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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5322_Библиотеки_им_академика_М_И_Перельмана.pdf
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248 Textbook of Pharmacognosy
in horses, in distemper in dogs and in septicaemia in all animals in addition to its use for parasitic skin affections. The plant is also used in the manufacture of paper, in the production of poles for huts and houses, in making plywood, etc.
Adulteration
The older leaves are often adulterated with the leaves from younger branches (ovate-oblong and opposite) and the leaves of allied species (less leathery and less fragrant).
GINGER
Synonyms
Zingiber, Rhizoma zingiberis, Ginger rhizome, Ingwer (German), Gingembre (French). Zangebilarataba (Persian), Sheng-jiang or Gan-jiang—dried (Chinese), Shringavera or Adrakam—dried or Sunta or Mahaushada (Sanskrit), Aadrak or adrak (Bengali, Punjabi, Hindi and Urdu), Adhu (Gujarati), Sho-ont (Kashmiri), Sunt (Konkani and Maharastrian), Zanjabil (Arabic), Vona Shunti or Hashi sonti—dried (Kannada), Allam or Sonti— dried (Telugu), Shuku or Inji—dried (Tamil), Chukka (Malayalam), Alay (Marathi), Inguru (Sinhalese), Aduwa (Nepali), Sinjibil (Somaliland), Aadha (Bangladesh), Gyin or Ginsi-khiav or Gin-sin—dried (Burmese).
Biological Source
Ginger is the scraped or unscraped fresh or dried rhizome of Zingiber officinale Roscoe (Family: Zingiberaceae). The English name ginger comes from the French, gingimbre, from medieval Latin, gingiber, from Greek, zingiberis, from Pali, sringivera, finally of Dravidian origin from Tamil, inji ver (meaning root of inji). The word Zingiber is thought to have come from the Sanskrit word, shringavera (horn-root) derived from Arabic and Greek
Zingiber officinale
Ginger plant
Systematic Pharmacognostic Study of Volatile Oils 249
Young rhizome
Dry rhizome Fresh rhizome
Leaves
Ginger flower
Ginger powder
words meaning ‘shaped like a horn’ as the rhizomes often look like the antlers of a deer.
250 Textbook of Pharmacognosy
Geographical Source
The habitat of the plant is South Asia and ginger has been cultivated in India from the earliest times; the plant is unknown in the wild state. It is also grown in many parts of the world, the chief countries producing it are West Indies, Africa, India, Japan, Jamaica, China and Africa, and extensively cultivated in tropical and subtropical areas of both the Eastern and Western Hemisphere. In India, it is cultivated on a large scale in Tamil Nadu, Kerala, and Karnataka and also in West Bengal and Punjab.
Collection and Preparation
The plants of ginger emit their aerial shoots that dry up after flowering and fruiting in about 8 to 10 months time. The rhizomes are dug upon the death of the older portions and washed. Abundant rainfall is necessary during the growing season and at no time water logging should be permitted. They are peeled and washed in clean water with lime juice and dried in the sun. Sometimes, they are washed in boiling water and dried (African and Indian varieties) in the sun for 5–6 days. They are then bleached by washing and dried again for 2 days (Jamaica ginger). In Indian and African varieties, the rhizome is peeled on the flat sides, and then treated with boiling water and dried in the sun. Sometimes, the rhizomes are washed with carbonate or sulphate of lime to prevent the insect larval attack. The rhizomes are also bleached with sulphurous acid or chloride of lime (Bleached ginger). The oil is extracted by distillation. The important commercial varieties include ginger from Jamaica, Kerala and Africa.
Characters
Macroscopic Characters
It occurs in branched pieces called races or hands. These are 8–14 cm long and 2–3 cm thick. Each hand or finger has a depressed scar or bud capable of giving birth to a new plant. Externally, the drug is pale yellowish buff with longitudinally striated surfaces. Fracture is short with projecting fibres, hard and resinous. Odour is agreeable and aromatic. Taste is pungent, aromatic and spicy.
