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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5463_Библиотеки_им_академика_М_И_Перельмана.pdf
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
-
al., 2019), acrylic acid (AA), PEO, PEG, and PLA. In most cases, other
polymers have been applied to create blends, such as alginate, dimethoxy-
PVP, and Precirol
®
immediately printed drug-release tablets, changes have been made in
-
lose sodium (Cui et al., 2020), crospovidone (Omari et al., 2022), sodium
7.4.3 MICRONEEDLES
to 2000 mm on a tiny patch. It is primarily used to deliver drugs trans-
dermally (
3D Printed Devices as Drug Delivery Systems
219
Drug skin permeability is selectively limited by the physical structure
circulates (Economidou et al., 2018). During drug release, external stimuli
the tissue.
mechanical strength. Some solid microneedles did not contain any drug.
can serve as a rate-controlling membrane (Li et al., 2022). In contrast,
-
cate complex geometries, and reproducibility. In most cases, microneedles
220
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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reported in the literature.
the most promising. Commonly used polymers include resins, PEG, PVA,
PLA, GelMA, polyethylene glycol diacrylate (PEGDA), tricalcium phos-
7.4.4 CAPSULE
-
microparticles.
Fudim, 1988), especially HPMC, PVA, PEG, and PLA. Recent studies
-
dipyridamole.
has also been explored, including DPE and microscaled electrohydrody-
namic (EHD) printing.
7.4.5 FILMS
3D Printed Devices as Drug Delivery Systems
221
Karki et al., 2016). Drug action
-
including chitosan, PVA, alginate, cellulose and derivatives, maltodextrins,
PVP, lactic acid, and PEO.
and electrospinning, 3D printing processes have been explored, such as
7.5 MAIN FACTORS IN DRUG DELIVERY
7.5.1 NATURE OF POLYMERS
-
release rate (
-
(Fina et al., 2018).
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
FIGURE 7.3
7.5.2 MATRIX PERMEABILITY
changing their structural composition, it is possible to produce a solid matrix
7.5.3 POLYMER BLENDS
Polymer blends can be explored as an elegant approach to achieving inter-
Liang et al., 2018).
Other studies have explored more complex polymer mixtures to modulate
-
FDA-approved polymers that present limited and even lack printability in AM
-
®
3D Printed Devices as Drug Delivery Systems
223
7.5.4 SPECIFIC SURFACE AREA
7.5.5 INFILL DENSITY AND PATTERNS
224
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
Goyanes
include line, cubic, grid, triangle, trihexagon, honeycomb, octet, gyroid,
-
7.5.6 PORES
-
niques, micro- and macro-porosity 3D printed devices have recently been
designed (
explored a dual methodology to produce 3D-printed porous PCL devices.
2
-adsorption–desorp-
7.5.7 CROSS-LINKING
3D Printed Devices as Drug Delivery Systems
225
-
(2017).
7.5.8 COATING
(
avoid undesirable initial burst releases (Sun and Soh, 2015). Moreover, the
modulating drug release using 3D printing.
7.5.9 CORE/SHELL AND MULTICOMPARTMENT
polymer (Kadry et al., 2018). Kadry et al. (2018), using HPMC as an excip-
in its entirety, does the drug-loaded core start to release. Consequently, by
226
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
-
A multicomponent device, such as a capsule, is designed to isolate
multiple incompatible drugs (Genina et al., 2017) and to control the rate at
®
gastric route, as illustrated in vivo using rabbit models (Fu et al., 2018)
7.6 FINAL CONSIDERATIONS AND FUTURE PERSPECTIVES
maintained remains a challenge.
3D Printed Devices as Drug Delivery Systems
227
KEYWORDS
• 3D printing
• drug delivery systems
• precision medicine
• additive manufacturing
• polymers
• drug release
REFERENCES
Marine Drugs 2022, 20 (6), 364.
Directions. Molecules 2021, 26 (19), 5905.
Pharmaceutics 2021, 13 (12), 2151.
Pharmaceuticals: Contemporary Research and Applications. Curr. Pharm. Des. 2018, 24
(42), 4991–5008.
via Fused Deposition Modeling (FDM) 3D Printing. Eur. J. Pharm. Biopharm. 2016, 108,
111–125.
Int. J. Pharm. 2019, 570,
118651.
Eur. J. Pharm.
Biopharm. 2022, 177, 211–223.
Sci. Rep. 2020, 10 (1), 1–16.
Biomaterials 2017, 128, 1–7.