •Suggested Reading
- •Websites
- •32: Acute Febrile Encephalopathy
- •Suggested Reading
- •33: Sedation and Analgesia
- •Suggested Reading
- •Websites
- •34: Brain Death
- •Suggested Reading
- •Websites
- •35: Upper Gastrointestinal Bleeding
- •Suggested Reading
- •36: Lower Gastrointestinal Bleeding
- •Suggested Reading
- •37: Acute Diarrhea
- •Suggested Reading
- •38: Acute Abdominal Distension
- •Suggested Reading
- •39: Intra-abdominal Hypertension
- •Suggested Reading
- •Website
- •40: Acute Pancreatitis
- •Suggested Reading
- •Website
- •41: Acute Liver Failure
- •Suggested Reading
- •Suggested Reading
- •Websites
- •43: Nutrition Support
- •Suggested Reading
- •44: Acute Renal Failure
- •Suggested Reading
- •Websites
- •45: Renal Replacement Therapy
- •Suggested Reading
- •Website
- •46: Managing a Patient on Dialysis
- •Suggested Reading
- •Websites
- •47: Drug Dosing
- •Suggested Reading
- •Websites
- •48: General Measures of Infection Control
- •Suggested Reading
- •Websites
- •49: Antibiotic Stewardship
- •Suggested Reading
- •Website
- •50: Septic Shock
- •Suggested Reading
- •51: Severe Tropical Infections
- •Suggested Reading
- •Websites
- •52: New-Onset Fever
- •Suggested Reading
- •Websites
- •53: Fungal Infections
- •Suggested Reading
- •Suggested Reading
- •Website
- •55: Hyponatremia
- •Suggested Reading
- •56: Hypernatremia
- •Suggested Reading
- •57: Hypokalemia and Hyperkalemia
- •57.1 Hyperkalemia
- •Suggested Reading
- •Website
- •58: Arterial Blood Gases
- •Suggested Reading
- •Websites
- •59: Diabetic Emergencies
- •59.1 Hyperglycemic Emergencies
- •59.2 Hypoglycemia
- •Suggested Reading
- •60: Glycemic Control in the ICU
- •Suggested Reading
- •61: Transfusion Practices and Complications
- •Suggested Reading
- •Websites
- •Suggested Reading
- •Website
- •63: Onco-emergencies
- •63.1 Hypercalcemia
- •63.2 ECG Changes in Hypercalcemia
- •63.3 Superior Vena Cava Syndrome
- •63.4 Malignant Spinal Cord Compression
- •Suggested Reading
- •64: General Management of Trauma
- •Suggested Reading
- •65: Severe Head and Spinal Cord Injury
- •Suggested Reading
- •Websites
- •66: Torso Trauma
- •Suggested Reading
- •Websites
- •67: Burn Management
- •Suggested Reading
- •68: General Poisoning Management
- •Suggested Reading
- •69: Syndromic Approach to Poisoning
- •Suggested Reading
- •Websites
- •70: Drug Abuse
- •Suggested Reading
- •71: Snakebite
- •Suggested Reading
- •72: Heat Stroke and Hypothermia
- •72.1 Heat Stroke
- •72.2 Hypothermia
- •Suggested Reading
- •73: Jaundice in Pregnancy
- •Suggested Reading
- •Suggested Reading
- •75: Severe Preeclampsia
- •Suggested Reading
- •76: General Issues in Perioperative Care
- •Suggested Reading
- •Web Site
- •77.1 Cardiac Surgery
- •77.2 Thoracic Surgery
- •77.3 Neurosurgery
- •Suggested Reading
- •78: Initial Assessment and Resuscitation
- •Suggested Reading
- •79: Comprehensive ICU Care
- •Suggested Reading
- •Website
- •80: Quality Control
- •Suggested Reading
- •Websites
- •81: Ethical Principles in End-of-Life Care
- •Suggested Reading
- •82: ICU Organization and Training
- •Suggested Reading
- •Website
- •83: Transportation of Critically Ill Patients
- •83.1 Intrahospital Transport
- •83.2 Interhospital Transport
- •Suggested Reading
- •84: Scoring Systems
- •Suggested Reading
- •Websites
- •85: Mechanical Ventilation
- •Suggested Reading
- •86: Acute Severe Asthma
- •Suggested Reading
- •87: Status Epilepticus
- •Suggested Reading
- •88: Severe Sepsis and Septic Shock
- •Suggested Reading
- •89: Acute Intracranial Hypertension
- •Suggested Reading
- •90: Multiorgan Failure
- •90.1 Concurrent Management of Hepatic Dysfunction
- •Suggested Readings
- •91: Central Line Placement
- •Suggested Reading
- •92: Arterial Catheterization
- •Suggested Reading
