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J. Wang et al.
Type I Normal type, B2 and B3 ducts join to form a sin­gle converge above or slightly outside the sagittal part of the portal vein, and then its trunk converges with B4.
Type II A common trunk of B3 and B4 ducts converges forms the common channel and B2 duct joins at the proxi­mal portal.
Type III A triple conuence of the B2, B3, and B4 ducts on the inside of the sagittal portal vein.
Preoperative evaluation of the conuence variation of left
hepatic duct plays an important role in guiding the correct understanding of the break point of bile duct during right tribectomy or left anatomic segmentectomy (Kitami et al.
2006).
17.3.1.2 Variation ofVascular Spatial Structure
inPerihilar Area
The perihilar area is traversed by three sets of vascular struc­tures that enter the hepatic portal, and the three ductal struc­tures intersect and form an intricate vascular conformation.
Spatial Relationship oftheExtrahepatic Hepatic Artery totheHepatic Duct andPortal Vein
Typically, the hepatic artery runs anterior to the portal vein within the hepatoduodenal ligament, then ascends obliquely to the right, coursing posterior to the common hepatic duct. Anatomy of the human body found that in a small proportion of the population, the right hepatic artery may pass in front of the common bile duct (Honma etal. 2013; Weiglein 1996) (Fig. 17.9). Also, in a small percentage of patients, the hepatic artery may run posterior to the portal vein (Matsumura
1998; Kuhns and Borlaza 1980; Chedid et al. 2012)
(Fig. 17.10). During perihilar surgery, attention should be paid to the spatial relationship between the hepatic artery and the hepatic portal bile duct and the portal vein to avoid inad­vertent intraoperative injuries. For example, when the right hepatic artery passes in front of the common bile duct, it is important to avoid inadvertent injuries in lowering the hilar plate; when the right hepatic artery passes posterior to the common bile duct, injuries should be prevented when dis­secting the common bile duct.
Spatial Conformation ofVessels inRight Perihilar Region
Spatial Relationship Between Right Hepatic Artery and Right Branch of Portal Vein
Yoshioka et al. (2011) pro-
posed that the relationship between the right hepatic artery and the right branch of the portal vein can be divided into three categories:
• Infraportal type, the right posterior hepatic artery (RPHA) runs caudally to the right portal vein and dominates the right posterior lobe of the liver (segments VI, VII).
• Supraportal type, the RPHA runs cranially around the right portal vein and dominates the right posterior lobe of the liver.
• Combined type, the right posterior hepatic artery is divided into two branches: one duct runs infraportally and
Fig. 17.7 The trap of left hemihepatectomy when the right anterior hepatic duct merges into the left hepatic duct. The green dotted line indicates the correct position, and the red dotted line indicates the wrong position. RAHD right anterior hepatic duct, RPHD right poste­rior hepatic duct, LHD left hepatic duct
the other supraportally to the right portal vein, dominating the right posterior lobe of the liver (Fig.17.11).
ab c
Fig. 17.8 Common pattern of conuence variation of left hepatic duct. (a) type I; (b) type II; (c) type III. UP umbilical portion of the left portal vein
abc
17 Application of3D Visualization Technology inPerihilar Surgery
Fig. 17.9 The right hepatic artery runs anterior to the common bile duct
429
The infraportal RPHAs account for the vast majority. The
supraportal RPHAs run beneath the right hepatic duct. It is important to avoid inadvertent injuries to the RPHA during mobilization of the right hepatic duct in radical resection of hilar cholangiocarcinoma. In patients with supraportal RPHA, when the tumor invades the left hepatic duct and requires left trisectionectomy+ caudate lobectomy, the RPHA needs to be resected, and reconstructed in case of tumor invasion. Resection and reconstruction may be dif­cult because the right posterior hepatic artery runs cranially around the right branch of the portal vein (Yoshioka et al.
2011; Kokudo etal. 2013) (Fig.17.12).
Spatial Relationship Between the Right Hepatic Duct and Right Branch of Portal Vein Shimizu et al. (2009)
proposed that the spatial relationship between the right hepatic duct and the right portal vein branch can be divided into three categories:
• Supraportal type: The right posterior hepatic duct runs cranially around the right portal vein and drains bile from the right posterior lobe of the liver.
