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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_585_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword I
- •Foreword II
- •Foreword III
- •Foreword IV
- •Contributors
- •Manuscripts Translation and Preparation
- •1.1 Introduction
- •Preface
- •Acknowledgments
- •Contents
- •Editors and Contributors
- •Deputy Editors
- •1.2.2.2 Gallbladder
- •1.2.2.3 Cystic Duct
- •1.2.2.4 Common Bile Duct
- •Supraduodenal Portion
- •Retroduodenal Portion
- •Pancreatic Portion
- •Intraduodenal Portion
- •1.3.2 Data Acquisition
- •1.3.2.2 Bile Duct Perfusion
- •1.3.2.3 Hepatic Artery Perfusion
- •1.3.2.4 Specimen Perfusion Fixation
- •1.4.1 Liver Dissection after Biliary Tract Perfusion
- •1.4.3.1 Image Registration After Bile Duct Perfusion
- •References
- •2.1 Introduction
- •2.2.1 Basic Principles
- •2.2.2.1 Methods
- •Preparation
- •Scanning Modalities
- •Contrast-Enhanced Scanning
- •Contrast-Enhanced Examination
- •Shaded Surface Display
- •Maximum Intensity Projection
- •Volume Rendering
- •2.3.1.1 MRI Devices
- •The Magnet
- •The Gradient System
- •The Radiofrequency System
- •Radiofrequency Coils
- •The Computer System
- •Other Auxiliary Equipment
- •2.3.2.1 MRI Preparations
- •Patient Preparation
- •2.3.2.2 Regular Scan Sequences
- •Single-Shot Turbo Spin-Echo Coronal Sequences
- •2D or 3D T2W1
- •Transaxial Single-Shot Turbo Spin-Echo Fat Suppression Sequences
- •Dynamic Enhancement Sequence
- •3D Volumetric Acquisitions
- •Advantages
- •Disadvantages
- •2D Continuous Thin-Slice Scanning
- •Advantages
- •Disadvantages
- •2D Thick-Slice Projection Imaging
- •Advantages
- •Disadvantages
- •References
- •3.1 Introduction
- •3.2 Congenital Biliary Diseases
- •3.2.1 Congenital Extrahepatic Biliary Atresia
- •3.2.1.1 CT Features
- •3.2.1.2 MRI Features
- •3.2.2 Biliary Dilatation
- •Type I
- •Type II
- •Type III
- •Type IV
- •Type V
- •3.2.2.2 Radiographic Features
- •CT Features
- •MRI Features
- •3.2.3 Bile Duct Hamartomas
- •3.2.3.1 CT Features
- •3.2.3.2 MRI Features
- •3.3 Common Gallbladder Diseases
- •3.3.1 Acute Cholecystitis
- •3.3.1.1 Radiographic Features
- •CT Features
- •MRI Features
- •Gangrenous Cholecystitis
- •Emphysematous Cholecystitis
- •Pediatric Cholecystitis
- •Pregnancy Cholecystitis
- •Gallbladder Empyema
- •Gallbladder Perforation
- •Hemorrhagic Cholecystitis
- •3.3.5 Other Gallbladder Tumors
- •3.3.5.3 Primary Gallbladder Lymphoma
- •3.3.5.4 Gallbladder Fibrosarcoma
- •3.3.6 Xanthogranulomatous Cholecystitis
- •3.3.6.1 CT Features
- •3.3.6.2 MRI Features
- •3.3.7 Gallbladder Adenomyomatosis
- •3.3.2 Chronic Cholecystitis
- •3.3.2.1 CT Features
- •3.3.2.2 MRI Features
- •3.3.3 Gallstones
- •3.3.3.1 CT Features
- •3.3.3.2 MRI Features
- •3.3.4 Gallbladder Cancer
- •3.3.4.1 CT Features
- •3.3.4.2 MRI Features
- •3.3.4.3 MRCP Features
- •3.3.7.1 CT Features
- •3.3.7.2 MRI Features
- •3.3.8.1 CT Features
- •3.3.9 Gallbladder Torsion
- •3.3.9.1 Type I
- •3.3.9.2 Type II
- •3.3.10.2 Gallbladder Sludge
- •3.3.11 Mirizzi’s Syndrome
- •3.3.11.1 CT Features
- •3.3.11.2 MRI Features
- •3.3.12 Post-Cholecystectomy Syndrome
- •3.4.1 Bile Duct Stones
- •CT Findings
- •MRI Findings
- •CT Findings
- •MRI Findings
- •3.4.2 Suppurative Cholangitis/Acute Cholangitis
- •3.4.3 Primary Sclerosing Cholangitis
- •3.4.3.1 CT Findings
- •3.4.3.2 MRI Findings
- •3.4.4 Secondary Sclerotic Cholangitis
- •3.4.5 Recurrent Pyogenic Cholangitis
- •3.4.5.1 CT Findings
- •3.4.6 Extrahepatic Cholangiocarcinoma
- •3.4.6.1 CT Findings
- •MRI Findings
- •MRCP Features
- •3.4.7 Intrahepatic Cholangiocarcinoma
- •3.4.7.3 Special Manifestations
- •3.4.8 Periampullary Carcinoma
- •3.4.8.1 Radiographic Findings
- •3.4.8.2 CT Findings
- •3.4.8.3 MRI Findings
- •3.4.9 Combined Hepatocellular-Cholangiocarcinoma
- •3.4.9.1 Imaging Findings
- •3.4.9.2 MRI Findings
- •3.5.1.1 Intrahepatic Biliary Dilatation
- •CT Findings
- •MRI Findings
- •3.5.1.2 Extrahepatic Bile Duct Dilatation
- •3.5.2.1 Hilar Obstruction
- •3.5.2.3 Pancreatic Obstruction
- •References
- •4.1 Introduction
- •4.1.2.1 CT Acquisition Protocols
- •4.1.2.2 Data Preprocessing
- •4.1.2.3 Medical Image Segmentation
- •4.1.2.4 3D Visualization
- •4.2.1 Image Registration
- •4.2.1.1 Template Matching Algorithm
- •4.2.1.2 Registration Steps
- •Step 1
- •Step 2
- •Step 3
- •4.2.2 Image Segmentation
- •Pixel Based Methods
- •Region Based Methods
- •Edge Based Methods
- •Model Based Methods
- •4.2.2.3 Serialized Segmentation Model
- •4.2.2.4 Adaptive Region Growing Algorithm
- •4.2.3 3D Reconstruction
- •References
- •5.1 Introduction
- •Fused Deposition Modeling
- •Stereolithography
- •Selected Laser Sintering
- •Direct Metal Laser Sintering
- •Laminated Object Manufacturing
- •Electron Beam Melting
