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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5322_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Preface to the Second Edition
- •Preface to the First Edition
- •Contents
- •Introduction
- •Pharmacognosy–Definition
- •Pharmacognosy–History
- •Animal Source
- •Pharmacognosy–Scope and Development
- •Review Questions
- •Plant (Vegetable) Source
- •Mineral (Earth) Source
- •Marine (Aquatic) Source
- •Microorganisms (Microbiological) Source
- •Review Questions
- •Alphabetical Classification
- •Morphological Classification
- •Taxonomical (Biological) Classification
- •Pharmacological (Therapeutic or Physiological orPharmacodynamical) Classification
- •Chemical Classification
- •Chemotaxonomic Classification
- •Serotaxonomical Classification
- •Review Questions
- •Introduction
- •Cultivation
- •Breeding for Improvement
- •Review Questions
- •Introduction
- •Botanical Identity
- •Specimens
- •Seeds and other Propagation Material
- •Cultivation
- •Site Selection
- •Climate
- •Soil
- •Irrigation and Drainage
- •Plant Maintenance and Protection
- •Harvest
- •Primary Processing
- •Packaging
- •Storage and Transport
- •Personnel
- •Documentation
- •Review Questions
- •Carbohydrate Derivatives
- •Agar
- •Pectin
- •Honey
- •Review Questions
- •Lipids
- •Simple Lipids
- •Neutral Fats
- •Fats and Oils
- •Waxes
- •Compound Lipids
- •Derived Lipids
- •Review Questions
- •Review Questions
- •Appendix
- •Subject Index

68 Textbook of Pharmacognosy
Period of cultivation: ...................................................................................
Cultivation begins on (Date/Month/Year): ............................................
Cultivation ends on (Date/Month/Year): ...............................................
d. Seeds and other Propagation Materials
Source of the planted material: ..................................................................
Physical description of the planted material: ..........................................
Whether commercially available? (Strike off which is not applicable):
Yes/No
If YES, name of the cultivator: ....................................................................
Name of the supplier: ..................................................................................
e. Method of Cultivation
Method of establishment of the propagation material (Strike off which
is not applicable):
DIRECT SEED SOWING/TRANSPLANTS
Date of first sowing/transplanting (Date/Month/Year): .....................
Percentage emergence: ................................................................................
Date of re-sowing/re-planting (Date/Month/Year): ............................
Percentage of stand establishment: ...........................................................
Spacing between the rows (in centimeters):.............................................
Spacing between the plants (in centimeters): ..........................................
Size of the planted (covered) area (in square-meters): ...........................
Number of plants per unit area: .................................................................
Crop rotation methods followed: ..............................................................
f. Soil and Irrigation
Type of the soil (Strike off which is not applicable):
CLAYEY/SANDY/SILTY/LOAMY
Percentage of clay:........................................................................................
Percentage of sand: ......................................................................................
Percentage of silt:..........................................................................................
Percentage of organic matter: .....................................................................
Percentage of others (if any describe): ......................................................
Soil pH:...........................................................................................................

Good Agriculture Practices (GAP) Strategies of Obtaining Improved .... 69
Soil fertility (strike off which is not applicable): Good/Poor
Soil moisture retention (strike off which is not applicable): Good/Poor
Soil drainage (strike off which is not applicable): Good/Poor
Irrigation (strike off which is not applicable): Yes/No
Land (topography) [strike off which is not applicable]: Even/Sloping
Type of irrigation system (strike off which is not applicable):
FLOOD/FURROW/SPRINKLER/DRIP
Source of water (strike off which is not applicable):
MUNICIPAL OR CORPORATION SUPPLY/LAKE/
RIVER/WELL/OTHERS
If other, please specify the water source: ..................................................
Water quality (strike off which is not applicable): Good/Bad
Description of the quality of water: ...........................................................
Salt concentration in water (strike off which is not applicable): High/
Low
Name(s) of the adjacent plants (scientific/local names): .......................
Types of insects on the adjacent plants:
APHIDS/SCALE INSECTS/CATERPILLARS/LOCUSTS/OTHERS
If others, please specify: ..............................................................................
g. Agrochemicals Applied
1. Fertilisers applied before planting (strike off which is not
applicable)
Organic (composted animal manure)/Chemical
Name: ........................................................................................................
Method of application: ...........................................................................
Time (Date/Month/Year): ....................................................................
Rate of application: .................................................................................
2. Fertilisers applied after planting (top dressing) (strike off which
is not applicable)
Organic (composted animal manure)/Chemical
Name: ........................................................................................................
Method of application: ...........................................................................

