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15

Nutraceuticals and Cosmeceuticals

Charulata T. Nemade1, Nayana S. Baste1, Manisha M. Bihani2, Shilpa S. Raut
1
Department of Pharmacognosy, SNJB’s Shriman Sureshdada Jain College of Pharmacy, Nashik, India
2
Department of Pharmacognosy, Krupanidhi College of Pharmacy, Bengaluru, India
3
Department of Pharmaceutics, K.K. Wagh College of Pharmacy, Nashik, India
3
15.1 Introduction

15.1.1 Definition of Nutraceuticals and Cosmeceuticals

The phrase was first used in 1989 by Cranford, New Jersey’s Stephen DeFelice, MD, who is also the Chairman and Founder of Foundation for Innovation in Medicine (FIM). He explains the term “nutraceutical” by combining “nutri­tion” and “pharmaceutical.” DeFelice defines a nutraceuti­cal as a food or component of food that provides therapeutic or health advantages, including both treatment and pre­vention of illnesses [1]. Typically, nutraceuticals come in a recommended dosage and are packaged in a pill, capsule, powder, or liquid. The phrase also suggests that there is proof of a physiological advantage or defense against a long-term sickness in the extract or source of food [2].
Nutraceuticals include everything from diet plans, nutri­tional additives, and isolated nutrients to genomically modi­fied “designer” foods, herbal goods, and canned goods including soups, drinks, and cereals. Without a doubt, a huge number of these phytocompounds have beneficial biological actions in addition to significant physiological roles [3].
The idea of nutraceuticals originated with a survey con­ducted in Germany, the United Kingdom, and France. The poll found that consumers place a higher value on nutrition than on exercise or genetics when it comes to maintaining good health. Nutraceuticals were widely uti­lized in the United States, although there was no official definition at the time. The Canadian Health Ministry has redefined nutraceuticals as products derived from food,
usually sold in medicinal forms separate from typical food items, and proven to offer physiological benefits and defense against long-term illnesses. Similarly, the Government Department of British for Agriculture, Food, and Fisheries defines functional foods as those that con­tain added components providing specific medical or physiological advantages beyond basic nutritional value.
The legal classification of a nutraceutical under European Union (EU) law is often based on the substance’s acknowledged physiological effects. Therefore, the sub­stance may be regarded as a food ingredient if its primary function is to support the upkeep of tissues and organsin a healthy state. It most certainly qualifies as a medicinal substance if it exhibits a moderating effect on any of the internal physiological systems [4].
“Cosmeceuticals” is a term that combines “cosmetics” and “pharmaceuticals.” As a noun, it refers to cosmetics with biologically active components allegedly having thera­peutic or pharmaceutical effects. These substances serve a dual purpose by enhancing appearance and providing thera­peutic benefits. A cosmeceutical, to put it technically, is a substance with medical qualities that exhibits advantageous topical effects and provides defense against degenerative skin disorders [5]. These products often bridge the gap between traditional cosmetics and pharmaceuticals, offering a unique blend of aesthetic enhancement and therapeutic effects for the skin. Cosmeceuticals represent a fusion of cos­metics and pharmaceuticals, designed to promote skin health and beauty. These products incorporate a variety of functional ingredients, some sourced naturally and others
298 15 Nutraceuticals and Cosmeceuticals
Table 15.1 Three categories of cosmeceuticals.
Cosmeceuticals
Cosmeceutical products for skin
Antiaging creams Gel and creams Lipstick
Moisturizers Hair colorants and dyes Nail polish
Facial products Shampoos Toothpaste
Lotions Growth stimulators Powders
Cosmeceutical products for hair
Conditioners
Others
synthesized, all with therapeutic, disease-fighting, or heal­ing properties [2]. The term “cosmeceutical” gained promi­nence through the efforts of Raymond Reed, the American Society of Cosmetic Chemists’ founder. However, it was American dermatologist Albert Kligman who popularized the concept in the late 1970s. This innovative category of skincare products exemplifies a holistic approach, combin­ing aesthetic enhancement with medicinal and healing attributes, providing consumers with a comprehensive solu­tion for their skincare needs [3]. Cosmeceuticals can be cat­egorized into three main groups (Table 15.1):