• Infraportal type, the right posterior hepatic duct runs cau­dally to the right branch of the portal vein and drains bile from the right posterior lobe of the liver.
• Combined type, the bile ducts of segments VI and VII runs cranially around the inferior aspect of the right portal vein and the superior aspect of the right portal vein, respectively, draining bile from the right posterior lobe of the liver (Fig.17.13).
The right posterior hepatic bile of supraportal type
accounts for the majority, while the right posterior hepatic duct is located in a relatively shallow position due to a lack of cover for the right branch of the portal vein. During sur­gery for hilar cholangiocarcinoma, resection can be per­formed all the way to the bifurcation of bile ducts in segments
Fig. 17.10 The hepatic artery runs posterior to the portal vein (The hepatic artery originates from the superior mesenteric artery)
VI and VII, which would be benecial to obtain satisfactory
Fig. 17.11 Spatial relationship between right hepatic artery and right branch of portal vein. (a) Supraportal type; (b) infraportal type; (c) com- bined type. RPHA right posterior hepatic artery, A6 hepatic artery of hepatic segment VI, A7 hepatic artery of hepatic segment VII
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Fig. 17.12 Schematic diagram of left trisectionectomy+ caudate lobectomy for hilar cholangiocarcinoma involving supraportal RPHA. (a) Hilar cholangiocarcinoma involving supraportal RPHA; (b) left trisectionectomy+ caudate lobectomy
ab
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Fig. 17.13 Spatial relationship between right hepatic duct and right portal vein. (a) Supraportal type; (b) Infraportal type; (c) Combined type. RASBD right anterior sectional bile duct; RPSBD right posterior
sectional bile duct, LHD left hepatic duct, RHD right hepatic duct, B6 bile duct in segment VI, B7 bile duct in segment VII, PV portal vein
Fig. 17.14 Right posterior hepatic duct stump after left hepatectomy extending to segment V and caudate lobe. (a) Right posterior hepatic duct stump in supraportal type; (b) Right posterior hepatic duct stump in infraportal type. RPSBD right posterior sectional bile duct, B5 bile duct in segment V, B6 bile duct in segment VI, B7 bile duct in segment VII, B8 bile duct in segment VII, HA hepatic artery, PV portal vein
ab
biliary anastomosis (Kitami etal. 2006; Shimizu etal. 2009; Takeishi etal. 2015; Ohkubo etal. 2004) (Fig.17.14).
Spatial Conformation ofVessels intheLeft PerihilarArea
Spatial relationship between the left hepatic artery (LHA) and the umbilical portion of the left portal vein (UP). Shimizu et al. (2014) divided the spatial relationship between the LHA and the UP into three categories. L-UP type (Fig.17.15a): the LHA runs into the left lateral section from the left caudal side of the UP; R-UP type (Fig.17.15b): the LHA runs into the left lateral section from the right cranial
side of the UP; combined type (Fig.17.15c, d): the LHA is divided into two branches, one running into the left lateral section from the right cranial side of the UP, and the other from the left caudal side of the UP (Fig.17.15). The R-UP type LHA runs from the caudal side of the left hepatic duct and is vulnerable to tumor invasion when a hilar cholangio­carcinoma invades the left hepatic duct.