70 Textbook of Pharmacognosy
Time (Date/Month/Year): ....................................................................
Rate of application: .................................................................................
3. Herbicides applied before planting (if any)
Name: ........................................................................................................
Method of application: ...........................................................................
Time (Date/Month/Year): ....................................................................
Rate of application: .................................................................................
4. Herbicides applied after planting (if any)
Name: ........................................................................................................
Method of application: ...........................................................................
Time (Date/Month/Year): ....................................................................
Rate of application: .................................................................................
5. Pesticides applied (if any)
Name: ........................................................................................................
Method of application: ...........................................................................
Time (Date/Month/Year): ....................................................................
Rate of application: .................................................................................
6. Special operations done (if any)
Name: ........................................................................................................
Method of application: ...........................................................................
Time (Date/Month/Year): ....................................................................
Rate of application: .................................................................................
7. Plant protection chemicals applied (if any)
Name: ........................................................................................................
Method of application: ...........................................................................
Time (Date/Month/Year): ....................................................................
Rate of application: .................................................................................
h. Harvest/Collection
Date/Month/Year of harvest:....................................................................
Time of the day: ............................................................................................
Conditions of the day at the time of harvest (specify):...........................
Method of harvest: .......................................................................................
Amount of yield per unit area: ...................................................................

Good Agriculture Practices (GAP) Strategies of Obtaining Improved .... 71
i. Drying Practice Adapted
Drying method: Strike off which is not applicable
SUN DRYING/SHADE DRYING/MECHANICAL DRYING
Duration of drying (in days):......................................................................
Moisture content after drying (percentage): ............................................
j. Unusual Circumstances which may influence the quality (strike off
which is not applicable):
EXPOSURE TO EXTREME WEATHER CONDITIONS/EXPOSURE TO
HAZARDOUS SUBSTANCES/OUTBREAK OF THE PESTS, etc.
Please specify and describe the circumstances and reasons thereof, if
any: .................................................................................................................
.........................................................................................................................
.........................................................................................................................
REVIEW QUESTIONS
1. Essay and Short Answer Questions:
1. Briefly describe the good agricultural practices employed in the
cultivation of medicinal plants.
2. Write an account of various good practices employed for obtaining
better quality drugs with examples.
3. Briefly discuss the strategies for obtaining the improved varieties
of medicinal plants.
4. Write an account of good agricultural practices which aim at the
improvement of medicinal plants.
2. Choose the Correct Alternative:
1. General agricultural practices are the technical guidelines
proposed by: [ ]
a. UNESCO b. FAO
c. WHO d. UNICEF
2. These guidelines ensure: [ ]
a. Medicines of good quality
b. Safe and sustainable medicines
c. Postharvest operations
d. All
3. Codex Alimentarius Commission is a joint venture of: [ ]
a. UNICEF/FAO b. UNESCO/UNICEF
c. FAO/WHO d. FAO/FDA

72 Textbook of Pharmacognosy
4. The alternate systems under National Health Policy of India
are: [ ]
a. Unani b. Siddha
c. Ayurveda d. All
5. Botanical identity of selected medicinal plant refers to: [ ]
a. Scientific name b. Common name
c. Cultivar name d. All
3. Fill in the Blanks:
1. Expand the term GCP .............................................................................
2. Expand the term GHP ............................................................................
3. Expand the term GAP ............................................................................
4. Expand the term GACP .........................................................................
5. Expand the term AYUSH ......................................................................
6. Expand the term CITES ..........................................................................
4. True or False Statements:
1. For cultivation of plants, the sites nearer to grave yards and
crematoria should be avoided. [True/False]
2. The stem cuttings chosen for root induction should be of uniform
dimension, in terms of length and diameter. [True/False]
3. The seed material free from contamination and diseases should be
used for cultivation. [True/False]
4. The introduction of non-indigenous plant species into the
cultivation may have a detrimental effect on the biological and
ecological balance of the region. [True/False]
5. For commercial cultivars of medicinal plants, the name of the
cultivar and the name of the supplier should be necessarily
recorded. [True/False]
5. Match the following:
1. Packing labels [ ] a. Misidentification
2. Naturopathy and Yoga [ ] b. WHO-GACP voucher specimen
3. Contamination of drug [ ] c. Non-toxic material
4. First registration [ ] d. Protective clothing
5. Agrochemicals [ ] e. Alternate system of medicine

