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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5442_Библиотеки_им_академика_М_И_Перельмана.pdf
TABLE 8.1 In vitro antimalarial activity of the main West African plants studied.
Plant family Botanical name Used part Type of extract
Plasmodium
strain
IC50*
(μg/mL)
Selectivity
indexy References
Annonaceae Enantia polycarpa Stem bark Ethanol 90% K1 0.126 616
Kamanzi Atindehou, Schmid,
Brun, Kone
´
, and Traore (2004)
Monanthotaxis
caffra
Leaves and
twigs
Ethanol 70% FcB1 5.86 15.12 Laryea and Borquaye (2019)
W2 18.94 4.68
CAM06 18.54 4.78
Polyalthia
longifolia
Leaves Aqueous NF54 24.00 .4.17
Kwansa-Bentum, Agyeman,
Larbi-Akor, Anyigba, and
Appiah-Opong (2019)
Ethanol 70% 22.46 . 4.45
Ethyl acetate 9.50 .10.53
Apocynaceae Funtumia elastic Stem bark Ethanol FcB1 3.3 Nd
Zirihi, Mambu, Gue
´
de
´
-Guina,
Bodo, and Grellier (2005)
Rauvolfia
vomitoria
Root bark Ethanol FcB1 2.5 .100 Zirihi et al. (2005)
Amaranthaceae Gomphrena
celosioides
Aerial parts Methylene chloride 3D7 14.41 Nd Weniger et al. (2004)
Methanol K1 6.83 Nd
Arecaceae Borassus
aethiopum
Roots Dichloromethane FCR3 25 Nd
Gruca et al. (2015)
Cocos nucifera Husk fibers Ethyl acetate W2 10.94 30.3 Adebayo et al. (2013)
Asteraceae Acanthospermum
hispidum
Whole plant Aqueous Dd2 3.70 Nd Adukpo et al. (2020)
3D7 3.66 Nd
Aerial parts Dichloromethane 3D7 7.5 4.7
Bero et al. (2009)
W2 4.8 4.7
Bidens pilosa Leaves and
twigs
Ethanol 70% FcB1 23.48 4.34
Laryea and Borquaye (2019)
W2 4.60 22.17
CAM06 21.43 4.76
Dicoma tomentosa Whole plant Dichloromethane 3D7 3.4 3.3
Jansen et al. (2012)
W2 1.9 6.1
Diethyl ether 3D7 3.9 1.6
W2 4.8 1.3
Ethyl acetate 3D7 4.4 1.3
W2 4.6 1.3
Methanol 3D7 5.8 3.5
W2 3 6.7
Erigeron
floribundus
Leaves Pentane Nigerian
patient isolate
6Nd
Me
´
nan et al. (2006)
FcM29 4 4.6
Launaea
taraxacifolia
Leaves Chloroform D6 21 .2.1
Bello et al. (2017)
W2 18 . 2.6
(Continued)
TABLE 8.1 (Continued)
Plant family Botanical name Used part Type of extract
Plasmodium
strain
IC50*
(μg/mL)
Selectivity
indexy References
Cochlospermaceae Cochlospermum
planchonii
Rhizome
and leaves
Dichlorome
´
thane 3D7 2.4 Nd
Lamien-Meda et al. (2015)
Ethyl acetate 3D7 11.5 Nd
Roots Methylene chloride K1 4.4 15
Vonthron-Se
´
ne
´
cheau et al.
(2003)
Cochlospermum
tinctorium
Roots Ethanol 3D7 2.3 Nd Togola, Diallo, Dembe
´
le
´
,
Barsett, and Paulsen (2005)
Dd2 3.8 Nd
Combretaceae Anogeissus
leiocarpus
Leaves Methylene chloride K1 3.8 19
Vonthron-Se
´
ne
´
cheau et al.