The spatial relationship between the left hepatic duct and
the sagittal part of the portal vein. Ozden etal. (2002) classi­ed the vertical spatial relationship between bile ducts of segments 3 (B3) and umbilical portion of the portal vein (UP) into three categories (Fig.17.16). Supraportal type: B3
abcd
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17 Application of3D Visualization Technology inPerihilar Surgery
Fig. 17.15 Spatial relationship between left hepatic artery and sagittal portal vein. (a) Type L-UP, (b) Type R-UP, (c) Combined type. UP umbili- cal portion of the portal vein, LHA left hepatic artery, A2 hepatic artery in segment II, A3 hepatic artery in segment III
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Fig. 17.16 Spatial relationship between left hepatic duct and UP of the portal vein. (a) Supraportal type B3 bile duct; (b) Subportal type B3 bile duct; (c) Mixed type B3 bile duct. LPV left portal vein, LHD left hepatic duct, B2 bile duct in segment II, B3 bile duct in segment III,
with two branches (B3a and B3b, respectively), B4 bile duct in segment IV, P2 portal branch in segment II, P3 portal branch in segment III, P4 portal branch in segment IV
is located at the cranial side of the UP; infraportal type: B3 is located at the caudate side of the UP; combined type: B3 is divided into two branches, passing cranially and caudally around the UP, respectively. In infraportal type, B3 and B2 converge with B4 individually, unlike the co-trunk of B3 and B2in supraportal type, in which B2 and B3 form a common trunk rst and then converge with B4. Thus, during right tri­sectionectomy, B2 and B3 in infraportal type need to be reshaped and joined together to form a common orice for anastomosis; while in combined type, before the anastomo­sis is performed, the co-trunk of B3a and B2 needs to be combined with B3b to form a common orice. The vertical spatial relationship between B3 and UP is closely related to the conuence pattern of B2, B3, and B4.
Concept andClinical Signicance ofP andU Points
Fig. 17.17 Schematic diagram of the location of bile duct detachment. The letters X, Y, W, and Z in the gure represent the limit points of bile duct dissociation during right hemihepatectomy, left hemihepatectomy, right trisectionectomy, and left trisectionectomy, respectively
Anatomically, the common hepatic duct (common bile duct) lies laterally to the hepatic artery in the hepatoduodenal liga­ment, and the right hepatic artery typically passes behind the common hepatic duct, making the right hepatic artery more susceptible to tumor invasion. Since the left hepatic duct invariably has a long extrahepatic course (the transverse part of the left hepatic duct), it is easier to obtain a negative mar­gin of the bile duct in right hepatectomy for Bismuth-Corlette IIIa hilar cholangiocarcinoma than in left hepatectomy for Bismuth-Corlette IIIb hilar cholangiocarcinoma (Kawasaki
et al. 2003; Neuhaus etal. 1999). “P point” refers to the bifurcation of the right anterior and posterior branches of the portal vein (the position represented by the letter Z in Fig.17.18), which is the limit point of the right bile duct dis­section in left trisectionectomy; “U point” refers to the bend between the transverse and umbilical portions of the left por­tal vein (the position represented by the letter W in Fig.17.17), which is the limit point of the left bile duct dis­section in right trisectionectomy (Miyazaki etal. 2015). The
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Fig. 17.18 CT and surgical exploration show atrophy of the right hepatic lobe, compensatory hyperplasia of the left lobe, and rotation of the hepatic hilum to the back and upper right, raising and deepening the hilum position
P point may move toward the hepatic hilum due to variations

17.3.2 Complex Pathophysiology

in portal venous conuence, for example, the anterior sec­toral branch of the right portal vein arises from the left portal vein. Hirose etal. (2015) demonstrated that the limit to the length of the left bile duct that could be severed was signi­cantly greater than that on the right. A tumor extending beyond both the P and U points is regarded as unresectable.
Variations of three sets of vascular system in the hilar region and changes in spatial conformation result in complex anatomical conformation with lesions as the essential ele­ment. Consequently, there are no xed surgical plans, and the management of this condition is complex and requires specic formulation of individualized surgical planning under the guidance of general surgical principles combined with and the respective anatomical characteristics of indi­viduals, which adds much uncertainty to the perihilar operation.
The normal anatomical position of the hilar region is main­tained based on the normal anatomy of liver segment in the hilar area. Hepatic segmental hypertrophy and atrophy can cause marked rotation of the hepatic hilum. The liver is asso­ciated with many functions and it shows compensatory func­tion under normal circumstances. When a part of the liver loses or misses its physiological function capacity for some reason, this part of the liver becomes atrophied, and another part of the liver hypertrophic, thus compensating to maintain the viability of the organism. The atrophy and compensatory hypertrophy around the hilar axis change the equilibrium of the liver volume of the two hepatic lobes, resulting in dis­placement of the liver and hepatic hilum. This pathologic pattern has been clinically described as atrophy–hypertrophy complex (Huang etal. 2002).