Microscopic Characters
A cross section of unpeeled rhizome shows a zone of cork tissue and inner cortex. The outer zone of cork consists of irregularly arranged cells and an inner zone consists of cells arranged in radial rows. However, the cork is absent in Jamaica Ginger. Cork cambium is indistinct. Cortex is differentiated into an outer zone of flattened parenchyma and an inner zone of normal parenchyma. Cortical cells contain simple, ovate or sack­shaped starch grains within hilum at the pointed end. The inner cortical zone usually contains about three rings of collateral, closed vascular
Systematic Pharmacognostic Study of Volatile Oils 251
bundles. The inner limit of the cortex is marked by a single-layered endodermis free from starch. The outermost layer of the stele is marked by a single-layered pericycle. The stele consists of scattered vascular bundles.
Ginger is mainly of three types, namely, Jamaica ginger (uncoated and unbleached ginger—Jamaica is the major exporter to all parts of the world), Cochin ginger (cultivated in South India—coated and bleached ginger—less aromatic than Jamaica ginger) and African ginger (darker and smaller than Cochin ginger—more pungent but lacks the aroma of the Jamaica ginger).
Chemical Constituents
Ginger contains about 1–3% volatile oil and 5–8% of resinous matter (gingerin–oleoresin which is yellow and pungent), starch and mucilage. The principal constituents of volatile oil are a small fraction of monoterpenes (β-phellandrene, dextro-camphene, cineol, citral and borneol), sesquiterpene hydrocarbons (zingiberene as the main component, smaller amounts of β-bisabolene, farnesene, β-sesquiphellandrene and curcumene) and sesquiterpene alcohol zingiberol. The characteristic odour of ginger is due to a mixture of zingerone, shogaol and gingerol, a yellowish oily mixture of homologous phenols. This gives hot pungent taste to the drug.
Zingiberene (C15H24)
Farnesene (C15H24)
Beta-sesquiphellandrene (C15H24)
Beta-bisabolene (C15H26)
Curcumene (C15H22)
Zingerone (C
11H14O2
)
252 Textbook of Pharmacognosy
Shogaol (C17H24O3)
Gingerol (C17H26O4)
History of Ginger
Ginger cultivation began in tropical Asia and spread to West Africa and the Caribbean in the 16th century. Ginger is an ancient spice which was exported as dried powder from India to Roman empire 2000 years ago, mainly as a medicine. Arabs traded in ginger for centuries and carried the rhizomes to East Africa to plant them on the coasts of Zanzibar. People have valued the qualities of ginger for more than 5000 years. The earliest use as a flavouring agent pre-dates the historical records but its origin is uncertain, though it is believed to have originated in Southern China. In the 5th century AD and before the potted plants were carried along the maritime trade routes of Indian Ocean and South China Sea. In South Asia it has a long history of use. The Hindu epic, Mahabharata, describes a meal where meat is stewed with ginger and other spices. Ginger was also a plant of immense importance in Ayurveda. It was mentioned as a flavouring agent for buttermilk drinks in the Manasollasa literature in the 11th century AD. With the advent of the Muslim rule in the 13th century AD its use in food became widespread. The culinary use of ginger in Asia dates back to 4400 years. In France, it was used around 1200. It was known that in Senegal, West Africa, it has been used in love rituals and women wore belts of ginger rhizomes to arouse their partner’s desire. In 1800s, the Eclectics used the powder for relief from many digestive complaints like indigestion, gas, nausea and infant diarrhoea. In Africa, this was used to treat yellow fever and malaria.
Medicinal Uses
Ginger is used as a carminative, stomachic, sialagogue, digestive, rubefacient and stimulant. It is also useful in cold, cough and asthma,
Systematic Pharmacognostic Study of Volatile Oils 253
sore throat, dyspepsia and colic. It is used as a good stomachic also. Ginger promotes the secretion of bile, decreases pains from arthritis, thins blood and lowers cholesterol. It has proven effective for nausea caused by sea sickness, morning sickness, pregnancy and chemotherapy. Ginger is useful in flu, common cold, headache, fatigue, rheumatoid arthritis, migraine, sore throat, dyspepsia, flatulence, colic, vomiting, spasms, etc. and also to improve circulation and reduce the blood cholesterol, minimise the risk of thrombosis and also help in preventing cancer (due to its antioxidant properties). In Ayurveda, it is used as a cure for cholera, anorexia and inflammed liver. Ginger oil is used in various beverages and liquors, mouth washes, gargles, etc. The ginger is also used as a condiment in culinary preparations. In laboratory animals, gingerols increase the motility of the gastrointestinal tract and are analgesic, sedative, antipyretic and antibacterial properties. The oil has been shown to prevent skin cancer in mice and can kill the cells of ovarian cancer. Ginger is also an irritant and was used as a horse suppository by the mounted regiments of pre-World War I. It also possesses a sialagogue action and stimulates the production of saliva and makes swallowing easier.
