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Алябьева Ю.М., Клинг В.И. English listening com...doc
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Vocabulary:

harbour – место, убежище,

notorious – печально известный,

«peau d’orange» - апельсиновая корка.

What are - in general - the complaints or symptoms, concerning one or both breasts, which will bring the patient to the doctor? And which points are important in the taking of the pa­tient’s history?

The symptoms of breast abnormalities are:

  • tenderness or pain in the breast

  • palpable lumps

  • skin or nipple retraction

  • nipple discharge

  • eczema of the nipple

  • infiltration.

We shall now discuss these symptoms, some of which will alert you to malignancy earlier than others.

Always be aware of the fact that the patient may give an indirect signal by coming to the doctor with another complaint, only mentioning the breast casually. The reason for this may be:

  • fear of the consequences of the diagnosis

  • embarrassment.

Many patients consult their doctor with complaints of tender­ness or pain in one or both breasts, with or without feeling a lump. The patient then often expresses a "feeling of heaviness". It is important to know whether this is related to the menstru­al cycle. If it is, then it is most likely to be benign. However, a carcinoma still remains a possibility.

As a general rule, complaints and symptoms which completely disappear after menstruation are rarely caused by a malignant process. Even so, it is still sensible to make a second check after several months, as changes in the biological behaviour of a breast tumor can occasionally be brought about by hormonal fluctuations.

Palpable nodules can be the result of cysts or solid tumors. Solid tumors can be either benign or malignant. Cysts only very rarely harbour carcinoma in the walls. Palpable tumors in young women are often benign. With increasing age, and definitely abo­ve 45, the chance of carcinoma is much greater.

Skin retraction is often presented by the patient as a small "dent" in the breast. In the case of skin retraction breast cancer must always be considered, even if no lump is palpable.

Skin retraction can be seen better if the patient raises her arms during the examination. The examination will be discussed later in the program.

Nipple retraction occurs frequently, it is important to ask whether the nipple has been like this for a long time, or whe­ther it changed recently. Whenever there is a recent change in the shape or the form of the nipple, you must always suspect a carcinoma, even if no lump behind the nipple or areola can be felt.

Complaints of spontaneous nipple discharge are not uncommon. However, they are seldom caused by a carcinoma. Serous nipple discharge, on one or on both sides, usually results from the use of certain medicines. The most notorious of these are: aldomet, digoxin, thyroid gland preparations and tranquillizers However, if the discharge contains blood, then breast cancer must be suspected.

This is the clinical appearance of Paget’s disease of the nipple. There is a superficial erosion of the nipple and the areola.

Sometimes the patient consults her doctor when the lesion is still very small, as shown here.

In cases of inflammation of the breast you must always think of inflammatory carcinoma, which can mimic all the character­istics of a harmless infection. The classical history is: pa­in, swelling, redness, fever and general malaise. It is there­fore essential to examine and follow up every infection with extreme care and attention.

In this patient you can see, apart from the inflammation, the so-called «peau d’orange». This condition appears when the tumor blocks the lymph drainage from the skin and from the subcutaneous tissues.

And beware? Breast cancer can also occur during pregnancy or the lactation period! It can mimic the symptoms of an in­fection, or can accompany one. Breast complaints must therefo­re also be taken seriously during pregnancy and the lactation period.

Ulceration is a late characteristic of breast cancer. Some patients, however, come to the doctor in such a late stage of the disease.

Outline of the patient history

In taking the history the following information is requi­red:

  • the type of complaints

  • the duration of complaints

  • the relationship with the menstrual cycle

  • the use of medication

  • the previous history of the patient, especially whether she has previously had a breast operation - the family history.

High risk factors

The high risk factors for breast. cancer are as follows:

  • A family history of breast cancer, especially in mother or sister(s).

  • Previous breast cancer in the other breast.

  • A previously biopsied breast lesion which was diagnosed as premalignant.

The literature reports several other factors which could en­hance the risk of breast cancer, such as early menarche and breast feeding. However, in 1986, these factors are not con­sidered to be important determinants.

Summary

Early diagnosis of breast cancer increases the chance of cure.

The larger the tumor, the greater the chance of metastatic disease.

The warning signs for breast cancer are:

  • a palpable nodule in a woman elder than 45 years of age

  • skin retraction

  • nipple retraction

Breast cancer can also develop during pregnancy or during the lactation period.

The physical examination

For the physical examination the patient should be requested to remove her upper clothing.

While the patient is sitting or standing opposite you, inspect both breasts according to a fixed pattern, systematically comparing right and left, first the one breast, and then the other. You must look for differences in contour and in skin retraction: and you must look to see whether the nipples and areolas appear normal. Also notice whether there are differences in contour below and above the collar bone, resulting from sub and supraclavicular lymph node metastases.

Examine the breast from the side, both from the left... and from the right…

Ask the patient to raise her arms and compare, again syste­matically, the right and left breast. A previously invisible swelling or skin retraction may now be seen. You are looking for differences in contour or retraction.