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Hepatic lobar atrophy, and rotation and displacement of the hepatic hilum are common in hepatolithiasis associated with stricture of the hilar bile duct (Wang 2016, 2017a, b). Since it is a benign disease, sufcient time passes for the liver to develop atrophy and hypertrophy. Right lobe atro­phy and left lobe hypertrophy result in rotation of the liver with the hepatic hilum as the axis of rotation. The enlarged hypertrophied quadrate and caudate lobes overhang the hilum and make access to the hepatic hilum difcult (Fig. 17.18). Conversely, with left lobe atrophy, the liver does not rotate to the left posterior direction because the left lobe of the liver has a smaller volume and it lies close to the vertebral column; when the right lobe is hypertro­phied, the hepatic hilum is closer to the midline and it becomes shallow, and thus it is easier to approach hepatic hilum in front.
Perihilar disease is often characterized by obstructive jaundice and recurrent episodes of cholangitis (Moole etal.
2016; da Fonseca-Neto et al. 2015; Sinanan 1992).
Obstructive jaundice may lead to biliary tract infection, coagulation disorders, endotoxemia, hepatorenal syndrome, malnutrition, and cardiovascular dysfunction (Wang and Yu
2014). Recurrent infection of the biliary tract can also cause
liver abscess and sepsis, increasing the difculty of periop­erative preparation and surgical risk.
Particularly when perihilar disease is associated with por­tal hypertension, the duodenal ligament is lled with vari­cose veins and even forms cavernous transformation of the portal vein, which easily leads to intraoperative hemorrhage and the embarrassing situation of not being able to perform surgery.
and loss of anatomical space in normal hilar stricture; result­ing in less concise imaging and difculty discerning the local anatomy.
17.4 Diagnosis andManagement ofPerihilar Diseases
Diagnosis and treatment of perihilar diseases require precise preoperative assessment, preparation and surgical planning, intricate intraoperative surgical maneuvers, and excellent postoperative management (Wang and Chen 2015). In view of the complexity of perihepatic hilar diseases, to effect improved diagnosis and treatment, and reduce postoperative complications and mortality, it is necessary to carry out a comprehensive and systematic evaluation of liver function, and perihilar imaging to including three-dimensional visual­izations. This will enable the surgeon to grasp the correct and appropriate surgical opportunity, to make a surgical plan and master the correct operating techniques of perihepatic hilar surgery.
17.4.1 Precise Preoperative Assessment andPreparation
The preoperative evaluation and preparation of perihilar dis­eases include assessment of resectability, assessment of hepatic functional reserve and liver volume, preoperative measures to reduce jaundice, and evaluation of surgical time based on imaging examination and three-dimensional visual­ization of the hilar area.
17.3.3 Invasiveness ofthePerihilar Disease
Perihilar bile duct tumors are characterized by axial spread along the bile duct mucosa and radial invasion along trans­verse diameter of the bile duct. Since the bile duct, hepatic artery, and portal vein are surrounded by the brous connec­tive tissue of the hilar plate, the tumor can easily invade the accompanying hepatic artery and portal vein once it breaks through the bile duct wall, which makes surgical resection or radical resection impossible.
HCC invading the hilar area may extend into the hepatic artery, portal vein, common hepatic duct, or/and inferior vena cava in the porta hepatis, resulting in difculty in surgi­cal resection. Inammatory stricture is caused by hilar cal­culi. Due to the long-term existence of chronic inammation, the hilar bile duct can easily form dense adhesion with blood vessels. Adhesion caused by inammation tends to be more extensive, bleeds more easily, and is more difcult to sepa­rate during operation. Repeated operations in the hepatic hilar area can cause scarring (brosis), closure of the hilar,
17.4.1.1 Imaging and3D Visualization Assessment oftheHilar Area
It is recommended to perform thin-slice CT, MRI, and MRCP examination of the upper abdomen in patients with perihilar disease preoperatively. CT and MRI have their spe­cic advantages and emphasis in preoperative imaging eval­uation of perihilar diseases, which can complement but not replace each other. Prior to imaging, interventional proce­dures such as PTCD and biliary stent implantation should be avoided, as they may reduce the accuracy of preoperative CT and MRI evaluation (Ni et al. 2017). Three-dimensional visualization of thin-slice enhanced CT imaging data pro­cessed by computer software can display the relationship between the lesion, bile ducts, and blood vessels in the hilar area stereoscopically. It can greatly improve the resectable evaluation accuracy of perihilar tumor; and can clearly dis­play the location and characteristics of lesions such as high bile duct stenosis, and central choledochal cystic dilatation, which is the basis of formulating reasonable surgical planning.
