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47 Advanced Considerations inCross-Sectional Imaging inTrauma
409
Fig. 47.2 Subtle fracture in MVC trauma. A nondisplaced right L1 transverse process fracture which could easily be overlooked or interpreted as artifact on 5mm soft tissue algorithm reconstructions (black arrow, a) is much more apparent on 1.25mm bone algorithm reconstruction (white arrow, b)
a
CT angio runoff imaging of the lower extremities may be included as clinically indicated. CT angio of the upper extrem­ities can also be performed at the time of initial CT but may require repositioning of the patient. Detection and character­ization of upper or lower fractures, including imaging for pre­operative planning, can often be performed at the time of initial CT, and may or may not mandate CT angio depending on clinical neurovascular status. 3D reformatted images gen­erated from these studies can assist in preoperative planning.
To reduce the total volume of administered contrast and time on the table, the number of full contrast boluses administered should be limited where possible. Depending on specic scanner parameters, there may be restrictions to the craniocaudad extent of adequate arterial phase imaging that can be obtained with a single contrast bolus. This is of particular importance given the increasing role of nonopera­tive management by Interventional Radiology, which often requires administration of signicant volumes of iodinated contrast but also requires good vascular road mapping for procedure planning. This again emphasizes the importance of good communication with the radiology department to ensure all areas of concern are adequately imaged at the time of initial CT.
Incorporating appropriate reformations into a baseline trauma protocol or requesting these early in the imaging pro­cess can prevent delays in diagnosis of subtle injury. For example, diaphragmatic injuries may be apparent only on multiplanar reformatted images. A dedicated CT of the facial bones should be added to initial imaging where clinically appropriate. While a CT of the chest, abdomen, and pelvis includes the entire thoracolumbar spine and sacrum, subtle fractures may not be apparent without appropriate reforma­tions (Fig.47.2). Imaging of the spine should be reviewed with soft tissue and bone reformats in multiple planes, typi­cally at a thickness of no less than 1.25mm [13].
Oral and rectal contrast can also be considered either as part of a baseline trauma protocol or for specic clinical sce-
b
narios to better delineate potential bowel injury. While some centers routinely administer oral and rectal contrast as part of their baseline trauma protocol (so-called triple-contrast CT), others selectively administer rectal contrast only in penetrat­ing ank injuries or as a problem-solving tool after initial imaging [14]. There are no randomized controlled studies comparing single-contrast CT with rectal contrast in the detection of bowel injury, although single-contrast CT has been found to have comparable accuracy to triple-contrast CT, and leakage of enteric contrast material is a relatively insensitive marker for bowel injury seen in only 15–29% of cases [15]. Workow and potential delays in imaging related to enteric contrast administration must also be taken into consideration. Ultimately, in the absence of denitive evi­dence one way or the other, local factors and preferences should guide protocol selection in these cases.
Approaches toAdvanced Workup
After initial cross-sectional imaging there may be additional diagnostic questions. Some of these will be raised by nd­ings on the initial imaging, as in equivocal ndings of bowel or pancreatic ductal injury. Others may be clinical, as in the case of suspected spinal cord injury with no vertebral frac­ture or dislocation identied on initial CT.Finally, there are sometimes questions remaining after initial intervention, whether invasive or noninvasive. Our discussion of this nal category will be limited in scope, as these questions only rarely fall under the umbrella of acute trauma management.
Adjunct CT Series Based onInitial CT Findings
Injury to the renal collecting system, ureters, or bladder may be best characterized with delayed CT urography imaging. First, the potential injury must be identied either based on
410
S. Holmes
clinical factors such as hematuria or unstable pelvic fracture or by initial imaging review by the radiologist. Delayed imaging is preferred for assessment of the renal collecting systems and ureters, however, may not lead to sufcient bladder distension to rule out bladder injury. Retrograde CT or uoroscopic cystography is performed via Foley catheter, where the bladder is distended to a minimum of 300 cc, which is required for reliable assessment [16] (Fig.47.3). It should be noted that delayed imaging will be ineffective for assessment of the urinary tracts in the setting of severe renal impairment due to lack of contrast excretion by the kidneys.
While CT angio imaging of the neck is clearly indicated in penetrating neck trauma, blunt cerebrovascular injury (BCVI) is an increasingly recognized, potentially devastating entity that is important to identify and treat early to reduce the risk of complicating stroke [17]. As mentioned above, CT angio may be performed in initial patient imaging when there are clinical risk factors for BCVI including high energy mechanism, dis­placed midface, complex skull fracture, or near hanging. In other cases, risk of BCVI may not be recognized until initial noncontrast CT of the cervical spine is complete. In these cases, either following on-table or other preliminary review of the images by the radiologist, CT angio carotids should be added where and when patient stability permits. The two most widely applied sets of guidelines for BCVI screening are the Western Trauma Association/modied Denver (WTA) recom­mendations and the Eastern Association for the Surgery of Trauma (EAST) guidelines, which differ slightly in which cat­egories of cervical spine fracture and/or ligamentous injury merit screening [18, 19]. The more conservative WTA recom­mendations would advise BCVI screening in all cervical spine fractures, subluxations, and conrmed ligamentous injuries.
