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Взгляд на фармацию. Учебное пособие для студентов фармацевтического факультета

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and can be found in many plants and herbs, cheaply and easily bought at your home market or Herbalist, why not use them? If taken in the appropriate dose and form, they can be as eective as pharmaceutical drugs.
e chemistry of herbs is subtle and complex, all herbs being very powerful chemical factories. e main active constituents fall into eight main groups: acids; carbohydrates; phenols; volatile (essential) oils; saponins; glycosides; bitters and alkaloids.
ACIDS: Present in all plants, e.g. cichroic acid in Echinacea; citric and ascorbic acid in oranges.
CARBOHYDRATES: Constructed from sugar (saccharides). Recent studies investigating polysaccharides have shown that some compounds have signicant immune system stimulating eects, most notably Echinacea augustiora, Calendula ocinalis and Matricaria recutita. Aloe vera is also very high in useful polysaccharides.
PHENOLS: ey provide a base for several important active constituents. ey are antibacterial and antiseptic, e.g., oil of yme contains phenols and can be used as an antiseptic. Another example is salicin, the precursor of salicylic acid, from white willow bark, the basis for the aspirin group. Two of the useful phenol subgroups are avonoids and tannins. Flavonoids have several signicant properties including antispasmodic, antiinammatory, antiseptic and diuretic actions. ey are the most widely found phenols in the plant kingdom. Commonly known plants such as ginkgo, crataegus and milk thistle, all contain avonoids. Tannins are also widely distributed. eir astringent properties are particularly useful for treating wounds and burns. Another group known as anthraquinones possesses valuable laxative actions, and is present in plants such as rhubarb, buckthorn and cascara.
VOLATILE OILS: oen referred to as «essential oils», volatile refers to their evaporative properties. ey oen have a pleasing fragrance, and many have antiseptic and warming properties, e.g., menthol, camphor, lavender oils.
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BITTERS: Stimulate the autonomic nervous system. An example of their use with centaury, is in improving digestive function. ey activate the bitter sensory area of the tongue, causing a reex secretion of hormones into the blood, increasing the production of gastric and pancreatic juices and bile.
ALKALOIDS: Commonly found in many plant tissues, they are colourless and odourless. ey behave in an alkaline fashion, and can combine with acids to form salts. ey all have a bitter taste, and most are soluble in alcohol, but not water. Caeine is an alkaloid. ey are the most potent of all plant constituents and many, though by no means all can be toxic, and require careful use. A plant generally contains a number of related alkaloids, for example the opium poppy contains morphine, codeine and papaverine.
VITAMINS AND MINERALS: Fruit and vegetable, indeed, plants in general, are a rich source of them. Trace elements and minerals are present in most plants.
MUCILAGES: Extremely common in plants, they are facilitatory to the eective action of many herbal prescriptions. ey are composed of polysaccharides, partly soluble in water, and swell up to form a mucilaginous gel. All mucilages soothe internal mucosa, especially upper respiratory tract and digestive mucosa. ey can help to promote regular, rhythmic bowel activity, aiding against constipation and problems arising from sluggish bowel.
Tasks:
1. Find in the text words with the suxes: -ly; -ive; -al;-ic. Dene the parts of speech and translate them.
2. Put questions to the words in bold types.
1. Most root systems have many branches.
2. e at, green part of a leaf is called the blade.
3. e fruits contain essential oil.
4. Roots and rhizomes were widely used by the ancient physicians.
5. e underground part consists of rhizome.
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3. Read and translate the sentences with Complex Subject.
1. Grippe is known to be a highly communicable disease.
2. Adonis vernalis is said not to be cumulative. 3. Our professor is likely to come soon. 4. Atoms are known to be tiny and invisible compounds. 5. Water pollution is considered to be perhaps an ever greater hazard to health than air pollution.
4. Read and translate the sentences with Complex Object.
1. I know him to have passed the exam very well. 2. e fact made him think. 3. e doctor told the patient to take the drug three times a day. 4. I want my friend to assist me during my work. 5. Doctors found interferon to be eective against u.
6. We know this professor to teach pharmacology very well.
7. e students want the teacher to explain the following phenomena.
5. Read and translate.
It is interesting to know
ere are four important groups of plants.
allophytes = allus Plants – ( ) includes the one-celled bacteria, the algae, and the fungi, like the molds that are oen seen growing on bread and cheese.
Bryophytes = Moss Plants – ( ) includes the mosses,lichens and liverworts that are found in forest.
Pteridophytes = Fernlike Plants – () includes the ferns, and club mosses.
Spermatophytes = Seed Plants – () includes our com­mon grasses, vegertables, most trees, shrubs, owers and so on.
Notes:
thallus – ,  algae (pl) –  fungi (pl) –  molds – 
lichen –  liverwort –  fern –  club mosses – 
moss – 
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6. Read attentively and entitle the text. Ask 10 questions to the text.
Goldenseal, ginseng, echinacea, gingo – visit your local drug storeor supermarket and you’ll nd large quantities of these products on the shelves, intermingled with old favourites like aspirin. Medicinal plants are used commercially, thanks to contributions of traditional cultures.
