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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_585_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword I
- •Foreword II
- •Foreword III
- •Foreword IV
- •Contributors
- •Manuscripts Translation and Preparation
- •1.1 Introduction
- •Preface
- •Acknowledgments
- •Contents
- •Editors and Contributors
- •Deputy Editors
- •1.2.2.2 Gallbladder
- •1.2.2.3 Cystic Duct
- •1.2.2.4 Common Bile Duct
- •Supraduodenal Portion
- •Retroduodenal Portion
- •Pancreatic Portion
- •Intraduodenal Portion
- •1.3.2 Data Acquisition
- •1.3.2.2 Bile Duct Perfusion
- •1.3.2.3 Hepatic Artery Perfusion
- •1.3.2.4 Specimen Perfusion Fixation
- •1.4.1 Liver Dissection after Biliary Tract Perfusion
- •1.4.3.1 Image Registration After Bile Duct Perfusion
- •References
- •2.1 Introduction
- •2.2.1 Basic Principles
- •2.2.2.1 Methods
- •Preparation
- •Scanning Modalities
- •Contrast-Enhanced Scanning
- •Contrast-Enhanced Examination
- •Shaded Surface Display
- •Maximum Intensity Projection
- •Volume Rendering
- •2.3.1.1 MRI Devices
- •The Magnet
- •The Gradient System
- •The Radiofrequency System
- •Radiofrequency Coils
- •The Computer System
- •Other Auxiliary Equipment
- •2.3.2.1 MRI Preparations
- •Patient Preparation
- •2.3.2.2 Regular Scan Sequences
- •Single-Shot Turbo Spin-Echo Coronal Sequences
- •2D or 3D T2W1
- •Transaxial Single-Shot Turbo Spin-Echo Fat Suppression Sequences
- •Dynamic Enhancement Sequence
- •3D Volumetric Acquisitions
- •Advantages
- •Disadvantages
- •2D Continuous Thin-Slice Scanning
- •Advantages
- •Disadvantages
- •2D Thick-Slice Projection Imaging
- •Advantages
- •Disadvantages
- •References
- •3.1 Introduction
- •3.2 Congenital Biliary Diseases
- •3.2.1 Congenital Extrahepatic Biliary Atresia
- •3.2.1.1 CT Features
- •3.2.1.2 MRI Features
- •3.2.2 Biliary Dilatation
- •Type I
- •Type II
- •Type III
- •Type IV
- •Type V
- •3.2.2.2 Radiographic Features
- •CT Features
- •MRI Features
- •3.2.3 Bile Duct Hamartomas
- •3.2.3.1 CT Features
- •3.2.3.2 MRI Features
- •3.3 Common Gallbladder Diseases
- •3.3.1 Acute Cholecystitis
- •3.3.1.1 Radiographic Features
- •CT Features
- •MRI Features
- •Gangrenous Cholecystitis
- •Emphysematous Cholecystitis
- •Pediatric Cholecystitis
- •Pregnancy Cholecystitis
- •Gallbladder Empyema
- •Gallbladder Perforation
- •Hemorrhagic Cholecystitis
- •3.3.5 Other Gallbladder Tumors
- •3.3.5.3 Primary Gallbladder Lymphoma
- •3.3.5.4 Gallbladder Fibrosarcoma
- •3.3.6 Xanthogranulomatous Cholecystitis
- •3.3.6.1 CT Features
- •3.3.6.2 MRI Features
- •3.3.7 Gallbladder Adenomyomatosis
- •3.3.2 Chronic Cholecystitis
- •3.3.2.1 CT Features
- •3.3.2.2 MRI Features
- •3.3.3 Gallstones
- •3.3.3.1 CT Features
- •3.3.3.2 MRI Features
- •3.3.4 Gallbladder Cancer
- •3.3.4.1 CT Features
- •3.3.4.2 MRI Features
- •3.3.4.3 MRCP Features
- •3.3.7.1 CT Features
- •3.3.7.2 MRI Features
- •3.3.8.1 CT Features
- •3.3.9 Gallbladder Torsion
- •3.3.9.1 Type I
- •3.3.9.2 Type II
- •3.3.10.2 Gallbladder Sludge
- •3.3.11 Mirizzi’s Syndrome
- •3.3.11.1 CT Features