Emergency Trauma MRI
Assessment of the pregnant trauma patient presents unique challenges covered elsewhere (Chapter 41). Initial imaging workup should minimize radiation exposure where possible,
but not at the expense of the immediate safety of the mother or fetus. Accordingly in major trauma, the same initial CT proto­col as in a nonpregnant patient is almost always the most appropriate rst step in imaging. One entity unique to preg­nancy which may be equivocal on initial CT is placental abrup­tion. The heterogeneous appearance of the mature placenta can mimic the appearance of partial abruption, in which case either ultrasound or MRI can be used for further characterization in the stable mother and fetus. MRI is the more sensitive and spe­cic modality for retroplacental hemorrhage [20].
MRI may have a limited role in characterization of sus­pected abdominal injuries. Pancreatic transections and lac­erations involving the main duct often require surgical repair but can be subtle on initial imaging [21]. Short interval fol­low- up pancreatic protocol CT in 24–48h is recommended in appropriate equivocal cases, but magnetic resonance chol­angiopancreatography (MRCP) can be used as an alternative for shorter interval problem-solving. Bile duct injuries can also be well demonstrated by MRI, typically after initial trauma management, particularly with the use of hepatobili­ary contrast agents which can more precisely localize active or contained bile leaks [22].
CT is the primary modality for assessment of patients meeting criteria for spinal imaging [23]. However, MRI offers markedly improved sensitivity for soft tissue ligamen­tous injury. Positive MRI ndings in the absence of CT nd­ings rarely require surgical intervention, so MRI is not routinely undertaken as part of the initial trauma imaging workup. However, this modality can serve as a highly useful adjunct in settings including persistent pain and/or neuro­logic defects with negative CT or advanced degenerative change on CT, unexaminable patients, for operative planning in the mechanically unstable spine, or in other signicant injury on CT [23, 24]. This typically does not require admin­istration of gadolinium-based contrast.
Noncontrast head CT permits identication of patholo­gies requiring intervention but lacks assessment of underly­ing perfusion status and poorly visualizes underlying posttraumatic parenchymal changes. CT perfusion imaging
a
Fig. 47.3 Assessment for bladder injury in the setting of pelvic hema­toma. Initial CT cystogram performed using a delayed urography tech­nique following intravenous contrast injection (a) demonstrates good bladder opacication (*) but poor distension. A repeat examination was
b
performed with retrograde contrast administration via an indwelling Foley catheter and demonstrates sufcient bladder distension to exclude leak (b). Adjacent uid and hematoma () can obscure or mimic leaks when cystography is not included in the imaging workup
47 Advanced Considerations inCross-Sectional Imaging inTrauma
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or MRI brain, with or without perfusion imaging, can typi­cally be deferred until after resuscitation and initial manage­ment of concurrent injuries, but at some centers rapid noncontrast MRI brain is now being trialed for initial imag­ing in certain settings including severe closed head trauma in the pediatric population and may in the future expand into more general usage [25].
Finally, MRI can be an appropriate adjunct in the stable patient with contraindications to iodinated contrast adminis­tration and equivocal ndings on non-contrast CT. These situations arise relatively infrequently, however, and should be discussed with the radiologist to optimize workup.
Considerations Guiding Advanced Cross­Sectional Imaging
Patients can always be returned for follow-up imaging after a period of observation or after either operative or nonopera­tive management. Imaging should never lead to delays in ongoing care of the acute trauma patient. Advances in cross­sectional imaging and the availability of problem-solving tools do not mandate that all imaging options be exhausted prior to denitive management. Adjunct tools including CT cystography, BCVI screening, and MRI for suspected biliary or pancreatic ductal injury may be performed as part of ini­tial imaging workup in a stable patient but may also be appropriate to defer in the setting of other signicant injury. Clinical factors remain the most important guide to the next best step for a given patient.
Advanced Techniques inTrauma Imaging
Beyond considerations of general CT protocol selection and of appropriate supplementation with MRI, there are several techniques which can be pursued to optimize cross-sectional imaging in the setting of trauma.
