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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5463_Библиотеки_им_академика_М_И_Перельмана.pdf
298
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
recently observed that 3D-printed biomimetic hydroxyapatite (HAp) proved
2016).
10.3 BIOCERAMICS IN ORTHOPEDIC APPLICATIONS
Ceramics are considered an excellent material to prepare orthopedic implants
-
other inorganic salts to produce bone cement (Vallet-Regi and Navarrete,
Bioceramics System for Biomedical Application
299
-
-
in addition, hybrid materials such as bioceramics–polymer have also been
2
–P
2
O
5
mate-
and less tissue damage as compared to pure silica materials (García et al.,
2
–P
2
O
5
300
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
Overall, the primary microstructure possessed by glasses and ceramics,
promising mechanical properties. In addition, these hierarchical materials
displayed excellent osteoconductive and osteointegration characteristics by
activity to stimulate bone regeneration in vivo
Metoki, 2017) (Fig. 10.1). Nonetheless, this limitation can be overcome by
Bioceramics System for Biomedical Application
301
characteristics to promote bone healing such as physiochemical properties,
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FIGURE 10.1
Source
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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implant consolidation based on postsurgical assessment (Marcacci et al.,
demonstrated that the implant promotes bone healing by encouraging angio-
-
genic protein 2 (BMP-2). In this experiment, HAp slurry and polymethylmeth-
p. 2). SiO
2
and SiO
2
to evaluate the in vivo bone healing potential. Postsurgical evaluation at 6,
-
strated that the SiO
2
use due to superior osteoinduction ability (Fielding and Bose, 2013). In addi-
tion, mesoporous bioactive glasses (MBGs) provide an interesting potential
Bioceramics System for Biomedical Application
303
Many investigations have been done to explore the bioactive behavior
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Biomedical science research including human clinical trials is conducted
research and development. For biomaterials and all pharmaceutical products,
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
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®
®
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®
®
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10.4 BIOCERAMICS IN MAXILLOFACIAL SURGERY
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-
Bioceramics System for Biomedical Application
305
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techniques are employed in clinical procedures such as sinus augmentation,
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attached morphologically. Nonresorbable bioactive ceramics stimulate a
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
contrary, resorbable bioceramics gradually degrade over time and are even-
disadvantage is the unmatched implant degradation and host tissue repair
(Adamopoulos and Papadopoulos, 2007).
TABLE 10.1
Category Reference
Inert
Alumina (Al
2
O
3
)
al., 2018)
2
)
Vigolo et al., 2006)
Carbon (C)
Bioactive
Nonresorbable
Calcium phosphate
ceramics (CPC)
Mostly HAp alone,
chitosan, collagen,
poly(l-lactide),
2+
,
2+
, Cd
2+
3+
2020)
Bioactive glasses
and glass ceramics
Mineral trioxide
Resorbable
Porous CPC,
CaSO
4
, coral, CaCO
3
Xiao et al., 2015) (Figure 10.2)
Bioceramics System for Biomedical Application
307
FIGURE 10.2
surgery
Source
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