- •Preface to the 3rd edition
- •General Pharmacology
- •Systems Pharmacology
- •Therapy of Selected Diseases
- •Subject Index
- •Abbreviations
- •General Pharmacology
- •History of Pharmacology
- •Drug and Active Principle
- •The Aims of Isolating Active Principles
- •European Plants as Sources of Effective Medicines
- •Drug Development
- •Congeneric Drugs and Name Diversity
- •Oral Dosage Forms
- •Drug Administration by Inhalation
- •Dermatological Agents
- •From Application to Distribution in the Body
- •Potential Targets of Drug Action
- •External Barriers of the Body
- •Blood–Tissue Barriers
- •Membrane Permeation
- •Binding to Plasma Proteins
- •The Liver as an Excretory Organ
- •Biotransformation of Drugs
- •Drug Metabolism by Cytochrome P450
- •The Kidney as an Excretory Organ
- •Presystemic Elimination
- •Drug Concentration in the Body as a Function of Time—First Order (Exponential) Rate Processes
- •Time Course of Drug Concentration in Plasma
- •Time Course of Drug Plasma Levels during Repeated Dosing (A)
- •Time Course of Drug Plasma Levels during Irregular Intake (B)
- •Accumulation: Dose, Dose Interval, and Plasma Level Fluctuation (A)
- •Dose–Response Relationship
- •Concentration–Effect Curves (B)
- •Concentration–Binding Curves
- •Types of Binding Forces
- •Agonists—Antagonists
- •Other Forms of Antagonism
- •Enantioselectivity of Drug Action
- •Receptor Types
- •Undesirable Drug Effects, Side Effects
- •Drug Allergy
- •Cutaneous Reactions
- •Drug Toxicity in Pregnancy and Lactation
- •Pharmacogenetics
- •Placebo (A)
- •Systems Pharmacology
- •Sympathetic Nervous System
- •Structure of the Sympathetic Nervous System
- •Adrenergic Synapse
- •Adrenoceptor Subtypes and Catecholamine Actions
- •Smooth Muscle Effects
- •Cardiostimulation
- •Metabolic Effects
- •Structure–Activity Relationships of Sympathomimetics
- •Indirect Sympathomimetics
- •Types of
- •Antiadrenergics
- •Parasympathetic Nervous System
- •Cholinergic Synapse
- •Parasympathomimetics
- •Parasympatholytics
- •Actions of Nicotine
- •Localization of Nicotinic ACh Receptors
- •Effects of Nicotine on Body Function
- •Aids for Smoking Cessation
- •Consequences of Tobacco Smoking
- •Dopamine
- •Histamine Effects and Their Pharmacological Properties
- •Serotonin
- •Vasodilators—Overview
- •Organic Nitrates
- •Calcium Antagonists
- •ACE Inhibitors
- •Drugs Used to Influence Smooth Muscle Organs
- •Cardiac Drugs
- •Cardiac Glycosides
- •Antiarrhythmic Drugs
- •Drugs for the Treatment of Anemias
- •Iron Compounds
- •Prophylaxis and Therapy of Thromboses
- •Possibilities for Interference (B)
- •Heparin (A)
- •Hirudin and Derivatives (B)
- •Fibrinolytics
- •Intra-arterial Thrombus Formation (A)
- •Formation, Activation, and Aggregation of Platelets (B)
- •Inhibitors of Platelet Aggregation (A)
- •Presystemic Effect of ASA
- •Plasma Volume Expanders
- •Lipid-lowering Agents
- •Diuretics—An Overview
- •NaCl Reabsorption in the Kidney (A)
- •Aquaporins (AQP)
- •Osmotic Diuretics (B)
- •Diuretics of the Sulfonamide Type
- •Potassium-sparing Diuretics (A)