- •Three-Dimensional Printing
- •High-Performance 3D Reconstruction Software
- •5.1.2.2 Medical Model Manufacturing
- •5.1.2.3 Tissue/Organ Regeneration
- •5.2.2 Digital Preparation
- •5.3.1.1 In Complex Liver Resection
- •5.3.1.2 In Liver Transplantation
- •5.3.2.1 In Cholangiocarcinoma Surgery
- •5.3.4 Prospects
- •References
- •6.1 Introduction
- •6.1.1 Virtual Anatomy
- •6.1.2 Surgical Simulation
- •Improved Doctor–Patient Relationship
- •Reduced Surgical Costs
- •Remote Intervention
- •6.2 Virtual Surgical Instruments
- •6.2.1 Geometric Modeling
- •6.2.2 Motion Modeling
- •6.2.3 Physical Modeling
- •6.3 Surgical Simulation
- •6.3.1 The Hardware System
- •6.3.2 Software System
- •6.3.2.1 FreeForm Modeling System
- •6.3.2.2 Open Graphics Library
- •6.3.2.3 Tactile Development Kit
- •6.4.4 Discussion
- •References
- •7.1 Introduction
- •References
- •8.1 Introduction
- •8.2 Duodenoscopy
- •8.3 Choledochoscopy
- •8.3.1 Preoperative Application
- •8.3.2 Intraoperative Application
- •8.3.3 Postoperative Application
- •8.4 Capsule Endoscopy
- •8.5 Laparoscope
- •8.6 Endoscopic Ultrasound
- •8.7 3D Visualization-Assisted Endoscopic Technology
- •References
- •9.1 Introduction
- •9.3.1.1 Arterial Phase
- •9.3.1.2 Portal Venous Phase
- •References
- •10.1 Introduction
- •10.2.1.2 Image Segmentation
- •10.2.1.3 3D Reconstruction
- •10.2.1.4 Surgical Simulation
- •Surgical Procedure
- •References
- •11.1 Introduction
- •11.2.2 Image Registration
- •References
- •12.1 Introduction
- •12.2.1 Imaging
- •12.2.2 Other Auxiliary Examinations
- •12.2.2.1 Biliary Manometry
- •12.2.2.2 Cholescintigraphy
- •12.2.2.3 Selective Celiac Arteriography
- •12.3.1 Collection Equipment
- •12.3.3 Plain Scan
- •12.3.4 Dynamic Enhanced CT Scan
- •12.4.1 Image Registration
- •12.6.1 Semiautomatic Liver Segmentation
- •Surgical Procedures
- •Surgical Procedures
- •12.10.2 Anatomical or Regular Hepatectomy Guided by 3D Visualization
- •12.10.2.1 Indications
- •12.10.2.2 Contraindications
- •12.10.2.4 Surgical Procedures
- •For Anatomical Right Hemihepatectomy
- •For Anatomical Left Hemihepatectomy
- •12.10.3.1 Contraindication
- •12.10.3.3 Surgical Procedures
- •Case 1
- •Case 2
- •12.10.4.1 Indications
- •12.10.4.2 Contraindication
- •12.10.4.4 Surgical Procedures
- •12.10.4.5 Attention
- •12.10.5.1 Indications
- •12.10.5.2 Contraindications
- •12.10.5.3 Surgical Procedures
- •12.10.5.4 Attention
- •12.10.6.1 Indications
- •12.10.6.2 Contraindications
- •12.10.6.3 Preoperative Imaging Evaluation
- •12.10.6.4 Surgical Procedures
- •12.10.6.5 Attention
- •12.10.7.1 Indications
- •12.10.7.2 Contraindications
- •12.10.7.3 Surgical procedures
- •12.10.7.4 Attention
- •12.10.8.1 Preoperative Evaluation
- •12.10.8.2 Preoperative Preparation
- •12.10.8.3 Contraindications
- •12.10.8.4 Operation Methods
- •12.10.8.5 Attention
- •12.10.9.1 Biliary Injury
- •Causes
- •Preventive Measures
- •12.10.9.2 Biliary Bleeding
- •12.10.9.3 Gastrointestinal Water Retention
- •Reasons
- •12.10.9.4 Biliary Leakage
- •12.11.1.1 Reasons
- •Main Reasons
- •Iatrogenic Biliary Tract Injury
- •Other Reasons
- •12.11.1.3 Surgical Procedures
- •Roux-en-Y Choledochojejunostomy
- •Hepatectomy
- •Intrahepatic Lithotripsy Through Sinus Tract or PTCS
- •Severe Symptomatic Patients
- •References
- •13.1 Introduction
- •13.3.1 Ultrasonography
- •13.3.2 Multi-Slice CT
- •13.3.5 Intraoperative Cholangiography
- •13.3.6 Radionuclide Hepatobiliary Scan
- •13.3.7 Digital Medicine Technology
- •Periampullary Tumor
- •Biliary Atresia
- •Acute Pancreatitis
- •Acute Cholecystitis
- •Hepatic Cyst
- •Hepatic Echinococcosis
- •Retroperitoneal Cystic Masses
- •13.4.2.1 Biliary Drainage
- •13.4.2.3 Liver Resection
- •13.4.2.4 Pancreaticoduodenectomy
- •13.4.2.5 Liver Transplantation
- •13.4.2.6 Laparoscopic Surgery
- •13.4.2.7 Reoperation
- •References
- •14.1 Introduction
- •14.1.1.1 Etiology
- •Anatomical Factors
- •Pathological Factors
- •Surgeon Factors
- •14.1.2.2 End-to-End Cholangiostomy
- •14.1.2.3 Choledochoduodenostomy
- •14.1.2.4 Roux-en-Y Cholangiojejunostomy
- •14.1.2.7 Liver Transplantation
- •14.2.2.1 Patient Information
- •14.2.2.2 Diagnosis
- •14.2.2.3 Complaint
- •14.2.2.4 History
- •14.2.2.5 Signs
- •14.2.2.6 Previous History
- •14.2.2.7 Laboratory Examination
- •Blood Routine
- •Coagulation Function
- •Liver Function
- •Renal Function
- •Tumor Markers
- •14.2.2.8 General Condition Assessment
- •Nutritional Status Evaluation
- •Liver Function Evaluation
- •Important Organ Function Evaluation
- •14.2.2.9 Imaging Evaluation
- •Evaluation by 3D Visualization
- •14.2.2.10 Surgical Planning
- •14.2.2.11 Surgical Procedures
- •Step 1
- •Step 2
- •Step 3
- •14.2.3.1 Patient Information
- •14.2.3.2 Diagnosis
- •14.2.3.3 Complaint
- •14.2.3.4 History
- •14.2.3.5 Signs