Ask the patient to place her hands on her hips... and to press firmly. This action makes the pectoralis mus­culature -contract, and a tumor attached to the muscle layer may now come into view. Pay attention to any differences in contour.

Ask the patient to bend forward and take her hands in yours. Again examine systematically. Skin retraction in the upper are­as, which was not visible earlier, may now be seen.

Palpation can be carried out while the patient is sitting or lying down. Each doctor has his own technique. First examine the normal breast. Than examine the other breast, starting at the non-pathological area and working towards the point whe­re the patient has indicated the complaint. The palpation sho­uld be carried out systematically, quadrant by quadrant, and with as little finger pressure as possible. If necessary, you can compare the quadrants one at a time, in both breasts.

Skin retraction or «dimpling», which you had not noticed be­fore, can be revealed by a bimanual examination, gently manipu­lating the indicated section of the breast. A palpable breast tumor can be sharply defined. But often, especially when malig­nant, the shape can be irregular and ill-defined. Palpation can be especially difficult in young women, whole glandular area, or a large part of it, can feel lumpy.

When the patient is lying down, some irregularities can also be felt more clearly when the arm is raised.

When palpating the axillary region for the presence of lymph node metastases, it is essential that the muscles be as relaxed as possible. Make sure that both the upper and lower levels of the axilla are thoroughly examined.

The examination of the axillary region can be carried out while the patient is sitting or standing. It is important that each individual doctor becomes accustomed to his own particular methods of examination.

If you prefer to palpate the axilla with the patient in a sit­ting or standing position, then you can ask the patient to rest her lower arm on your lower arm in order to achieve the necessary muscle relaxation.

To examine the supraclavicular areas you can stand behind the seated patient and compare both areas simultaneously while palpa­ting. The medial corners of these areas are especially important; since it is here that the first supraclavicular lymph node metastases arise.

Always be alert to the fact that breast cancer usually occurs in one breast, but it can arise in both, either at the same time or later on.

And another warning: it only happens sporadically, but breast cancer can also occur in men.

Special diagnostic procedures

The policy for special diagnostic procedures When can you say, after the first examination, that there is nothing wrong? The answer is: never! You can, of course, say. «I can't find anything wrong at the moment».

As a general rule it is advisable to adopt the following policy. All women over the age of 45 with breast complaints should be referred to a surgeon for further examination. Younger women, when there is no reason to suspect breast cancer at the first visit, should be asked to come back for a routine, checkup after the next menstruation. Whenever there is a consis­tent complaint, the safest policy is referral to a specialist. Even if the complaint seems to disappear after the menstruation, another check up in several months time is still important, sin­ce - as said before - breast cancer occasionally changes its bio­logical behaviour under hormonal fluctuations.

Referral

You ought to take into account that breast cancer, at the ti­me of clinical detection, has already been present for some ye­ars. In general, carcinomas grow at a steady rate, which is spe­cific for each type of carcinoma. The growth of breast cancer is usually slow. The average doubling time is two to three months. A breast carcinoma becomes clinically detectable when it teaches the size of about 1 cm in diameter. Assuming a doubling time of three months, the development of such a carcinoma takes about 8 years. Therefore, at the time the clinical diagnosis is confir­med, the tumor is several years «old», and has already had the opportunity to metastasize for a long time.

An emergency referral and treatment is therefore unnecessary. However, extra delay is undesirable, especially for psychologi­cal reasons.

Make sure that your patient is seen for further examination by the specialist within 3-4 days. In your referral letter, give the relevant information about the history, including the family history, your findings, and your specific request. Also, make sure that this further consultation actually takes place. The further examination requires:

  • diagnostic radiology

  • histopathological diagnosis.

The patient is usually referred to a surgeon. But sometimes the family physician refers the patient to a diagnostic radiolo­gist. This depends on the regional set-up, and the agreements made within the local medical group there. A good rule is: if the­re is a palpable lump, send the patient to the surgeon.

Diagnostic radiology

The diagnostic radiology consists of:

  • mammography

  • ultrasonography.

Mammography is by far the best method for detecting a breast tu­mor.

Ultrasonography can be useful in the diagnosis of cysts and is therefore especially important in the differential diagnosis of breast cancer.

The reliability of mammography is determined by two factors!

  • the quality of the radiograms

  • the age of the woman.

It is important to realize that mammography is not a routine procedure. The radiologist needs to know some information about the patient's history in order to interpret the mammograms pro­perly. For example, a scar or earlier mastitis could be mistakenly interpreted as a malignancy. The radiologist will, if a lump is present, also carry out palpation himself. This permits a more accurate interpretation of the mammograms.

This is what a normal mammogram of a postmenopausal woman lo­oks like. The glandular tissue has completely regressed. The con­nective tissue ligaments and. the blood vessels are easily visib­le is the fatty tissue. In such a breast even very small carcinomas can be easily seen.

From this picture you can see that functioning mammary gland tissue, before the menopause, gives a much denser picture. This mammogram of the same woman as that of the previous picture was taken two years before the menopause.