15.1.2 Historical Overview

During the Middle Ages, Arab and European physicians regarded herbal remedies, cosmetics, and fragrances as equally significant fields of study. Their research and devel­opment endeavors encompassed all these areas concur­rently. However, in the nineteenth century, a divergence occurred as the cosmetic and toiletry industries separated from the pharmaceutical business and pharmacy. This schism emerged with the drafting of the initial government statute regulating medication sales and the subsequent establishment of the modern pharmaceutical industry. Before its resurgence late in the 1970s and early in the 1980s, the role of cosmetics as a positive healing aid was disregarded. Kligman reignited interest in this area by cre­ating formulations with retinoic acid as the active compo­nent that improved the appearance of wrinkled and UV-damaged skin.
The concept of personal grooming is no longer limited to women; men are increasingly becoming concerned about their appearance as well. Present-day advertise­ments for anti-wrinkle and fairness creams often target men. Key cosmeceuticals for men encompass a range of products, such as astringents, antiaging treatments, anti­perspirants, hair growth solutions, and athlete’s foot
creams. Meanwhile, popular cosmetics among women focus on addressing issues like wrinkles, cellulite, hair removal, skin tanning, whitening, antioxidants, and cel­lular recovery [8].

15.1.3 Significance in Modern Healthcare and Beauty Industries

The contemporary work environment has given rise to a new category of ailments commonly referred to as lifestyle disorders. These are typically caused by factors, such as poor dietary habits, reliance on fast food, sedentary life­styles, disrupted sleep patterns, incorrect posture, too much stress, and insufficient rest. Nutraceuticals, which integrate modern science with natural ingredients, are seen as promising solutions for managing these conditions. Lifestyle disorders are thought to have an impact on the development of various complex medical conditions.
An array of nutraceutical products available on the mar­ket may help prevent lifestyle disorders from progressing into more serious illnesses. Consumer interest in nutraceu­ticals began to rise around the 1980s, coinciding with increased scientific scrutiny and media coverage of their efficacy. Factors, such as soaring medical costs, longer life expectancy, growing health consciousness, and mounting scientific evidence supporting the health benefits of nutra­ceuticals have all played roles in boosting consumer accept­ance of these products [4].
Personal grooming is no longer a domain exclusive to women; men are also showing a growing interest in their appearance. In modern advertising, there is a notable trend of targeting men with ads for anti-wrinkle and fairness creams. Essential cosmeceuticals for men now include vari­ous products like astringents, anti-aging treatments, anti­perspirants, and foot creams. Conversely, women’s cosmetics predominantly address concerns such as wrinkles, cellulite, hair removal, skin tanning, whitening, antioxidants, and cellular recovery [5].

15.2 Nutraceuticals

15.2.1 Definition and Classification

15.2.1.1 Functional Foods
Functional foods are those that include essential nutri­ents (vitamins, proteins, fats, carbs, etc.) that the body needs to survive in a healthy state. Nutraceuticals are functional foods that have the ability to prevent or cure diseases or conditions other than anemia. Functional foods are composed of various bioactive chemicals
15.2 Nutraceuticals 299
derived from plant (fruits and vegetables), marine, or ani­mal sources that offer pertinent health advantages [6].
15.2.1.2 Dietary Supplements
A dietary supplement is a product that is concentrated and typically comes in liquid, tablet, capsule, or powder form. It contains nutrients that are sourced from food items. The Food and Drug Administration (FDA) regulates dietary supplements like it does for foods, although it regulates them differently than it does medications or other foods [7].
In the United States, a dietary supplement is described as a product containing a “dietary ingredient” that is ingested orally, intended to enhance or supplement the diet, as defined by the Dietary Supplement Health and Education Act (DSHEA) of 1994. These products’ “dietary ingredi­ents” could consist of amino acids, vitamins, minerals, botanicals, and materials, including organ tissues, glandu­lars, metabolites, and enzymes. There are numerous ways to take dietary supplements, such as soft gels, capsules, liq­uids, gel caps, and powders. They can also be extracts or concentrates [8].