- •14.2.3.6 Previous History
- •14.2.3.7 Laboratory Examination
- •Blood Routine
- •Coagulation Function
- •Liver Function
- •Renal Function
- •Tumor Markers
- •14.2.3.8 General Condition Assessment
- •Nutritional Status Evaluation
- •Liver Function Evaluation
- •Important Organ Function Evaluation
- •14.2.3.9 Imaging Evaluation
- •Evaluation by 3D Visualization
- •14.2.3.10 Surgical Planning
- •14.2.3.11 Surgical Procedure
- •Step 1
- •Step 2
- •Step 3
- •References
- •15.1 Introduction
- •15.2 Clinical Stages
- •15.2.2 Surgical Strategy
- •Tis/T1a Stage
- •T1b Stage
- •Stage T2
- •Stage T3
- •Stage T4
- •15.2.2.2 Lymph Node Dissection Range
- •Stage Tis/T1a
- •Stage T1b
- •Stage T2
- •Stage T3
- •Stage T4
- •15.2.2.3 Extrahepatic Bile Duct Management
- •Stage Tis/T1a
- •Stage T1b
- •Stage T2
- •Stage T3
- •Stage T4
- •15.3.1 T Staging Assessment
- •15.3.1.1 Stage T2
- •MDCT
- •15.3.1.2 Stage T3
- •MDCT
- •15.3.1.3 Stage T4
- •15.3.3 Resectability Assessment
- •15.3.3.1 General Assessment
- •15.3.3.2 Liver Function Assessment
- •15.3.3.3 Virtual Surgery Assessment
- •15.4.1 Surgical Indications
- •15.4.2 Preoperative Preparation
- •15.4.2.3 Preoperative 3D Visualization Evaluation
- •15.4.3 Surgical Procedures
- •15.4.3.1 Resection Range
- •Radical Pancreaticoduodenectomy
- •15.4.4 Surgical Prognosis
- •References
- •16.1 Introduction
- •16.2.2.2 Imaging Diagnosis
- •16.2.2.3 Pathological Diagnosis
- •16.2.2.4 Clinical Staging
- •16.2.3.1 Preoperative Assessment
- •Liver Function Assessment
- •Resectability Assessment
- •3D Visualization Assessment
- •16.2.3.2 Surgical Approach
- •16.2.3.3 Controversial Point
- •Lymphadenectomy
- •Extended Hepatectomy
- •Liver Transplantation
- •Operative Prognosis
- •16.2.4 Multidisciplinary Team
- •16.2.5 Conclusion
- •Notes
- •16.3.4 Surgical Planning Guided by 3D Visualization
- •Type I
- •Type II
- •Type IIIa
- •Type IIIb
- •Type IVa
- •Type IVb
- •Type V
- •16.3.6.2 Typical Case
- •Case 1
- •Case 2
- •Case 3
- •Case 4
- •Case 5
- •16.3.6.4 Lymphadenectomy
- •16.3.6.6 Laparoscopic Exploration
- •16.3.6.7 Intraoperative Frozen Section Consultation
- •16.3.6.8 Liver Transplantation
- •Common Type
- •Type II Variation
- •Type III Variation
- •16.3.10 Other Comprehensive Treatment
- •16.3.11 Other Perioperative Management
- •16.3.11.2 Postoperative Follow-Up
- •References
- •17.1 Introduction
- •17.2.2.1 Perihilar Tumor
- •17.2.2.2 High Biliary Stricture
- •Hepatic Arterial Variation
- •Portal Vein Variations
- •Bile Duct Variations
- •17.3.2 Complex Pathophysiology
- •17.4.1.3 Preoperative Biliary Drainage
- •17.4.2.3 Cholangiojejunostomy
- •17.6 3D Visualization Imaging
- •Viscera Reconstruction
- •Lesion Reconstruction
- •Vascular Reconstruction
- •References

428
J. Wang et al.
• Type I Normal type, B2 and B3 ducts join to form a single converge above or slightly outside the sagittal part of
the portal vein, and then its trunk converges with B4.
• Type II A common trunk of B3 and B4 ducts converges
forms the common channel and B2 duct joins at the proximal portal.
• Type III A triple conuence of the B2, B3, and B4 ducts
on the inside of the sagittal portal vein.
Preoperative evaluation of the conuence variation of left
hepatic duct plays an important role in guiding the correct
understanding of the break point of bile duct during right
tribectomy or left anatomic segmentectomy (Kitami et al.
2006).
17.3.1.2 Variation ofVascular Spatial Structure
inPerihilar Area
The perihilar area is traversed by three sets of vascular structures that enter the hepatic portal, and the three ductal structures intersect and form an intricate vascular conformation.
Spatial Relationship oftheExtrahepatic Hepatic
Artery totheHepatic Duct andPortal Vein
Typically, the hepatic artery runs anterior to the portal vein
within the hepatoduodenal ligament, then ascends obliquely
to the right, coursing posterior to the common hepatic duct.
Anatomy of the human body found that in a small proportion
of the population, the right hepatic artery may pass in front
of the common bile duct (Honma etal. 2013; Weiglein 1996)
(Fig. 17.9). Also, in a small percentage of patients, the
hepatic artery may run posterior to the portal vein (Matsumura
1998; Kuhns and Borlaza 1980; Chedid et al. 2012)
(Fig. 17.10). During perihilar surgery, attention should be
paid to the spatial relationship between the hepatic artery and
the hepatic portal bile duct and the portal vein to avoid inadvertent intraoperative injuries. For example, when the right
hepatic artery passes in front of the common bile duct, it is
important to avoid inadvertent injuries in lowering the hilar
plate; when the right hepatic artery passes posterior to the
common bile duct, injuries should be prevented when dissecting the common bile duct.