- •3.3.11.2 MRI Features
- •3.3.12 Post-Cholecystectomy Syndrome
- •3.4.1 Bile Duct Stones
- •CT Findings
- •MRI Findings
- •CT Findings
- •MRI Findings
- •3.4.2 Suppurative Cholangitis/Acute Cholangitis
- •3.4.3 Primary Sclerosing Cholangitis
- •3.4.3.1 CT Findings
- •3.4.3.2 MRI Findings
- •3.4.4 Secondary Sclerotic Cholangitis
- •3.4.5 Recurrent Pyogenic Cholangitis
- •3.4.5.1 CT Findings
- •3.4.6 Extrahepatic Cholangiocarcinoma
- •3.4.6.1 CT Findings
- •MRI Findings
- •MRCP Features
- •3.4.7 Intrahepatic Cholangiocarcinoma
- •3.4.7.3 Special Manifestations
- •3.4.8 Periampullary Carcinoma
- •3.4.8.1 Radiographic Findings
- •3.4.8.2 CT Findings
- •3.4.8.3 MRI Findings
- •3.4.9 Combined Hepatocellular-Cholangiocarcinoma
- •3.4.9.1 Imaging Findings
- •3.4.9.2 MRI Findings
- •3.5.1.1 Intrahepatic Biliary Dilatation
- •CT Findings
- •MRI Findings
- •3.5.1.2 Extrahepatic Bile Duct Dilatation
- •3.5.2.1 Hilar Obstruction
- •3.5.2.3 Pancreatic Obstruction
- •References
- •4.1 Introduction
- •4.1.2.1 CT Acquisition Protocols
- •4.1.2.2 Data Preprocessing
- •4.1.2.3 Medical Image Segmentation
- •4.1.2.4 3D Visualization
- •4.2.1 Image Registration
- •4.2.1.1 Template Matching Algorithm
- •4.2.1.2 Registration Steps
- •Step 1
- •Step 2
- •Step 3
- •4.2.2 Image Segmentation
- •Pixel Based Methods
- •Region Based Methods
- •Edge Based Methods
- •Model Based Methods
- •4.2.2.3 Serialized Segmentation Model
- •4.2.2.4 Adaptive Region Growing Algorithm
- •4.2.3 3D Reconstruction
- •References
- •5.1 Introduction
- •Fused Deposition Modeling
- •Stereolithography
- •Selected Laser Sintering
- •Direct Metal Laser Sintering
- •Laminated Object Manufacturing
- •Electron Beam Melting
- •Three-Dimensional Printing
- •High-Performance 3D Reconstruction Software
- •5.1.2.2 Medical Model Manufacturing
- •5.1.2.3 Tissue/Organ Regeneration
- •5.2.2 Digital Preparation
- •5.3.1.1 In Complex Liver Resection
- •5.3.1.2 In Liver Transplantation
- •5.3.2.1 In Cholangiocarcinoma Surgery
- •5.3.4 Prospects
- •References
- •6.1 Introduction
- •6.1.1 Virtual Anatomy
- •6.1.2 Surgical Simulation
- •Improved Doctor–Patient Relationship
- •Reduced Surgical Costs
- •Remote Intervention
- •6.2 Virtual Surgical Instruments
- •6.2.1 Geometric Modeling
- •6.2.2 Motion Modeling
- •6.2.3 Physical Modeling
- •6.3 Surgical Simulation
- •6.3.1 The Hardware System
- •6.3.2 Software System
- •6.3.2.1 FreeForm Modeling System
- •6.3.2.2 Open Graphics Library
- •6.3.2.3 Tactile Development Kit
- •6.4.4 Discussion
- •References
- •7.1 Introduction
- •References
- •8.1 Introduction
- •8.2 Duodenoscopy
- •8.3 Choledochoscopy
- •8.3.1 Preoperative Application
- •8.3.2 Intraoperative Application
- •8.3.3 Postoperative Application
- •8.4 Capsule Endoscopy
- •8.5 Laparoscope
- •8.6 Endoscopic Ultrasound
- •8.7 3D Visualization-Assisted Endoscopic Technology
- •References
- •9.1 Introduction
- •9.3.1.1 Arterial Phase
- •9.3.1.2 Portal Venous Phase
- •References
- •10.1 Introduction
- •10.2.1.2 Image Segmentation
- •10.2.1.3 3D Reconstruction
- •10.2.1.4 Surgical Simulation