(2003)
Methanol FcB1 6.3 Nd Okpekon et al. (2004)
Methylene chloride FcB1 9.3 Nd
Roots Methanol FcB1 2.6 Nd
Methylene chloride FcB1 2.6 Nd
Bark Methanol FcB1 4.8 Nd
Methylene chloride FcB1 19.5 Nd
Combretum
collinum
Leaves Dichloromethane K1 4 6.5
Ouattara et al. (2014)
Total alkaloids K1 4 9
Combretum
fragrans
Leaves Dichloromethane K1 5 9
Methanol K1 9 4.6
MeOH/H
2
O (1/1) K1 12 .4.2
Aqueous K1 11 1.7
Total alkaloids K1 3 .8.3
Combretum
micranthum
Leaves Aqueous W2 0.8 Nd
Benoit et al. (1996)
Terminalia albida Stem bark Aqueous K1 1.5 Nd Camara et al. (2019)
Terminalia
macroptera
Leaves Ethanol 90% FcB1 1.2 Nd Haidara et al. (2018)
Roots FcB1 1.6 Nd
Root bark Aqueous W2 1 Nd
Sanon et al. (2003)
Terminalia
ivorensis
Leaves Aqueous 3D7 0.64 9.77 Komlaga et al. (2016)
W2 10.52 0.5
Petroleum ether 3D7 14.8 .14
Ethyl acetate 3D7 16 6
Terminalia
avicennioides
Leaves Methanol K1 6.5 1.9
Ouattara et al. (2014)
MeOH/H
2
O (1/1) K1 3.5 9.3
Ethyl acetate K1 7 3
Terminalia
glaucescens
Stem, leaves Aqueous FcM29 2.34 Nd
Mustofa et al. (2000)
FcB1 4.21 Nd
Nigerian
patient isolate
2.36 Nd
Ethanol FcM29 0.41 Nd
FcB1 0.50 Nd
(Continued)
TABLE 8.1 (Continued)
Plant family Botanical name Used part Type of extract
Plasmodium
strain
IC50*
(μg/mL)
Selectivity
indexy References
Nigerian
patient isolate
0.55 Nd
Pentane FcM29 4.60 Nd
FcB1 8.08 Nd
Nigerian
patient isolate
26.8 Nd
Bark Methanol FcB1 2 Nd
Okpekon et al. (2004)
Methylene chloride FcB1 1.8 Nd
Terminalia
schimperiana
Young
Leaves
Ethanol 90% K1 2.4 33
Kamanzi Atindehou et al.
(2004)
Cucurbitaceae Momordica
balsamina
Nd Heptane 1 EtOAc F32 4 Nd Benoit-Vical et al. (2006)
FcM29 3 Nd
Euphorbiaceae Acalypha
wilkesiana
Leaves Methanol 70% 3D7 ,0.39 .100
Amlabu et al. (2018)
Alchornea
cordifolia
Stem, leaves Aqueous FcM29 3.51 Nd Valentin et al. (2000)
FcBI 4.01 Nd
Nigerian
patient isolate
2.47 Nd
Ethanol FcM30 3.20 Nd
FcBI 3.95 Nd
Nigerian
patient isolate
2.90 Nd
Chrozophora
senegalensis
Leaves Aqueous FcM29 1.85 8 Garcia-Alvarez et al. (2013)
FcB1 1.9
F32 0.8
W2 0.33
Croton lobatus Roots Methylene chloride 3D7 4.42 Nd
Weniger et al. (2004)
K1 2.80 Nd
Methanol 3D7 6.56 Nd
K1 4.91 Nd
Aerial parts Methylene chloride 3D7 3.74 Nd
K1 3.64 Nd
Methanol 3D7 0.38 Nd
K1 .20 Nd
Croton
penduliflorus
Leaves and
twigs
Ethanol 70% FCB 5.37 50.65
Laryea and Borquaye (2019)
W2 14.03 19.39
CAM06 14.66 18.55
Phyllanthus
fraternus
Whole plant Aqueous 3D7 4.07 7.64
Komlaga et al. (2016)
Methanol 3D7 0.44 410
Sebastiana
chamaelea
Whole plant Aqueous FcM29 6.6 7.5
Garcia-Alvarez et al. (2013)
FcB1 10
F32 14
W2 12
(Continued)
TABLE 8.1 (Continued)
Plant family Botanical name Used part Type of extract
Plasmodium
strain
IC50*
(μg/mL)
Selectivity
indexy References
Fabaceae Cassia alata Leaves Dichloromethane/
methane (1:1)
D10 7.02 Nd
Da et al. (2016)
Erythrina
senegalensis
Stem bark Ethanol 90% K1 1.8 Nd Kamanzi Atindehou et al.