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17.4.1.2 Assessment ofHepatic Functional Reserve andLiver Volume
Most perihilar diseases can also present with obstructive jaundice, and some may be complicated by chronic active hepatitis and fatty liver; meanwhile, extended hepatectomy is often required. Thus, a precise assessment of hepatic func­tional reserve and liver volume is very important. Individualized surgical decision-making and planning for the maximum amount of liver resection in clinical practice are based on an assessment system for the safety limits of hepatectomy founded on assessment of hepatic functional reserve and liver volume (Dong etal. 2013a, b). The safety limits for extensive hepatic resection can be predicted based on the Expert Consensus on Assessment of Hepatic Functional Reserve before Hepatectomy (2011 edition) (Dong etal. 2011) (Fig.17.19). By using three-dimensional visualization, liver segmentation, and liver volume measure­ment can be accurately performed. However, during exten­sive liver resection such as a right trisectionectomy or left trisectionectomy, the limit for safe resection (20% of residual liver volume) should not be challenged even in patients with normal liver function. Clinicians often focus only on the harm of chronic viral hepatitis to liver function, ignoring the potential impact of fatty liver. Even if the liver function of some fatty liver patients is normal before operation, it may lead to residual liver dysfunction after extreme liver resection.
17.4.1.3 Preoperative Biliary Drainage
Perihilar diseases are usually preceded by severe obstructive jaundice and complicated with various degrees of biliary tract infection preoperatively, mostly requiring extended hepatectomy. Therefore, it is particularly important to decrease preoperative bilirubin levels (Noie et al. 2001; Kennedy etal. 2009). Though the academia’s standards and
duration for preoperative reduction of bilirubin levels remain controversial, most scholars support that biliary drainage is necessary for portal surgery requiring an extended hepatec­tomy, since decreasing the bilirubin level is benecial to hepatic regeneration, intestinal function recovery, relief of cholangitis, prevention of renal failure, and liver failure. Preoperative biliary drainage is indicated for improving operative safety and reducing the incidence of postoperative mortality and complications (Kennedy et al. 2009; Farges etal. 2013). In recent years, endoscopic retrograde cholan­giopancreaticogram (ERCP) with biliary stent placement has been advocated by Japanese scholars in situations where bili­rubin level decrease is desired to avoid sinus metastasis of PTCD; however, we still recommend percutaneous transhe­patic cholangial drainage (PTCD) as the preferable method of biliary drainage given the fact that:
• PTCD catheter placement longer than 60days is an inde­pendent risk factor for sinus metastasis of tumor (Takahashi etal. 2010).
• In patients with potentially resectable hilar cholangiocar­cinoma, the incidence of complications by using PTCD is signicantly lower than by using ERCP (Al Mahjoub etal. 2017).
• Endoscopic biliary stenting is technically demanding in which it is difcult to achieve the goal of simultaneous drainage of bilateral branches of the bile ducts, and is prone to retrograde biliary tract infection.
• Edema of hepatoduodenal ligament caused by stent placement.
