Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_6035_Библиотеки_им_академика_М_И_Перельмана.pdf
TABLE 4.4 Antimicrobial Effect of Chemical Compounds Isolated from Microorganisms
Producer
Microorganism
Aspergillus
ochraceopetaliformis
MN0-83316
Aspergillus versicolor
Streptomyces sp.
Streptomyces
misionensis V16R3Y1
Streptomyces
cavourensis YBQ59
Antimicrobial
Compounds
Ditryptophenaline 20 mg/ml
Siderin 50 µg/disk
Isorhodoptilometrin-1methyl
3-Phenylpyrazin-2
(1H)-one and
3-O-methylviridicatin
d cyclic dipeptide
(l-Leucyl-l-Proline)
1-Monolinolein
Bafilomycin D
Nonactic acid
Daidzein
3′-Hydroxydaidzein
Dose Species of Target Organism Effect Reference
50 µg/disk
4 and 4.5 μg/ml
1 and 9 μg/ml
2 and 4.5 μg/ml
50 µg/ml
32 µg/ml
30 µg/ml
230 µg/ml
11 µg/ml
12 µg/ml
16 µg/ml
30 µg/ml
34 µg/ml
8.5 and 14.6
11.1 and 30.3
18.6 and 23.9
24.8 and 35.2
36.1 and 54.2
B. subtilis subsp. spizizenii
E. coli
C. parapsilosis
B. cereus
B. subtilis
S. aureus
B. cereus
B. subtilis
S. aureus
S. aureus
L. monocytogenes
S. typhimurium
C. albicans
C. metapsilosis
C. parapsilosis
E. fergusonii
S. enterica
E. faecalis
B. cereus
S. aureus
P. aeruginosa
MRSA
MRSE
⏎
Growth inhibition
Growth inhibition
Growth inhibition
Growth inhibition
Growth inhibition
Growth inhibition
Abd El-Rahman
(2020)
et al. (2012)
Hawas
El Euch
Saadouli et al. (2020)
Vu et al. (2018)
et al.
et al. (2018)
73
TABLE 4.4 (Continued)
74
Producer
Microorganism
Streptomyces mutabilis
Bacillus sp.
Micrococcus sp. SCS1
Micrococcus sp.
Antimicrobial
Compounds
Treponemycin 4.17 µg/ml
Diketopiperazines: Cyclo
(l-Pro-l-Leu), Cyclo
(d-Pro-l-Leu) and Cyclo
(d-Pro-l-Tyr)
Ethyl acetate extract of 128 µg/ml
Methanolic pigment
extract (carotenoid)
Dose Species of Target Organism Effect Reference
1.7 µg/ml
2.1 µg/ml
2.9 µg/ml
8.3 µg/ml
16.7 µg/ml
16.7 µg/ml
26.7 µg/ml
11.3 µg/ml
13.3 µg/ml
16–50 µg/ml
16–32 µg/ml
32–64 µg/ml
16–250 µg/ml
256 µg/ml
128 µg/ml
128 µg/ml
64 µg/ml
256 µg/ml
256 µg/ml
128 µg/ml
4.2 mg/ml
5.0 mg/ml
7.5 mg/ml
M. tuberculosis
S. epidermidis
S. pyogenes
B. subtilis
E. coli
C. perfringens
B. melitensis
P. aeruginosa
P. mirabilis
C. albicans
C. albicans
B. subtilis
S. aureus
E. coli
E. coli
S. shiga
S. dysenteriae
S. sonnei
K. pneumoniae
S. typhi
B. subtilis
S. aureus
S. aureus
E. coli
P. aeruginosa
Growth inhibition
Growth inhibition
Growth inhibition
Growth inhibition Karbalaei-Heidari
Yassien
et al. (2015)
Nishanth Kumar et al.
(2012)
Sharma
et al. (2012)
et al. (2020)
TABLE 4.4
(Continued)
75
Producer
Microorganism
Staphylococcus capitis
APC2923
Staphylococcus hominis
MBBL
Staphylococcus
pseudintermedius 222
Antimicrobial
Dose Species of Target Organism Effect Reference
Compounds
170 mm
102 mm
135 mm
153 mm
159 mm
395 mm
136 mm
248 mm
2
2
2
2
2
2
2
2
2
Nisin J 37 mm
Hominicin 0.06 mg/ml
0.96 mg/ml
3.82 mg/ml
BacSp222 0.16 µM
0.11 µM
0.92 µM
0.89 µM
L. monocytogenes
E. faecium
E. faecalis
MRSA
S. aureus
S. epidermidis
S. simulans
S. agalactiae
S. uberis
S. aureus
MRSA
VISA
B. subtilis
M. luteus
S. aureus
MRSA
Growth inhibition
Growth inhibition
Growth inhibition
Notes: MRSA: methicillin-resistant S. aureus; MRSE: methicillin-resistant S. epidermidis; VISA: vancomycin-intermediate S. aureus.
