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6.3.2.1.5
transport (Dolatabadi and de la Guardia, 2011).
condense and transport DNA (Kneuer et al., 2000). It has been demonstrated
rat Achilles tendons Park et al. (2008) linked the mannosylated PEI to the
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silica nanoparticles through receptor-mediated endocytosis and to lessen
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Bhakta et al. (2011) developed gadolinium-oxide-doped silica nanoparticles
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tively via endocytosis, BPEI-silica nanotubes delivered plasmid DNA into
3
3
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Guardia, 2011).
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Metallic nanoparticles may be used in imaging and diagnostic procedures.
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applications (Heinemann et al., 2013). Due to their extraordinary physical,
chemical, and biological characteristics, gold glyconanoparticles (GlycoNPs)
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response. Additionally, siRNAGlycoNPs given via the lungs in vivo are able
6.4 CONCLUSION AND FUTURE PROSPECTS
species, disease type, and tumor environment. Nonetheless, this chapter
employed and their interactions. Moreover, in vitro and preclinical studies
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into clinical trials using nanoparticle-mediated gene delivery. Although the
extended to people because human physiology is not likely to be adequately
more extracellular barriers to gene delivery to patients than there are to cell
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attack, DNA release, and transcription, must also be understood to achieve
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KEYWORDS
• delivery systems
• nanoparticles
• nucleic acids
• vectors
• nanomedicine
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Advances in Pharmaceutical T echnology for Drug Delivery Systems (PTDDS), Volume 2: Recent Progress
in Biomedical Applications. Sougata Jana (Ed.)
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)
3D Printed Devices as Drug Delivery
Systems
ITALO RODRIGO CALORI, ANA PAULA PEREIRA GUIMARÃES, and
ANTONIO CLAUDIO TEDESCO
Department of Chemistry, Center of Nanotechnology and Tissue
CHAPTER 7
ABSTRACT
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humans, the orodispersible tablet Spritam
®
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systems, the main chemical ingredients used as additives in pharmacology,
drug release.