- •Vasopressin and Derivatives (B)
- •Drugs for Gastric and Duodenal Ulcers
- •Laxatives
- •Antidiarrheal Agents
- •Drugs Affecting Motor Function
- •Muscle Relaxants
- •Nondepolarizing Muscle Relaxants
- •Depolarizing Muscle Relaxants
- •Antiparkinsonian Drugs
- •Antiepileptics
- •Pain Mechanisms and Pathways
- •Eicosanoids
- •Antipyretic Analgesics
- •Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
- •Cyclooxygenase (COX) Inhibitors
- •Local Anesthetics
- •Opioid Analgesics—Morphine Type
- •General Anesthesia and General Anesthetic Drugs
- •Inhalational Anesthetics
- •Injectable Anesthetics
- •Sedatives, Hypnotics
- •Benzodiazepines
- •Pharmacokinetics of Benzodiazepines
- •Therapy of Depressive Illness
- •Mania
- •Therapy of Schizophrenia
- •Psychotomimetics (Psychedelics, Hallucinogens)
- •Hypothalamic and Hypophyseal Hormones
- •Thyroid Hormone Therapy
- •Glucocorticoid Therapy
- •Follicular Growth and Ovulation, Estrogen and Progestin Production
- •Oral Contraceptives
- •Antiestrogen and Antiprogestin Active Principles
- •Aromatase Inhibitors
- •Insulin Formulations
- •Treatment of Insulin-dependent Diabetes Mellitus
- •Treatment of Maturity-Onset (Type II) Diabetes Mellitus
- •Oral Antidiabetics
- •Drugs for Maintaining Calcium Homeostasis
- •Drugs for Treating Bacterial Infections
- •Inhibitors of Cell Wall Synthesis
- •Inhibitors of Tetrahydrofolate Synthesis
- •Inhibitors of DNA Function
- •Inhibitors of Protein Synthesis
- •Drugs for Treating Mycobacterial Infections
- •Drugs Used in the Treatment of Fungal Infections
- •Chemotherapy of Viral Infections
- •Drugs for the Treatment of AIDS
- •Drugs for Treating Endoparasitic and Ectoparasitic Infestations
- •Antimalarials
- •Other Tropical Diseases
- •Chemotherapy of Malignant Tumors
- •Targeting of Antineoplastic Drug Action (A)
- •Mechanisms of Resistance to Cytostatics (B)
- •Inhibition of Immune Responses
- •Antidotes and Treatment of Poisonings
- •Therapy of Selected Diseases
- •Hypertension
- •Angina Pectoris
- •Antianginal Drugs
- •Acute Coronary Syndrome— Myocardial Infarction
- •Congestive Heart Failure
- •Hypotension
- •Gout
- •Obesity—Sequelae and Therapeutic Approaches
- •Osteoporosis
- •Rheumatoid Arthritis
- •Migraine
- •Common Cold
- •Atopy and Antiallergic Therapy
- •Bronchial Asthma
- •Emesis
- •Alcohol Abuse
- •Local Treatment of Glaucoma
- •Further Reading
- •Further Reading
- •Picture Credits
- •Drug Indexes
Contents IX
II. Pharmacodynamic Therapy with Glucocorticoids (A) . . . . . . . . . . . 244 Androgens, Anabolic Steroids, Antiandrogens . . . . . . . . . . . . . . 248
Inhibitory Principles . . . . . . . . . . 248 Follicular Growth and Ovulation,
Estrogen and Progestin Production . . 250 Oral Contraceptives . . . . . . . . . . . 252 Antiestrogen and Antiprogestin
Active Principles . . . . . . . . . . . . . 254 Aromatase Inhibitors . . . . . . . . . . 256 Insulin Formulations . . . . . . . . . . . 258 Variations in Dosage Form . . . . . . 258 Variation in Amino Acid Sequence. . 258
Treatment of Insulin-dependent
