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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5463_Библиотеки_им_академика_М_И_Перельмана.pdf
108
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
2020).
Rutin is a lipophilic compound that is a potent antioxidant used as a treat-
pass metabolism (V iskupicova et al., 2015). Rutin has an increased tar geting
nanoparticles using the ionotropic gelation method, as it expressed improved
model (Ahmad et al., 2019a).
Glycyrrhiza glabra are
another antioxidant and neuroprotective agent that may be used as a
caprolactone loaded nanoparticles, administered intranasally, increased
-
(Ahmad et al., 2019b).
by coupled bimodal single-photon emission computed tomography (
-
acute migraine management, this mucoadhesive nanoemulsion preparation
marketed drugs (Girotra et al., 2017).
Natural Biocarriers for Brain Targeting
109
-
Box–Behnken design (Shah et al., 2016a).
Chitosan nanocarriers have also been used to treat depression, as demon-
antidepressant. When used intranasally, chitosan-loaded nanocarriers
by encapsulating it in chitosan and cyclodextrin intranasal microemulsion,
(Bshara et al., 2014).
popularity (Lou et al., 2009).
chitosan and polyethyleneimine-coated magnetic micelles nanoparticles,
a potential magnetic resonance imaging contrast agent, to deliver DNA to
-
paramagnetic iron oxide nanoparticles in the chitosan-based nanoparticles
be delivered to the brain and potentially imaged using magnetic resonance
110
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
TABLE 4.1
Disease Drug Investigated delivery system/special
comment
References
disease
Memantine Chitosan nanoparticles prepared by gamma
al. 2020)
Curcumin- and
dexamethasone
vasculature and high permeation to the
blood–brain barrier endothelium.
et al. 2014)
intranasal administration.
(Bshara et al.
2014)
Rivastigmine Chitosan-based mucoadhesive microemul-
and achieved brain targeting via intranasal
delivery route.
(Shah et al.
2018)
Epilepsy
chitosan nanoparticles resulted in enhanced
administration.
(Liu et al.
2018)
Brain
ischemia
Rutin Rutin-loaded chitosan nanoparticles
administration.
(Ahmad et al.
2019a)
Migraine Nystatin
(Girotra et al.
2017)
tripolyphosphate nanoparticles prepared
administration.
(Mandlik et
al. 2018)
intravenous or the nasal solution.
(Abdou et al.
2017)
disease
Dopamine Chitosan-dopamine or chitosan tyrosine
-
(Cassano et
al. 2020)
Rotigotine Rotigotine-loaded chitosan nanoparticles
-
(Bhattamisra
et al. 2020)
Natural Biocarriers for Brain Targeting
111
Disease Drug Investigated delivery system/special
comment
References
Rasagiline Encapsulating rasagiline in chitosan nanopar-
ticles using an ionic gelation technique
dramatically increases bioavailability in the
(Mittal et al.
2016)
Ropinirole
hydrochloride
could enhance the drug permeation across the
cellular membranes using the intranasal route.
(Pardeshi and
2018)
Psychiatric
disorder
Quetiapine
(Shah et al.
2016a)
ionic gelation method using Box–Behnken
design.
-
intranasal route.
(Shah et al.
2016b)
Poly(lactic-co-glycolic acid)– chitosan
-
the nasal route.
2016)
Buspirone
hydrochloride
Chitosan and cyclodextrin intranasal micro-
emulsion, administrated via the intranasal
route revealed plasma concentration peaked at
(Bshara et al.
2014)
Reporter DNA
intranasally.
(Das et al.
2014)
Hyaluronic acid, given the name hyaluronan, is a natural polysaccharide
TABLE 4.1 (Continued)
112
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
in the central and peripheral nervous system (Bayer, 2020). It regulates the
motility (
nervous system disorders.
strategy (Wang et al., 2022).
In another study conducted by Lu et al., hyaluronic acid-based hydrogel
-
Natural Biocarriers for Brain Targeting
113
prepared gel. In addition, the in vivo
Other investigated delivery systems based on hyaluronic acid involved
loaded hyaluronic acid nanoparticles to convey neuroglobin through the
their cellular uptake by endocytosis, in addition to their positive charge
-
chyma (Blanco et al., 2020).
-
114
Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
TABLE 4.2
Disease Drug Special comment References
Mesenchymal stem
cells and nerve
and other tissue repair therapy.
(Wang et al.,
2022)
(a peptide that
mimicvascular
(Lu et al.,
2019)
Gallic acid
al., 2022b)
(Duan et al.,
2016)
Stem cells
(Li et al.,
2020)
Brain
ischemia
Neuroglobin
neuroprotective protein.
neuroprotective oxygen-sensing protein
(neuroglobin protein) to the damaged
(Blanco et
al., 2020)
-
-
chitosan. In contrast to the intranasal solution and oral tablet, the results
Natural Biocarriers for Brain Targeting
115
immobility (Haque et al., 2014).
(Lv et al., 2018).
used to treat various neurological diseases to achieve a greater therapeutic
-
-
4.2.2 PROTEIN CARRIERS
-
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Advances in Pharmaceutical Technology for Drug Delivery Systems (PTDDS), Volume 2
using either animal-derived or plant-derived source proteins. Animal
Being the most abundant protein in human body, albumin is considered
biocompatible, biodegradable, and nontoxic, in addition to the abundance
-
2020). Several researchers have investigated albumin-based nanoparticles as
-
-
edema (Xue et al., 2020).
Natural Biocarriers for Brain Targeting
117
-
to augment drug delivery to the brain (Rich et al., 2020).
Gao et al. prepared curcumin-loaded human serum albumin nanoparticles
-
-
the brain (Gao et al., 2020).
-
biopolymer-based nanocarriers to increase drug permeability to the brain.