15.2.2 Key Components and Ingredients

15.2.2.1 Vitamins and Minerals
The majority of nutritional therapy products and nutraceu­ticals include some vitamins, including basic vitamins like A, B vitamins, C, D, and E. Since plant foods provide a sig­nificant amount of human vitamin intake, plant biotech­nology has been utilized to increase the amount of vitamins in crops. “Golden Rice” is a transgenic rice variety that has a high concentration of pro-vitamin A β carotenoids in its grains. Lactococcus lactis, the bacterium that starts dairy products, can produce riboflavin (vitamin B2) and folate (vitamin B11). To avoid connective tissue-related diseases, vitamin C is crucial. Mineral elements, such as Ca, I, Fe, Zn, Mn, and Mg are vital to human health. Any one of these mineral deficiencies can lead to dangerous health issues. Meats as well as plant meals provide dietary cal­cium, zinc, iron, and other nutrients (14).
15.2.2.2 Antioxidants
Free radical-induced cell damage is regarded as a crucial element contributing to the aging processand the develop­ment of illness. Our first line of protection against the harm caused by free radicals is antioxidants, which are also essential for preserving our best possible health and wellness. Being a very reactive atom, oxygen can combine to form potentially harmful compounds known as “free radicals.” The body’s healthy cells can be attacked by free
radicals, which can result in the loss of their structural integrity. Free radicals can be stabilized or rendered inac­tive by antioxidants prior to their damaging effects on cells. To preserve the best possible cellular and systemic health and well-being, antioxidants are vital. An extremely complex and effective antioxidant defense mechanism has evolved in humans. It involves a number of different ele­ments that have both exogenous and endogenous origins and work cooperatively to neutralize free radicals. These components include:
1. Antioxidants are generated from nutrients, such as
ascorbic acid, carotenoids, tocopherols and tocotrien­ols, and other low molecular weight substances like lipoic acid and glutathione.
2. Antioxidant enzymes that catalyze reactions that
quench free radicals, such as superoxide anion radical scavenger, glutathione-disulfide reductase, and glu­tathione hydroperoxidase.
3. Metal-chelating proteins that can catalyze oxidative
processes, including ferritin, ceruloplasmin, lactofer­rin, and albumin. These proteins trap copper and iron ions that are free.
A multitude of additional antioxidant phytonutrients are found in a varied range of plant-based diets [15].
15.2.2.3 Omega-3 Fatty Acids
Omega-3 polyunsaturated fatty acids (PUFAs) are defined as those with more than one carbon–carbon double bond in their backbone. The way the body functions and how it uses energy can be greatly influenced by nutrition. PUFAs have received special attention since they may be found in both marine and terrestrial habitats. PUFAs have the potential to decrease inflammation and diminish the likeli­hood of chronic ailments, such as arthritis, cancer, and heart disease. They also regulate glucose tolerance, blood pressure, coagulation, and the development and operation of the neurological system. Alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are examples of omega-3 fatty acids, which are sometimes referred to as “vitamin F” from the word “fatty acids.” Marine fatty fish, such as salmon, mullet, and mackerel are the primary dietary sources of EPA and DHA for humans. However, other sources of EPA and DHA, including bacteria, fungus, plants, and microalgae, are cur­rently being studied for commercial production. Many foods (such as spinach, broccoli, tomatoes, brussels sprouts, and rice bran) and meats can contain ALA in the form of lipoyl lysine, which is ALA combined with binding lysine residues [16].
300 15 Nutraceuticals and Cosmeceuticals
15.2.2.4 Probiotics
Probiotics collaborate with the human digestive system to combat pathogens, such as bacteria, viruses, and yeasts, which could otherwise induce illness. They exert antimicro­bial effects by altering the microflora, hindering pathogen adherence to the gut lining, competing for essential nutri­ents, producing antitoxins, and mitigating infection-related changes in the gut lining, including secretory alterations and neutrophil migration. Through synthesizing the par­ticular enzyme ß-galactosidase, probiotics can alleviate lac­tose intolerance by hydrolyzing lactose into its component sugars. Yogurt exemplifies one of the richest sources of pro­biotics, beneficial microorganisms that promote health. Kefir, a fermented probiotic, is another example [7].