ECG-gated thoracic CT is a broad term encompassing multiple techniques for reducing motion artifact which may obscure or mimic cardiac and aortic root injury. Where avail­able, this tool can be utilized either for immediate character­ization of suspected injury or for short-term follow-up of nonoperatively managed injury. ECG-gated CT also
improves detection of coronary artery lacerations and subtle pericardial injury [26].
Dual-energy CT (DECT) is an emerging area of interest in trauma imaging, with broad potential applications [27,
28]. This technique involves acquisition of data both at high
and low kilovolt peaks, allowing differentiation and quanti­cation of materials with different X-ray absorption behav­iors. Iodine selective imaging renders areas of abnormal bowel wall enhancement and subtle solid organ parenchymal injury more apparent. Virtual noncontrast images can increase conspicuity of hemorrhage, including bowel wall hemorrhage. Calcium subtraction from bone, particularly vertebral bodies, is a promising alternative to MRI for iden­tifying marrow edema in the settings of microfracture and in age indeterminate fractures [29]. Virtual monoenergetic images can be used to reduce artifact from hardware, from equipment external to the patient, and from bullet or shrapnel fragments (Fig.47.4).
Split bolus single pass CT was developed in an attempt to reduce radiation exposure resulting from multiphase imaging. This technique consists of two or three sequen­tial boluses of intravenous contrast followed by a single CT acquisition of the chest, abdomen, and pelvis reflect­ing a combination of arterial and portal venous phases, plus or minus a urinary excretory phase. Subjective image quality and diagnostic accuracy for abdominal injuries are quite promising, but there remain concerns in the assessment of splenic parenchyma, which can appear het­erogeneous, and in the characterization of areas of active extravasation particularly within the pelvis [30]. Accordingly, acceptance of this technique remains site-specific.
Trajectory analysis can serve as an important tool in the assessment of penetrating abdominal and pelvic trauma. This consists of double-obliqued reformatted imaging based on entry and exit wound sites to identify potential sites of subtle injury along the tract (Fig.47.5) [31]. Trajectory analysis can provide valuable information by drawing attention to injuries which might otherwise have been overlooked, particularly in the setting of complex polytrauma, and by conrming sus­pected artifacts are outside the path of potential injury. This technique has been found to have similar accuracy with improved sensitivity when compared to enteric contrast in the detection of colorectal injury [32].
412
S. Holmes
Fig. 47.4 DECT for metal artifact reduction in gunshot injury of the lower extremity with multiple bullet fragments (white arrows). Axial (a and b) and sagittal (c and d) imaging demonstrating improved image quality when comparing baseline images (a and c) to images following application of metal artifact reduction (b and d) using dual-energy CT
a
c
b
d
a
Fig. 47.5 Trajectory analysis in gunshot injury of the abdomen. Axial images (a) demonstrate blood products (*) in the retroperitoneum tracking adjacent to the descending colon (d), raising concern for
Key Points
• The radiologist remains the principal resource for determining how advanced cross-sectional imaging may benet either a general institutional protocol or an individual patient.
• Modern CT and MRI scanners allow a range of meth­ods for problem-solving based either on clinical nd­ings or initial CT ndings. Good communication between the trauma team and the radiologist and prompt review of the initial CT are therefore critical.
b
colonic injury. Multioblique reformatted trajectory analysis (b) shows a bullet tract away from the descending colon. Absence of colonic injury was conrmed at laparotomy
• The increasing role of Interventional Radiology and nonoperative management mandates both accurate detection and characterization of signicant injuries and good vascular road mapping.
• New and emerging cross-sectional techniques for initial trauma imaging including DECT and trajec­tory analysis are variably accessible and may lack high-level evidence at this stage in their develop­ment but can provide valuable information when integrated appropriately.
47 Advanced Considerations inCross-Sectional Imaging inTrauma
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2. Bashir AA, Kong V, Skinner D, Bruce J, Laing G, Brysiewicz P, Clarke D. Contrast-induced nephropathy following CT scan for trauma is not rare and is associated with increased mortal­ity in South African trauma patients. Eur J Trauma Emerg Surg. 2019;45(6):1129–35.
3. Kelemen JA, Kaserer A, Jensen KO, Stein P, Seifert B, Simmen HP, Spahn DR, Pape HC, Neuhaus V. Prevalence and outcome of contrast- induced nephropathy in major trauma patients. Eur J Trauma Emerg Surg. 2020:1–7.
4. Pantel H, Stensland KD, Hashim J, Rosenblatt M. Is mea­surement of renal function necessary for all trauma patients before iodinated contrast administration? Emerg Radiol. 2017;24(5):541–6.