O’Sullivan et al.
(2020)
et al. (2010)
Sung
Wladyka et al. (2015)
76
L. monocytogenes LO28, and L. innocua FH1848. Similarly, nisin V was twice as effective
(MIC of 62.5 μg/ml) as nisin A (MIC of 125 μg/ml) against L. monocytogenes F2365 and L.
monocytogenes 33013.
Another study , macedocin ST91KM which is produced by S. gallolyticus, was assessed
for its effectiveness against mastitis pathogens. Bacteriocin showed bactericidal action to
S. agalactiae (76.8 AU/mg), S. dysgalactiae (76.8 AU/mg), S. uberis (7.2–76.8 AU/mg),
and S. aureus (76.8 AU/mg) strains (Pieterse et al., 2010). The possible mode of action
was related to the deformation of cells and released nucleotides, K+ and β-galactosidase
upon exposure to macedocin ST91KM. The peptide’ s binding to tar get cells reduced in the
presence of solvents, indicating that cell surface receptors might contain lipid components.
The disruption observed in the target cells exposed to macedocin ST91KM suggests that
the peptide creates pores in the cell membrane. The effectiveness of macedocin ST91KM’s
mode of action was not reliant on adsorption, as both sensitive and nonsensitive strains
displayed comparable levels of peptide attachment (Pieterse et al., 2010).
Various antimicrobial substances obtained from microorganisms have been tested
in vivo in murine models against human pathogenic strains. The bacteriocin lantibiotic
NAI-107 demonstrated bactericidal activity in lethal infections caused by different
strains. In immunocompetent mice, it effectively treated infections caused by a penicillinintermediate S. pneumoniae strain. In contrast, in neutropenic mice, it targeted MRSA,
glycopeptide-intermediate S. aur eus (GISA), and vancomycin-resistant enterococci (VRE)
strains. When administered intravenously, the effective dose (ED50) of NAI-107 ranged
from 0.51 to 14.2 mg/kg of body weight. Additionally, a dose of 40 mg/kg were used in rats
with induced granuloma pouch by MRSA strain, exhibited bactericidal activity, leading
to a reduction of viable MRSA by 3 log10 CFU/ml in exudates, and this effect persisted
for over 72 h. Furthermore, when rat endocarditis was induced with an MRSA strain,
NAI-107 effectively reduced the number of microorganism present in heart vegetation in a
quantity-proportional manner when administered at 5, 10, or 20 mg/kg/day over 5 days. In
a separate assay, a regimen of 10 mg/kg at 12-h intervals was compared to 20 mg/kg/day
intravenously, and both dosages demonstrated efcacy in reducing the bacterial load in the
heart vegetation (Jabés et al., 2011).
Sublancin is a bacteriocin produced by B. subtilis 168 and was effective in inhibiting S.
aureus MRSA (MIC: 15 µM). The mode of action was related to the disruption of the cell
wall from bacteria. The amount of sublancin given to mice (2.0 mg/kg) signicantly alleviated the bacterial load caused by infection with MRSA and signicantly reduced weight
loss (19.2 g versus 20.6 g for MRSA, on day 3) and mortality in MRSA-challenged mice.
Sublancin was further found to balance the immune response during infection and relieve
intestinal inammation through inhibition of nuclear factor-kappa B (Wang et al., 2017).
Campion et al. (2013), assessed the nisin A and nisin V ability to control L. monocytogenes
EGDe (bioluminescent strain) in a murine infection model. In-vitro analysis showed that
nisin V was more effective in inhibiting Listeria at MIC 6.22 mg/l than Nisin A (MIC12.57
5
mg/l). For the in-vivo analysis, infection of mice was via intraperitoneal with 1 × 10
CFU
of L. monocytogenes EGDe. After 30 min, mice were treated intraperitoneally with 58.82
mg/kg of nisin A andnisin V, or phosphate buffer saline (PBS) (negative control). In another
study, L. salivarius produced the bacteriocin Abp118 that protected the liver and spleen of
77
mice from infection with L. monocytogenes. This effect was veried with the help of a
mutant strain of L. salivarius UCC118, which cannot produce the bacteriocin Abp118. As
a result, this mutant strain failed to inhibit L. monocytogenes infection, thus conrming
that the production of the bacteriocin is the primary factor mediating protection against this
organism (Corr et al., 2007).
Microbial-produced antimicrobial compounds, such as nisin, have been employed
for human treatment, an effective substitute for antibiotics in managing staphylococcal
mastitis. In one study, a bacteriocin nisin solution (6 µg/ml) was applied to the nipple and
mammary areola in women with clinical signs of staphylococcal mastitis for 2 weeks. At
day 0, the breast milk staphylococcal counts in the nisin and control groups were comparable, measuring 5.04 and 4.88 log10 CFU/ml, respectively. However, at day 14, the counts
of the treatment group (3.22 log10 CFU/ml) were statistically lower than the control (5.01
log10 CFU/ml), and women showed no clinical signs of mastitis. In contrast, women in the
control group continued to experience symptoms throughout the study (Fernández et al.,
2008).
