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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5463_Библиотеки_им_академика_М_И_Перельмана.pdf
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
polyethylene glycol (PEG) has been demonstrated to increase cell adhesion
to polymers in various applications (Samir et al., 2022).
Polylactic acid (PLA) is an aliphatic linear thermoplastic polyester composed
-
temperature (T
c
T
m
to 162°C (
applications in tissue engineering and regenerative medicine. Its hydropho-
distribution, and morphological properties. In vivo, it has a prolonged degra-
biomedical technology (Shi et al., 2022). PEG is a hydrophilic polyether
-
mately 25°
; and hard
°C, respectively,
3D Printed Devices as Drug Delivery Systems
209
-
PVA is a hydrophilic, biodegradable, and nontoxic synthetic thermoplastic
-
as adhesives, in tissue engineering, regenerative medicine, and in the resin
industry (Jain et al., 2017), morphologically presenting themselves in the
7.3.2.5 POLYVINYLPYRROLIDONE
Polyvinylpyrrolidone (PVP) is a nontoxic, nonionic, inert, temperature-re-
sistant, pH-stable, biocompatible semisynthetic polymer (Franco and De
-
210
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
acids, and amines, and insoluble in ethers, hydrocarbons, esters, ketones,
external agents (temperature and pH) (Franco and De Marco, 2020).
-
-
processing (DLP) bioprinting processes.
®
-
32 k to 280 k g mol
–1
the same main chemical structure, varying only in their substituents (
chemical properties. Eudragit polymers are mostly cationic, anionic, or
neutral. Eudragit E (EE) is a cationic copolymer that is soluble at a pH above
3D Printed Devices as Drug Delivery Systems
211
5. Eudragit RL (ERL) is a permeable, cationic polymer that is chemically
7.0, 6.0, and 5.5, respectively. Eudragit FS 30 D (EFS30D) is an anionic
HME and FDM 3D processes to develop pharmaceutical products to obtain
sustained release systems.
7.4 COMMON 3D-PRINTED DOSAGE FORMS
complicated, and time-consuming. 3D printing technologies have emerged
®
to complex geometric devices. Figure 7.2 illustrates the most common 3D
7.4.1 SCAFFOLDS
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
FIGURE 7.2
applications.
neighboring tissue biochemically (Shao et al., 2018).
-
Niclot et al., 2022), endothelial cell repair (Wu et al., 2019), cartilage
(Wen et al., 2019), and tissue engineering (Jain et al., 2018), but also to
3D Printed Devices as Drug Delivery Systems
213
TABLE 7.1
3D printing Forms Polymers Drugs
FDM Film PVA-based
PEO N80 (Polyox-N80) Adipic acid (Elkanayati et al., 2022)
Capsule PVA-based Amoxicillin (Charoenying et al., 2020)
Eudragit (EPO and
ERL)
PLA-based
HPMC-based
HPC-based
PEG-based
PVA
(Obeid et al., 2021)
PEO
PLA-based
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
3D printing Forms Polymers Drugs
PCL
Indomethacin (Viidik et al., 2021)
Eudragit-based
EVA
PVP
Kollidon-based
Hypromellose acetate
succinate
PEG-based
HPC Paracetamol (Fina et al., 2020)
PLA Methotrexate (Schmid et al., 2021)
PCL-based
Micro-
needles
PLA
PEG-based
T. indica and V. agnus-castus extracts (Amer et al., 2020)
Resin Vero Clear VEGF (Barnum et al., 2021)
SSE Film Carboxymethyl
cellulose (CMC)
Gelatin-based
HPMC-based
Kolliphor EL
TABLE 7.1 (Continued)
3D Printed Devices as Drug Delivery Systems
215
3D printing Forms Polymers Drugs
HPMC
Hydroxyethylcellulose
PCL
PVA-based
PVP
Cellulose ethers
HPC Levetiracetam (Cui et al., 2020)
Hypromellose
PLA and HA Amikacin (Cui et al., 2022)
SLA Capsule PEG-based
PEG-based Paracetamol (Healy et al., 2019), Aspirin (Healy et al., 2019)
Micro-
needles
Resin dental SG
Methacrylic
oligomer-based
Any cubic-colored resin
BJP – Levetiracetam (Li et al., 2021)
SLS Kollidon VA64
HPMC
Eudragit (L100–55 and
RL)
TABLE 7.1 (Continued)
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
N-(pyridin-4-yl), minocycline (Martin et al., 2019), methotrexate (Mei et
al., 2021), cyclohexanecarboxamide, Erythropoietin (Wu et al., 2019), and
(Chen et al., 2020), human bone morphogenetic protein-2 (BMP-2) (Ji et
et al., 2019). In addition to several biopolymers and compounds currently
al., 2022) alginate (Akkineni et al., 2021), PLA (Schmid et al., 2021), PLGA
F127 (Lee et al., 2022), gelatin (
-
needed to reduce polymer hydrophobicity , control drug release, and enhance
Bose et al., 2022).
Recently, Sun et al. (2022) designed a 3D-printed calcium phosphate
3D Printed Devices as Drug Delivery Systems
217
2017). HA 3D-printed ceramics are biocompatible, bioactive, and osteocon-
control-release system (CMR) to HA remains a key challenge. Chen et al.
-
2
groups by incubating
their structure (Chen et al., 2019a)
7.4.2 TABLETS
on a genetic, biomarker, phenotypic or psychosocial characteristics
-