The same drugs used to “manage” physical ailments also make our gut leaky, leading to downstream catastrophic events in our body system like metabolic disorders, allergies, and autoimmune disorders. The most common and frequently used classes of drugs used are the antibiotics. Antibiotics wipe out the majority of the bacteria in our gut, and some studies also indicate that even a single course of antibiotics may inflict irreparable harm to our gut’s microbial community and result in the disruption of gut bacteria that may otherwise serve to keep us healthy and prevent chronic disease (Tulstrup et al., 2015). The intestinal microbiota is altered by oral antibiotic use as a result of the interaction between the chemicals released by the antibiotic and the commensal and pathogenic bacteria residing in the gut, increasing the likelihood of pathogen colonization in the gut (Bäumler and Sperandio, 2016). Many anti-inflammatory medications like aspirin and ibuprofen are also reported to cause and increase intestinal permeability , whose long-term usage can also cause gastric and duodenal ulcers (Lambert et al., 2012; Tugendreich et al., 2006). Prednisone and hydrocortisone, two steroids that help restrict immunological activity and reduce inflammation, are frequently used to treat autoimmune illnesses. These steroids cause weakening of the intestinal epithelium by modulating the gut barrier function (Gianotti et al., 1996).