Finally, the use of antimicrobials produced by microorganisms has proven to be of
signicant medical importance. These compounds have been utilized in the treatment
of various infectious diseases caused by both bacteria and fungi, being effective against
multidrug-resistant pathogens and less toxic than conventional antibiotics (Amaning
Danquah et al., 2022). Furthermore, the production of these antimicrobials can be achieved
through sustainable and eco-friendly methods, which makes them a promising alternative
to synthetic drugs (Meade et al., 2020). The use of antimicrobial compounds produced by
microorganisms has also led to the discovery of new drugs and targets for the treatment
of infectious diseases. However, it is important to note that the overuse and misuse of
antimicrobials, including those produced by microorganisms, can lead to the emergence
of resistance. Therefore, proper usage and regulation of these compounds are essential to
preserve their efcacy and ensure their continued medical importance.
4.5 CONCLUSIONS AND FUTURE TRENDS
The emergence of antibiotic-resistant strains has become a severe health problem worldwide,
since routinely used antibiotic therapies have lost their efficacy, which makes infections
caused by these strains difficult to treat, and the ravages to health are increasing as well
as their severity and high mortality rates produced by these infections (Razzaque, 2021).
In this way, it is necessary to find new effective treatment alternatives against bacterial
infections. In this sense, research is aimed at exploring new sources with antimicrobial
potential. Among these options, the natural origin source stand out, such as plants, marine
sources, and metabolites produced by microorganisms. Several investigations have shown
that these sources have a promising antimicrobial effect against different strains of impact
in the health area, in addition to showing antimicrobial effects against resistant strains
from clinical isolates (Chassagne et al., 2021). In turn, some research studied the combined
effect of antibiotics with natural products, observing in some cases a synergistic effect
of both treatments, which could represent a treatment option for hard-to-treat infections.
78
Besides, some studies have explored the antimicrobial effect of extracts or compounds
purified from natural products in in-vivo systems, which have shown effectiveness in
reducing the microbial load and the number of deaths in animals (Yildirim et al., 2013).
In turn, some of the most advanced research on natural products has reached clinical trials
showing encouraging results (Stange et al., 2017).
On the other hand, in the analysis of the compounds puried from natural compounds,
they have shown essential parameters for developing potential drugs through in-silico
studies, such as compliance with the Lipinsky rules and interaction with certain enzymes
of vital importance in their metabolism (Alam et al., 2021; Borges et al., 2017). In turn,
computational chemistry studies have shown that active molecules derived from natural
products can interact with vitally important bacterial cell components, providing information about the action mechanism (Alam et al., 2021; Turabi et al., 2023). In addition to the
above, it has also been shown that these have low cytotoxicity against noncancerous cell
lines, which is a signicant factor since provides valuable information about the selectivity
these compounds can present.
Another essential aspect to highlight is the effect of natural products and isolated
compounds against bacterial biolms, which are an important bacterial virulence factor
and represent a continuous source of infection and persistence (Srinivasan et al., 2021).
In this sense, it has been shown that natural sources can inhibit the formation of these
structures and eliminate these communities after their formation. Same inhibition effect
has been reported on abiotic surfaces, such as catheters, stainless steel surfaces, silicone
surfaces, polystyrene, and polyethylene, among others (Adesina et al., 2015; Guiotti et al.,
2016; Zameer et al., 2016). These natural sources can also be used to develop antibiotic,
antiseptic and disinfectant substances, among others.
Natural products could represent a feasible alternative for developing new antimicrobial
therapies against infections produced by clinically relevant pathogenic bacteria. In turn,
the extracts could represent a promising treatment option as they have various groups of
chemical compounds and exert different mechanisms of action simultaneously, hindering
or delaying the resistance development process. However, it is essential to mention that
strong scientic evidence of effectiveness must be available and go through the different
clinical phases of the study to guarantee its safe application and effectiveness.
KEYWORDS
• antimicrobial effects
• herbal therapy
• antibiotics
• antibiofilm
• ethanolic extracts
79
REFERENCES
Abd El-Rahman, T. M.; Tharwat, N. A.; Abo El-Souad, S. M.; El-Beih, A. A.; El-Diwany, A. I. Biological
activities and variation of symbiotic fungi isolated from Coral reefs collected from Red Sea in Egypt.
Mycology. 2020, 11(3), 243–255.
Abdallah, E. M. Antibacterial activity of Hibiscus sabdariffa L. calyces against hospital isolates of multidrug
resistant Acinetobacter baumannii. J. Acute Dis. 2016, 5(6), 512–516.
Adesina, T.; Nwinyi, O.; Olugbuyiro, J. Prevention of bacterial biofilms formation on urinary catheter by
selected plant extracts. Pak. J. Biol. Sci.: PJBS. 2015, 18(2), 67–73.
