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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5463_Библиотеки_им_академика_М_И_Перельмана.pdf
48
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
TABLE 2.1
Supplementation Cardiotoxicity Models Cardiac function Reference
Vitamin D
Orally
Doxorubicin
(Dox)
Female rats
Lee et al.
(2021)
2
+ curcumin (300 mg)
Paclitaxel-placebo
Paclitaxel
breast cancer
Saghatelyan
et al. (2020)
Doxorubicin
Male albino
Wistar rats
al. (2019)
Ganodermalucidum
polysaccharides
Doxorubicin In-vivo male rats
In-vitro rat
cardiomyocytes
H9c2 and human
breast cancer cells
MCF-7
Evidence that GLPS could inhibit DOX-induced cardiomyocytes death,
-
Xu et al.
(2017)
Pera orange (Citrus
sinensis) and Moro
orange (Citrus
sinensis (L.) Osbeck)
Doxorubicin Male Wistar rats
remodeling induced by doxorubicin, improved myocardial energy
oxidative stress
Ribeiro et
al. (2021)
Cinnamomum
zeylanicum Blume
(Ceylon cinnamon)
Doxorubicin Wister rats
C. zeylanicum to
Sandamali
et al. (2021)
Advances for Medical Applications in Breast Cancer and Cardiotoxicity
49
al., 2017).
-
sion took place at the transcriptional level through an autophagy-dependent
in edible plants and spices such as cloves, hops, pepper, oregano, and rose-
antimicrobial, analgesic, anticancer, and antioxidant activities. Currently, it
et al., 2016).
-
-
-
-
50
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
-
-
et al., 2021).
G. lucidum
Asian countries to treat numerous diseases and promote health and longevity
G. lucidum
-
-
G. lucidum
-
Sohretoglu and Huang, 2018).
-
Advances for Medical Applications in Breast Cancer and Cardiotoxicity
51
Citrus sinensis) and Moro
orange (Citrus sinensis-
C. zeylanicum
C.
zeylanicum
against doxorubicin-induced cardiotoxicity. Flavonoids have important
as quercetin, hesperidin, luteolin, anthocyanin, and naringenin (NRG),
2.1.4 ADVANCES IN THE APPLICATION OF NANOTECHNOLOGY IN
BREAST CANCER
increased in recent years. Natural compounds can be a viable alternative to
reactions that traditional drugs cause (Su et al., 2022).
Salvia sclarea) (Cosco et al., 2019),
Silybum marianum
et al., 2020), hydroxytyrosol (phenolic phytochemical) (Ahmed Wani et al.,
Helianthus tuber osus L. (Mariadoss et al., 2020) tetrahy-
52
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
TABLE 2.2 In-vitro
Nanosystem Bioactive compound Drug delivery Cancer cell line References
Polimeric nanoparticles
(PLGA)
Sclareol (bicyclic diterpene
alcohol)
– Human colorectal adenocarcinoma cells (CaCo-2)
and human breast cancer cells (MCF-7 e
MDA-MB468)
Cosco et al. (2019)
Mesoporous bioactive
glass nanoparticles
Silibinin Metastatic breast cancer cells MDA-MB-231 and
nonmetastatic breast cell line MCF-10A
Chitosan Hydroxytyrosol Human lung adenocarcinoma cells (A549) and
human breast cancer cells (MDA-MB-231)
Ahmed Wani et al.
(2022)
Copper oxide nanoparticles and
Helianthus tuberosus extracts
Human breast cancer MDA-MB-231 Mariadoss et al. (2020)
Solid lipid nanopar-
chitosan
MDA-MB-231, and the human keratinocyte cell
phosphatidylcholine
Isoliquiritigenin
Wang et al. (2023)
Niosomes Farnesol-gingerol
Cell lines MCF7, SKBR3, and HFF Lalami et al. (2022)
guava
Human breast cancer cell line (MCF-7) Vasconcelos et al.
(2020)
Hybridcasein-calcium
Genistein
MDA-MB-231
Bindhya et al. (2021)
polyethylene glycol
Naringenin
Eudragit L100 Black pepper essential oil
Solidlipid
Teucrium polium extract
Roumi et al. (2021)
Chitosan Resveratrol
Advances for Medical Applications in Breast Cancer and Cardiotoxicity
53
Teucrium polium extract
lipid matrix (Matos et al., 2019).
Polymeric nanoparticles have properties that include controlled release,
improvements in the therapeutic index. A nanocapsule has an aqueous or
such as optical, electronic, and magnetic properties. Metal nanoparticles can
-
-
bioaccessibility
C. longa
curcumin molecules (Chen et al., 2020). Nanoparticles containing curcumin
(i.e., increased heart rate) and improved alterations in electrocardiogram,
54
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
H. tuberosus
pharmacological properties (Mariadoss et al., 2020). Reduced copper oxide
H. tuberosus
to be a viable therapy (Mariadoss et al., 2020).
Black pepper essential oils (Piper nigrum L.) have excellent antioxidant
(CaCo-2) (Cosco et al., 2019).
shells and has been used in nano-encapsulation processes due to their biocom-
-
W ani et al., 2022). On the other hand, resveratrol has antioxidant, anticancer ,
Advances for Medical Applications in Breast Cancer and Cardiotoxicity
55
T. polium extract (Roumi et al., 2021),
et al., 2022).
T. polium extract exhibited anti-
apoptosis induction in Ntra-2 cells (Roumi et al., 2021).
at any tested concentration (Vasconcelos et al., 2020).
-
enhances skin permeation, cell uptake, and cytotoxicity against MDA-MB-
al., 2022).
-
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
both phytochemical compounds (Lalami et al., 2022).
-
induced cell apoptosis, and remained stable in relation to normal cells
-
-
2.2 CONCLUSIONS
undergoing chemotherapy treatment, although incidental, reveal a reduction
Advances for Medical Applications in Breast Cancer and Cardiotoxicity
57
-
to prevent cardiotoxicity is still unclear, making additional results neces-
models. It should also be noted that, depending on the type and concentra-
-
in the targeted site.
ACKNOWLEDGMENTS
KEYWORDS
• cardiac rehabilitation
• physical exercises
• nutritional supplementation
• nanotechnology