Spatial Conformation ofVessels inRight Perihilar
Region
Spatial Relationship Between Right Hepatic Artery and
Right Branch of Portal Vein
Yoshioka et al. (2011) pro-
posed that the relationship between the right hepatic artery
and the right branch of the portal vein can be divided into
three categories:
• Infraportal type, the right posterior hepatic artery (RPHA)
runs caudally to the right portal vein and dominates the
right posterior lobe of the liver (segments VI, VII).
• Supraportal type, the RPHA runs cranially around the
right portal vein and dominates the right posterior lobe of
the liver.
• Combined type, the right posterior hepatic artery is
divided into two branches: one duct runs infraportally and
Fig. 17.7 The trap of left hemihepatectomy when the right anterior
hepatic duct merges into the left hepatic duct. The green dotted line
indicates the correct position, and the red dotted line indicates the
wrong position. RAHD right anterior hepatic duct, RPHD right posterior hepatic duct, LHD left hepatic duct
the other supraportally to the right portal vein, dominating
the right posterior lobe of the liver (Fig.17.11).
ab c
Fig. 17.8 Common pattern of conuence variation of left hepatic duct. (a) type I; (b) type II; (c) type III. UP umbilical portion of the left portal
vein

abc
17 Application of3D Visualization Technology inPerihilar Surgery
Fig. 17.9 The right hepatic artery runs anterior to the common bile
duct
429
The infraportal RPHAs account for the vast majority. The
supraportal RPHAs run beneath the right hepatic duct. It is
important to avoid inadvertent injuries to the RPHA during
mobilization of the right hepatic duct in radical resection of
hilar cholangiocarcinoma. In patients with supraportal
RPHA, when the tumor invades the left hepatic duct and
requires left trisectionectomy+ caudate lobectomy, the
RPHA needs to be resected, and reconstructed in case of
tumor invasion. Resection and reconstruction may be difcult because the right posterior hepatic artery runs cranially
around the right branch of the portal vein (Yoshioka et al.
2011; Kokudo etal. 2013) (Fig.17.12).
Spatial Relationship Between the Right Hepatic Duct
and Right Branch of Portal Vein Shimizu et al. (2009)
proposed that the spatial relationship between the right
hepatic duct and the right portal vein branch can be divided
into three categories:
• Supraportal type: The right posterior hepatic duct runs
cranially around the right portal vein and drains bile from
the right posterior lobe of the liver.
• Infraportal type, the right posterior hepatic duct runs caudally to the right branch of the portal vein and drains bile
from the right posterior lobe of the liver.
• Combined type, the bile ducts of segments VI and VII
runs cranially around the inferior aspect of the right portal
vein and the superior aspect of the right portal vein,
respectively, draining bile from the right posterior lobe of
the liver (Fig.17.13).
The right posterior hepatic bile of supraportal type
accounts for the majority, while the right posterior hepatic
duct is located in a relatively shallow position due to a lack
of cover for the right branch of the portal vein. During surgery for hilar cholangiocarcinoma, resection can be performed all the way to the bifurcation of bile ducts in segments
Fig. 17.10 The hepatic artery runs posterior to the portal vein (The
hepatic artery originates from the superior mesenteric artery)
VI and VII, which would be benecial to obtain satisfactory
Fig. 17.11 Spatial relationship between right hepatic artery and right branch of portal vein. (a) Supraportal type; (b) infraportal type; (c) com-
bined type. RPHA right posterior hepatic artery, A6 hepatic artery of hepatic segment VI, A7 hepatic artery of hepatic segment VII

430
J. Wang et al.
Fig. 17.12 Schematic
diagram of left
trisectionectomy+ caudate
lobectomy for hilar
cholangiocarcinoma involving
supraportal RPHA. (a) Hilar
cholangiocarcinoma involving
supraportal RPHA; (b) left
trisectionectomy+ caudate
lobectomy
ab
abc
Fig. 17.13 Spatial relationship between right hepatic duct and right
portal vein. (a) Supraportal type; (b) Infraportal type; (c) Combined
type. RASBD right anterior sectional bile duct; RPSBD right posterior
sectional bile duct, LHD left hepatic duct, RHD right hepatic duct, B6
bile duct in segment VI, B7 bile duct in segment VII, PV portal vein
Fig. 17.14 Right posterior
hepatic duct stump after left
hepatectomy extending to
segment V and caudate lobe.
(a) Right posterior hepatic
duct stump in supraportal
type; (b) Right posterior
hepatic duct stump in
infraportal type. RPSBD right
posterior sectional bile duct,
B5 bile duct in segment V, B6
bile duct in segment VI, B7
bile duct in segment VII, B8
bile duct in segment VII, HA
hepatic artery, PV portal vein
ab
biliary anastomosis (Kitami etal. 2006; Shimizu etal. 2009;
Takeishi etal. 2015; Ohkubo etal. 2004) (Fig.17.14).
Spatial Conformation ofVessels intheLeft
PerihilarArea
Spatial relationship between the left hepatic artery (LHA)
and the umbilical portion of the left portal vein (UP). Shimizu
et al. (2014) divided the spatial relationship between the
LHA and the UP into three categories. L-UP type
(Fig.17.15a): the LHA runs into the left lateral section from
the left caudal side of the UP; R-UP type (Fig.17.15b): the
LHA runs into the left lateral section from the right cranial
side of the UP; combined type (Fig.17.15c, d): the LHA is
divided into two branches, one running into the left lateral
section from the right cranial side of the UP, and the other
from the left caudal side of the UP (Fig.17.15). The R-UP
type LHA runs from the caudal side of the left hepatic duct
and is vulnerable to tumor invasion when a hilar cholangiocarcinoma invades the left hepatic duct.
