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Polyphenols
Polyphenols
Food, Nutraceutical, and Nanotherapeutic Applications
Edited by
Mithun Rudrapal
Department of Pharmaceutical Sciences
School of Biotechnology and Pharmaceutical Sciences
Vignan's Foundation for Science, Technology & Research
Guntur, India
Copyright © 2024 by John Wiley & Sons, Inc. All rights reserved.
Published by John Wiley & Sons, Inc., Hoboken, New Jersey.
Published simultaneously in Canada.
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Library of Congress Cataloging-in-Publication Data
Names: Rudrapal, Mithun, editor.
Title: Polyphenols: food, nutraceutical, and nanotherapeutic applications / edited by Mithun Rudrapal, Department
of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan’s Foundation for
Science, Technology & Research, Guntur, India.
Description: Hoboken, New Jersey : John Wiley & Sons, [2024] | Includes bibliographical references and index.
Identifiers: LCCN 2023026387 (print) | LCCN 2023026388 (ebook) | ISBN 9781394188833 (hardback) |
ISBN 9781394188857 (epdf) | ISBN 9781394188840 (epub) | ISBN 9781394188864 (ebook)
Subjects: LCSH: Polyphenols. | Polyphenols--Physiological effect. | Polyphenols--Therapeutic use. |
Functional foods.
Classification: LCC QP671.F52 P658 2024 (print) | LCC QP671.F52 (ebook) | DDC 572/.2--dc23/eng/20230621
LC record available at https://lccn.loc.gov/2023026387
LC ebook record available at https://lccn.loc.gov/2023026388
Cover Image: © altmodern/Getty Images
Cover Design: Wiley
Set in 9.5/12.5pt STIXTwoText by Integra Software Services Pvt. Ltd, Pondicherry, India
v
Contents
List of Contributors vii
Preface
xiii
1 Food Polyphenols: Antioxidant Properties and Health Benefits 1
Pruthvi G.R, Apoorva M.R., Anuthilakesh T., Bhargavi K., Nithish G.S., and Raghu Ram Achar
2 Plant Polyphenols as Nutraceuticals and Their Antioxidant Potentials
21
Neelesh Kumar Nema, Nayana Rajan, Merin Babu, Sachithra Sabu, Swapnil Devidas
Khamborkar, Smitha Sarojam, Linson Cheruveettil Sajan, Aneena Peter, Baby
Kumaranthara Chacko, and Viju Jacob
3 Polyphenols: Plant-based Nutraceuticals in Human Health
45
Monalisa Kesh and Sachin Goel
4 Nanotechnological Approach in Nutraceuticals
67
Manohar M.V., Amogha G. Paladhi, Sugumari Vallinayagam, and Mithun Rudrapal
5 Polyphenols: Nutraceutical and Nanotherapeutic Approaches
82
Mustansir Bhori, Ameyota De, Shreya Das, Aayushi Kadam, Jyotirmoi Aich, and
Kanchanlata Tungare
6 Polyphenols in Food Products – Nutraceutical Applications
105
André M. Oliveira and Mithun Rudrapal
7 Functionalization of Food Polyphenols for Nanodeliveries
134
Koyel Kar
8 Nanodeliveries of Food Polyphenols as Nutraceuticals
155
Santwana Palai and Mithun Rudrapal
9 Polyphenol Rich Extracts from Spices and Nanodelivery Systems
176
Neelesh Kumar Nema, Baby Kumaranthara Chacko, and Viju Jacob
https://t.me/medicina_free
Contents
vi
10 Nanodelivery of Polyphenols as Nutraceuticals in Anticancer Interventions 188
Kamoru A. Adedokun, Sikiru O. Imodoye, Zwanden S.Yahaya, Ifeoluwa T. Oyeyemi,
Ibrahim O. Bello, Mujidat T. Adeyemo-Imodoye, Malik A. Sanusi, and Ramat
T.Kamorudeen
11 Nanodelivery of Polyphenols as Nutraceuticals for CNS Disorders
225
Puneet K. Samaiya, Rakesh Sagar, Sharad P. Pandey, Gourav Jain, and Abhishek K. Sah
12 Nanodelivery of Polyphenols as Nutraceuticals for Neurological Disorders
248
Arpita Paul, Madhusmita Gogoi, and Kamaruz Zaman
13 Addressing Antimicrobial Resistance by Repurposing Polyphenolic Phytochemicals
with Novel Antibacterial Potential
260
Mithun Rudrapal, Biswatrish Sarkar, Prashanta Kumar Deb, Atul R. Bendale, and