5. Gurm HS, Dixon SR, Smith DE, Share D, Lalonde T, Greenbaum A, Moscucci M. BMC2 (Blue Cross Blue Shield of Michigan Cardiovascular Consortium) Registry. Renal function-based con­trast dosing to dene safe limits of radiographic contrast media in patients undergoing percutaneous coronary interventions. J Am Coll Cardiol. 2011;58(9):907–14.
6. Bush WH, Segal AJ.Recognition and treatment of acute contrast reactions. Appl Radiol. 2009 Dec;38:16–21.
7. Iyer RS, Schopp JG, Swanson JO, Thapa MM, Phillips GS.Safety essentials: acute reactions to iodinated contrast media. Can Assoc Radiol J. 2013 Aug;64(3):193–9.
8. Huynh K, Baghdanian AH, Baghdanian AA, Sun DS, Kolli KP, Zagoria RJ.Updated guidelines for intravenous contrast use for CT and MRI.Emerg Radiol. 2020;27(2):115–26.
9. ACR Committee on Drugs and Contrast Media. ACR manual on contrast media, Version 7. 2010;5–6, 20–1.
10. Sierink JC, Treskes K, Edwards MJ, Beuker BJ, den Hartog D, Hohmann J, Dijkgraaf MG, Luitse JS, Beenen LF, Hollmann MW, Goslings JC. REACT-2 study group. Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. Lancet. 2016;388(10045):673–83.
11. Salim A, Sangthong B, Martin M, Brown C, Plurad D, Demetriades D.Whole body imaging in blunt multisystem trauma patients with­out obvious signs of injury: results of a prospective study. Arch Surg. 2006;141(5):468–73. discussion 473–5
12. Coccolini F, Montori G, Catena F, Kluger Y, Bif W, Moore EE, etal. Splenic trauma: WSES classication and guidelines for adult and pediatric patients. World J Emerg Surg. 2017;12:40.
13. Jo AS, Wilseck Z, Manganaro MS, Ibrahim M.Essentials of spine trauma imaging: radiographs, CT, and MRI.Semin Ultrasound CT MR. 2018;39(6):532–50.
14. Ozimok CJ, Mellnick VM, Patlas MN.An international survey to assess use of oral and rectal contrast in CT protocols for penetrating torso trauma. Emerg Radiol. 2019;26(2):117–21.
15. Jawad H, Raptis C, Mintz A, Schuerer D, Mellnick V. Single­contrast CT for detecting bowel injuries in penetrating abdomino­pelvic trauma. AJR Am J Roentgenol. 2018;210(4):761–5.
16. Dane B, Baxter AB, Bernstein MP.Imaging genitourinary trauma. Radiol Clin North Am. 2017;55(2):321–35.
17. Rutman AM, Vranic JE, Mossa-Basha M.Imaging and management of blunt cerebrovascular injury. Radiographics. 2018;38(2):542–63.
18. Bif WL, Cothren CC, Moore EE, etal. Western Trauma Association critical decisions in trauma: screening for and treatment of blunt cerebrovascular injuries. J Trauma. 2009;67(6):1150–3.
19. Bromberg WJ, Collier BC, Diebel LN, etal. Blunt cerebrovascular injury practice management guidelines: the Eastern Association for the Surgery of Trauma. J Trauma. 2010;68(2):471–7.
20. Fadl SA, Linnau KF, Dighe MK. Placental abruption and hemorrhage-review of imaging appearance. Emerg Radiol. 2019;26(1):87–97.
21. Heiken JP, Katz DS, Menu Y.Chapter 13: Emergency radiology of the abdomen and pelvis: imaging of the non-traumatic and traumatic acute abdomen. In: Hodler J, Kubik-Huch RA, von Schulthess GK, editors. Diseases of the abdomen and pelvis 2018–2021: diagnostic imaging– IDKD book [Internet]. Cham: Springer; 2018.
22. LeBedis CA, Bates DDB, Soto JA.Iatrogenic, blunt, and penetrating trauma to the biliary tract. Abdom Radiol (NY). 2017;42(1):28–45.
23. Theocharopoulos G, Chatzakis JD.Is radiography justied for the evaluation of patients presenting with cervical spine trauma? Med Phys. 2009;36(10):4461–70.
24. Yelamarthy PKK, Chhabra HS, Vaksha V, Agarwal Y, Agarwal A, Das K, Erli HJ, Bapat M, Singh R, Gautam D, Tandon R, Balamurali G, Rajan S. Radiological protocol in spinal trauma: literature review and Spinal Cord Society position statement. Eur Spine J. 2020;29(6):1197–211.
25. Smith LGF, Milliron E, Ho ML, Hu HH, Rusin J, Leonard J, Sribnick EA.Advanced neuroimaging in traumatic brain injury: an overview. Neurosurg Focus. 2019;47(6):E17.