Al Jahid, A.; Elamrani, A.; Lahlou, F. A.; Hmimid, F.; Bourhim, N.; Blaghen, M.; Eddine, J. J. Chemical
composition and antibacterial activity of the essential oil isolated from the seeds of Moroccan Artemisia
campestris L. J. Essent. Oil Bear. Plants. 2017, 20(2), 375–384.
Alam, S.; Rashid, M. A.; Sarker, M. M. R.; Emon, N. U.; Arman, M.; Mohamed, I. N.; Haque, M. R.
Antidiarrheal, antimicrobial and antioxidant potentials of methanol extract of Colocasia gigantea Hook. f.
leaves: Evidenced from in vivo and in vitro studies along with computer-aided approaches. BMC Complement.
Med. Ther. 2021, 21(1), 1–12.
Aleksic Sabo, V.; Knezevic, P. Antimicrobial activity of Eucalyptus camaldulensis Dehn. plant extracts and
essential oils: A review. Ind. Crops Pr od. 2019, 132, 413–429. doi: https://doi.org/10.1016/j.indcrop.2019.02.051
Aljabeili, H. S.; Barakat, H.; Abdel-Rahman, H. A. Chemical composition, antibacterial and antioxidant activities
of thyme essential oil (Thymus vulgaris). Food Nutr. Sci. 2018, 09(No.05), 13. doi: 10.4236/fns.2018.95034
Amaning Danquah, C.; Minkah, P. A. B.; Osei Duah Junior, I.; Amankwah, K. B.; Somuah, S. O. Antimicrobial
compounds from microorganisms. Antibiotics. 2022, 11(3), 285.
Amankwah, S.; Abdella, K.; Kassa, T. Bacterial biofilm destruction: A focused review on the recent use of
phage-based strategies with other antibiofilm agents. Nanotechnol. Sci. Appl. 2021, 14, 161–177.
Atanasov, A. G.; Zotchev, S. B.; Dirsch, V. M.; Supuran, C. T. Natural products in drug discovery: Advances
and opportunities. Nat. Rev. Drug Discov. 2021, 20(3), 200–216.
Bączek, K. B.; Kosakowska, O.; Przybył, J. L.; Pióro-Jabrucka, E.; Costa, R.; Mondello, L.; Gniewosz, M.;
Synowiec, A.; Węglarz, Z. Antibacterial and antioxidant activity of essential oils and extracts from costmary
(Tanacetum balsamita L.) and tansy (Tanacetum vulgare L.). Ind. Crops Prod. 2017, 102, 154–163. doi:
https://doi.org/10.1016/j.indcrop.2017.03.009
Bělonožníková, K.; Sladkovská, E.; Kavan, D.; Hýsková, V.; Hodek, P.; Šmíd, D.; Ryšlavá, H. Effect of
Agrimonia eupatoria L. and Origanum vulgare L. leaf, flower, stem, and root extracts on the survival of
Pseudomonas aeruginosa. Molecules. 2023, 28(3), 1019.
Borges, A.; Lopez-Romero, J.; Oliveira, D.; Giaouris, E.; Simões, M. Prevention, removal and inactivation of
Escherichia coli and Staphylococcus aureus biofilms using selected monoterpenes of essential oils. J. Appl.
Microbiol. 2017, 123(1), 104–115.
Busetti, A.; Thompson, T. P.; Tegazzini, D.; Megaw, J.; Maggs, C. A.; Gilmore, B. F. Antibiofilm activity of the
brown alga Halidrys siliquosa against clinically relevant human pathogens. Mar . Drugs. 2015
Cai, X.; Wang, X.; Chen, Y.; Wang, Y.; Song, D.; Gu, Q. A natural biopreservative: Antibacterial action and
mechanisms of Chinese Litsea mollis Hemsl. extract against Escherichia coli DH5α and Salmonella spp. J.
Dairy Sci. 2019, 102(11), 9663–9673.
Campion, A.; Casey, P. G.; Field, D.; Cotter, P. D.; Hill, C.; Ross, R. P. In vivo activity of Nisin A and Nisin V
against Listeria monocytogenes in mice. BMC Microbiol. 2013, 13(1), 1–8.
Coppola, D.; Buonocore, C.; Palisse, M.; Tedesco, P.; de Pascale, D. Exploring oceans for curative compounds:
Potential new antimicrobial and anti-virulence molecules against Pseudomonas aeruginosa. Mar. Drugs. 2022,
21(1), 9.
Corr, S. C.; Li, Y .; Riedel, C. U.; O'T oole, P . W .; Hill, C.; Gahan, C. G. M. Bacteriocin production as a mechanism
for the antiinfective activity of Lactobacillus salivarius UCC118. Biol. Sci. 2007, 104(18), 7617–7621. doi:
doi:10.1073/pnas.0700440104
Cruz-V alenzuela, M. R.; Ayala-Soto, R. E.; Ayala-Zavala, J. F.; Espinoza-Silva, B. A.; González-Aguilar , G. A.;
Martín-Belloso, O.; Soliva-Fortuny, R.; Nazzaro, F.; Fratianni, F.; Tapia-Rodríguez, M.R.; Bernal-Mercado,
, 13(6), 3581–3605.