Akhil Nagar
14 Toxicity of Polyphenols Consumed as Food and Nutraceuticals: Remedies through
Nanotherapeutic Approaches
290
Anyanwu O. Gabriel and Ogah F. Chinenye
15 Nanodelivery of Food Polyphenols for Nutraceutical Applications
312
Aamena Yusuf, Tanisha Ambawat, Sneha Dokhale, Shine Devarajan, and Samiksha Garse
16 Polyphenols in Food Products and Nutraceuticals: Bioavailability and
Pharmacokinetic Issues
343
Priaunsh Dutt, Yashika Shadija, Sneha Dokhale, Sweta Das, Shine Devarajan, and
Samiksha Garse
Index 361
https://t.me/medicina_free
vii
List of Contributors
Raghu Ram Achar
Division of Biochemistry, School of Life Sciences
JSS Academy of Higher Education and Research
Mysuru
Karnataka
India
Kamoru A. Adedokun
Roswell Park Comprehensive Cancer Center
University at Buffalo
Buffalo
NY
USA
Mujidat T. Adeyemo-Imodoye
Department of Medical Laboratory Science
Somolu General Hospital
Lagos Health Service Commission
Lagos State
Nigeria
Jyotirmoi Aich
School of Biotechnology and Bioinformatics
D Y Patil Deemed to be University
Navi Mumbai
Maharashtra
India
Tanisha Ambawat
School of Biotechnology and Bioinformatics
D Y Patil Deemed to be University
Navi Mumbai
Maharashtra, India
Anuthilakesh T.
Division of Biochemistry, School of Life Sciences
JSS Academy of Higher Education and Research
Mysuru
Karnataka
India
Anyanwu O. Gabriel
Department of Biochemistry
Bingham University
Karu
Nasarawa
Nigeria
Apoorva M.R.
Division of Biochemistry, School of Life Sciences
JSS Academy of Higher Education and
Research
Mysuru
Karnataka
India
Merin Babu
Synthite Industries Pvt. Ltd.
Synthite Valley
Kadayiruppu
Kerala
India
Ibrahim O. Bello
Department of Biological Sciences
Southern Illinois University Edwardsville
Edwardsville
IL
USA
https://t.me/medicina_free
List of Contributors
viii
Atul R. Bendale
Mahavir Institute of Pharmacy
Nashik
Maharashtra
India
Bhargavi K.
Division of Biochemistry, School of Life Sciences
JSS Academy of Higher Education, and
Research
Mysuru
Karnataka
India
Mustansir Bhori
School of Biotechnology and Bioinformatics
D Y Patil Deemed to be University
Navi Mumbai
Maharashtra
India
Baby Kumaranthara Chacko
C.V.J. Creative Centre
Bio Ingredients, Synthite Industries Pvt. Ltd.
Synthite Valley
Kadayiruppu
Kerala
India
Shreya Das
School of Biotechnology and Bioinformatics
D Y Patil Deemed to be University
Navi Mumbai
Maharashtra
India
Sweta Das
B. K. Birla College
Birla College Campus Rd
Kalyan
Maharashtra
India
Ameyota De
School of Biotechnology and Bioinformatics
D Y Patil Deemed to be University
Navi Mumbai
Maharashtra
India
Prashanta Kumar Deb
Department of Pharmaceutical Sciences and
Technology
Birla Institute of Technology
Ranchi
Jharkhand
India
Shine Devarajan
School of Biotechnology and Bioinformatics
D Y Patil Deemed to be University
Belapur
Navi Mumbai
Maharashtra
India
Sneha Dokhale
B. K. Birla College
Birla College Campus Rd
Kalyan
Maharashtra
India
Priaunsh Dutt
School of Biotechnology and
Bioinformatics
D Y Patil Deemed to be University
Navi Mumbai
Maharashtra
India
Samiksha Garse
School of Biotechnology and
Bioinformatics
D Y Patil Deemed to be University
Navi Mumbai
Maharashtra, India
Sachin Goel
Department of Biological Sciences and
Engineering
Netaji Subhas University of Technology
New Delhi
India
https://t.me/medicina_free
List of Contributors ix
Madhusmita Gogoi
Department of Pharmaceutical Sciences
Faculty of Science and Engineering
Dibrugarh University
Dibrugarh
Assam
India
Sikiru O. Imodoye
Huntsman Cancer Institute
University of Utah
Salt Lake City
UT
USA
Viju Jacob
Nutraceuticals Division, Bio Ingredients
Synthite Industries Pvt. Ltd.