- •Surgical Procedure
- •References
- •11.1 Introduction
- •11.2.2 Image Registration
- •References
- •12.1 Introduction
- •12.2.1 Imaging
- •12.2.2 Other Auxiliary Examinations
- •12.2.2.1 Biliary Manometry
- •12.2.2.2 Cholescintigraphy
- •12.2.2.3 Selective Celiac Arteriography
- •12.3.1 Collection Equipment
- •12.3.3 Plain Scan
- •12.3.4 Dynamic Enhanced CT Scan
- •12.4.1 Image Registration
- •12.6.1 Semiautomatic Liver Segmentation
- •Surgical Procedures
- •Surgical Procedures
- •12.10.2 Anatomical or Regular Hepatectomy Guided by 3D Visualization
- •12.10.2.1 Indications
- •12.10.2.2 Contraindications
- •12.10.2.4 Surgical Procedures
- •For Anatomical Right Hemihepatectomy
- •For Anatomical Left Hemihepatectomy
- •12.10.3.1 Contraindication
- •12.10.3.3 Surgical Procedures
- •Case 1
- •Case 2
- •12.10.4.1 Indications
- •12.10.4.2 Contraindication
- •12.10.4.4 Surgical Procedures
- •12.10.4.5 Attention
- •12.10.5.1 Indications
- •12.10.5.2 Contraindications
- •12.10.5.3 Surgical Procedures
- •12.10.5.4 Attention
- •12.10.6.1 Indications
- •12.10.6.2 Contraindications
- •12.10.6.3 Preoperative Imaging Evaluation
- •12.10.6.4 Surgical Procedures
- •12.10.6.5 Attention
- •12.10.7.1 Indications
- •12.10.7.2 Contraindications
- •12.10.7.3 Surgical procedures
- •12.10.7.4 Attention
- •12.10.8.1 Preoperative Evaluation
- •12.10.8.2 Preoperative Preparation
- •12.10.8.3 Contraindications
- •12.10.8.4 Operation Methods
- •12.10.8.5 Attention
- •12.10.9.1 Biliary Injury
- •Causes
- •Preventive Measures
- •12.10.9.2 Biliary Bleeding
- •12.10.9.3 Gastrointestinal Water Retention
- •Reasons
- •12.10.9.4 Biliary Leakage
- •12.11.1.1 Reasons
- •Main Reasons
- •Iatrogenic Biliary Tract Injury
- •Other Reasons
- •12.11.1.3 Surgical Procedures
- •Roux-en-Y Choledochojejunostomy
- •Hepatectomy
- •Intrahepatic Lithotripsy Through Sinus Tract or PTCS
- •Severe Symptomatic Patients
- •References
- •13.1 Introduction
- •13.3.1 Ultrasonography
- •13.3.2 Multi-Slice CT
- •13.3.5 Intraoperative Cholangiography
- •13.3.6 Radionuclide Hepatobiliary Scan
- •13.3.7 Digital Medicine Technology
- •Periampullary Tumor
- •Biliary Atresia
- •Acute Pancreatitis
- •Acute Cholecystitis
- •Hepatic Cyst
- •Hepatic Echinococcosis
- •Retroperitoneal Cystic Masses
- •13.4.2.1 Biliary Drainage
- •13.4.2.3 Liver Resection
- •13.4.2.4 Pancreaticoduodenectomy
- •13.4.2.5 Liver Transplantation
- •13.4.2.6 Laparoscopic Surgery
- •13.4.2.7 Reoperation
- •References
- •14.1 Introduction
- •14.1.1.1 Etiology
- •Anatomical Factors
- •Pathological Factors
- •Surgeon Factors
- •14.1.2.2 End-to-End Cholangiostomy
- •14.1.2.3 Choledochoduodenostomy
- •14.1.2.4 Roux-en-Y Cholangiojejunostomy
- •14.1.2.7 Liver Transplantation
- •14.2.2.1 Patient Information
- •14.2.2.2 Diagnosis
- •14.2.2.3 Complaint
- •14.2.2.4 History
- •14.2.2.5 Signs
- •14.2.2.6 Previous History
- •14.2.2.7 Laboratory Examination
- •Blood Routine
- •Coagulation Function
- •Liver Function
- •Renal Function
- •Tumor Markers
- •14.2.2.8 General Condition Assessment
- •Nutritional Status Evaluation