- •93: Pulmonary Artery Catheterization
- •Suggested Reading
- •Website
- •Suggested Reading
- •95: Temporary Pacemaker Insertion
- •Suggested Reading
- •96: Percutaneous Tracheostomy
- •Suggested Reading
- •97: Thoracentesis
- •Suggested Reading
- •98: Chest Tube Placement
- •Suggested Reading
- •99: Pericardiocentesis
- •Suggested Reading
- •100: Lumbar Puncture
- •Suggested Reading
- •Website
- •101: Intra-aortic Balloon Pump
- •Suggested Reading
- •Appendices
- •Appendix A
- •Appendix B
- •Common ICU Formulae
- •Appendix C
- •Appendix D: Syllabus for ICU Training
- •Index
Aortic Dissection |
25 |
|
Shyam Sunder Tipparaju, Gopinath Ramachandran,
Ravinuthala Venkat Kumar, and Muppiri Vijay Kumar
A 57-year-old male patient with long-term, poorly controlled hypertension developed severe precordial chest pain, radiating to the back while gardening. The physical examination showed temperature 99°F, pulse 110/min, respiration 20/min, BP 200/100 mmHg (right arm) and 180/90 mmHg (left arm), decreased left brachial and radial pulses, and diastolic murmur along the left sternal border.
Aortic dissection is a relatively uncommon disorder as compared to other cardiac emergencies such as acute myocardial infarction (AMI) or congestive heart failure (CHF). It carries a high mortality of 1% every hour for initial 48 h, if not properly recognized and managed.
Step 1: Resuscitate urgently
•Emergent control of hypertension and maintaining organ perfusion is the priority in initial resuscitation (see Chap. 24).
Step 2: Assess urgently
•Time is of essence in managing aortic dissection, and a focused history and focused physical examination should be quickly performed to differentiate causes of acute chest pain (Tables 25.1 and 25.2).
S.S. Tipparaju, M.D., P.D.C.C. (*)
Critical Care, Continental Hospitals, Hyderabad, India e-mail: shyamsundert@rediffmail.com
G. Ramachandran, M.D., F.F.A.R.C.S.
Department of Anaesthesiology & Critical Care, Nizam Institute of Medical Sciences, Hyderabad, India
R.V. Kumar, M.S., M.Ch. • M.V. Kumar, M.S., M.Ch.
Department of Cardiothoracic Surgery, Nizam’s Institute of Medical Sciences, Hyderabad, India
R. Chawla and S. Todi (eds.), ICU Protocols: A stepwise approach, |
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DOI 10.1007/978-81-322-0535-7_25, © Springer India 2012 |
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S.S. Tipparaju et al. |
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Table 25.1 Causes of acute |
Acute coronary syndrome with and without ST elevation |
chest pain |
Acute aortic regurgitation without dissection |
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|
Aortic aneurysms without dissection |
|
Musculoskeletal pain |
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Pericarditis |
|
Mediastinal tumors |
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Pleuritis |
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Pulmonary embolism |
|
Cholecystitis |
Table 25.2 Clinical features of aortic dissection
Sudden severe chest pain radiating to back |
96% |
Syncope (cardiac tamponade or new stroke) |
13% |
Congestive cardiac failure (severe AR or |
7% |
tamponade) |
|
Cerebrovascular accident |
6% |
Ischemic peripheral neuropathy/paraplegia/ |
|
cardiac arrest/sudden death |
|
Hypertension |
70% of cases with type B dissections and |
|
36% with type A dissection |
Hypotension |
25% of cases with proximal dissections and |
|
4% with distal dissection |
Acute severe aortic regurgitation |
33% |
Pulse deficit |
30% of proximal dissection and 15% of |
|
distal dissection |
Neurological manifestations |
6–19% |
Acute MI |
1–2% |
Renal ischemia |
5–8% |
Mesenteric ischemia |
3–5% |
Diminished femoral pulses |
12% |
•An urgent 12-lead ECG should be performed to look for features of AMI.