Without plants most medicines you take would not exist. Over 40% of medicines now prescribed in the U.S. contain chemicals derived from plants. Historically, plant medicines were discovered by trial and error. Our ancestors noticed that aches and pains went away when they drank tea made from the bark of a willow tree. Later, scientists found that willow bark contains salicylic acid, the active ingredient in aspirin.
is process continues today. roughout the world, including the wild places in the U.S., botanists and chemists search the Plant Kingdom for new medicines. ey sometimes nd treasures in other people’s trash. For years, the native Pacic yew was burned as trash generated by logging operations in the Pacic Northwest. In 1975, a substance in its bark, taxol, was found to reduce the production of cancerous tumours.
A comprehensive search of known plants for medicinal chemicals is an enormous task. Of the estimated 250,000 plant species on earth, only 2% have been thoroughly screened for chemicals with potential medicinal use. Because native plant habitats are destroyed almost daily, many medicinally valuable plants will be gone before scientists can even investigate them.
7. Render this text in English.
 
 () (Aloe),    .   340 ,    ­   ,         .  ,  
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,  .          (  -).  ­   ,       - (    ).
 18 .,  ,      (A. arborescens)    ,     ­.     , ,  .  ­     , ,   . ,      ­,     .
       ­;  10 .     ,  12 .-  .     .          «­  »   ­.    ,    «­ »,    ,  ­.      ,  ­       ­  .      ­      18 .  ,  ­,     .      .
  1930- . . .     ­,    .  ­   ,    ,   ­ ()  (   ­  20-25      + 4° ), ­  ,   ­    .            .
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Lesson 18.
1. Dene the part of speech and explain the reason of your choice.
erminal, formerly, make, copious, assuredly, bitterish, com­mencement, perspiration, sweeten, decoction, preventive, tooth­ache, protable, tell.
2. Read the sentences aloud. Make them negative and interrogative. Be ready to translate them into Russian.
1. is plant grows in the gardens. 2. ey become troublesome
weeds everywhere. 3. People cultivate it in the gardens of England.
4. It owers from June to September. 5. e pharmaceutists still make an ointment from it. 6. Both owers and leaves have bitterish taste. 7. Yarrow Tea is a good remedy for severe colds.
3. Ask as many special questions as you can.
1. We can use this remedy to cure kidney disorders.
2. Many doctors recommended this decoction to be drunk warm.
YARROW
Tasks:
4. Find the pairs of antonyms.
Grow, earlier, inside, bitter, mild, useful, purify.
Severe, collect, later, outside, sweet, pollute, useless.
5. Dene the predicate. Translate the sentences.
1. Herbs are derived from leaves, bark, berries, roots, gums, seeds, stems, and owers of the Botanical Kingdom. 2. American Ginseng (panax ginseng) comes from the Greek for «panacea» meaning «all healing». 3. Celery seed is extremely efective in lowering blood pressure; eases joint pain discomfort that occurs due to inammation. 4. ere are over 80 species of ginger, historically found in China, Japan, Australia and Hawaii. 5. Motherwort leaf is used to regulate and strengthen the heartbeat; contains ursolic acid which possesses antiviral and antitumor properties.
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6. Read and translate the sentences with Complex Subject.
1. She seems to be unhappy. 2. He doesn’t seem to know this subject. 3. Cod liver oil is known to be an eective remedy in the treatment of rickets. 4. e herbal stimulant ephedra is said to have fewer side eects than ephedrine, one of its ingredients. 4. Vitamin C appears to be lacking in seeds, white bread, fats, yeast, puried proteins and carbohydrates. 5. He is unlikely to help you. 6. She is sure to take this mixture.
7. Read and learn the following words and word combinations.
8. Read and translate the following text.
YARROW
Botanical: Achillea millefolium. Family: Compositae. Synonyms: Milfoil. Herba Militaris. ousand Weed. Nose Bleed.
Carpenter’s Weed.
Bloodwort. Staunchweed. Sanguinary. Devil’s Nettle. Devil’s
Plaything. Bad Man’s Plaything. Yarroway.
Part Used – Whole Herb. Habitat – Yarrow grows everywhere, in the grass, in meadows,
pastures, and by the roadside. As it creeps greatly by its roots and multiplies by seeds it becomes a troublesome weed in gardens, into which it is seldom admitted in this country, though it is cultivated in the gardens of Maderia.
Description – e stem is angular and rough, the leaves alternate,
3 to 4 inches long and 1 inch broad, clasping the stem at the base, bipinnatid, the segments very nely cut, giving the leaves a feathery appearance.
It owers from June to September, the owers, white or pale lilac, being like minute daisies, in attened, terminal, loose heads, or cymes. e whole plant is more or less hairy, with white, silky appressed hairs.
Yarrow was formerly much esteemed as a vulnerary, and its old names of Soldier’s Wound Wort and Knight’s Milfoil testify to this. e Highlanders still make an ointment from it, which they apply
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to wounds, and Milfoil tea is held in much repute in the Orkneys for dispelling melancholy. Gerard tells us it is the same plant with which Achilles stanched the bleeding wounds of his soldiers, hence the name of the genus Achillea. Others say that it was discovered by a certain Achilles, Chiron’s disciple. It was called by the Ancients, the Herba Militaris, a military herb.