In women younger than 30 the density of mammary gland tissue can make interpretation of the mammograms difficult. The radio­logist should always mention in his report whether the tissue structure hampers the reliability of his judgement of the films. The reason for this is, that in the case of a palpable tumor and a mammogram which is difficult to interpret, it would be essen­tial to carry out further diagnostic tests, such as histopathological examination.

This is a large carcinoma in atrophic mammary tissue in an older woman; the tumor does not have a sharp border and shows extensions, called spiculae. Since functioning mammary gland tis­sue is absent we see a so-called «empty» picture.

This is a mammogram showing a small carcinoma situated against the thorax wall.

A good example of the importance of clinical examination by the radiologist is that, when a tumor feels larger by palpation and is actually smaller on the mammogram, it is highly suspect for carcinoma.

Small carcinomas, whether they are infiltrating of not, can be detected by mammography, even before they are palpable. This is a magnification detail of a small intraductal carcinoma that was not palpable at the time.

Breast tumors as small as 0.5 cm in diameter can be detected by mammography. It is therefore an important tool in early detec­tion. The period between seeing the breast cancer of the mammogram and the time that the tumor becomes palpable is called the «lead time».

You must always realize that when there is clinical suspicion of breast cancer, a negative mammogram (i.e. «no tumor visible») is certainly no guarantee that there is nothing wrong! Histopathological examination should be carried out whenever there is a cause for suspicion. Referral to the surgeon in these cases is therefore essential.

Histopathology and cytology.

Material for the pathological diagnostic evaluation is obta­ined by:

  • fine needle aspiration cytology

  • and/or biopsy

The procedure used depends on what the surgeon and the patholo­gist have previously agreed upon together.

For aspiration cytology the tissue is punctured with a fine needle with an exterior diameter of 0.6 mm. A positive result confirms carcinoma. A negative result, i.e. «no tumor cells se­en» must always be interpreted with caution. If there is clini­cal suspicion of breast cancer, then a biopsy - usually perfor­med under general anesthesia - is always essential.

Clinical staging – general remarks.

Once the diagnosis of breast cancer has been established, ca­reful staging follows. This work up is important in order to de­sign a tailored treatment plan.

It is advisable to explain to the patient that there is no stan­dard treatment for breast cancer, and that a careful choice will be made from the different possibilities of therapy based upon the thorough staging procedures.

Therapy – general remarks.

Discussion of the therapeutic possibilities and the indications for them do not fall into the subject of this program. Here are just a few general remarks. A curative treatment can consist of:

– Radical mastectomy, with or without radiotherapy and someti­mes supported by systemic chemotherapy. Radical mastectomy inc­ludes removal of the regional lymph nodes. In some cases, a breast conserving therapy is possible. This treatment combines limited surgery and intensive radiotherapy.

Palliative treatment can consist of:

  • Radiotherapy, both for recurrent tumor control in the breast area and for control of distant metastases.

  • Hormonal therapy, chemotherapy or a combination of these tre­atments.

Summary.

  • If a woman has complaints associated with one or both brea­sts, you can never merely dismiss them as unimportant.

  • Women older than 45 should be referred to a specialist for further examination.

  • If your clinical examination of a woman younger than 45 shows no suspicion of breast cancer, then it is a good policy to re­peat the examination after her next menstruation.

When there are clinical symptoms of breast cancer it is es­sential to carry out pathological examination, even when the result of the mammography is negative.

Epilogue.

In the Netherlands there are more than 7000 new cases of bre­ast cancer diagnosed every year. In 1984 the yearly death rate was approximately 3000. This accounts for more than a quarter of the deaths attributed to all the malignant tumors in women. Although the incidence and mortality rates of breast cancer, ve­ry considerably from country to country, breast cancer is often the chief cause of death for women. Many countries are therefo­re confronted with a serious Public Health problem.

Although it would be desirable to screen all high risk popu­lations with mammography, currently, this is legitimately and economically impossible in most countries.

What can be recommended in the meantime is:

  • to encourage the technique of breast self-examination

  • for family doctors to contact and examine the women who fall into the high risk category for breast cancer.

The high risk category consists of women with breast cancer in their family, especially in first degree relatives.

Answer the questions, please.

1. Is breast cancer a common disease in women?

2. Is early recognition of breast cancer important?

3. How can breast cancer manifest itself?

4. Is it easy to diagnose breast cancer?

5. What are the symptoms of breast cancer?

6. What is “Paget’s disease of the nipple”?

7. Where do the metastases spread?

8. What are the general complaints concerning breast?

9. What things must the doctor pay attention?

10. What information is important in taking the history?

11. What are the risk factors?

12. How must the doctor examine the breasts?

13. Is it important to compare both right and left breasts while examining? Why?

14. In what positions should the patient stay during the examination?

15. When does breast cancer change its biological behaviour?

16. What are the special diagnostic procedures?

17. What does diagnostic radiology consist of?

18. What is the best method for detecting a breast tumor?

19. What are the main factors of reliability of mammography?

20. What are the procedures of the breast pathological diagnostic evaluation?

21. What are the therapeutic possibilities of breast cancer?

22. Why is breast cancer considered as a serious medical problem?

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