80
A. T. Pomegranate (Punica granatum L.) peel extracts as antimicrobial and antioxidant additives used in
alfalfa sprouts. Foods. 2022, 11(17), 2588.
Chakotiya, A. S.; Tanwar, A.; Narula, A.; Sharma, R. K. Zingiber officinale: Its antibacterial activity on
Pseudomonas aeruginosa and mode of action evaluated by flow cytometry. Microb. Pathog. 2017, 107,
254–260. doi: https://doi.org/10.1016/j.micpath.2017.03.029
Chandran, H.; Meena, M.; Barupal, T.; Sharma, K. Plant tissue culture as a perpetual source for production of
industrially important bioactive compounds. Biotechnol. Rep. 2020, 26, e00450. doi: https://doi.org/10.1016/j.
btre.2020.e00450
Chassagne, F .; Samarakoon, T.; Porras, G.; Lyles, J. T.; Dettweiler, M.; Marquez, L.; Salam, A. M.; Shabih, S.;
Farrokhi, D. R.; Quave, C. L. A systematic review of plants with antibacterial activities: A taxonomic and
phylogenetic perspective. Front. Pharmacol. 2021, 11, 2069.
De Sales, N. F.; Silva da Costa, L.; Carneiro, T. I.; Minuzzo, D. A.; Oliveira, F. L.; Cabral, L. M.; Torres,
A. G.; El-Bacha, T. Anthocyanin-rich grape pomace extract (Vitis vinifera L.) from wine industry affects
mitochondrial bioenergetics and glucose metabolism in human hepatocarcinoma HepG2 cells. Molecules.
2018, 23(3), 611.
De Zoysa, M. H. N.; Rathnayake, H.; Hewawasam, R. P .; W ijayaratne, W. M. D. G. B. Determination of In vitro
antimicrobial activity of five Sri Lankan medicinal plants against selected human pathogenic bacteria. Int. J.
Microbiol. 2019, 2019, 7431439. doi: 10.1155/2019/7431439
Dharajiya, D.; Pagi, N.; Jasani, H.; Patel, P. Antimicrobial activity and phytochemical screening of Aloe vera
(Aloe barbadensis Miller). Int. J. Curr. Microbiol. App. Sci. 2017, 6(3), 2152–2162.
Efenberger-Szmechtyk, M.; Nowak, A.; Czyżowska, A.; Śniadowska, M.; Otlewska, A.; Żyżelewicz, D.
Antibacterial mechanisms of Aronia melanocarpa (Michx.), Chaenomeles superba Lindl. and Cornus mas L.
leaf extracts. Food Chem. 2021, 350, 129218. doi: https://doi.org/10.1016/j.foodchem.2021.129218
El Atki, Y.; Aouam, I.; El Kamari, F.; Taroq, A.; Nayme, K.; Timinouni, M.; Lyoussi, B.; Abdellaoui, A.
Antibacterial activity of cinnamon essential oils and their synergistic potential with antibiotics. J. Adv.
Pharm. Technol. Res. 2019, 10(2), 63.
El Euch, I. Z.; Frese, M.; Sewald, N.; Smaoui, S.; Shaaban, M.; Mellouli, L. J. M. C. R. Bioactive secondary
metabolites from new terrestrial Streptomyces sp. TN82 strain: Isolation, structure elucidation and biological
activity. Med. Chem. Res. 2018, 27, 1085–1092.
Feitosa, B. F .; de Alcântara, C. M.; de Lima, A. B. S.; Silva, A. S. A.; Araújo, A. d. S.; Cavalcanti, M. T.; Mori,
E.; Araújo, I. M.; de Farias, P. A. M.; Wilairatana, P. Bioactive natural products for chemical control of
microorganisms: Scientific prospecting (2001–2021) and systematic review. Molecules. 2022, 27(18), 5917.
Fernández, L.; Delgado, S.; Herrero, H.; Maldonado, A.; Rodriguez, J. M. J. J. o. H. L. The bacteriocin nisin,
an effective agent for the treatment of staphylococcal mastitis during lactation. Randomized Controlled T rial.
2008, 24(3), 311–316.