Synthite Valley
Kadayiruppu
Ernakulam
Kerala
India
C.V.J. Creative Centre
Bio Ingredients, Synthite Industries Pvt. Ltd.
Synthite Valley
Kadayiruppu
Kerala
India
Gourav Jain
Department of Pharmacy
Shri Govindram Seksariya Institute of
Technology & Science (SGSITS)
Indore
Madhya Pradesh
India
Aayushi Kadam
Department of Food and Human Nutritional
Sciences
University of Manitoba
Canada
Ramut T. Kamorudeen
Department of Public Health
University of South
Wales, Pontypridd
UK
Koyel Kar
Department of Pharmaceutical Chemistry
BCDA College of Pharmacy & Technology
Hridaypur
West Bengal
India
Monalisa Kesh
Amity Institute of Biotechnology
Amity University Uttar Pradesh
Noida
India
Swapnil Devidas Khamborkar
Synthite Industries Pvt. Ltd.
Synthite Valley
Kadayiruppu
Kerala
India
Manohar M.V.
Centre of excellence in Molecular Biology &
Regenerative Medicine
Department of Biochemistry
JSS Medical College, JSS-AHER
Mysuru
Karnataka, India
Akhil Nagar
Department of Pharmaceutical Chemistry
R. C. Patel Institute of Pharmaceutical
Education and Research
Shirpur
Maharashtra
India
Neelesh Kumar Nema
Nutraceuticals Division
Bio Ingredients, Synthite Industries Pvt. Ltd.
Synthite Valley
Kadayiruppu
Ernakulam
Kerala
India
https://t.me/medicina_free
List of Contributors
x
Nithish G.S.
Indian Institute of Science Education and
Research Tirupati
C/O Sree Rama Engineering College (Transit
Campus Mangalam)
Tirupati
Andhra Pradesh
India
Ogah F. Chinenye
Department of Biochemistry
Bingham University
Karu
Nigeria
André M. Oliveira
Federal Centre of Technological Education of
Minas Gerais (CEFET-MG)
Alameda das Perdizes
Contagem
MG
Brazil
Ifeoluwa T. Oyeyemi
Department of Biosciences and Biotechnology
University of Medical Sciences
Ondo
Nigeria
Department of Chemistry and Biochemistry
Old Dominion University
Hampton Boulevard
Norfolk
VA
USA
Amogha G. Paladhi
Department of Botany
CHRIST (Deemed to be) University
Bengaluru
Karnataka
India
Santwana Palai
Department of Veterinary Pharmacology &
Toxicology
College of Veterinary Science and Animal
Husbandry
Odisha University of Agriculture & Technology
Bhubaneswar
Odisha
India
Sharad P. Pandey
Department of Pharmacy
Shri Govindram Seksariya Institute of
Technology & Science (SGSITS)
Indore
Madhya Pradesh
India
Arpita Paul
Department of Pharmaceutical Sciences
Faculty of Science and Engineering
Dibrugarh University
Dibrugarh
Assam
India
Aneena Peter
Synthite Industries Pvt. Ltd.
Synthite Valley
Kadayiruppu
Kerala
India
Pruthvi G.R.
Division of Biochemistry
School of Life Sciences
JSS Academy of Higher Education and Research
Mysuru
Karnataka
India
https://t.me/medicina_free
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