- •Liver Function Evaluation
- •Important Organ Function Evaluation
- •14.2.2.9 Imaging Evaluation
- •Evaluation by 3D Visualization
- •14.2.2.10 Surgical Planning
- •14.2.2.11 Surgical Procedures
- •Step 1
- •Step 2
- •Step 3
- •14.2.3.1 Patient Information
- •14.2.3.2 Diagnosis
- •14.2.3.3 Complaint
- •14.2.3.4 History
- •14.2.3.5 Signs
- •14.2.3.6 Previous History
- •14.2.3.7 Laboratory Examination
- •Blood Routine
- •Coagulation Function
- •Liver Function
- •Renal Function
- •Tumor Markers
- •14.2.3.8 General Condition Assessment
- •Nutritional Status Evaluation
- •Liver Function Evaluation
- •Important Organ Function Evaluation
- •14.2.3.9 Imaging Evaluation
- •Evaluation by 3D Visualization
- •14.2.3.10 Surgical Planning
- •14.2.3.11 Surgical Procedure
- •Step 1
- •Step 2
- •Step 3
- •References
- •15.1 Introduction
- •15.2 Clinical Stages
- •15.2.2 Surgical Strategy
- •Tis/T1a Stage
- •T1b Stage
- •Stage T2
- •Stage T3
- •Stage T4
- •15.2.2.2 Lymph Node Dissection Range
- •Stage Tis/T1a
- •Stage T1b
- •Stage T2
- •Stage T3
- •Stage T4
- •15.2.2.3 Extrahepatic Bile Duct Management
- •Stage Tis/T1a
- •Stage T1b
- •Stage T2
- •Stage T3
- •Stage T4
- •15.3.1 T Staging Assessment
- •15.3.1.1 Stage T2
- •MDCT
- •15.3.1.2 Stage T3
- •MDCT
- •15.3.1.3 Stage T4
- •15.3.3 Resectability Assessment
- •15.3.3.1 General Assessment
- •15.3.3.2 Liver Function Assessment
- •15.3.3.3 Virtual Surgery Assessment
- •15.4.1 Surgical Indications
- •15.4.2 Preoperative Preparation
- •15.4.2.3 Preoperative 3D Visualization Evaluation
- •15.4.3 Surgical Procedures
- •15.4.3.1 Resection Range
- •Radical Pancreaticoduodenectomy
- •15.4.4 Surgical Prognosis
- •References
- •16.1 Introduction
- •16.2.2.2 Imaging Diagnosis
- •16.2.2.3 Pathological Diagnosis
- •16.2.2.4 Clinical Staging
- •16.2.3.1 Preoperative Assessment
- •Liver Function Assessment
- •Resectability Assessment
- •3D Visualization Assessment
- •16.2.3.2 Surgical Approach
- •16.2.3.3 Controversial Point
- •Lymphadenectomy
- •Extended Hepatectomy
- •Liver Transplantation
- •Operative Prognosis
- •16.2.4 Multidisciplinary Team
- •16.2.5 Conclusion
- •Notes
- •16.3.4 Surgical Planning Guided by 3D Visualization
- •Type I
- •Type II
- •Type IIIa
- •Type IIIb
- •Type IVa
- •Type IVb
- •Type V
- •16.3.6.2 Typical Case
- •Case 1
- •Case 2
- •Case 3
- •Case 4
- •Case 5
- •16.3.6.4 Lymphadenectomy
- •16.3.6.6 Laparoscopic Exploration
- •16.3.6.7 Intraoperative Frozen Section Consultation
- •16.3.6.8 Liver Transplantation
- •Common Type
- •Type II Variation
- •Type III Variation
- •16.3.10 Other Comprehensive Treatment
- •16.3.11 Other Perioperative Management
- •16.3.11.2 Postoperative Follow-Up
- •References
- •17.1 Introduction
- •17.2.2.1 Perihilar Tumor
- •17.2.2.2 High Biliary Stricture
- •Hepatic Arterial Variation
- •Portal Vein Variations
- •Bile Duct Variations
- •17.3.2 Complex Pathophysiology
- •17.4.1.3 Preoperative Biliary Drainage
- •17.4.2.3 Cholangiojejunostomy
- •17.6 3D Visualization Imaging
- •Viscera Reconstruction
- •Lesion Reconstruction
- •Vascular Reconstruction
- •References