Field, D.; Daly, K.; O'Connor, P. M.; Cotter, P. D.; Hill, C.; Ross, R. P. Efficacies of nisin A and nisin V
semipurified preparations alone and in combination with plant essential oils for controlling Listeria
monocytogenes. Appl. Environ. Microbiol. 2015, 81(8), 2762–2769. doi:10.1128/AEM.00070-15
Fournomiti, M.; Kimbaris, A.; Mantzourani, I.; Plessas, S.; Theodoridou, I.; Papaemmanouil, V.; Kapsiotis, I.;
Panopoulou, M.; Stavropoulou, E.; Bezirtzoglou, E. E. Antimicrobial activity of essential oils of cultivated
oregano (Origanum vulgare), sage (Salvia officinalis), and thyme (Thymus vulgaris) against clinical isolates of
Escherichia coli, Klebsiellaoxytoca, and Klebsiella pneumoniae. Micr ob. Ecol. Health Dis. 2015, 26(1), 23289.
Gajdács, M.; Urbán, E.; Stájer, A.; Baráth, Z. Antimicrobial resistance in the context of the sustainable
development goals: A brief review.
Ghareeb, M. A.; Refahy, L. A.; Saad, A. M.; Osman, N. S.; Abdel-Aziz, M. S.; ElShazly, M. A.; Mohamed, A.
S. In vitro antimicrobial activity of five Egyptian plant species. J. Appl. Pharm. Sci. 2015, 5(2), 045–049.
Gonelimali, F . D.; Lin, J.; Miao, W.; Xuan, J.; Charles, F .; Chen, M.; Hatab, S. R. Antimicrobial properties and
mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Front.
Microbiol. 2018, 9. doi: 10.3389/fmicb.2018.01639
Guiotti, A. M.; Cunha, B. G.; Paulini, M. B.; Goiato, M. C.; Dos Santos, D. M.; Duque, C.; Caiaffa, K. S.;
Brizzotti, N. S. Antimicrobial activity of conventional and plant-extract disinfectant solutions on microbial
biofilms on a maxillofacial polymer surface. J. Prosthet. Dent. 2016, 116(1), 136–143.
Eur. J. Investig. Health, Psychol. Educ. 2021, 11(1), 71–82.
81
Gutierrez-Pacheco, M. M.; Bernal-Mercado, A. T.; Vazquez-Armenta, F. J.; González-Aguilar, G.; Lizardi-
Mendoza, J.; Madera-Santana, T. J,; Nazzaro, F.; Ayala-Zavala, J. Quorum sensing interruption as a tool to
control virulence of plant pathogenic bacteria. Physiol. Mol. Plant Pathol. 2019, 106, 281–291.
Hao, K.; Xu, B.; Zhang, G.; Lv, F .; W ang, Y.; Ma, M.; Si, H. Antibacterial activity and mechanism of Litsea cubeba
L. essential oil against Acinetobacter baumannii. Nat. Prod. Commun. 2021, 16(3), 1934578X21999146.
Haroun, M. F.; Al-Kayali, R. S. Synergistic effect of Thymbra spicata L. extracts with antibiotics against
multidrug-resistant Staphylococcus aureus and Klebsiella pneumoniae strains. Iran. J. Basic Med. Sci. 2016,
19(11), 1193.
Hassan, S. T.; Berchová, K.; Majerová, M.; Pokorná, M.; Švajdlenka, E. In vitro synergistic effect of Hibiscus
sabdariffa aqueous extract in combination with standard antibiotics against Helicobacter pylori clinical
isolates. Pharm. Biol. 2016, 54(9), 1736–1740.
Hawas, U. W.; El-Beih, A. A.; El-Halawany, A. M. Bioactive anthraquinones from endophytic fungus
Aspergillus versicolor isolated from red sea algae. Arch. Pharm. Res. 2012, 35, 1749–1756.
Hossan, M. S.; Jindal, H.; Maisha, S.; Samudi Raju, C.; Devi Sekaran, S.; Nissapatorn, V.; Kaharudin, F.; Yi S.
L.; Khoo, T. J.; Rahmatullah, M.; Wiart, C. Antibacterial effects of 18 medicinal plants used by the Khyang
tribe in Bangladesh. Pharm. Biol. 2018, 56(1), 201–208. doi: 10.1080/13880209.2018.1446030
Jabés, D.; Brunati, C.; Candiani, G.; Riva, S.; Romanó, G.; Donadio, S. J. A. A. Chemotherapy. Efficacy
of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive
pathogens. Antimicrob Agents Chemother. 2011, 55(4), 1671–1676.
Jebakumar Solomon, R.; Satheeja Santhi, V. Purification of bioactive natural product against human microbial
pathogens from marine sea weed Dictyota acutiloba J. Ag. W orld J. Micr obiol. Biotechnol. 2008, 24, 1747–1752.
Jiang, P.; Li, J.; Han, F.; Duan, G.; Lu, X.; Gu, Y.; Yu, W. Antibiofilm activity of an exopolysaccharide from
marine bacterium Vibrio sp. QY101. PLoS One. 2011, 6(4), e18514.
Karbalaei-Heidari, H. R.; Partovifar, M.; Memarpoor-Y azdi, M. Evaluation of the bioactive potential of secondary
metabolites produced by a new marine micrococcus species isolated from the Persian Gulf. Avicenna J. Med.