Ginger is of immense importance in alternative medicine. In Ayurveda, Herbal medicine and Naturopathy, it is said that ginger clears congestion and helps detoxification by eliminating the wastes by sweating through the skin. The recent research shows that the ginger essence can be used to treat allergy, asthma, colds, infection, inflammation, nausea, internal parasites and controls the cholesterol. Some species of ginger are anti­bacterial, anti-inflammatory and anti-parasitic. The chemical constituents of ginger act as blood thinners, and thus reduce the risk of cardiovascular diseases. Ginger helps alleviate hypertension, colic, cough, flu, headache and muscle ache and also increases the energy and vitality. The practitioners of Naturopathy advocate the use of ginger to treat gallstones, sinus problems, toothache, motion sickness, abdominal cramps, stiffness of joints, skin burns, gout, spinal pain, swollen glands, menstrual cramps, etc.
Culinary and Other Uses
Ginger is commonly used as a spice and in the preparation of condiments. Young rhizomes are juicy and fleshy with a mild taste and are pickled in vinegar, used to make ginger tea with added honey or sliced orange and lemon. Mature ginger is fibrous and the juice is used as a spice in Indian recipes and Chinese cuisine to flavour seafood, goat meat or vegetarian dishes. It is also a food preservative and is known to kill Salmonella. As a dry powder it is used to flavour cookies, cakes, ginger ale and ginger beer. The powdered ginger is used in the food preparations for pregnant or nursing women. In South India, it is used in the preparation of a candy called Inji-murappa (Tamil) or Allam-murappa (Telugu) and is sold in bus stops and in tea stalls. In siddha medicine, ginger is used in coffee or tea.
254 Textbook of Pharmacognosy
In Bangladesh, ginger is used as a base for chicken and meat dishes. In Myanmar, it is used in cooking and is also a main ingredient of traditional medicines. In Indonesia, with palm sugar a beverage called Wedang Jahe is prepared. In Vietnam, the fresh ginger leaves are added to a soup called canh khoai mo. In China, whole/sliced ginger is used in savoury dishes of fish. In Japan, it is pickled to produce beni shoga and gari and raw ginger is used on tofu (noodles). In Western cuisine, ginger is used in ginger ale, ginger bread, ginger snaps, ginger biscuits, etc. Liquor called Canton is made in France and green ginger wine is produced in United Kingdom. In the Caribbean, a seasonal drink called sorrel is made during Christmas season, in Greece, a traditional drink, tsitsimpira (beer) is made and in Ivory Coast, a juice called Nyamanku is made along with orange, pineapple and lemon. In Tamil Nadu, South India, this is used as a folk medicine to treat cattle suffering from gastric upset, as a herbal paste mixed with black pepper (Piper nigrum), asafoetida (Ferula asafoetida) and sweet flag (Acorus calamus). If consumed as a powder, ginger can cause heartburn, bloating, gas, belching and nausea.
Adulteration
The ginger powder is adulterated with exhausted ginger. In addition, wheat middslings, wheat flour and ground turmeric are also often added.
CARDAMOM
Synonyms
Cardamom seeds, True cardamom, Cardamon, Lesser cardamom (English), Cardamomi Semen, Cardamom Elattarie (Greek), Kardamomen (German), Cardamome (French), Cardamomo (Italian and Portuguese), Kardamon (Russian), Karudamon (Japanese), Pai-tou-k’ou (Chinese), Ela or Ellka or Truti or Varni or Karangi (Sanskrit), Hal (Arabic), Palah or Bala (Burmese), Raputage pinvar (Malaysian), Chhoti elaechi (Hindi), Garate or Ghota elaichi (Bengali), Illychi (Urdu), Elachi (Gujarati and Punjabi), Elakki (Kannada), Elakkay (Malayalam), Aa’lbuduaa’l (Kashmiri), Elakkai or Elakaya (Tamil), Valdode or Elachi (Maharashtrian), Yelakkaya or Yelakulu (Telugu).