186
C. Fang et al.
portal vein, it is called the posterior portal vein artery, which is
divided into type I and type II.The two marginal arteries were
anastomosed to each other along the two sides of the bile duct
before the branches of the nutrient arteries entered into the bile
duct. According to their anatomical location, Northover named
them 3 o’clock and 9 o’clock arteries.
Chinese scholars (Fang 2014) used the surgical microscope to dissect and observe the blood supply arteries of the
hepatobiliary duct. After measuring their external diameter
and blood supply ratio, they pointed out that the blood supply
of extrahepatic bile ducts has two distinct characteristics. One
is essentially axial. The right hepatic artery above (the rst
hepatic hilum), and the retroduodenal artery below converge
in the supraduodenal bile duct. About 60% of the blood supply to the supraduodenal bile duct runs upward from vessels
below, whereas 38% runs downward from the right hepatic
arteries and cystic duct artery (Terblanche etal. 1983). Thus,
the second characteristic emerges. The primary source of
blood supply in each segment of the extrahepatic bile duct is
different, and the blood supply status is also quite different.
The blood vessel plexus in the lower segment of the bile duct
and the wall of the hilar bile duct are denser while the upper
duodenal bile duct is sparse. The upper duodenal bile duct is
also the critical site of biliary tract operation.
Historically, animal models suggested that achieving
good post-operative hepatic blood ow is essential to the
reduction of biliary strictures (Cameron and Hou 1962).
Most anastomotic strictures occur when the marginal arteries
on both sides of the anastomosis are ligated, and the blood
supply at the anastomotic site decreased to 30% of normal.
Studies on bile duct blood supply over the past halfcentury have conrmed that the bile duct is nourished by the
pericholangiovascular network formed by anastomosis of
terminal branches of multiple pericholangiovascular
branches rich in oxygen, such as a hepatic artery, gallbladder
artery, posterior duodenal artery, superior pancreaticoduodenal artery, and superior mesenteric artery. The arterial arch at
3 and 9 o’clock on both sides of the biliary tract is the main
branch of the biliary blood supply. The damage to the biliary
blood supply is closely related to the occurrence of biliary
stricture after biliary surgery.
9.2.2 Constructing 3D Visualization Platform
ofExtrahepatic Bile Duct Blood Supply
Based onSubmillimeter CT Data
andIts Clinical Signicance
Although scholars at home and abroad used cadaveric perfused specimens to better display the source and distribution
of extrahepatic bile duct blood supply in normal cadavers,
and conrmed the common main blood supply arteries of
extrahepatic bile duct and the anastomosis and direction of
these blood supply arteries around the bile duct; the extrahepatic bile duct supply characteristically has multiple sources,
complex distribution, and variation because the small arteries of extrahepatic bile duct are the end of the celiac arteries.
The variation of the celiac artery is complicated, especially
the high variation rate of the hepatic artery and gallbladder
artery, and characteristically complex distribution and variation. Besides, there must be distortion in the information of
the cadaveric cast specimen compared with the information
of the living human body, and there may be variations in the
blood supply of the extrahepatic bile duct under pathological
conditions. It is vital to have a deep understanding of the
characteristics of the blood supply and the distribution of
extrahepatic bile ducts in healthy human beings and the pathological conditions of the biliary tract. It is possible to provide a precise individualized morphological basis for the
rational selection of clinical biliary surgery schemes and the
prevention of postoperative biliary complications. Therefore,
it is crucial to solve the problem of how to obtain the threedimensional display of extrahepatic bile duct blood supply in
living human before the operation.