6
Systematic
Pharmacognostic
Study of Carbohydrates
and Derived Products
CARBOHYDRATES
The carbohydrates are one of the three main classes of food materials in
addition to proteins and fats and one of the most important groups of
natural products. These are the primary products of metabolism and are
utilised by the plants when required. These help in the production of
the secondary metabolites which are deposited in the cells. Carbohydrates
are organic compounds which contain carbon, hydrogen and oxygen in
the ratio of 1 : 2 : 1 and these are a less efficient source of energy than fats
and oils. These are regarded as hydrates of carbon. The final source of
carbohydrates in plants is photosynthesis. Widely distributed in plants
and animals, they serve as the main source of energy (represented by the
sugars) and also store energy (as starch and glycogen). Some carbohydrates
give the required support for the plant tissues (as chitin) while some are
associated with the shells of crabs and other animals. Other important uses
are: they produce alcohol on fermentation; cellulose materials supply
various raw materials and are the components of nucleic acids determining
the heredity. Thus, carbohydrates find a universal application in medicine,
pharmaceuticals and biochemicals.
Carbohydrates are classified into two broad groups namely, sugars and
non-sugars.
1. Sugars (saccharides): Sugars are sweet and soluble in water and their
molecular weights are fixed. These are subdivided into monosaccharides and oligosaccharides.
a. Monosaccharides:
with 3 to 9 carbons represented by a general formula C
cannot be further hydrolysed into simple sugars and are the
building blocks of major carbohydrates like oligosaccharides and
polysaccharides. Chemically, a monosaccharide is either an
aldehyde or a ketone and a substitution product of a polyhydroxy
alcohol. These are grouped according to the number of carbon
Monosaccharides are the simple carbohydrates
nH2nOn
73
and

74 Textbook of Pharmacognosy
atoms present in them as trioses (3C such as glyceraldehyde),
tetroses (4C which do not occur in a free state like erythroses),
pentoses (5C like arabinose, rhamnose, thevetose, xylose and
ribose), hexoses (6C like glucose, galactose and fructose)
and heptoses (7C such as sedoheptulose) out of which glucose and
fructose are the most common hexoses.
Arabinose (5C)
Ribose (5C) Fructose (6C)Glucose (6C)
Xylose (5C)Erythrose (4C)
Idose (6C)Mannose (6C)Galactose (6C)
Altrose (6C) Sedoheptulose (7C)Allose (6C)Talose (6C)

Systematic Pharmacognostic Study of Carbohydrates and Derived Products 75
b. Oligosaccharides: Oligosaccharides are composed of two to ten
monosaccharide molecules joined together by glycosidic linkages
and on hydrolysis yield simple sugars. On the basis of the
monosaccharide units present, they are called disaccharides
(2) producing 2 monosaccharides of same or different composition
on hydrolysis; trisaccharides (3) resulting in the formation of
3 monosaccharides upon hydrolysis and tetrasaccharides
(4) generating 4 monosaccharide molecules during hydrolysis. The
common examples are sucrose and maltose. Sucrose is the only
abundant disaccharide occurring in a free state in the plants while
maltose is present in the cell sap. Sucrose occurs in the juices of
sugarcane and sugar beet and also the sap of certain plants and
yields an invert sugar consisting of glucose and fructose.
MaltoseSucrose
Lactose
2. Non-sugars (polysaccharides):
Non-sugars or polysaccharides are the
complex molecules with a high molecular weight made of a large
number of repeating monosaccharide units (more than 10) held
together by glycosidic linkages and do not possess the properties of
sugars. They are represented by the general formula (C
nH2n-2On-1) n.
These can be broken down into their constituent sugars by hydrolysis.
These are usually amorphous, solid without a taste and are insoluble
in water or form a colloidal suspension, with a higher molecular
weight. The two most abundant polysaccharides in plants are starch
and cellulose.