Biological Source
Cardamom consists of the dried seeds recently removed from the nearly ripe fruits of Elettaria cardamomum White et Mason var. miniscula (Syn:
Amomum cardamomum: Family: Zingiberaceae). A. subulatum (Syn: Elettaria major: Black Cardamom) is the best known related species.
Systematic Pharmacognostic Study of Volatile Oils 255
Elettaria cardamomum
Inflorescence
Leaves
Unripe fruits
Geographical Source
The plant is native to India and Sri Lanka and occurs wild and introduced all over tropical Asia where it is cultivated. The habitat of the plant is Indo­China where it occurs in mountainous districts. It also occurs wild in Myanmar (earlier Burma) and Malaysia and grows wild in Kerala. In India it is cultivated in Karnataka, Kerala coast and Tamil Nadu. Guatemala is the largest producer of cardamom in the world. It is also grown on a small scale in Tanzania, Sri Lanka, El Salvador, Vietnam, Laos, Thailand, Cambodia, Honduras, Malaysia, Sumatra, Nepal and Papua & New Guinea.
Collection and Preparation
The cardamom fruits are in racemes and ripen at different times. It is important to collect the fruits when they are nearly ripe and before they split. Either the racemes or each fruit is cut off with a pair of short-bladed scissors. The fruits are dried slowly as rapid drying may cause splitting of the fruits. Sometimes, the fruits are bleached by exposing them to sun or
256 Textbook of Pharmacognosy
by placing trays of the fruit over burning sulphur. The fruits may have remains of the calyx at the apex and a stalk at the base. These are removed by hand-clipping or by machines. On the basis of the size, the cardamoms are classified into three categories namely, ‘shorts’ (which are 12 mm long and 6 mm broad and plump), ‘short-longs’ (18–25 mm long and 6 mm broad, finely ribbed and lighter than shorts) and ‘longs’ (25–30 mm long and 4 mm broad). According to the commercial source, there are four varieties namely, Malabar (finest grade), Mangalore, Mysore (second best grade) and Guatemala varieties. The inferior varieties of cardamom come from E. cardamomum var. major Smith (Ceylon cardamom—the source of oil), Amomum cardamomum L. of Siam and Java and A. globosum Loureiro of China (Round cardamom—with a taste of camphor),
A. aromaticum Roxb. (Bengal Cardamom—a taste of camphor) and A. maximum Roxb. (Winged Java Cardamom). In general, two varieties
of Indian cardamom are recognized, viz. Malabar cardamom and Mysore cardamom.
Characters
Macroscopic Characters
The cardamom fruit is an inferior, oblong or ovoid capsule, 1–2 cm long, greenish to pale buff or yellowish in colour. The apex is shortly beaked and the base is round with remains of the stalk. The capsule is 3-celled. In each cell there is a double row of seeds attached to axial placenta. The colour of the seeds is dark reddish-brown when fully ripe. The seeds are covered externally by a colourless, membranous arillus which becomes thicker and oily in the fully ripened seeds. The seeds have a powerful aromatic odour and an agreeable, pungent aromatic taste but the pericarp possesses neither aroma nor taste. The proportion by weight of pericarp to seeds of cardamom fruits is about 1 to 3.
Ripe fruits Dry fr uits and seeds
Systematic Pharmacognostic Study of Volatile Oils 257
Seed powder Cardamom oil
Microscopic Characters
The pericarp has an outer epidermis of small, polygonal, tabular cells and a mesocarp of thin-walled parenchyma in which are a few scattered cells with brown resinous contents. Some of the cells contain calcium oxalate in small or almost needle-shaped prisms and often radiating groups. The mesocarp is traversed longitudinally by vascular bundles, each of which is partially surrounded by a sheath of sclerenchymatous fibres, which are lignified. Transverse section of seed shows the presence of outermost layer of arillus, followed by two layers of testa which contain highly aromatic volatile oil. Perisperm, endosperm and embryo characteristic to the seed are observed in the section. Calcium oxalate crystals and starch grains are present in the perisperm.
Chemical Constituents
The principal constituent of the seeds is the volatile oil, the yield of which varies from 4 to 5% and may be as high as 8%. The active constituent of the volatile oil is 1, 8–cineole (2%). Other aromatic compounds present are palmitic acid, oleic acid, linoleic acid, borneol, pinene, humulene, limonene
Humulene (C14H22) Caryophyllene (C15H24)