(2004)
Mezoneuron
benthamianum
Leaves Ethanol 70%
(Precipitate)
3D7 6.4 Nd Jansen et al. (2017)
Pterocarpus
erinaceus
Leaves Ethanol 70% Patient isolate 14.63 Nd Karou, Dicko, Sanon,
Simpore, and Traore (2003)
Ether 7.38 Nd
Chloroform 1.93 Nd
Pericopsis laxiflora Bark Methanol NF54 11.5 Nd
Koffi, Silue
´
, Tano, Dable, and
Yavo (2020)
K1 7.4 Nd
Senna siamea Roots Aqueous Dd2 4.47 Nd
Adukpo et al. (2020)
3D7 3.95 Nd
Tetrapleura
tetraptera
Bark Dichloromethane 3D7 13.0 6.15
Lekana-Douki et al. (2011)
FcB1 10.1 7.91
Hypericaceae Harungana
madagascariensis
Bark Aqueous NF54 6.16 Nd
Koffi et al. (2020)
K1 7.3 Nd
Ethanol NF54 20.3 Nd
K1 22.2 Nd
Methanol NF54 23.9 Nd
K1 22.8 Nd
Lamiaceae Tectona grandis Leaves Aqueous 3D7 7.18 .13.93 Komlaga et al. (2016)
Petroleum ether 3D7 4.48 41
Ethyl acetate 3D7 14.15 12
Methanol 3D7 0.92 .217
Loganiaceae Anthocleista
djalonensis
Stem bark Ethanol 70% ANKTC023 9.94 Nd
Attemene et al. (2018)
ANKTC024 10 Nd
ANKTC024 9.69 Nd
ANKTC024 5.36 Nd
K1 15.94 Nd
Strychnos spinosa Leaves Dichloromethane 3D7 15.6 .6.4
Bero et al. (2009)
W2 8.9 .6.4
Malvaceae Clappertonia
ficifolia
Leaves Ethanol 70% FcB1 4.43 61.7
Laryea and Borquaye (2019)
W2 7.94 34.4
CAM06 6.56 41.7
Sida acuta whole plant Ethanol 70% Patient isolate 4.37 Nd
Karou et al. (2003)
Chloroform 0.87 Nd
Aqueous 0.92 Nd
Maranthaceae Thalia geniculata Roots Methylene chloride K1 14.33 Nd
Weniger et al. (2004)
Methanol 3D7 2.83 Nd
K1 6.38 Nd
(Continued)
TABLE 8.1 (Continued)
Plant family Botanical name Used part Type of extract
Plasmodium
strain
IC50*
(μg/mL)
Selectivity
indexy References
Meliaceae Azadirachta indica Leaves Ethanol D6 2.5 Nd
MacKinnon et al. (1997)
W2 2.48 Nd
Cedrela odorata Wood Ethanol D6 9.29 Nd
MacKinnon et al. (1997)
W2 2.77 Nd
Trichilia emetica Root bark Ethanol 90% K1 3.91 2.14
Kamanzi Atindehou et al.
(2004)
; Togola et al. (2005)
Leaves Methanol Dd2 2.5 3.34
Trichilia
monadelpha
Stem bark Ethanol 90% K1 3.6 Nd
Kamanzi Atindehou et al.
(2004)
Mimosaceae Schrankia
leptocarpa
Aerial parts Methylene chloride 3D7 16.58 Nd Weniger et al. (2004)
K1 3.38 Nd
Methanol 3D7 8.00 Nd
Cylicodiscus
gabunensis
Bark Ethanol 70% Dd2 20.8 2.9
Aldulaimi et al. (2017)
Ethanol/n-butanol 10.4 4.8
Moraceae Ficus thonningii Leaves Methanol NF54 5.3 . 3.8
Falade et al. (2014)
K1 21.1
Hexane NF54 2.7 .7.4
K1 10.4
Ethyl acetate NF54 5.3 . 3.8
K1 15.3
Myrtaceae Syzygium
guineense
Leaves Ethanol 70% FcB1 14.9 77.9 Laryea and Borquaye (2019)
W2 4.6 5.21
CAM06 5.5 16.9
Ochnaceae Lophira alata Leaves Methanol NF54 11.3 .1.7
Falade et al. (2014)
K1 5.3
Hexane NF54 2.5 .8.0
K1 2.5
Ethyl acetate NF54 9.7 . 2.0
Oleaceae Ximenia americana Nd Aqueous F32 0.62.6 Nd
Benoit et al. (1996)
FcB1 1.051.83 Nd
Oxalidaceae Biophytum
umbraculum
Aerial parts Dichloromethane K1 7.4 . 13.6
Austarheim et al. (2016)
Ethyl acetate NF54 6.7 19.1
K1 5.6
Papilionaceae Afrormosia
laxiflora
Leaves Methylene chloride FcB1 14.5 Nd
Okpekon et al. (2004)
Roots Methanol FcB1 7.5 Nd
Methylene chloride FcB1 1.5 Nd
Phyllanthaceae Phyllanthus niruri Whole plant Aqueous Dd2 5.7 Nd
Adukpo et al. (2020)
3D7 5.5 Nd
Piperaceae Pothomorphe
umbellata
Leaves Ethanol 90% K1 3.7 Nd
Kamanzi Atindehou et al.
(2004)
(Continued)