•If aortic dissection is a possibility, antiplatelet, anticoagulant, and thrombolysis should be avoided.
•Chest X-ray—a routine chest radiograph is abnormal in 60% of cases with suspected aortic dissection; the commonest finding are widening of mediastinum and left-sided pleural effusion.
•D-dimer may be falsely elevated in some cases.
Step 3: Initiate treatment for suspected aortic dissection (Table 25.3)
•All patients suspected of having acute aortic syndrome should be admitted to the ICU for invasive monitoring and hemodynamic stabilization.
•Pain control with morphine should be started.
25 Aortic Dissection |
205 |
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Table 25.3 Antihypertensive and heart rate control therapy |
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Drug |
Dosing |
Remarks |
Labetalol |
20 mg IV over 2 min, then 40–80 mg every 15 min |
Alphaand beta-blocker |
|
until adequate response or excessive bradycardia, |
|
|
then continuous. IV infusion at 2–10 mg/min, |
|
|
(maximum daily IV dose is 300 mg) titrated |
|
|
to effect (maximum daily IV dose is 300 mg), |
|
|
may be switched to oral once stabilized |
|
Esmolol |
500 mcg/Kg IV bolus, then continuous infusion at |
Short half-life |
|
50–200 mcg/Kg/min |
|
|
Titrated to effect |
|
Sodium |
No bolus, continuous infusion titrated to effect, |
Use only in presence of |
nitroprusside |
0.3–0.5 mcg/Kg/min titrated to a maximum of |
rate-controlling agent |
|
10 mcg/Kg/min |
|
Enalapril |
0.625–1.25 mg IV, then increase every 6 h to a |
Ideal for renal artery |
|
maximum of 5 mg every 6 h |
dissection |
Diltiazem |
0.25 mg/Kg IV over 2 min, then continuous IV |
Use when beta-blocker is |
|
infusion at 5–15 mg/h |
contraindicated |
•An arterial line in the well-perfused hand should be inserted.
•Reduction of systolic blood pressure, decreasing heart rate, and diminution of the rate of rise of the left ventricular ejection time (dP/dT) are the goals of the primary medical treatment.
•Beta-blockers (labetalol and esmolol) as a group of drugs that have the most desirable effect in reducing the force of the left ventricular ejection (dP/dT). However, if beta-blockers alone do not control hypertension, vasodilators are ideal additional agents to control blood pressure. Because vasodilators alone can increase the left ventricular ejection, they should always be combined with beta-blockers.
•The goal of therapy is to manage the heart rate less than 70 beats/min and to keep blood pressure as low as possible without compromising organ perfusion.
•In patients with hypotension at presentation, possible volume depletion, which may be the result of blood sequestration in the false lumen, pleura, or pericardial space, has to be ruled out.
•Pericardiocentesis is usually avoided for cardiac tamponade secondary to dissection, as bleeding is recurrent. A definitive surgery is indicated in these cases.
Step 4: Perform confirmatory investigation for acute aortic dissection (Table 25.4)
•The diagnostic goal of imaging is to achieve the following:
–Confirm diagnosis.
–Classify the dissection/delineate the extent.
–Differentiate true and false lumen, localize intimal tears, and distinguish between communicating and noncommunicating dissection.
–Assess side branch involvement (including coronary arteries).
–Detect and grade aortic regurgitation.
–Detect extravasation (periaortic or mediastinal hematoma, pleural or pericardial effusion).
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Table 25.4 Diagnostic imaging |
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|
|
Modality |
Sensitivity (%) |
Specificity (%) |
Comments |
CT scan |
90–100 |
90–100 |
Quick, readily available, familiarity |
|
|
|
Shows pleural/pericardial spaces |
|
|
|
Shows head and neck vessels |
|
|
|
IV contrast may cause renal failure |
MRI |
98–100 |
98–100 |
Gold standard |
|
|
|
Detailed dynamic images |
|
|
|
Flow in true and false lumen |
|
|
|
Branched vessels |
|
|
|
Limitation is availability |
|
|
|
Time taken in emergency situation |
Echo |
|
|
|
Transthoracic |
60–80 |
86–90 |
Readily available and can be used in |
|
|
|
emergency situations |
Transesophageal |
90–99 |
85–98 |
Shows coronary ostia, AR, and |
|
|
|
pericardium |
|
|
|
LV function |
|
|
|
Contraindicated in esophageal and |
|
|
|
cervical pathology |
Aortography |
80–90 |
88–94 |
Shows true and false lumen perfusion |
|
|
|
Flap, coronaries, AR |
|
|
|
Invasive, can precipitate rupture |
|
|
|
Facilities and expertise not widely |
|
|
|
available |
Intravascular |
94–100 |
97–100 |
Used to complement information of |
ultrasound |
|
|
aortography |
|
|
|
Clearly differentiates dissection |
|
|
|
Intramural hematoma, and |
|
|
|
penetrating ulcer |
•Assess clinical stability (for transport), availability, and experience with the investigation before deciding on the confirmatory imaging modality.