26. Gosavi S, Tyroch AH, Mukherjee D.Cardiac trauma. Angiology. 2016;67(10):896–901.
27. Wortman JR, Uyeda JW, Fulwadhva UP, Sodickson AD. Dual­energy CT for abdominal and pelvic trauma. Radiographics. 2018;38(2):586–602.
28. Hamid S, Nicolaou S, Khosa F, Andrews G, Murray N, Abdellatif W, Qamar SR.Dual-energy CT: a paradigm shift in acute traumatic abdomen. Can Assoc Radiol J. 2020;71(3):371–87.
29. Suh CH, Yun SJ, Jin W, Lee SH, Park SY, Ryu CW.Diagnostic performance of dual-energy CT for the detection of bone mar­row oedema: a systematic review and meta-analysis. Eur Radiol. 2018;28(10):4182–94.
30. Jeavons C, Hacking C, Beenen LF, Gunn ML.A review of split­bolus single-pass CT in the assessment of trauma patients. Emerg Radiol. 2018;25(4):367–74.
31. Sodagari F, Katz DS, Menias CO, Moshiri M, Pellerito JS, Mustafa A, Revzin MV. Imaging evaluation of abdominopelvic gunshot trauma. Radiographics. 2020;40(6):1766–88.
32. Dreizin D, Boscak AR, Anstadt MJ, Tirada N, Chiu WC, Munera F, Bodanapally UK, Hornick M, Stein DM.Penetrating colorectal injuries: diagnostic performance of multidetector CT with trajec­tography. Radiology. 2016;281(3):749–62.
Part VI
Tactical Emergency and Disaster Medicine

Disaster Medicine

MichelangeloBortolin andGregoryR.Ciottone
48
Abbreviations
CBRN Chemical, Biologic, Radiological, and
Nuclear COVID-19 Coronavirus Disease 2019 CWA Chemical-Warfare Agents EMS Emergency Medical Services EOP Emergency Operations Plan HIV Human Immunodeciency Virus HVA Hazard and Vulnerabilities Assessments IAP Incident Action Plan IC Incident Commander ICS Incident Command System PTS Posttraumatic Stress SARS Severe Acute Respiratory Syndrome SOP Standard Operating Procedures
Disasters include natural events like the Australian bush­re (2020) and the COVID-19 pandemic (2019–2020); intentional events like the terrorist attacks in Paris (2015), Nice (2016), and Vienna (2020); and accidental man­made events like the August 2020 Beirut explosion and demonstrate the ubiquitous nature of such devastating incidents.
Disaster is dened as any event that causes “A serious dis­ruption of the functioning of a community or a society involv­ing widespread human, material, economic or environmental
M. Bortolin (*) BIDMC Fellowship in Disaster Medicine, Boston, MA, USA
CRIMEDIM - Center for Research and Training in Disaster Medicine, Humanitarian Aid, and Global Health, UPO - University of Eastern Piedmont, Novara, Italy;
http://www.disasterfellowship.org
G. R. Ciottone BIDMC Fellowship in Disaster Medicine, Boston, MA, USA
Harvard Medical School, Boston, MA, USA Harvard T.H.Chan School of Public Health, Boston, MA, USA
e-mail: gciotton@bidmc.harvard.edu;
http://www.disasterfellowship.org
losses and impacts, which exceeds the ability of the affected community or society to cope using its own resources” [1].
Considering that any number of different events can strike a population at any time, there is no place on earth com­pletely immune to disasters. However, communities must be able to mitigate against and be prepared to respond to these situations, in short, be resilient to disaster.
Disaster Medicine was created as a broad specialty grounded in Emergency Medicine but also utilizing the skill sets of other surgical and medical specialties, in combina­tion with the systems supported by Disaster Management, which applies organizational, management, and leadership knowledge to mitigate, prepare, and respond to these events. For example, during an earthquake several specialties are involved in the response and immediate care of the victims: emergency physicians, surgeons, anesthesiologists, and orthopedics; however, other subspecialties are also required in the ongoing care of victims. These include nephrologists to treat acute renal failure related to crush syndrome, and in the days following the event, primary care, psychosocial, and rehabilitation specialties for continued care. These med­ical and surgical specialists are only able to perform their roles under the umbrella of Disaster Management. Without being enabled by the logistics and operations capabilities seen in a large-scale disaster response, these specialists would not be functional. The global experience of the COVID-19 pandemic has emphasized how Disaster Medicine is a broad specialty that requires specic knowl­edge from different elds, including epidemiology, virol­ogy, emergency medicine, critical care, public health, statistics, respiratory medicine, leadership, and crisis management.