Biotechnol. 2020, 12(1), 61.
Khameneh, B.; Iranshahy, M.; Soheili, V.; Fazly Bazzaz, B. S. Review on plant antimicrobials: A mechanistic
viewpoint. Antimicrob. Resist. Infect. Control. 2019, 8(1), 118. doi: 10.1186/s13756-019-0559-6
Kurhekar, J. V. Antimicrobial lead compounds from marine plants. In: Phytochemicals as Lead Compounds for
New Drug Discovery. Elsevier. 2020, pp. 257–274.
Leoni, G.; De Poli, A.; Mardirossian, M.; Gambato, S.; Florian, F.; Venier, P.; Wilson, D. N.; Tossi, A.;
Pallavicini, A.; Gerdol, M. Myticalins: A novel multigenic family of linear, cationic antimicrobial peptides
from marine mussels (Mytilus spp.). Mar. Drugs. 2017, 15(8), 261.
Lestari, S. R.; Witjoro, A.; Poejiani, S. The potential of single garlic oil in inhibiting the growth and damaging
the membrane of pseudomonas aeruginosa bacteria. J. Trop. Biodivers. Biotechnol. 2018, 3(3), 67–72.
López-Malo, A.; Alzamora, S. M.; Paris, M. J.; Lastra-Vargas, L.; Coronel, M. B.; Gómez, P. L.; Palou, E.
Naturally occurring compounds—Plant sources. Antimicrob. Food.
Mahyari, S.; Mahyari, B.; Emami, S. A.; Malaekeh-Nikouei, B.; Jahanbakhsh, S. P.; Sahebkar, A.;
Mohammadpour, A. H. Evaluation of the ef ficacy of a polyherbal mouthwash containing Zingiber officinale,
Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized doubleblind placebo-controlled trial. Complement. Ther. Clin. Pract. 2016, 22, 93–98.
Makabenta, J. M. V.; Nabawy, A.; Li, C.-H., Schmidt-Malan, S.; Patel, R.; Rotello, V. M. Nanomaterial-based
therapeutics for antibiotic-resistant bacterial infections. Nat. Rev. Microbiol. 2021, 19(1), 23–36.
Manandhar, S.; Luitel, S.; Dahal, R. K. In vitro antimicrobial activity of some medicinal plants against human
pathogenic bacteria. J. Trop. Med. 2019, 2019, 1895340. doi: 10.1155/2019/1895340
Meade, E.; Slattery, M. A.; Garvey, M. Bacteriocins, potent antimicrobial peptides and the fight against multi
drug resistant species: Resistance is futile? Antibiotics. 2020, 9(1), 32.
Mombeshora, M.; Mukanganyama, S. Antibacterial activities, proposed mode of action and cytotoxicity of leaf
extracts from Triumfetta welwitschii against Pseudomonas aeruginosa. BMC Complement. Alternat. Med.
2019, 19(1), 315. doi: 10.1186/s12906-019-2713-3
Moubayed, N. M.; Al Houri, H. J.; Al Khulaifi, M. M.; Al Farraj, D. A. Antimicrobial, antioxidant properties
and chemical composition of seaweeds collected from Saudi Arabia (Red Sea and Arabian Gulf). Saudi J.
Biol. Sci. 2017, 24(1), 162–169.
2020, 527–594.
82
Moulai-Hacene, F.; Boufadi, M. Y.; Keddari, S.; Homrani, A. Chemical composition and antimicrobial
properties of Elettaria cardamomum extract. Pharm. J. 2020, 12(5).
Naylor, N. R.; Atun, R.; Zhu, N.; Kulasabanathan, K.; Silva, S.; Chatterjee, A.; Knight, G. M.; Robotham, J. V.
Estimating the burden of antimicrobial resistance: A systematic literature review. Antimicrob. Resist. Infect.
Control. 2018, 7, 1–17.
Ngan, L. T. M.; Tan, M. T.; Hoang, N. V. M.; Thanh, D. T.; Linh, N. T. T.; Hoa, T. T. H.; Nuong, N. T. M.;
Hieu, T . T. Antibacterial activity of Hibiscus rosasinensis L. red flower against antibiotic-resistant strains of
Helicobacter pylori and identification of the flower constituents. Braz. J. Med. Biol. Res. 2021, 54.
Nishanth Kumar, S.; Mohandas, C.; Siji, J. V.; Rajasekharan, K. N.; Nambisan, B. Identification of antimicrobial
compound, diketopiperazines, from a Bacillus sp. N strain associated with a rhabditid entomopathogenic
nematode against major plant pathogenic fungi. J. Appl. Microbiol. 2012, 113(4), 914–924. doi: 10.1111/
j.1365-2672.2012.05385.x
O’Sullivan, J. N.; O’Connor, P. M.; Rea, M. C.; O’Sullivan, O.; Walsh, C. J.; Healy, B.; Mathur, H.; Field, D.;
Hill, C.; Ross, R. P . Nisin J, a novel natural nisin variant, is produced by Staphylococcus capitis sourced from
the human skin microbiota. J. Bacteriol. 2020, 202(3), e00639–00619.