Diabetes Mellitus. . . . . . . . . . . . . 260 Undesirable Effects . . . . . . . . . . 260
Treatment of Maturity-Onset
(Type II) Diabetes Mellitus. . . . . . . . 262 Oral Antidiabetics . . . . . . . . . . . . 264 Drugs for Maintaining Calcium
Homeostasis . . . . . . . . . . . . . . . 266
Antibacterial Drugs . . . . . . . . . . . 268
Drugs for Treating Bacterial
Infections . . . . . . . . . . . . . . . . . 268 Inhibitors of Cell Wall Synthesis . . . . 270 Inhibitors of Tetrahydrofolate
Synthesis . . . . . . . . . . . . . . . . . 274 Inhibitors of DNA Function . . . . . . . 276 Inhibitors of Protein Synthesis . . . . . 278 Drugs for Treating Mycobacterial
Infections . . . . . . . . . . . . . . . . . 282 Antitubercular drugs (1) . . . . . . . 282 Antileprotic drugs (2) . . . . . . . . . 282
Antifungal Drugs . . . . . . . . . . . . |
284 |
Drugs Used in the Treatment of
Fungal Infections . . . . . . . . . . . . . 284
Antiviral Drugs . . . . . . . . . . . . . . 286
Chemotherapy of Viral Infections. . . . 286 Drugs for the Treatment of AIDS . . . . 290
I. Inhibitors of Reverse Transcriptase—Nucleoside Agents . . 290 Nonnucleoside Inhibitors . . . . . . . 290 II. HIV protease Inhibitors . . . . . . . 290 III. Fusion Inhibitors . . . . . . . . . . 290
Antiparasitic Drugs . . . . . . . . . . . 292
Drugs for Treating Endoparasitic
and Ectoparasitic Infestations . . . . . . 292 Antimalarials . . . . . . . . . . . . . . . 294 Other Tropical Diseases . . . . . . . . . 296
Anticancer Drugs . . . . . . . . . . . . |
298 |
Chemotherapy of Malignant
Tumors . . . . . . . . . . . . . . . . . . 298 Targeting of Antineoplastic Drug
Action (A) . . . . . . . . . . . . . . . . . 302 Mechanisms of Resistance to
Cytostatics (B) . . . . . . . . . . . . . . 302
Immune Modulators . . . . . . . . . . 304
Inhibition of Immune Responses . . . . 304
Antidotes . . . . . . . . . . . . . . . . . 308
Antidotes and Treatment of
Poisonings. . . . . . . . . . . . . . . . . 308
Therapy of Selected Diseases |
|
313 |
|
Hypertension . . . . . . . . . . . . . . . |
314 |
Osteoporosis . . . . . . . . . . . . . . |
. 330 |
Angina Pectoris . . . . . . . . . . . . . |
316 |
Rheumatoid Arthritis. . . . . . . . . . . |
332 |
Antianginal Drugs . . . . . . . . . . . . |
318 |
Migraine . . . . . . . . . . . . . . . . . . |
334 |
Acute Coronary Syndrome— |
|
Common Cold . . . . . . . . . . . . . . |
336 |
Myocardial Infarction . . . . . . . . . . |
320 |
Atopy and Antiallergic Therapy . . . . . |
338 |
Congestive Heart Failure . . . . . . . . |
322 |
Bronchial Asthma. . . . . . . . . . . . . |
340 |
Hypotension . . . . . . . . . . . . . . . |
324 |
Emesis . . . . . . . . . . . . . . . . . . . |
342 |
Gout. . . . . . . . . . . . . . . . . . . . |
326 |
Alcohol Abuse. . . . . . . . . . . . . . . |
344 |
Obesity—Sequelae and |
|
Local Treatment of Glaucoma . . . . . . |
346 |
Therapeutic Approaches. . . . . . . . . |
328 |
|
|
X |
Contents |
|
|
Further Reading |
|
349 |
|
Drug Indexes |
|
351 |
|
Trade Name – Drug Name . . . . . . . |
352 Drug Name – Trade Name. . . . . . . |
. 369 |
|
Subject Index |
|
381 |