The spatial relationship between the left hepatic duct and
the sagittal part of the portal vein. Ozden etal. (2002) classied the vertical spatial relationship between bile ducts of
segments 3 (B3) and umbilical portion of the portal vein
(UP) into three categories (Fig.17.16). Supraportal type: B3

abcd
abc
17 Application of3D Visualization Technology inPerihilar Surgery
Fig. 17.15 Spatial relationship between left hepatic artery and sagittal portal vein. (a) Type L-UP, (b) Type R-UP, (c) Combined type. UP umbili-
cal portion of the portal vein, LHA left hepatic artery, A2 hepatic artery in segment II, A3 hepatic artery in segment III
431
Fig. 17.16 Spatial relationship between left hepatic duct and UP of the
portal vein. (a) Supraportal type B3 bile duct; (b) Subportal type B3
bile duct; (c) Mixed type B3 bile duct. LPV left portal vein, LHD left
hepatic duct, B2 bile duct in segment II, B3 bile duct in segment III,
with two branches (B3a and B3b, respectively), B4 bile duct in segment
IV, P2 portal branch in segment II, P3 portal branch in segment III, P4
portal branch in segment IV
is located at the cranial side of the UP; infraportal type: B3 is
located at the caudate side of the UP; combined type: B3 is
divided into two branches, passing cranially and caudally
around the UP, respectively. In infraportal type, B3 and B2
converge with B4 individually, unlike the co-trunk of B3 and
B2in supraportal type, in which B2 and B3 form a common
trunk rst and then converge with B4. Thus, during right trisectionectomy, B2 and B3 in infraportal type need to be
reshaped and joined together to form a common orice for
anastomosis; while in combined type, before the anastomosis is performed, the co-trunk of B3a and B2 needs to be
combined with B3b to form a common orice. The vertical
spatial relationship between B3 and UP is closely related to
the conuence pattern of B2, B3, and B4.
Concept andClinical Signicance ofP andU Points
Fig. 17.17 Schematic diagram of the location of bile duct detachment.
The letters X, Y, W, and Z in the gure represent the limit points of bile
duct dissociation during right hemihepatectomy, left hemihepatectomy,
right trisectionectomy, and left trisectionectomy, respectively
Anatomically, the common hepatic duct (common bile duct)
lies laterally to the hepatic artery in the hepatoduodenal ligament, and the right hepatic artery typically passes behind the
common hepatic duct, making the right hepatic artery more
susceptible to tumor invasion. Since the left hepatic duct
invariably has a long extrahepatic course (the transverse part
of the left hepatic duct), it is easier to obtain a negative margin of the bile duct in right hepatectomy for Bismuth-Corlette
IIIa hilar cholangiocarcinoma than in left hepatectomy for
Bismuth-Corlette IIIb hilar cholangiocarcinoma (Kawasaki
et al. 2003; Neuhaus etal. 1999). “P point” refers to the
bifurcation of the right anterior and posterior branches of the
portal vein (the position represented by the letter Z in
Fig.17.18), which is the limit point of the right bile duct dissection in left trisectionectomy; “U point” refers to the bend
between the transverse and umbilical portions of the left portal vein (the position represented by the letter W in
Fig.17.17), which is the limit point of the left bile duct dissection in right trisectionectomy (Miyazaki etal. 2015). The

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Fig. 17.18 CT and surgical exploration show atrophy of the right hepatic lobe, compensatory hyperplasia of the left lobe, and rotation of the
hepatic hilum to the back and upper right, raising and deepening the hilum position
P point may move toward the hepatic hilum due to variations
17.3.2 Complex Pathophysiology
in portal venous conuence, for example, the anterior sectoral branch of the right portal vein arises from the left portal
vein. Hirose etal. (2015) demonstrated that the limit to the
length of the left bile duct that could be severed was signicantly greater than that on the right. A tumor extending
beyond both the P and U points is regarded as unresectable.
Variations of three sets of vascular system in the hilar
region and changes in spatial conformation result in complex
anatomical conformation with lesions as the essential element. Consequently, there are no xed surgical plans, and
the management of this condition is complex and requires
specic formulation of individualized surgical planning
under the guidance of general surgical principles combined
with and the respective anatomical characteristics of individuals, which adds much uncertainty to the perihilar
operation.
The normal anatomical position of the hilar region is maintained based on the normal anatomy of liver segment in the
hilar area. Hepatic segmental hypertrophy and atrophy can
cause marked rotation of the hepatic hilum. The liver is associated with many functions and it shows compensatory function under normal circumstances. When a part of the liver
loses or misses its physiological function capacity for some
reason, this part of the liver becomes atrophied, and another
part of the liver hypertrophic, thus compensating to maintain
the viability of the organism. The atrophy and compensatory
hypertrophy around the hilar axis change the equilibrium of
the liver volume of the two hepatic lobes, resulting in displacement of the liver and hepatic hilum. This pathologic
pattern has been clinically described as atrophy–hypertrophy
complex (Huang etal. 2002).

17 Application of3D Visualization Technology inPerihilar Surgery
433
Hepatic lobar atrophy, and rotation and displacement of
the hepatic hilum are common in hepatolithiasis associated
with stricture of the hilar bile duct (Wang 2016, 2017a, b).
Since it is a benign disease, sufcient time passes for the
liver to develop atrophy and hypertrophy. Right lobe atrophy and left lobe hypertrophy result in rotation of the liver
with the hepatic hilum as the axis of rotation. The enlarged
hypertrophied quadrate and caudate lobes overhang the
hilum and make access to the hepatic hilum difcult
(Fig. 17.18). Conversely, with left lobe atrophy, the liver
does not rotate to the left posterior direction because the
left lobe of the liver has a smaller volume and it lies close
to the vertebral column; when the right lobe is hypertrophied, the hepatic hilum is closer to the midline and it
becomes shallow, and thus it is easier to approach hepatic
hilum in front.
Perihilar disease is often characterized by obstructive
jaundice and recurrent episodes of cholangitis (Moole etal.
2016; da Fonseca-Neto et al. 2015; Sinanan 1992).
Obstructive jaundice may lead to biliary tract infection,
coagulation disorders, endotoxemia, hepatorenal syndrome,
malnutrition, and cardiovascular dysfunction (Wang and Yu
2014). Recurrent infection of the biliary tract can also cause
liver abscess and sepsis, increasing the difculty of perioperative preparation and surgical risk.
Particularly when perihilar disease is associated with portal hypertension, the duodenal ligament is lled with varicose veins and even forms cavernous transformation of the
portal vein, which easily leads to intraoperative hemorrhage
and the embarrassing situation of not being able to perform
surgery.
and loss of anatomical space in normal hilar stricture; resulting in less concise imaging and difculty discerning the local
anatomy.