Natural or Man-made Disaster

Disasters are typically categorized as being from natural or man-made events. Natural disasters such as oods, tsunamis, and earthquakes typically have a more extensive impact on
© Springer Nature Switzerland AG 2025 L. Marshall Gillman, S. Widder (eds.), Trauma Team Dynamics, https://doi.org/10.1007/978-3-031-86312-7_48
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M. Bortolin and G. R. Ciottone
population centers, causing more disruption. The 2020 Australian bushre crisis killed at least 25 people, destroyed 2000 homes, and burned more than 15.6million acres [2]. Hurricane Katrina in 2005 ravaged Louisiana, Mississippi, Alabama, and Florida causing death, numerous casualties, mass evacuations, and broad societal disruptions.
Natural disasters also include epidemics and pandemics. In the past, inuenza, cholera, bubonic plague, and other dis­eases affected entire nations causing millions of casualties. Today the entire world has gained rsthand experience with a pandemic’s effect on populations and economies. The COVID-19 pandemic has changed how everyone lives through the implementation of non-pharmaceutical interven­tions (NPI). However, the consequences have not been the same everywhere. Some countries have been more devas­tated by COVID-19 than others, whether because of incom­petence, indifference, or ill luck [3], highlighting the importance of Disaster Medicine to enhance resiliency. Another viral pandemic that has resulted in differences in transmission and death rate, particularly in developing coun­tries, is Human Immunodeciency Virus (HIV). It is esti­mated that since its emergence in the early 1980s, HIV has caused more than 33million deaths around the world, further demonstrating that an estimated 97% of natural disaster­related deaths occur in developing countries (World Bank, 2000–2001) [4].
Man-made disaster is dened as any event that is caused by the activity of human beings. Explosions, building col­lapses, civil wars, and radiation accidents are some exam­ples. The collapse of the Hyatt Regency Hotel in Kansas City in 1981 is one such example. Investigations found that the cause of the collapse was due to an engineering problem. There were more than one hundred deaths and more than two hundred casualties from that disaster.
The transportation industry is commonly involved in inci­dents that cause large numbers of injured and deaths. In 1998, a high-speed train derailed in Eschede, Germany, causing 101 fatalities. Other industrial sectors, such as the chemical industry, have also been involved in man-made catastrophes. In December 1983in Bhopal, India, more than half a million people were exposed to methyl isocyanate. In the immediate phase after the leak almost 10,000 people died. The Indian Government has calculated that this event has caused over the years almost 600,000 casualties due to lingering effects of the chemical exposures. The ammonium nitrate explosion in Beirut in August 2020 caused more than 170 deaths, 6,500 injuries, and left an estimated 300,000 people homeless.
The 9/11/2001 terrorist attack in New York and the Oklahoma City bombing (1995) are intentional man-made disasters. It is important to recognize and underline that disasters can also result from war, and conict zones, as well as economic and social policies, particularly in developing
countries [5]. The Syrian civil war arose in 2011 and has caused more than 400,000 deaths and 5.5 million refugees since 2013 [6].

The Disaster’s Cycle

Disasters and the response to them follow a pattern called the Disaster Cycle, which is dened in four phases: mitigation and prevention, preparedness and planning, response, and recovery.
Mitigation and prevention involve measures designed either to prevent hazards from occurring or to lessen the effects of the disasters [7]. These measures involve multiple different agencies and commissions, for example, policy­makers introduce regulations regarding the storage, transpor­tation, and disposal of chemical substances. Another example of mitigation is to empower a public health system to moni­tor and conduct surveillance for infectious diseases and at the same time introduce rules regarding health screening at the borders. The importance of the mitigation phase is to avoid disaster or to reduce the impact on the population.
It becomes clear if we compare the 2010 earthquake in Haiti, with a magnitude of 7.0, and similar earthquakes in Japan where despite the same magnitude the number of dead and injured was much more limited. The effects of a disaster are often dependent on the underlying conditions of the area affected. For decades Japan has introduced strict building codes that follow seismic regulations. Nevertheless, it is not possible to fully mitigate against all disaster events. For instance, the 2011 earthquake in the Pacic Ocean produced a tsunami that hit the east coast of Japan and caused severe damage, in particular a failure of the nuclear plant in Fukushima, with release of radiation that affected the local community.