•Because of good sensitivity and specificity, CT angiography and MRI angiography are considered current standards of evaluation.
•If the patient is hemodynamically unstable and cannot be shifted for imaging, transesophageal echocardiography can be done to confirm the diagnosis.
•Transthoracic echo has a low sensitivity and specificity especially for type B dissection.
•Coronary angiography—because the recent generation CT/MRI imaging modalities can demonstrate proximal third of coronary arteries, routine use of conventional coronary angiogram is not recommended.
Step 5: Understand types of aortic dissection and their outcome (Fig. 25.1)
•Aortic dissection refers to formation of a tear in aortic intima, directly exposing the blood to the diseased medial layer and splitting the aortic wall, producing true lumen and false lumen with driving force (pulse pressure).
25 Aortic Dissection |
207 |
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Fig. 25.1 Classification of aortic dissection
•The dissecting process extends antegradely but sometimes retrogradely from the site of intimal tear.
•For prognostic and therapeutic reasons, aortic dissections are classified into three major types, which share the basic principle whether the ascending aorta is involved (Fig. 25.1).
•Proximal dissection (involves ascending aorta) includes De Bakey type I and type II or Stanford type A.
•Distal dissection (spares ascending aorta) includes De Bakey type III or Stanford type B.
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•For prognostic reasons, dissection has also been classified as acute or chronic depending on duration (less or more than 2 weeks).
•Recent years have brought recognition of two important variants of aortic dissection.
–Intramural hematoma (IMH)
•Aortic IMH is considered as a precursor of dissection originating from ruptured vasa vasorum in the aortic medial wall layer and resulting in an aortic wall infarct that may provoke a secondary tear, causing a classic aortic dissection. Although clinical manifestations of IMH are similar to acute aortic dissection, IMH is an imaging diagnosis in an appropriate clinical setting. Treatment is similar to classic aortic dissection.
–Penetrating aortic ulcer
•Deep ulceration of atherosclerotic plaque can lead to IMH, aortic dissection, or perforation. In association with IMH, these ulcers are seen almost exclusively with type B dissection.
•At present, these three lesions—aortic dissection, IMH, and penetrating aortic ulcers—are called acute aortic syndromes.
•Acute aortic dissection of ascending aorta (De Bakey type I and type II, Stanford type A) is highly lethal, with a mortality rate of 1–2% every hour after the onset of symptoms. Without surgery, the mortality rate exceeds 50% after 1 month.
•Uncomplicated type B (De Bakey type III) aortic dissection has a 30-day mortality of 10% and may be managed medically.
•Intramural hematoma of ascending aorta has a prognosis similar to type A dissection.
Step 6: Definitive surgery
•Type I and II (A) dissections are managed primarily by surgery.
•Type III (B) is managed conservatively, and surgery is only indicated if complications such as organ hypoperfusion, refractory hypotension, refractory pain, or aortic rupture occur.
•There is increasingly use of percutaneous endovascular stent grafting in selected cases of distal dissection.
Step 7: Identify underlying risk factors for aortic dissection
•These include hypertension, hyperlipidemia, trauma, hereditary connective tissue disorders like Marfan’s syndrome, arteritis, and cocaine use.
Step 8: Long-term follow-up and treatment
•The cornerstone of medical therapy is with beta-blockers. Excellent blood pressure control, less than 120/80 mmHg, is paramount to prevent long-term complications. Close follow-up by a specialized team includes the assessment of signs of aortic expansion, aneurysm formation, signs of leakages at anastomoses/ stent sites, and malperfusion.