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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5463_Библиотеки_им_академика_М_И_Перельмана.pdf
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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observed that hydrothermally prepared system (RGPP) had higher gene trans-
processesendorse covalent nucleophilic interaction among the epoxy moieties
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∼
2
∼
FIGURE 5.5
Nanocomposites.
Source
Society.
Graphene-based System for Drug Delivery and Biomedical Application
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5.4.3 BIOIMAGING
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ment, and prognosis compared to the normal physiological condition. In the
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cability in this sector.
Despite various limitations such as background scoring, and photo-
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2010).
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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FIGURE 5.6 In vivo
Source
Chemical Society.
Graphene-based System for Drug Delivery and Biomedical Application
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While the other noninvasive, hybrid imaging technique, photoacoustic
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2012). Other group developed graphene-tied poly(vinyl alcohol) microbub-
5.4.4 PHOTOTHERMAL THERAPY
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peutic strategies. Photothermal therapy is one such novel approach. In
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
irradiation, thereby, killing both Staphylococcus aureus (Gram-positive)
and Escherichia coli
graphene nanomaterials plays a critical role in its applications. In a study ,
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cidal activity through photothermal therapy compared to the negatively
E. coli
al., 2017).
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study exposed the BSA-rGO and DOX-BSA-rGO-treated U87MG cells
2
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and enhanced photothermal properties. Such nanopatch exhibited a higher
Graphene-based System for Drug Delivery and Biomedical Application
163
FIGURE 5.7
2
culture medium, (B) BSA-rGO, and (C) DOX-BSA-rGO nanosheets. NIR irradiation groups:
Source
Chemical Society.
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
compared to uncoated rGO and gold-coated GO (Lim et al., 2013). Due to
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context, a research group developed tripeptide -arginyl-glycyl--aspartic
5.4.5 TISSUE ENGINEERING
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graphene and its derivatives in various tissue engineering applications.
and obesity demand bone tissue engineering. Due to the extraordinary
Graphene-based System for Drug Delivery and Biomedical Application
165
et al., 2022). In another study, researchers have developed hydroxyapatite
3
) and tensile strength (105
MPa) compared to the hydroxyapatite-PLA matrix. Such mechanically
tough matrix promotes bone regeneration (Chen et al., 2018). Furthermore,
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
FIGURE 5.8 Specimen
Chemical Society.
collagen, glycosaminoalycan, proteoglycans, and non-collagenous proteins,
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not regenerate upon damage. In this regard, cartilage tissue engineering
murine chondrocyte cells, and SW1353 cells. In vivo results depicted the
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tions (Lyu et al., 2022).
Graphene-based System for Drug Delivery and Biomedical Application
167
In this scenario, several cardiac tissue constructs have developed to mimic the
ECM in the cardiac tissue through tissue engineering approaches. Graphene
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very close electrical conductivity and mechanical property compared to
is, Nkx 2.5and Connexin-43 could be observed (Pilato et al., 2023). Besides
engineering applications such as skin, muscle, and neural tissue engineering
due to their unique properties.
5.5 SUMMARY AND FUTURE PROSPECT
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the end product. Furthermore, more in vivo