17.4 Diagnosis andManagement
ofPerihilar Diseases
Diagnosis and treatment of perihilar diseases require precise
preoperative assessment, preparation and surgical planning,
intricate intraoperative surgical maneuvers, and excellent
postoperative management (Wang and Chen 2015). In view
of the complexity of perihepatic hilar diseases, to effect
improved diagnosis and treatment, and reduce postoperative
complications and mortality, it is necessary to carry out a
comprehensive and systematic evaluation of liver function,
and perihilar imaging to including three-dimensional visualizations. This will enable the surgeon to grasp the correct and
appropriate surgical opportunity, to make a surgical plan and
master the correct operating techniques of perihepatic hilar
surgery.
17.4.1 Precise Preoperative Assessment
andPreparation
The preoperative evaluation and preparation of perihilar diseases include assessment of resectability, assessment of
hepatic functional reserve and liver volume, preoperative
measures to reduce jaundice, and evaluation of surgical time
based on imaging examination and three-dimensional visualization of the hilar area.
17.3.3 Invasiveness ofthePerihilar Disease
Perihilar bile duct tumors are characterized by axial spread
along the bile duct mucosa and radial invasion along transverse diameter of the bile duct. Since the bile duct, hepatic
artery, and portal vein are surrounded by the brous connective tissue of the hilar plate, the tumor can easily invade the
accompanying hepatic artery and portal vein once it breaks
through the bile duct wall, which makes surgical resection or
radical resection impossible.
HCC invading the hilar area may extend into the hepatic
artery, portal vein, common hepatic duct, or/and inferior
vena cava in the porta hepatis, resulting in difculty in surgical resection. Inammatory stricture is caused by hilar calculi. Due to the long-term existence of chronic inammation,
the hilar bile duct can easily form dense adhesion with blood
vessels. Adhesion caused by inammation tends to be more
extensive, bleeds more easily, and is more difcult to separate during operation. Repeated operations in the hepatic
hilar area can cause scarring (brosis), closure of the hilar,
17.4.1.1 Imaging and3D Visualization
Assessment oftheHilar Area
It is recommended to perform thin-slice CT, MRI, and
MRCP examination of the upper abdomen in patients with
perihilar disease preoperatively. CT and MRI have their specic advantages and emphasis in preoperative imaging evaluation of perihilar diseases, which can complement but not
replace each other. Prior to imaging, interventional procedures such as PTCD and biliary stent implantation should be
avoided, as they may reduce the accuracy of preoperative CT
and MRI evaluation (Ni et al. 2017). Three-dimensional
visualization of thin-slice enhanced CT imaging data processed by computer software can display the relationship
between the lesion, bile ducts, and blood vessels in the hilar
area stereoscopically. It can greatly improve the resectable
evaluation accuracy of perihilar tumor; and can clearly display the location and characteristics of lesions such as high
bile duct stenosis, and central choledochal cystic dilatation,
which is the basis of formulating reasonable surgical
planning.

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17.4.1.2 Assessment ofHepatic Functional
Reserve andLiver Volume
Most perihilar diseases can also present with obstructive
jaundice, and some may be complicated by chronic active
hepatitis and fatty liver; meanwhile, extended hepatectomy
is often required. Thus, a precise assessment of hepatic functional reserve and liver volume is very important.
Individualized surgical decision-making and planning for
the maximum amount of liver resection in clinical practice
are based on an assessment system for the safety limits of
hepatectomy founded on assessment of hepatic functional
reserve and liver volume (Dong etal. 2013a, b). The safety
limits for extensive hepatic resection can be predicted based
on the Expert Consensus on Assessment of Hepatic
Functional Reserve before Hepatectomy (2011 edition)
(Dong etal. 2011) (Fig.17.19). By using three-dimensional
visualization, liver segmentation, and liver volume measurement can be accurately performed. However, during extensive liver resection such as a right trisectionectomy or left
trisectionectomy, the limit for safe resection (20% of residual
liver volume) should not be challenged even in patients with
normal liver function. Clinicians often focus only on the
harm of chronic viral hepatitis to liver function, ignoring the
potential impact of fatty liver. Even if the liver function of
some fatty liver patients is normal before operation, it may
lead to residual liver dysfunction after extreme liver
resection.
17.4.1.3 Preoperative Biliary Drainage
Perihilar diseases are usually preceded by severe obstructive
jaundice and complicated with various degrees of biliary
tract infection preoperatively, mostly requiring extended
hepatectomy. Therefore, it is particularly important to
decrease preoperative bilirubin levels (Noie et al. 2001;
Kennedy etal. 2009). Though the academia’s standards and
duration for preoperative reduction of bilirubin levels remain
controversial, most scholars support that biliary drainage is
necessary for portal surgery requiring an extended hepatectomy, since decreasing the bilirubin level is benecial to
hepatic regeneration, intestinal function recovery, relief of
cholangitis, prevention of renal failure, and liver failure.
Preoperative biliary drainage is indicated for improving
operative safety and reducing the incidence of postoperative
mortality and complications (Kennedy et al. 2009; Farges
etal. 2013). In recent years, endoscopic retrograde cholangiopancreaticogram (ERCP) with biliary stent placement has
been advocated by Japanese scholars in situations where bilirubin level decrease is desired to avoid sinus metastasis of
PTCD; however, we still recommend percutaneous transhepatic cholangial drainage (PTCD) as the preferable method
of biliary drainage given the fact that:
• PTCD catheter placement longer than 60days is an independent risk factor for sinus metastasis of tumor
(Takahashi etal. 2010).
• In patients with potentially resectable hilar cholangiocarcinoma, the incidence of complications by using PTCD is
signicantly lower than by using ERCP (Al Mahjoub
etal. 2017).
• Endoscopic biliary stenting is technically demanding in
which it is difcult to achieve the goal of simultaneous
drainage of bilateral branches of the bile ducts, and is
prone to retrograde biliary tract infection.
• Edema of hepatoduodenal ligament caused by stent
placement.