15.2.3 Health Benefits

15.2.3.1 Nutraceutical in Disease Prevention
A combination of the words “nutrition” and “pharmaceu­ticals,” “nutraceuticals” refers to food or food items that offer more than just their fundamental nutritional worth. Because of their ability to lessen a variety of health issues, they have garnered a significant interest in the domain of disease prevention. According to research, some nutraceu­ticals may be able to help prevent chronic illnesses like can­cer, diabetes, heart disease, immune boosters, chronic inflammatory disorders, and neurological conditions [9].
For instance, due to their antioxidant and anti-inflammatory properties, polyphenols found in tea, fruits, vegetables, and wine have been linked to a decreased likelihood of cardio­vascular ailments and certain cancers [10, 11]. Walnuts, fatty fish, and flaxseeds are popular sources of omega-3 fatty acids, which have been related to decreased inflammation and better cardiovascular health [12]. Furthermore, because of its antioxidant and anti-inflammatory properties, the phy­tochemical curcumin, which is found in turmeric, has shown promise in the prevention and treatment of a number of diseases, including cardiovascular disease, cancer, and neurological disorders [13, 14].
Live microorganisms called probiotics, which are included in fermented foods like kimchi and yogurt, have been demonstrated to strengthen the immune system and gut health, which may lower the risk of gastrointestinal disorders and enhance general health [15]. These illustra­tions highlight the potential utility of nutraceuticals in the fight against illness. To completely comprehend their modes of action and the ideal dosages for particular medi­cal situations, more research is necessary.
15.2.3.2 Immune System Support
Since ancient times, a number of therapeutic herbs and phy­tochemicals have been known for their capacity to alter
immune system function. They function particularly as immune system boosters by promoting cellular immunity and humoral and adaptive immunity as important immu­nomodulatory pathways. Echinacea purpurea, sometimes known as echinacea, is the most well-known species known for its ability to stimulate both innate and adaptive immune responses. It is also linked to antiviral, anti-inflammatory, and antibacterial actions. More recently, it has been shown to have the ability to boost immunity indirectly by influenc­ing the gut flora. Curcuma longa L. has been shown in numerous preclinical and clinical studies to have the capac­ity to stimulate cellular immunity and inhibit inflammation, hence functioning as an immunological enhancer [16].
15.2.3.3 Cognitive Health
Nutraceuticals are being used as supplements or integrated into functional foods with nonpharmacological methods to prevent and treat a variety of disorders, such as geriatric ailments and chronic neurodegenerative diseases. Due to their nontoxic, non-habit-forming, and effective bioactivi­ties for pushing neurological well-being, including their capacity to exert an impact on cellular processes like syn­aptogenesis, neurogenesis, synaptic transmission, oxida­tive stress, cell death modulation, neuroinflammation, and neuronal survival, nutraceuticals are well-suited for the protection and curing of such disorders. The ability of nutraceuticals to facilitate these processes suggests the pos­sibility of creating dietary-based methods to support brain growth and function, stop and lessen neurodegeneration, and potentially even reverse the cognitive decline linked to Alzheimer’s disease [17].
15.2.3.4 Anti-inflammatory Effects
Anti-inflammatory properties of polyphenol diferuloyl­methanein curcumin have anti-inflammatory, anticarci­nogenic, and antioxidative qualities. It has been observed that the rhizomes of turmeric plants, spinach leaves, cucumber fruits, and beetroots have antitumor properties. Gamma linolenic acid is used to treat autoimmune and inflammatory illnesses. It is present in leafy vegetables, almonds, and vegetable oils, such as hemp, blackcurrant, and evening primrose oil. It can also be derived from cyanobacteria and spirulina. Osteoarthritis is treated with glucosamine and chondroitin sulfate, which also control PGE2 production and gene expression. Cat’s claw has strong anti-inflammatory properties. The two recognized species of cat’s claw are Uncaria tomentosa, which has sev- eral medical applications and is most frequently present in supplements, and Uncaria guianensis, which is tradition­ally used for wound healing. The phytocompounds like alkaloids, flavonoids, glycosides, tannins, sterol fractions, and other substances are abundant in cat’s claws [15].