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Wasim Akram
Neeraj Mishra
Tanweer Haider Editors
Inulin
for Pharmaceutical
Applications
A Versatile Biopolymer
Inulin for Pharmaceutical Applications
Wasim Akram • Neeraj Mishra •
Tanweer Haider
Editors
Inulin for Pharmaceutical
Applications
A Versatile Biopolymer
Editors
Wasim Akram
Department of Pharmaceutics
Amity Institute of Pharmacy, Amity
University Madhya Pradesh
Gwalior, Madhya Pradesh, India
Tanweer Haider
Gyan Vihar School of Pharmacy
Suresh Gyan Vihar University
Jagatpura, Jaipur, Rajasthan, India
Neeraj Mishra
Department of Pharmaceutics
Amity Institute of Pharmacy, Amity
University
Gwalior, Madhya Pradesh, India
ISBN 978-981-97-9055-5 ISBN 978-981-97-9056-2 (eBook)
https://doi.org/10.1007/978-981-97-9056-2
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore
Pte Ltd. 2025
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether
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v
Preface
Inulin is a versatile biopolymer for Pharmaceutical Applications and is a compre-
hensive guide for scientists, researchers, and pharmaceutical professionals inter-
ested in understanding the various applications of inulin in the pharmaceutical
industry. This book explores the different uses of inulin in pharmaceutical formula-
tions, its potential therapeutic benets, and the regulatory considerations involved
in developing inulin-based pharmaceutical products.
The book is divided into several chapters, each concentrating on a specic aspect
of inulin in pharmaceutical applications. The initial chapters introduce inulin, its
properties, and its use in the pharmaceutical industry. It covers inulin’s physical and
chemical properties and their applications in drug delivery, controlled release sys-
tems, and biocompatible materials.
The subsequent chapters explore the use of inulin in different therapeutic appli-
cations, comprising its potential to manage metabolic disorders, gastrointestinal
disorders, immune function, bone health, and brain health. Each chapter covers the
current research on the therapeutic potential of inulin, the mechanisms of action,
and the potential for future therapies.
Another important chapter in the book is the regulatory aspect of inulin-based
pharmaceutical products. This chapter explores an overview of the regulatory agen-
cies responsible for the approval of pharmaceutical products, the guidelines for
developing inulin-based pharmaceutical products, and the quality control and qual-
ity assurance of inulin-based pharmaceutical products.
The book aims to provide a complete understanding of the various applications
of inulin in the pharmaceutical industry, from drug delivery to therapeutic effects. It
is relevant and signicant for pharmaceutical professionals who are looking to
develop new drugs, better drug delivery systems, and improve the efcacy and
safety of pharmaceutical products.
The book is also relevant to researchers and scientists working on inulin-based
treatments and formulations. It provides a wealth of information on the current
research on inulin and its therapeutic potential, and the regulatory considerations
involved in developing and marketing inulin-based pharmaceutical products.
Overall, Inulin: A Versatile Biopolymer for Pharmaceutical Applications sets out
to solve the problem of the need for more comprehensive information on the differ-
ent uses of inulin in the pharmaceutical world. The book thoroughly explores the
vi
various applications of inulin, its therapeutic potential, and the regulatory consider-
ations involved in developing inulin-based pharmaceutical products.
We would also like to express our sincere gratitude to Honorable Founder-
President Dr. Ashok K Chauhan, Ritnand Balved Education Foundation (RBEF)
and Dr. Aseem Chauhan, Chancellor, Amity University Madhya Pradesh. We are
thankful to Honorable Pro-Chancellor Lt. Gen. V.K. Sharma, AVSM (Retd.), Amity
University Madhya Pradesh, Gwalior, India, Pro-Vice Chancellor (Research) Prof.
(Dr.) M.P.Kaushik, Amity University Madhya Pradesh, Gwalior, India, for his con-
tinuous encouragement. We are also grateful to Prof. (Dr.) S.Mohana Lakshmi,
Director, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior,
for her support during the writing of this book. Finally, we would like to express our
wholehearted appreciation to the faculty and staff members of Amity Institute of
Pharmacy, Amity University, Madhya Pradesh, Gwalior.