It is suggested that PTCD should be performed after
MDCT and MRCP since (a) the dilatation of the bile duct becomes no longer evident after PTCD drainage, which might affect the accuracy of biliary tract assessment; (b) The
Fig. 17.19 Schematic diagram of quantitative decision system for hepatectomy. R standard liver volume ratio
functional to
ES
ab
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presence of PTCD drainage tube affects the accuracy of por­tal involvement assessment (Ni etal. 2017; Unno etal. 2007). Bilateral biliary drainage should be performed because peri­hilar diseases often lead to separation of left and right hepatic ducts, especially the bile ducts of the preserved liver. For obstructed intrahepatic cholangitis caused by hilar choleli­thiasis and inammatory hilar strictures, preoperative biliary drainage is also required to control biliary tract infection. Additionally, administration of the contrast medium is not recommended after PTCD, as it may lead to cholangitis.
17.4.1.4 Evaluation ofOperative Timing
For patients with perihilar diseases requiring extended hepa­tectomy, the risk of surgery can be reduced if the preopera­tive total bilirubin level decreases from more than 200μmol/L to less than 80 μmol/L (Biliary Surgery Group 2013a, b; Belghiti and Ogata 2005; Farges etal. 2013). The operation timing for high biliary stricture should be determined by local inammation, biliary blood ow, and systemic condi­tions. It has been reported that surgical repair after bile duct injury in the presence of local peritonitis is a poor prognostic factor for postoperative restenosis (Schmidt etal. 2005). For patients with severe portal hypertension, a shunt surgery should be performed prior to attempting a secondary treat­ment of biliary stricture. For perihilar diseases associated with biliary tract infection, biliary tract interventions and drainage such as PTCD are carried out to control infection before denitive surgery is performed. Unless absolutely compelled, surgery should be avoided in the case of acute biliary tract infection.
17.4.2 Anatomy andManeuver
oftheHilarArea
Three sets of vessels with different courses and patterns of conuence converge in the hilar area, resulting in differences in spatial conguration and individual variations in anatomi­cal structure. Different techniques should be adopted accord­ing to the hilar anatomy, taking the bifurcation and conuence of the hepatic portal bile duct, hepatic artery, and portal vein into account, in accordance with the preoperative imaging evaluation, and the hilar area requiring surgical exposure.
17.4.2.1 Exposure oftheHilar
Separation Technique oftheHilar Plate
The separation technique of the hilar plate is the most com­monly used technique for hilar exposure. The hilar plate refers to the thickened brous connective tissue fused by the hepatic capsule and Glisson sheath at the hepatic hilum, extending to the right side by the gallbladder plate and to the left by the umbilical plate (Kawarada et al. 2000) (Fig.17.20). There is a certain space between the hilar plate and the liver parenchyma, and there are few blood vessels communicating branches. After detachment of the hilar plate from the liver parenchyma, the rst hepatic hilum will naturally descend. The anterior wall of the bile duct covered by the square lobe of the liver will be fully exposed, which will increase the anatomical space to the left and right hepatic ducts sufciently to reduce the difculty (Kawarada etal. 2000). Under normal circumstances, the extrahepatic
Fig. 17.20 Schematic diagram of the hilar plate. (a) Location of the hilar plate; (b) composition of hepatic portal plate. S4a quadrate lobe, S5 segment V, S6 segment VI, S7 segment VII
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bile duct can be exposed for approximately 2 cm. For patients with lower bifurcation of the bile duct, it is possible to completely expose the conuence of the left and right hepatic ducts outside the liver. Generally, the right hepatic artery courses posterior to the common hepatic duct. However, in some patients it courses anterior to the common hepatic duct. Lowering the hilar plate reduces opportunities for inadvertent injuries, which is also one of the key points for preoperative evaluation based on three-dimensional visualization. Since the left and right hepatic ducts do not lie within the hepatic parenchyma but in transverse groove of the hepatic hilum, the lesions in most diseases such as high biliary injuries or stenoses and hilar cholangiocarcinoma, can be exposed through separation of the hilar plate, so that the hilar area becomes relatively supercial and is benecial to the maneuver (Jiang and Zhang 2001). Because the hilar plate and gallbladder plate on the right extend each other, cholecystectomy is helpful for the anatomy of the right hilar structures.