Its specic name, millefolium, is derived from the many segments of its foliage, hence also its popular name, Milfoil and ousand Weed. Another popular name for it is Nosebleed, from its property of stanching bleeding of the nose, though another reason given for this name is that the leaf, being rolled up and applied to the nostrils, causes a bleeding from the nose, more or less copious, which will thus aord relief to headache. Parkinson tells us that if it is put into nose, assuredly it will stay the bleeding of it – so it seems to act either way.
It was one of the herbs dedicated to the Evil One, in earlier days, being sometimes known as Devil’s Nettle, Devil’s Plaything, bad man’s Plaything, and was used for divination in spells.
Yarrow, in the eastern counties, is termed Yarroway, and there is a curious mode of divination with its serrated leaf, with which the inside of the nose is tickled while the following lines are spoken. If the operation causes the nose to bleed, it is a certain omen of success.
‘Yarroway, Yarroway, bear a white blow,
If my love loves me, my nose will bleed now.’
It has been employed as snu, and is also called Old Man’s Pepper, on account of the pungency of its foliage. Both owers and leaves have a bitterish, astringent, pungent taste. In the seventeenth century it was an ingredient of salads.
Parts Used – e whole plant, stems, leaves and owers collected in the wild state in August when in ower.
Constituents – A dark green, volatile oil, a peculiar principle, achillein, and achilleic acid, which is said to be identical with aconitic acid, also resin, tannin, gum and earthy ash, consisting of
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nitrates, phosphates and chlorides of potash and lime.
Medicinal Action and Uses – Diaphoretic, astringent, tonic, stimulant and mild aromatic.
Yarrow Tea is a good remedy for severe colds, being most useful in the commencement of fevers, and in cases of obstructed perspiration. e infusion is made with 1 oz. of dried herb to 1 pint of boiling water, drunk warm, in wineglassful doses. It may be sweetened with sugar, honey or treacle, addinga little Cayenne Pepper, and to each dose a teaspoonful of Composition Essence. It opens the pores freely and puries the blood, and is recommended in the early stages of children’s colds, and in measles and other eruptive diseases.
A decoction of the whole plant is employed for bleeding piles, and is good for kidney disorders. It has the reputation also of being a preventative of baldness, if the head be washed with it.
Preparations – Fluid extract, ½ to 1 drachm. An ointment made by the Highlanders of Scotland of the fresh herb is good for piles and is also considered good against the scab in sheep.
An essential oil has been extracted from the owers, but is not now used.
Linnaeus recommended the bruised herb, fresh, as an excellent vulnerary and styptic. It is employed in Norway for the cure of rheumatism, and the fresh leaves chewed are said to cure toothache.
In Sweden it is called ‘Field Hop’ and has been used in the manufacture of beer. Linnaeus considered beer thus brewed more intoxicating than when hops were used.
It is said to have a similar use in Africa.
Culpepper spoke of Yarrow as a protable herb in cramps, and Parkinson recommends a decoction to be drunk warm for ague.
e medicinal values of the Yarrow and the Sneewort (A. millefolium and A. ptarmica), once famous in physic, were discarded ocially in 1781.
Woolly Yellow Yarrow (A. tomentosa) is very rare, and a doubtful native; its leaves are divided and woolly, the owers bright yellow.
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Tasks:
1. Find the odd word out:
1. a) Milfoil b) ousand Weed c) Daisy d) Bloodwort
2. a) seeds b) garden c) roots d) leaves
3. a) ointment b) decoction c) acid d) infusion
4. a) remedy b) resin c) tannin d) gum
5. a) sugar b) honey c) treacle d) salt
2. Complete the following sentences.
1. Yarrow grows everywhere … .
2. It owers from June to September … .
3. e Highlanders still make … .
4. Parkinson tells us that … .
5. It has been employed as snu and … .
6. Yarrow Tea is a good remedy for … .
7. A decoction of the whole plant is employed for … .
3. Write out from the text four sentences in Past Simple Active and Passive. Translate them. Make them interrogative.
4. Dene the function of ing-forms in the sentences.
1. e leaves alternate, 3 to 4 inches long and 1 inch broad, clasping the stem at the base. 2. e segments very nely cut, giving the leaves a feathery appearance. 3. It owers from June to September, the owers, white or pale lilac, being like minute daisies. 4. Milfoil tea is held in much repute in the Orkneys for dispelling melancholy.
5. It is the plant with which Achilles stanched the bleeding wounds of his soldiers. 6. It may be sweetened with sugar, honey or treacle, adding a little Cayenne Pepper. 7. If it is put into nose, assuredly it will stay the bleeding of it.
5. Translate the sentences. Explain the use of tenses.
1. It has been employed as snu, and is also called Old Man’s Pepper, on account of the pungency of its foliage. 2. An essential oil has been extracted from the owers, but is not now used.
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