Gwalior, India WasimAkram
Gwalior, India NeerajMishra
Jaipur, India TanweerHaider
Preface
vii
1 Introduction to Inulin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Anshika Bhatnagar, Kajal Bhadouriya, Tanweer Haider, Wasim
Akram, Hero Khan Pathan, and Neeraj Mishra
2 Extraction and Purification of Inulin . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Monika Vishwakarma, Kantrol Kumar Sahu, Laxmikant Gautam,
Shweta Parihar, Wasim Akram, and Tanweer Haider
3 Inulin: A Versatile Polymer for Drug Delivery System . . . . . . . . . . . . . 53
Pankaj Sharma, T. Yunus Pasha, T. Naga Aparna, Gokulakannan
Singaram, Mrunal K. Shirsat, Vinod Kumar, and Gaurav Tiwari
4 Inulin as Stabilizer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Brahma Srinivasa Rao Desu, Rajkumar M. Biradar, Methaku
Sundarraja
Vijaykanth, Pranshul Sethi, Karthikeyan Krishnan, S. Prema,
Hanamanth J. Kallur, and Amudha Senthamaraikannan
5 Inulin as a Coating Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
Shweta Mishra, Adarsh Sahu, S. Anakha, and Mayank Choubey
6 Inulin as a Prebiotic and Its Effect on Gut Microbiota . . . . . . . . . . . . . 113
Amit Anand, Santhepete Nanjundiah Manjula, Neeraj Kumar
Fuloria, Himanshu Sharma, and Kenganora Mruthunjaya
7 Inulin as a Natural Ingredient in Cosmetics and Personal
Care Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137
Praveen Halagali, Vamshi Krishna Tippavajhala, Mahalaxmi
Rathnanand, Himanshu Sharma, and Rashmi Pathak
8 Inulin as a Pharmaceutical Excipient . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Vishnu Mittal, Anjali Sharma, and Devkant Sharma
9 Toxicity and Safety Aspects of Inulin . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Sanjay Kumar Gupta and Astha Verma
10 Role of Inulin in the Management of Metabolic Disorders . . . . . . . . . . 189
Contents
viii
Sanzia Mehjabin, Md. Khokon Miah Akanda, A. H. M. Nazmul
Hasan, and G. M. Masud Parvez
11 Inulin and Gastrointestinal Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . 215
Sunil Kumar Kadiri, Prashant Tiwari, Deepak S. Khobragade,
and Dhritija Sathavalli
12 Inulin: A Versatile Polymer in Colon Drug Targeting . . . . . . . . . . . . . . 263
Nimeet Desai, Vaskuri G. S. Sainaga Jyothi, Derajram Benival,
Sagar Salave, and Dignesh Khunt
13 Regulatory Aspects of Inulin-Based Pharmaceutical Products . . . . . . 289
Priya Jindal, Sarjana Raikwar, Balak Das Kurmi, and Nikhar
Vishwakarma
14 Therapeutic Role of Inulin in Disease Management . . . . . . . . . . . . . . . 303
Anchala Guglani, Swati Shukla, and Ravi Tripathi
15 Future Prospects in Inulin Research . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325
Akshay Kumar Lunawat, Nikhar Vishwakarma, and Sarjana Raikwar
16 Potential of Inulin to Revolutionize Pharmaceutical Industries . . . . . . 343
Prathap Madeswara Guptha, T. Deepan, V. Alekkhya, Raghavendra
Kumar Gunda, Molakpogu Ravindra Babu, and Sagar Pamu
Contents
ix
Editors and Contributors
About the Editors
Wasim Akram passed his B.Pharm with distinction
from Jiwaji University and M.Pharm from Guru
Ghasidas Vishwavidyalaya (A Central University) in
2012 and 2014, respectively. He earned a PhD in the
year 2022. He has a total experience of 8 years in teach-
ing, research, and the pharmaceutical industry.
Presently, he is working as an Assistant Professor at the
Amity Institute of Pharmacy, Amity University, Madhya
Pradesh, Gwalior. His primary focus within the research
realm revolves around enhancing drug delivery preci-
sion, mainly through utilizing biopolymer-based drug
delivery systems. He is actively involved in formulating
nanoparticulate drug delivery systems for treating
Inammatory bowel disorders and cancer. He has pub-
lished 15 peer-reviewed papers in the eld of pharma-
ceutical sciences in national and international journals,
written 4 Books and 8 book chapters in various publica-
tions. He has also been granted one Indian patent. He is
also active as a reviewer for several international scien-
tic journals. He is a member/Life member of several
Indian scientic organizations.
Dr. Akram has been bestowed with several honours;
a few of them worth mentioning include the Young
Talent Award by the Indian Pharmaceutical Education
Society, the Young Researcher Award by Arjyopa dur-
ing the World Congress on Drug Development, Awarded
JRF & SRF By the University Grant Commission
(UGC), New Delhi; in addition, several awards for best
paper presentations at conferences; Indian Pharmacy
Graduate Association, and Controlled Release Society,
Indian Chapter. As a representative or invited speaker,
x
Dr. Akram shared his research and teaching experience
in several conferences, seminars, symposiums, and
workshops. He is also actively engaged in various
department, Institute and University committees.
Recently, He got a project entitled “Ligand tethered
polymer-lipid based self-assembled nanoconstruct(s)
for the effective brain targeting against glioma”,
approved by MPCST Project A/RD/RP-2/3.
NeerajMishra is working as Professor and HOD in
Amity Institute of Pharmacy, Gwalior since July 2019.
He has around 20 years of teaching and research experi-
ence. He has more than 115 publications of International
and National repute in recent concepts of novel drug
delivery systems, localized drug delivery, targeted and
controlled drug delivery of nanocarriers/microparticles
for the treatment of breast, colon cancer, and neurode-
generative disorders. Dr. Mishra has around 3650 cita-
tions with h-index 32, i-Index 64. The total cumulative
Impact Factor of his published papers is more than 300.
He has also written 14 Books and 25 book chapters. He
has also been granted three international patents and
one Indian patent. He has received “Distinguished
Professor Award” 2019 from DST-NSTMIS,SPAICS,
Indore, M.P in September 2019. He has also received
the “Outstanding Scientist Award” 2020, 6th
International Scientist Awards on Engineering, Science,
and Medicine, 20–21 June 2020, Chennai, India.
Recently, He received the “Distinguished Professor
Award” 2021 from IPA, MP State Branch, Indore. He
was recipient of ICMR-SRF (New Delhi, India) (Grant:
45/02/2007-BMS/ PHA Dated 06\07\2007\H.S.Gour)
under supervision of Prof. S.P. Vyas. Recently, He got
project entitled “Dual functional Colon-Targeted
Tofacitinib and Probiotics Loaded Microparticles for
the Treatment of Inammatory Bowel Disease” got
approved by MPCST Project A/RD/RP-2-231.
Editors and Contributors