It is suggested that PTCD should be performed after
MDCT and MRCP since (a) the dilatation of the bile duct
becomes no longer evident after PTCD drainage, which
might affect the accuracy of biliary tract assessment; (b) The
Fig. 17.19 Schematic
diagram of quantitative
decision system for
hepatectomy. R
standard liver volume ratio
functional to
ES

ab
17 Application of3D Visualization Technology inPerihilar Surgery
435
presence of PTCD drainage tube affects the accuracy of portal involvement assessment (Ni etal. 2017; Unno etal. 2007).
Bilateral biliary drainage should be performed because perihilar diseases often lead to separation of left and right hepatic
ducts, especially the bile ducts of the preserved liver. For
obstructed intrahepatic cholangitis caused by hilar cholelithiasis and inammatory hilar strictures, preoperative biliary
drainage is also required to control biliary tract infection.
Additionally, administration of the contrast medium is not
recommended after PTCD, as it may lead to cholangitis.
17.4.1.4 Evaluation ofOperative Timing
For patients with perihilar diseases requiring extended hepatectomy, the risk of surgery can be reduced if the preoperative total bilirubin level decreases from more than 200μmol/L
to less than 80 μmol/L (Biliary Surgery Group 2013a, b;
Belghiti and Ogata 2005; Farges etal. 2013). The operation
timing for high biliary stricture should be determined by
local inammation, biliary blood ow, and systemic conditions. It has been reported that surgical repair after bile duct
injury in the presence of local peritonitis is a poor prognostic
factor for postoperative restenosis (Schmidt etal. 2005). For
patients with severe portal hypertension, a shunt surgery
should be performed prior to attempting a secondary treatment of biliary stricture. For perihilar diseases associated
with biliary tract infection, biliary tract interventions and
drainage such as PTCD are carried out to control infection
before denitive surgery is performed. Unless absolutely
compelled, surgery should be avoided in the case of acute
biliary tract infection.
17.4.2 Anatomy andManeuver
oftheHilarArea
Three sets of vessels with different courses and patterns of
conuence converge in the hilar area, resulting in differences
in spatial conguration and individual variations in anatomical structure. Different techniques should be adopted according to the hilar anatomy, taking the bifurcation and conuence
of the hepatic portal bile duct, hepatic artery, and portal vein
into account, in accordance with the preoperative imaging
evaluation, and the hilar area requiring surgical exposure.
17.4.2.1 Exposure oftheHilar
Separation Technique oftheHilar Plate
The separation technique of the hilar plate is the most commonly used technique for hilar exposure. The hilar plate
refers to the thickened brous connective tissue fused by the
hepatic capsule and Glisson sheath at the hepatic hilum,
extending to the right side by the gallbladder plate and to the
left by the umbilical plate (Kawarada et al. 2000)
(Fig.17.20). There is a certain space between the hilar plate
and the liver parenchyma, and there are few blood vessels
communicating branches. After detachment of the hilar
plate from the liver parenchyma, the rst hepatic hilum will
naturally descend. The anterior wall of the bile duct covered
by the square lobe of the liver will be fully exposed, which
will increase the anatomical space to the left and right
hepatic ducts sufciently to reduce the difculty (Kawarada
etal. 2000). Under normal circumstances, the extrahepatic
Fig. 17.20 Schematic diagram of the hilar plate. (a) Location of the hilar plate; (b) composition of hepatic portal plate. S4a quadrate lobe, S5
segment V, S6 segment VI, S7 segment VII

436
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bile duct can be exposed for approximately 2 cm. For
patients with lower bifurcation of the bile duct, it is possible
to completely expose the conuence of the left and right
hepatic ducts outside the liver. Generally, the right hepatic
artery courses posterior to the common hepatic duct.
However, in some patients it courses anterior to the common
hepatic duct. Lowering the hilar plate reduces opportunities
for inadvertent injuries, which is also one of the key points
for preoperative evaluation based on three-dimensional
visualization. Since the left and right hepatic ducts do not lie
within the hepatic parenchyma but in transverse groove of
the hepatic hilum, the lesions in most diseases such as high
biliary injuries or stenoses and hilar cholangiocarcinoma,
can be exposed through separation of the hilar plate, so that
the hilar area becomes relatively supercial and is benecial
to the maneuver (Jiang and Zhang 2001). Because the hilar
plate and gallbladder plate on the right extend each other,
cholecystectomy is helpful for the anatomy of the right hilar
structures.
Transection ofMedian Hepatic Fissure
Hepatic resection by hepatic parenchymal transection along
the interlobar plane will fully expose the hilar plate when
the conuence of hilar bile duct cannot be completely
exposed by separating the hilar plate; due to its high position, or when the hilar is closed by hypertrophic scar tissue
caused by stricture of high bile duct. Through transection of
the median hepatic ssure, the hilar plate can be completely
exposed. At this time, the left and right hepatic ducts and the
junction of the conuence and the secondary hepatic duct
can be fully exposed, which is conducive to creating more
surgical space for resection and reconstruction of the diseased bile ducts (Jiang and Zhang 2001). The median
hepatic ssure is the boundary between the left and right
half of the liver. Since there are no other important blood
vessels passing through the liver parenchyma except the
middle liver vein, it is safe and feasible to transect the liver
parenchyma directly to the hepatic portal along the middle
hepatic ssure. In clinical practice, however, separation can
be performed along the resection plane 1.0–1.5cm to the
left of the median hepatic ssure, so as to avoid inadvertent
injury of the middle hepatic vein. It is best to transect the
median hepatic ssure after identifying the course of middle
hepatic vein by intraoperative ultrasound. The length of
incision measures two-thirds of the liver anteriorly, and the
appropriate depth of incision is to fully expose the hilar bile
duct. Small blood vessels or bile ducts on the separation section should be properly ligated or suture ligated to avoid
postoperative bleeding or bile leakage. The use of CUSA
devices for dissection of major intrahepatic vascular trunk
can signicantly reduce intraoperative bleeding and bile
duct injuries.
Caudate Lobe Resection andPerihilar Resection
Hypertrophy of the quadrate lobe will hinder the anatomy of
the hepatic hilum, resulting in a deeper hepatic hilum structure. CUSA devises can be used to resect the quadrate lobe or
liver tissues above transverse sulcus of the porta hepatis (part
of the right anterior lobe of the liver), and then the top of the
porta hepatis can be opened to offer a complete exposure of
the bifurcation of the hilar bile duct and the transverse part of
the left hepatic duct, thus providing space for operation.