Okoh, S. O.; Iweriebor, B. C.; Okoh, O. O.; Nwodo, U. U.; Okoh, A. I. Antibacterial and antioxidant properties
of the leaves and stem essential oils of Jatropha gossypifolia L. BioMed. Res. Int. 2016, 2016, 9392716. doi:
10.1155/2016/9392716
Parasuraman, P.; Devadatha, B.; Sarma, V. V.; Ranganathan, S.; Ampasala, D. R.; Reddy, D.; Kumavath, R.;
Kim, I. W.; Patel, S. K. S.; Kalia, V. C.; Lee, J. K.; Siddhardha, B. Inhibition of microbial quorum sensing
mediated virulence factors by Pestalotiopsis sydowiana. J. Microbiol. Biotechnol. 2020, 30(4), 571.
Pieterse, R.; Todorov, S. D.; Leon, M. T. D. Mode of action and in vitro susceptibility of mastitis pathogens to
macedocin ST91KM and preparation of a teat seal containing the bacteriocin. Braz. J. Microbiol. 2010, 41,
133–145.
Piper, C.; Draper, L. A.; Cotter, P. D.; Ross, R. P.; Hill, C. A comparison of the activities of lacticin 3147 and
nisin against drug-resistant Staphylococcus aureus and Enterococcus species. J. Antimicrob. Chemother.
2009, 64(3), 546–551. doi: 10.1093/jac/dkp221 %J.
Ramalingam, V.; Mahamuni, D.; Rajaram, R. In vitro and in silico approaches of antibiofilm activity of
1-hydroxy-1-norresistomycin against human clinical pathogens. Microb. Pathog. 2019, 132, 343–354.
Razzaque, M. S. Implementation of antimicrobial stewardship to reduce antimicrobial drug resistance. Expert
Rev. Anti Infect. Ther. 2021, 19(5), 559–562.
Rezzoug, M.; Bakchiche, B.; Gherib, A.; Roberta, A.; FlaminiGuido, Kilinçarslan, Ö.; Mammadov, R.;
Bardaweel, S. K. Chemical composition and bioactivity of essential oils and Ethanolic extracts of Ocimum
basilicum L. and Thymus algeriensis Boiss. & Reut. from the Algerian Saharan Atlas. BMC Complement.
Alternat. Med. 2019, 19(1), 146. doi: 10.1186/s12906-019-2556-y
Ribeiro, R.; Pinto, E.; Fernandes, C.; Sousa, E. Marine cyclic peptides: Antimicrobial activity and synthetic
strategies. Mar. Drugs. 2022, 20(6), 397.
Romandini, A.; Pani, A.; Schenardi, P. A.; Pattarino, G. A. C.; De Giacomo, C.; Scaglione, F . Antibiotic resistance
in pediatric infections: Global emerging threats, predicting the near future. Antibiotics. 2021, 10(4), 393.
Saadouli, I.; Zendah El Euch, I.; Trabelsi, E.; Mosbah, A.; Redissi, A.; Ferjani, R.; Fhoula, I.; Cherif, A.;
Sabatier, J. M.; Sewald, N.; Ouzari, H.-I. Isolation, characterization and chemical synthesis of large spectrum
antimicrobial cyclic dipeptide (l-leu-l-pro) from Streptomyces misionensis V16R3Y1 bacteria extracts. a
novel 1H NMR metabolomic approach. Antibiotics. 2020, 9(5), 270.
Sadiq, M. B.; T arning, J.; Aye Cho, T. Z.; Anal, A. K. Antibacterial activities and possible modes of action of Acacia
nilotica (L.) Del. against multidrug-resistant Escherichia coli and Salmonella. Molecules. 2017, 22(1), 47.
Saki, M.; Seyed-Mohammadi, S.; Montazeri, E. A.; Siahpoosh, A.; Moosavian, M.; Latifi, S. M. In vitro
antibacterial properties of Cinnamomum zeylanicum essential oil against clinical extensively drug-resistant
bacteria. Eur. J. Integr. Med. 2020, 37, 101146. doi: https://doi.org/10.1016/j.eujim.2020.101146
Sakkas, H.; Papadopoulou, C. Antimicrobial activity of basil, oregano, and thyme essential oils. J. Microbiol.
Biotechnol. 2017, 27(3), 429–438.
Sankar Ganesh, P .; Ravishankar Rai, V. Attenuation of quorum-sensing-dependent virulence factors and biofilm
formation by medicinal plants against antibiotic resistant Pseudomonas aeruginosa. J. Tradit. Complement.
Med. 2018, 8(1), 170–177. doi: https://doi.org/10.1016/j.jtcme.2017.05.008