The preparedness and planning phase includes activities that occur on an ongoing basis, in advance of any potential incident. Preparedness involves an integrated combination of assessment, planning, procedures and protocols, training and exercises, personnel qualications, licensure, and certica­tion and should undergo regular evaluation and revision [8]. The rst step of preparedness is dening what events are more likely to strike and how well prepared the community is for them. The Hazard Vulnerability Analysis (HVA) is a way to objectively risk-stratify those hazards that are more likely to strike a given community. The HVA takes into account different events: natural, man-made, and CBRN (Chemical, Biologic, Radiological, and Nuclear), among others. The output from an HVA prioritizes the risks to which a population is most susceptible and should therefore be pre­pared for. After the HVA, it is possible to then establish Standard Operating Procedures (SOP) and the Emergency Operations Plan (EOP) for the community or hospital. It is a
48 Disaster Medicine
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good rule that the EOP adopts an all-hazards approach to preparedness, with annexes and appendices specic for every type of probable event [9].
An important part of the preparedness phase is training. In particular, every healthcare professional must be trained when to activate disaster response and their own specic roles and responsibilities within the framework of the response. The drills commonly used are tabletop and full­scale exercises. They are important also to identify shortfalls, bottlenecks, and gaps in the EOP.The staff should take part in the training and the EOP should be tested, reviewed, and updated at least once per year.
Response is the phase in which agencies and sections with responsibility to deploy to disasters activate their emer­gency response plan as a result of specic threats or situa­tions and can incorporate local, regional, and federal response agencies [10]. The response is conducted through a collabo­ration between several agencies and must be exible and adaptable for any type of event.
It is important to immediately establish a response frame­work with a unied command structure that establishes a chain of command and control and coordinates the resources, in terms of staff, stuff, and space. The Incident Command System (ICS) provides a structure to enable agencies with different legal, jurisdictional, and functional responsibilities to coordinate, plan, and interact effectively on scene [11]. The medical response is provided at the scene by the Emergency Medical Services (EMS), with triage, treatment, and transport to the hospitals, which plays a crucial role in the immediate phase of the response to disaster. The response must be quick and effective, on-scene as well as in the deter­mination of hospital destinations for every patient, to guaran­tee an appropriate standard of care and to avoid bottlenecks and congestion at hospitals. Rarely, EMS is able to triage, treat, and transport every single patient from the scene. More often some casualties reach the closest hospital on their own, giving rise to disruption in the chain of triage and to the hos­pital. The ability of a healthcare system to suddenly expand its capacity beyond normal services to meet the increased demand for qualied medical staff and services during a large-scale event is dened as “surge capacity” [12]. The surge capacity depends on the features of the healthcare sys­tem, but also by an effective EOP and training level of the staff.
The post-impact period revolves around disaster recovery in which the goal is to eliminate impairment caused by a disaster and rebuild communities and infrastructures [13]. This phase involves several agencies and may be long­lasting, ranging from weeks to years. People affected by a catastrophic disaster often face a long recovery phase. Survivors of the September 11, 2001, terrorist attacks on the Twin Towers not only had immediate treatment in the eld and in the hospitals that day, but their treatment has contin-
ued for years. The majority of people exposed to disasters do well; however, some individuals develop psychiatric disor­ders, distress, or risky behaviors such as an increase in alco­hol or tobacco use [14]. The Department of Health and Human Services spent months and years addressing this fol­lowing the 9/11 attacks and has gone on to provide health­care, both physical and mental, to those who were, and continue to be, affected and in need [15]. The recovery phase often also involves rescue workers as their exposure to the traumatic event can have a severe impact on their mental health. Studies conrm that rescue workers are prone to have diseases or documented behavioral health disturbances dur­ing and following events. For example, several articles describe how the acute and prolonged exposures were both associated with a large burden of asthma and posttraumatic stress (PTS) symptoms years after the 9/11 attack. In addi­tion, the suicides of a prominent NewYork City emergency physician and a nurse in Italy, both of whom had been on the frontlines of the COVID-19 response, are tragic indicators of the traumatic events incurred by many healthcare workers during disasters [16].

Incident Command System

During an incident the response must be effective and ef­cient. To achieve this, and thereby ensure that the best care possible is rendered to victims, it is fundamental to have a well-prepared and organized system. The Incident Command System (ICS) is a standardized, on-scene, all-hazard incident management system and allows its users to adopt an inte­grated organizational structure to match the complexities and demands of single or multiple incidents without being hin­dered by jurisdictional boundaries [17].
The ICS was developed in the 1970s in California to man­age, command, and control re brigades during their opera­tions to extinguish wildres. It was then adopted by EMS and other agencies, as well as endorsed by the U.S.Department of Homeland Security as a fundamental element of incident management.
The ICS is used for all events and is modied depending on the size of the incident. Its goal is to manage and resolve the incident with an efcient use of resources while protect­ing all persons involved. The ICS is a modular and exible organizational system that can be standardized for multiple uses. The ICS is modied according to the size and complex­ity of the incident, specicity of the hazard, environment affected by the incident, the incident planning process, and incident objectives (ICS expansion and contraction) [18].