17.4.2.2 Lesions Excision andVascular
Reconstruction
Sufcient exposure of lesions and separation of vessels in
the hilar region are the preconditions for excision of perihepatic hilar lesions. For cystic dilatation of the common bile
duct, the proximal and distal diseased bile ducts should be
excised. For high biliary strictures, if stones are present, the
stones should be removed and the strictures and scar tissue of
the bile duct should be resected to expose the soft healthy
bile duct tissue above the stenosed section. Radical resection
is the only effective way to achieve long-term survival of the
patients with perihilar tumors. Seyama etal. (2003) showed
that the long-term survival rate of the patients with the tumornegative bile duct margin >5 mm was signicantly higher
than that of patients with the tumor-negative bile duct margin
<5 mm, indicating that it was necessary to ensure at least
5 mm of the tumor-negative bile duct margin for radical
resection of the hilar cholangiocarcinoma.
Tumor invasion of blood vessels is one of the important
reasons why radical resection is impossible. Combined portal vein resection and reconstruction can signicantly
improve the R0 resection rate and long-term survival rate of
locally advanced hilar cholangiocarcinoma (Chen et al.
2014). Because the bile duct lies anteriorly to the portal vein,
dissection of the bile duct after opening the hepatic hilum is
safer and also more conducive to the management of the
involved portal vein. Although the overall prognosis remains
poor for patients with hepatic artery resection and reconstruction, it is better than that of patients who are unresectable. When hepatic artery invasion becomes the only factor
hindering R0 resection, hepatic artery resection and reconstruction should be considered (Matsuyama etal. 2016).
17.4.2.3 Cholangiojejunostomy
Hilar cholangioplasty and Roux-en-Y hepaticojejunostomy
claim to be additional challenging points in perihilar surgery.
After resection of the lesion, the left and right half of the
liver often retains multiple secondary and tertiary branches
of bile ducts. The thin and slender wall of bile duct, accompanied by blood vessels and the narrow space of portal hepatis, increase the difculty of operation. In order to avoid
postoperative bile leakage, each bile duct should be fully

17 Application of3D Visualization Technology inPerihilar Surgery
437
exposed according to preoperative imaging characteristics.
In addition, the bile duct of the caudate lobe and variant right
posterior sectoral duct should not be omitted when performing hepatic portal choledochoplasty. In order to avoid missing the transected bile duct, 5-0 PDS suture can be used for
traction when transecting each bile duct. The right anterior
and posterior sector bile ducts, and the left medial and lateral
sector bile ducts can be united respectively to form a single
orice and anastomosis can be performed. When the two bile
ducts are far apart, they are anastomosed separately. To prevent postoperative anastomotic restenosis, the principle of
“mucosa-to-mucosa” anastomosis should be adhered. PDS
sutures 5-0 or 4-0 can be selected for anastomosis according
to bile duct diameter and its wall thickness. When the bile
duct is very thin, silicone tubes can be implanted for support.
Surgical excision of hilar scar tissue stenosis should be performed and large-caliber biliary anastomoses should be performed after biliary plasty.
17.5 Application Value of3D Visualization
Technology inPerihepatic Portal
Surgery
Three-dimensional visualization technology based on stereo
modelling can display the variations of hepatic vessels more
intuitively and show the degree of perihepatic portal diseases
such as the relationship between hepatic hilar cholangiocarcinoma and blood vessels. Individualized liver segmentation
and volume calculation can be carried out to evaluate the
safety of surgery, and simulated surgery can be carried out to
improve the success rate of surgery (Ni etal. 2016; Wigmore
etal. 2001; Rau etal. 2000; Marescaux etal. 1998).
the conuence pattern of the portal vein and its dominated
hepatic segments, and it is also of great signicance to avoid
inadvertent injury of portal vein branches with abnormal
conuence (Lau etal. 2017a, b) (Fig.17.22).
17.5.1.3 Individualized 3D Model oftheBile
Duct
The establishment of a three-dimensional visualization
model based on individualized bile ducts is helpful to visualize the liver segments drained by different biliary branches,
which is important for avoiding injury of conuent abnormal bile ducts and omission of important bile ducts
(Fig.17.23).
17.5.1.4 Individualized Model oftheSpatial
Relationship Between theExtrahepatic
Hepatic Artery andtheBile Duct
andPortal Vein
Three-dimensional visualization processing can intuitively
display the spatial relationship of the extrahepatic hepatic
artery to the bile duct and the portal vein, which can avoid
inadvertent intraoperative injuries (Fig.17.24).
17.5.1.5 Individualized Model oftheSpatial
Relationship Between theRight
Posterior Hepatic Artery andRight
Branch ofPortal Vein
Three-dimensional visualization can visualize whether the
spatial relationship between the right posterior hepatic artery
and the right portal vein is infraportal type, supraportal type,
or combined type, so as to avoid inadvertent injury to the
right posterior hepatic artery, and to predict the difculty of
resection and reconstruction of the right posterior hepatic
artery (Yoshioka etal. 2011) (Fig.17.25).
17.5.1 Evaluation ofPerihepatic Portal
Anatomy Based on3D Visualization
Technology
17.5.1.1 Individualized 3D Model
oftheHepatic Artery
Based on the three-dimensional visualization technology, for
patients requiring peri-hepatic hilar surgery, a threedimensional visualization model of individual hepatic artery
is developed based on the CRL classication system before
surgery, which is important for preventing hepatic artery
injury and guiding the resection and reconstruction of the
hepatic arteries (Fig.17.21).
17.5.1.2 Individualized 3D Model ofthePortal
Vein
The individualized three-dimensional visualization model of
the portal vein is helpful for the surgeon to better understand
17.5.1.6 Individualized Model oftheSpatial
Relationship Between theRight
Posterior Hepatic Duct andRight
Branch ofthePortal Vein
Three-dimensional visualization can visualize whether the
spatial relationship between the right posterior hepatic duct
and the right portal vein branch is infraportal type, supraportal type, or combined type. It is helpful to assess the exposure
difculty of the right posterior hepatic duct and to predict the
location and number of hepatic duct openings on the hepatic
section (Fig.17.26).
17.5.1.7 Individualized Model oftheSpatial
Relationship Between theLeft Hepatic
Artery andUmbilical Portion
ofthePortal Vein
Three-dimensional visualization can visualize whether the
spatial relationship between the left hepatic artery and portal
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