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Acknowledgments

I am extremely grateful to:

Myteachersinschool,whohelpedmetoacquiregoodcommandoverspoken and written English language.

My lecturers and professors in medical college, who taught me the science and art of bedside cardiology.

My heart patients, whose findings on clinical examination and results of investigations made me wiser.

Learned authors of textbooks on clinical cardiology to which I referred liberally, while preparing the manuscript.

My esteemed readers of earlier books, whose generous appreciation and constructive criticism keep me going.

M/s Jaypee Brothers Medical Publishers (P) Ltd., New Delhi, India, who repose their unflinching faith in me and provide excellent editorial support.

Contents

Section 1: Congenital Heart Diseases

Case 1

:

Ventricular Septal Defect

3

Case 2

:

Atrial Septal Defect

7

Case 3

:

Fallot’s Tetralogy

11

Case 4

:

Ebstein’s Anomaly

15

Case 5

:

Patent Ductus Arteriosus

19

Section 2: Mitral Valve Diseases

Case 6

:

Mitral Stenosis

25

Case 7

:

Mitral Regurgitation

29

Case 8

:

Mitral Valve Prolapse

33

Section 3: Aortic Valve Diseases

Case 9

:

Aortic Stenosis

39

Case 10

:

Aortic Regurgitation

43

Case 11

:

Aortic Sclerosis

48

Section 4: The Cardiomyopathies

Case 12

:

Dilated Cardiomyopathy

55

Case 13

:

Restrictive Cardiomyopathy

59

Case 14

:

Hypertrophic Cardiomyopathy

63

Case 15

:

Takotsubo Cardiomyopathy

67

Section 5: Aortic Diseases

Case 16

:

Aneurysm of Aorta

73

Case 17

:

Dissection of Aorta

77

Case 18

:

Coarctation of Aorta

81

Case 19

:

Sinus of Valsalva Aneurysm

85

xiv

 

50 Cases in Clinical Cardiology: A Problem Solving Approach

 

 

 

Section 6: Pulmonary Diseases

Case 20

:

Pulmonary Stenosis

91

Case 21

:

Pulmonary Hypertension

95

Case 22

:

Pulmonary Embolism

99

Case 23

:

Obstructive Pulmonary Disease

103

Section 7: Pericardial Infections

Case 24

:

Acute Pericarditis

109

Case 25

:

Pericardial Effusion

113

Case 26

:

Constrictive Pericarditis

117

Section 8: Myocardial Infections

Case 27

:

Rheumatic Fever

123

Case 28

:

Acute Myocarditis

127

Section 9: Endocardial Infections

Case 29

:

Aortic Valve Endocarditis

133

Case 30

:

Tricuspid Valve Endocarditis

137

Section 10: Intracardiac Masses

Case 31

:

Atrial Myxoma

143

Case 32

:

Atrial Thrombus

147

Case 33

:

Ventricular Thrombus

151

Section 11: Typical ECG Abnormalities

Case 34

:

Left Ventricular Hypertrophy

157

Case 35

: Left Bundle Branch Block

161

Case 36

:

Features of Hypokalemia

165

Case 37

:

Features of Hyperkalemia

169

Section 12: Electrocardiac Syndromes

Case 38

:

Prolonged Q-T Syndrome

175

Case 39

:

Sick Sinus Syndrome

179

Case 40

:

Early Repolarization Syndrome

183

Case 41

:

Brugada Syndrome

186

Case 42

:

WPW Syndrome

189

Contents

 

xv

 

 

 

Section 13: Cardiac Arrhythmias

Case 43

:

Supraventricular Tachycardia

195

Case 44

:

Atrial Fibrillation

199

Case 45

:

Ventricular Premature Beats

203

Case 46

:

Ventricular Tachycardia

207

Section 14: Coronary Artery Diseases

Case 47

:

Chronic Stable Angina

213

Case 48

:

Acute Coronary Syndrome

217

Case 49

:

Papillary Muscle Rupture

222

Case 50

:

Left Ventricular Aneurysm

226

Index

 

 

231

S E C T I O N

1

Congenital Heart

Diseases

 

 

C A S E

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1

 

Ventricular

 

 

 

 

 

 

 

 

 

 

 

 

Septal Defect

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Case Presentation

A 31-year old man was referred to the cardiologist by a general physician, for evaluation of a heart murmur. This young man had been denied a life insurance policy because the physician, empanelled by the insurance company, had incidentally noticed the murmur during medical examination. The man was normally very active and denied complaints of chest pain, breathlessness, palpitations or syncope. There was no history of cyanotic spells, joint pains or repeated chest infections during childhood and he regularly played cricket and football in school. However, the patient recollected that the doctor in the school medical room had noticed the murmur and made a note of it in his medical report.

On examination, the man was of average built and height and looked healthy. The pulse was 84 beats/min. and regular with no special character. The BP was 134/76 mm Hg in the right arm while sitting. There was no anemia, cyanosis or clinical sign of congestive heart failure. The apex beat was ill-sustained, heaving in nature and slightly displaced towards the axilla. There was a pansystolic murmur over the middle of the left sternal border with a S3 sound in early diastole. The murmur did not radiate towards the axilla. There was no parasternal heave and the lower border of the liver was not palpable. The lung fields were clear.

CLINICAL DISCUSSION

From the history and physical examination, this asymptomatic young man had a parasternal pansystolic murmur. Typical causes of a pansystolic murmur are mitral regurgitation, ventricular septal defect and tricuspid regurgitation. Sometimes, tight coarctation of aorta or a patent ductus arteriosus with pulmonary hypertension can also produce a pansystolic murmur but these murmurs are usually located at the upper left sternal edge. The murmur of mitral regurgitation radiates towards the axilla while the murmur of tricuspid regurgitation is usually associated with engorged neck veins and an enlarged pulsatile liver.

ECG of the patient showed biphasic RS complexes in the mid-precordial leads. X-ray chest showed mild cardiomegaly with minimal signs of pulmonary congestion. On ECHO, the left ventricle was normal in size with normal ejection fraction. A signal drop-out was noticed in the mid-portion of the interventricular

4

 

Section 1 Congenital Heart Diseases

 

 

 

Figure 1.1: Color flow map extending from left ventricle to right ventricle

septum. There was no abnormality of the cardiac valves and the estimated pulmonary artery pressure was normal. On color Doppler, an abnormal flow map was observed extending from the left ventricle to the right ventricle (Fig. 1.1), with a high velocity jet on continuous wave Doppler. Therefore, the definite diagnosis in this case is ventricular septal defect (VSD).

Figure 1.2: Ventricular septal defect

In VSD, a breach in the continuity of the interventricular septum creates a left-to-right shunt between the ventricles (Fig. 1.2). This congenital cardiac defect occurs due to complexity of embryological development of the septum, which has a membranous and a muscular portion. Most (80%) VSDs occur at the junction of these sections and are termed as perimembranous VSD (Fig. 1.3). Some VSDs occur in the muscular section (muscular VSD) and may be multiple (sieve-like). Rare varieties of VSD are endocardial cushion defects (supracristal VSD) and outlet septal defect (subpulmonic VSD) (Table 1.1).

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