Transection ofMedian Hepatic Fissure
Hepatic resection by hepatic parenchymal transection along the interlobar plane will fully expose the hilar plate when the conuence of hilar bile duct cannot be completely exposed by separating the hilar plate; due to its high posi­tion, or when the hilar is closed by hypertrophic scar tissue caused by stricture of high bile duct. Through transection of the median hepatic ssure, the hilar plate can be completely exposed. At this time, the left and right hepatic ducts and the junction of the conuence and the secondary hepatic duct can be fully exposed, which is conducive to creating more surgical space for resection and reconstruction of the dis­eased bile ducts (Jiang and Zhang 2001). The median hepatic ssure is the boundary between the left and right half of the liver. Since there are no other important blood vessels passing through the liver parenchyma except the middle liver vein, it is safe and feasible to transect the liver parenchyma directly to the hepatic portal along the middle hepatic ssure. In clinical practice, however, separation can be performed along the resection plane 1.0–1.5cm to the left of the median hepatic ssure, so as to avoid inadvertent injury of the middle hepatic vein. It is best to transect the median hepatic ssure after identifying the course of middle hepatic vein by intraoperative ultrasound. The length of incision measures two-thirds of the liver anteriorly, and the appropriate depth of incision is to fully expose the hilar bile duct. Small blood vessels or bile ducts on the separation sec­tion should be properly ligated or suture ligated to avoid postoperative bleeding or bile leakage. The use of CUSA devices for dissection of major intrahepatic vascular trunk can signicantly reduce intraoperative bleeding and bile duct injuries.
Caudate Lobe Resection andPerihilar Resection
Hypertrophy of the quadrate lobe will hinder the anatomy of the hepatic hilum, resulting in a deeper hepatic hilum struc­ture. CUSA devises can be used to resect the quadrate lobe or liver tissues above transverse sulcus of the porta hepatis (part of the right anterior lobe of the liver), and then the top of the porta hepatis can be opened to offer a complete exposure of the bifurcation of the hilar bile duct and the transverse part of the left hepatic duct, thus providing space for operation.
17.4.2.2 Lesions Excision andVascular
Reconstruction
Sufcient exposure of lesions and separation of vessels in the hilar region are the preconditions for excision of perihe­patic hilar lesions. For cystic dilatation of the common bile duct, the proximal and distal diseased bile ducts should be excised. For high biliary strictures, if stones are present, the stones should be removed and the strictures and scar tissue of the bile duct should be resected to expose the soft healthy bile duct tissue above the stenosed section. Radical resection is the only effective way to achieve long-term survival of the patients with perihilar tumors. Seyama etal. (2003) showed that the long-term survival rate of the patients with the tumor­negative bile duct margin >5 mm was signicantly higher than that of patients with the tumor-negative bile duct margin <5 mm, indicating that it was necessary to ensure at least 5 mm of the tumor-negative bile duct margin for radical resection of the hilar cholangiocarcinoma.
Tumor invasion of blood vessels is one of the important
reasons why radical resection is impossible. Combined por­tal vein resection and reconstruction can signicantly improve the R0 resection rate and long-term survival rate of locally advanced hilar cholangiocarcinoma (Chen et al.
2014). Because the bile duct lies anteriorly to the portal vein,
dissection of the bile duct after opening the hepatic hilum is safer and also more conducive to the management of the involved portal vein. Although the overall prognosis remains poor for patients with hepatic artery resection and recon­struction, it is better than that of patients who are unresect­able. When hepatic artery invasion becomes the only factor hindering R0 resection, hepatic artery resection and recon­struction should be considered (Matsuyama etal. 2016).