76 Textbook of Pharmacognosy
Starch
Cellulose
The drugs containing the different categories of carbohydrates are
classified as: sugars and sugar containing drugs (sucrose in sugarcane,
lactose in cow milk, xylose or wood sugar and honey), drugs with the
compounds which are metabolically related to sugars (cherry juice,
raspberry juice, citric acid, lactic acid and ethanol), drugs containing the
products of reductive metabolism (mannitol and sorbitol),
polysaccharides used in coating drugs (starch, inulin, dextran and
cellulose) and gums and mucilages (acacia, tragacanth, karaya gum, guar
gum and agar).
Carbohydrates make-up the bulk of the dry weight of the plant of which
sugars, starches and cellulose predominate. The sugars and starches are
digested by humans while cellulose which is insoluble in water cannot be
digested but can be easily decomposed by the microbes.
CARBOHYDRATE DERIVATIVES
Hexoses contain the terminal alcoholic groups attached to a pyrane ring
and these are easily oxidised. The reaction products are called the uronic
acids which occur as constituents of a large number of complex
carbohydrates in plants and animals. The aldehyde group on oxidation
forms a carboxyl group as a result of which onic acid is produced (gluconic
acid) and as a result of reduction of the aldehyde or ketonic group, a
corresponding polyalcohol is produced. In some sugars, the terminal
alcoholic groups and occasionally, the hydroxyl groups on second carbon
are selectively reduced. The hexoses without a hydroxyl group at sixth
carbon are referred to as methyl pentoses. In a monosaccharide, when the
hydroxyl group gets replaced by a hydrogen atom, the resulting compound

Systematic Pharmacognostic Study of Carbohydrates and Derived Products 77
is a deoxy sugar and such compounds are the characteristic components
of some cardiac glycosides. Variations also occur due to esterification with
acids (acetate). Such esters serve as important metabolites and occur in
some products of polymerisation such as mucus and nucleic acids. In
addition, sugar ethers are the important constituents of some natural drugs.
Amino groups also replace the hydroxyl groups of sugars to generate
structural variation in some drugs. Acacia gum, gum tragacanth, guar gum,
starch, agar, pectin, isabgol and honey are discussed below.
ACACIA
Synonyms
Gum Acacia, Chaar gund, Char goond, Meska, Acacia gum, Egyptian thorn,
Gum Arabic, Indian gum, Gum Senegal, Galam gum, Gomme Arabique,
Gomme de Senegal, Gomme Mimosae, Gummi Africanum, Khadir, Kher
(English), Kumatia, Turkey gum, Meska harra (Moraccan Arabic),
Driehaakdoring (Afrikaans), Gummic arabique, Acacia a gomme arabique
(French), Gummiarabikumbaum, Senegal-Akazie, Arabisches gummi
(German), Arap zamki (Turkish), Khor (Sindhi), Kumta, Kumat (Hindi and
Rajasthani), Somali gum, Sudan gum Arabic, Yellow thorn.
Biological Source
Gum Acacia (Gum Arabic) is a natural gum made of hardened sap (dried
gum) obtained from the stem and branches of two species of Acacia, Acacia
senegal Willd. (= A. verek Guill. et Perr.) and
Acacia (Vachellia) seyal belonging to family
Mimosaceae or Leguminosae. The taxon,
Senegalia senegal (L.) Britton is recognised by
some authors as the correct name for the gum
Arabic tree. However, the name, Acacia
senegal (L.) Willd. remains widely in use. A.
senegal is native to semi-desert regions of sub-
Saharan Africa as well as Oman, Pakistan
and North-Western India. In India, the gum
is collected from Acacia nilotica (=Mimosa
nilotica), Acacia arabica Willd. and some other
species of Acacia and though inferior is used
as a substitute for the official Gum Acacia.
This is sweeter in taste than other varieties.
Botanical variations are represented by
Acacia senegal
(L.) Willd.
Acacia senegal var. leiorhachis, A. senegal var.
rostrata and A. senegal var. senegal. About 500 species of Acacia are distributed
over tropical and sub-tropical areas of Africa, India, Australia, Central
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