The ICS establishes an Incident Commander (IC), who is in charge of all the activities regarding the incident; a chain of command; and unied command between the agencies. The priorities of the IC are three: the safety of the casualties
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and the rescue team, incident stabilization, and property preservation. Every incident must have an Incident Action Plan (IAP) that establishes incident goals, operational period objectives, set activities, and the response strategy dened by the IC during response planning [19].
The IC manages and carries out their responsibilities with three features of command that are important for every role within the framework of the ICS: the chain of command, the unity of command, and the span of control. The chain of command is a key part of the ICS and is dened as a structure with a clear line of authority. The unity of command infers that every responder knows without question who their supervisor is. Span of control describes the typically 6–7 people a supervisor directly leads.
During a disaster, it is extremely important to establish a Unied Command, because it enables all responsible agen­cies to manage and coordinate an incident together by estab­lishing a common approach and a single IAP.It permits the integration of stafng and shared facilities, with everyone having the same objectives and not replicating efforts [20].
The IAP describes activities, responsibilities, and com­munication procedures. This system is fundamental to avoid confusion and lack of communication. Adequate and redun­dant communication systems are very important during the response to disaster. It is essential that the ICS uses common terminology and integrated communications among agencies and establishes precise ways of communication. The com­munication systems should be: interoperable between agen­cies; reliable to function in the context of any kind of emergency; portable, built on standardized radio technolo­gies, protocols, and frequencies; scalable as the needs of the incident dictate; resilient to perform despite damaged or lost infrastructure; and redundant to enable use of alternate com­munication methods when primary systems go out [21].
The ICS is supported by a command staff that includes a safety manager, a liaison ofcer, and a public information ofcer. It is organized into four sections which support the ICS: operation, planning, logistics, and nance/administra­tion. The operation section is in charge of managing all activ­ities on the scene including re brigades, EMS, and all agencies required for the incident. The planning section is responsible for drafting the IAP; receiving, assimilating, and sharing information; and tracking all resources. The logistics section provides the required equipment and facilities and supports personnel with food and water. The nance/admin­istration section provides funding, tracks all costs, and man­ages contracts.
These sections, like the ICS, are modular organizations and can be further expanded into: units (the organizational element with functional responsibility for specic incident planning, logistics, or nance/administration activity), divi­sions (only for the operations section and used to divide an incident geographically), groups (only for operation section
and established to divide the incident management structure into functional areas), and branches (used when the number of divisions or groups exceeds the span of control and can be either geographical or functional for major aspects of inci­dent operations) [22].

Triage

The word triage is derived from the French word “trier” that literally means “to categorize, or to sort.” The concept of tri­age was proposed for the rst time by Baron Dominique Jean Larrey, Surgeon in Chief to Napoleon’s Imperial Guard in the eighteenth century. The innovation of Baron Larrey was that he was the rst to implement the idea of treating the sickest rst and evacuating them to the most appropriate care facility in priority order, thereby maximizing the use of available resources for optimal patient benet, and aiming for a minimum time to denitive treatment [23].
The most commonly used disaster triage system places casualties into four classes: black (expectant), red (immedi­ate priority), yellow (delayed priority), or green (minor pri­ority), depending on the severity of the injuries. When sorting casualties, it is important to give immediate medical care to critical patients that have a chance of survival with prompt, advanced treatment. In less critical patients, and patients who are so severely injured that they have very little chance of survival, treatment is delayed. The goal is to provide the greatest good for the greatest number of patients, forcing the triage ofcer to decide whether the chance of a patient sur­viving is so low in comparison to the burden such care would place on the medical system that the patient must be con­signed to the “expectant” category (dying; little or no treat­ment) [24]. Triage will be discussed further in Chapter 49.
The concept of triage must be seen in a wider context and is composed of the following elements: rapid evaluation of all disaster victims; assessment of the nature and severity of the injuries and its consequences on the vital functions of the casualties, categorization of the casualties, resuscitation, sta­bilization for transport, distribution, and evacuation of the casualties [25]. Triage is a quick and dynamic process. This means that it must be repeated often and at every moment in which a new healthcare professional takes control of a patient. For example, during transport, upon arrival at the hospital, or if there is a suspicion that the state of the patient has changed.
One concern in disaster triage is the possible use of chem­ical or radiation weapons in a terrorist attack. The recent use of chemical weapons (CW) on civilian populations, as seen in the Syrian civil war and in assassination attempts in the United Kingdom, Malaysia, and Russia, has increased that concern. This has demonstrated the importance of a new sys­tem of triage to use for these CW attacks to quickly