17.4.2.3 Cholangiojejunostomy
Hilar cholangioplasty and Roux-en-Y hepaticojejunostomy claim to be additional challenging points in perihilar surgery. After resection of the lesion, the left and right half of the liver often retains multiple secondary and tertiary branches of bile ducts. The thin and slender wall of bile duct, accom­panied by blood vessels and the narrow space of portal hepa­tis, increase the difculty of operation. In order to avoid postoperative bile leakage, each bile duct should be fully
17 Application of3D Visualization Technology inPerihilar Surgery
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exposed according to preoperative imaging characteristics. In addition, the bile duct of the caudate lobe and variant right posterior sectoral duct should not be omitted when perform­ing hepatic portal choledochoplasty. In order to avoid miss­ing the transected bile duct, 5-0 PDS suture can be used for traction when transecting each bile duct. The right anterior and posterior sector bile ducts, and the left medial and lateral sector bile ducts can be united respectively to form a single orice and anastomosis can be performed. When the two bile ducts are far apart, they are anastomosed separately. To pre­vent postoperative anastomotic restenosis, the principle of “mucosa-to-mucosa” anastomosis should be adhered. PDS sutures 5-0 or 4-0 can be selected for anastomosis according to bile duct diameter and its wall thickness. When the bile duct is very thin, silicone tubes can be implanted for support. Surgical excision of hilar scar tissue stenosis should be per­formed and large-caliber biliary anastomoses should be per­formed after biliary plasty.
17.5 Application Value of3D Visualization Technology inPerihepatic Portal Surgery
Three-dimensional visualization technology based on stereo modelling can display the variations of hepatic vessels more intuitively and show the degree of perihepatic portal diseases such as the relationship between hepatic hilar cholangiocar­cinoma and blood vessels. Individualized liver segmentation and volume calculation can be carried out to evaluate the safety of surgery, and simulated surgery can be carried out to improve the success rate of surgery (Ni etal. 2016; Wigmore etal. 2001; Rau etal. 2000; Marescaux etal. 1998).
the conuence pattern of the portal vein and its dominated hepatic segments, and it is also of great signicance to avoid inadvertent injury of portal vein branches with abnormal conuence (Lau etal. 2017a, b) (Fig.17.22).
17.5.1.3 Individualized 3D Model oftheBile Duct
The establishment of a three-dimensional visualization model based on individualized bile ducts is helpful to visu­alize the liver segments drained by different biliary branches, which is important for avoiding injury of conuent abnor­mal bile ducts and omission of important bile ducts (Fig.17.23).
17.5.1.4 Individualized Model oftheSpatial Relationship Between theExtrahepatic Hepatic Artery andtheBile Duct andPortal Vein
Three-dimensional visualization processing can intuitively display the spatial relationship of the extrahepatic hepatic artery to the bile duct and the portal vein, which can avoid inadvertent intraoperative injuries (Fig.17.24).
17.5.1.5 Individualized Model oftheSpatial Relationship Between theRight Posterior Hepatic Artery andRight Branch ofPortal Vein
Three-dimensional visualization can visualize whether the spatial relationship between the right posterior hepatic artery and the right portal vein is infraportal type, supraportal type, or combined type, so as to avoid inadvertent injury to the right posterior hepatic artery, and to predict the difculty of resection and reconstruction of the right posterior hepatic artery (Yoshioka etal. 2011) (Fig.17.25).
17.5.1 Evaluation ofPerihepatic Portal Anatomy Based on3D Visualization Technology
17.5.1.1 Individualized 3D Model
oftheHepatic Artery
Based on the three-dimensional visualization technology, for patients requiring peri-hepatic hilar surgery, a three­dimensional visualization model of individual hepatic artery is developed based on the CRL classication system before surgery, which is important for preventing hepatic artery injury and guiding the resection and reconstruction of the hepatic arteries (Fig.17.21).
17.5.1.2 Individualized 3D Model ofthePortal
Vein
The individualized three-dimensional visualization model of the portal vein is helpful for the surgeon to better understand
17.5.1.6 Individualized Model oftheSpatial Relationship Between theRight Posterior Hepatic Duct andRight Branch ofthePortal Vein
Three-dimensional visualization can visualize whether the spatial relationship between the right posterior hepatic duct and the right portal vein branch is infraportal type, suprapor­tal type, or combined type. It is helpful to assess the exposure difculty of the right posterior hepatic duct and to predict the location and number of hepatic duct openings on the hepatic section (Fig.17.26).
17.5.1.7 Individualized Model oftheSpatial Relationship Between theLeft Hepatic Artery andUmbilical Portion ofthePortal Vein
Three-dimensional visualization can visualize whether the spatial relationship between the left hepatic artery and portal