Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5264_Библиотеки_им_академика_М_И_Перельмана.pdf
164
Plant-based Foods and their Implications in Brain Health
Fungus
Sl. No. Marine source Scientific name Source of collection Chemical compound isolated Nature of chemical Chemical structure Mechanism of action References
(22E,24R)- ergosta- 5,22- dien-
(22E,24R)- ergosta- 4,6,8(14),22-
tetraen- 3- one
9. Marine originated
fungus
Aspergillus sp.
SCS- KFD66
isolated from a bivalve mollusc
Sanguinolaria chinensis, which
was collected from Haikou Bay,
China
Asperpenes D Terpenoids
Asperpenes E
10. Marine originated
fungus
A. terreus
BCC51799
isolated from a decayed wood
sample from the Gulf of Thailand
Territrem B Terpenoids
11. Marine originated
fungus
A. terreus
SCSGAF0162
isolated from a gorgonian coral
Echinogorgia aurantiaca, which
was collected from the South
China Sea
Territrems C Terpenoids
TABLE 8.2 (Continued)
The structure of various chemical compounds isolated from marine sources of fungus
165165
Marine Plant Species: Nutritional and Medicinal Value
(continued)
Terpenoids
(Meroterpenoids)
weak inhibitory activity
against AChE
145
Terpenoids
(Meroterpenoids)
anti- AChE activity with
IC
50
= 0.071 µM (IC
50
of galantamine
146
Terpenoids
(Meroterpenoids)
anti- AChE activity 147
166
Plant-based Foods and their Implications in Brain Health
Fungus
Sl. No. Marine source Scientific name Source of collection Chemical compound isolated Nature of chemical Chemical structure Mechanism of action References
Territrems D
Territrems E
Arisugacin
Terreulactone C
12. endophytic fungus Penicillium sp.
SK5GW1L
isolated form leaves of a
mangrove tree
K. candel
Terpenoids
3- epiarigsugacin E
Arisugacin B
Arisugacin D
13. endophytic fungus A. avus (8E,12Z)- 10,11-
dihydroxyoctadeca- 8,12-
dienoic acid
TABLE 8.2 (Continued)
The structure of various chemical compounds isolated from marine sources of fungus
167
Marine Plant Species: Nutritional and Medicinal Value
(Meroterpenoids)
potent inhibitory activity 148
Marine Fatty Acids
weak AChE inhibitory
activity
149
(continued)
168
Plant-based Foods and their Implications in Brain Health
Fungus
Sl. No. Marine source Scientific name Source of collection Chemical compound isolated Nature of chemical Chemical structure Mechanism of action References
14. marine originated
fungus
Biscogniauxia
mediterranea
strain LF657
isolated from a sediment collected in
Eastern Mediterranean Sea
cyclo- (L- Phe- L- Leu- L- Val- L-
Leu- L- Leu)
15. Marine originated
fungus
Biscogniauxia
mediterranea
isolated from a sediment collected
in the Eastern Mediterranean Sea
(2800 m depth)
Biscogniauxone Alkaloids
16. Marine originated
fungus
Penicillium sp.
KF620
isolated from the water sample of
the North Sea
Eutypoids B
Eutypoids C
Eutypoids D
Eutypoids E
17. marine- derived
fungus
Aspergillus sp.
strains LF666
isolated from a deep- sea sediment
sample which was collected from
the Mediterranean Sea
Pannorin oxygenated
18. marine- derived
fungus
Xylaria sp. obtained by
mangrove fungus of the South China
Sea coast.
Xyloketal B showed that the
TABLE 8.2 (Continued)
The structure of various chemical compounds isolated from marine sources of macroalgae
169
Marine Plant Species: Nutritional and Medicinal Value
cyclopentapeptide exhibited anti- AChE
activity with a
minimal inhibition
concentration
(MIC) = 5.87 µM.
Huperzine A
150
(isopyrrolonaph-
thoquinone)
IC
50
= 8.04 µM.
150
Phenolics (Aromatic
butenolides)
moderate inhibitory
activity against
IC
50
= 0.78, 0.67, 4.08,
and 2.26 µM,
respectively
151
oxygenated
benzo- coumarins
151
showed that the
modulation of
elements in the
could regulate neurons
state
152
170
Plant-based Foods and their Implications in Brain Health
TABLE 8.3
The structure of various chemical compounds isolated from marine sources of macroalgae
Macroalgae
Sl.
No. Marine source Scientific name
Source of
collection
Chemical compound
isolated Nature of chemical Chemical structure
1. brown alga Ecklonia maxima The aqueous
methanol extract
and organic
solvent fractions
of this algae,
collected on the
West coast of
South Africa
phloroglucinol Phenolics displayed anti-
dibenzo[1,4]
dioxine- 2,4,7,9- tetraol
eckol
2. red alga Grateloupia
elliptica
collected offshore of
Jeju Island, Korea
6,6´- bieckol Phenolics moderate inhibitory
3. red alga Symphyocladia
latiuscula
collected in Korean
water, by using a
Multiple Enzyme
Targets approach
2,3,6- tribromo- 4,5-
dihydroxybenzyl alcohol
Phenolics inhibited both
171
Marine Plant Species: Nutritional and Medicinal Value
Mechanism of
action
Results of animal
studies
Outcomes
of clinical
Studies References
displayed anti-
AChE inhibitory
activity with
IC
50
= 84.48
and 76.70 µM,
respectively
153
activity toward
AChE and
BuChE compared
to donepezil;
however, its anti-
BuChE activity
(IC
50
= 27.4 µM)
was more potent
than its anti-
AChE activity
(IC
50
= 44.5 µM)
154
inhibited both
AChE and
BuChE
activities, (IC
50
= 7.31 for AChE
and 8.95 µM for
BuChE)
155
(continued)
172
Plant-based Foods and their Implications in Brain Health
Macroalgae
Sl.
No. Marine source Scientific name
Source of
collection
Chemical compound
isolated Nature of chemical Chemical structure
2,3,6- tribromo- 4,5-
dihydroxybenzyl methyl
ether
bis- (2,3,6- tribromo- 4,5-
dihydroxybenzyl) ether
4. isolated from
different
populations of
a red alga
Laurencia
dendroidea
collected from the
coast of Brazil
(- ) elatol
halogenated
sesquiterpenes)
(+ )- elatol AChE inhibitory
(+ )- obtusol AChE inhibitory
(- )dendroidol AChE inhibitory
(- ) cartilagineol AChE inhibitory
TABLE 8.3 (Continued)
The structure of various chemical compounds isolated from marine sources of macroalgae
173
Marine Plant Species: Nutritional and Medicinal Value
Mechanism of
action
Results of animal
studies
Outcomes
of clinical
Studies References
inhibited both
AChE and
BuChE
activities, (IC
50
=
9.61 µM for AChE
and 14.41 µM
for BuChE)
inhibited both
AChE and
BuChE activities,
(IC
50
= 2.66 µM
for AChE and
4.03 µM for
BuChE),
AChE inhibitory
activity
156
activity
activity
activity
activity
(continued)