The 64-slice spiral CT adopts the detector layer of 64 *
0.4 ~ 0.625 mm, which is in the real sense submillimeter
CT.Submillimeter CT angiography (CTA) can obtain highquality three-dimensional reconstructed images because of its
fast data acquisition, wide coverage, and isotropy. Compared
with traditional digital subtraction angiography (DSA), it has
become the least invasive new technique to observe human
vascular anatomy. The clinical application and development
of submillimeter CT and angiography make it possible to
observe the blood supply of the extrahepatic bile duct gradually. However, the extrahepatic bile duct has no independent
blood supply artery and is supplied by the terminal branch of
the celiac artery. The image processing software provided by
CT itself is unable to segment and extract a three-dimensional
reconstruction of the blood supply arterioles of the extrahepatic bile duct through maximum density projection (MIP) or
volume rendering (VR). Meanwhile, because of the particularity of biliary tract structure and physiological function, CT
is not sufciently sensitive to display the bile duct system,
and it is difcult to achieve ideal imaging of the bile duct
system under non- invasive conditions. Also, the 3D reconstruction function of CT has the following shortcomings in
displaying 3D anatomical structure of extrahepatic bile duct
and its blood supply:
• The organs in arterial phase, venous phase, and portal
phase cannot be registered simultaneously, which results
in the difference of reconstruction quality.
• The difference of interaction: the 3D reconstruction of CT
machine must be operated by radiologists, which signicantly restricts the clinician’s operations.
• The 3D model generated from CT cannot be used in any
combination, splitting, staining, transparency, and subsequent virtual operations in blood vessels, bile ducts, and
other organs.

9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
187
The rapid development of 3D visualization technology
makes it possible to visualize the blood supply of the extrahepatic bile duct in the living human body. The reconstruction by computer, using three-dimensional image processing
technology of the extrahepatic bile duct and blood supply,
can not only solve the problem of distorted blood supply
information of extrahepatic bile duct obtained from a
cadaver, but also provide more realistic and accurate individualized anatomical guidance for clinical surgical procedures, which is of great signicance for the design of a
reasonable surgical mode and safe operation.
Based on high-quality submillimeter CT data, a threedimensional visualization model of the individualized extrahepatic bile duct and its blood supplying artery was
successfully constructed using a proprietary MI-3DVS.
Figure9.1 is a 3D model of the extrahepatic bile duct blood
supply in a patient undergoing choledochojejunostomy,
clearly showing that after the gallbladder artery originates
from the right hepatic artery, the main trunk moves close to
the right side of the common hepatic duct and becomes part
of the 9 o’clock artery supplying the bile duct. Then the
anterior and posterior branches of the gallbladder artery are
sent out in the neck of the gallbladder. According to the
information provided by the 3D model, when the gallbladder is removed, the left side of the gallbladder neck is closed
and the cystic artery is severed. Excessive separation of the
common hepatic duct should be avoided, which can protect
the 9 o’clock artery from injury. Meanwhile, the distance
between the anterior and posterior branches of the main
gallbladder artery and the right hepatic artery (Fig.9.1) is
measured in the 3D model to guide the position at which to
disconnect the donor bile duct during the operation. While
preserving the length of the extrahepatic bile duct, the blood
supply of the common hepatic duct is preserved to the maximum extent, thus avoiding ischemic lesions of the bile duct
caused by the postoperative destruction of the blood circulation of the bile duct.
In the diagnosis and management of extrahepatic bile
duct hemorrhage, it is necessary to deal with the anatomical
characteristics of biliary blood supply. A 3D model can accurately display the parts of the extrahepatic bile duct and its
blood supply distribution, as well as the location of the extrahepatic bile duct hemorrhage, to guide the accurate ligation
of the corresponding biliary blood supply artery. In the common bile duct exploration, the 3D model of the extrahepatic
bile duct and its blood supply can show whether there is a
transverse supply artery in the anterior wall of the extrahepatic bile duct, avoiding damage to the artery during bile
duct incision, resulting in postoperative bile duct ischemic
stenosis or complications such as bile leakage. In the jejunal
anastomosis of the common bile duct, the 3D model can
guide the site of anastomotic selection and avoid stenosis or
bile leakage after ischemic choledochojejunostomy.
In summary, the construction of a three-dimensional visualization platform for biliary blood supply has opened up a
new path for safe implementation of biliary tract surgery,
adequate protection of biliary blood supply, and effective
prevention of ischemic biliary disease.
9.3 3D Modelling ofExtrahepatic Bile
Duct Blood Supply Based
onSubmillimeter CT Data
9.3.1 Submillimeter CT Scanning
ofExtrahepatic Bile Duct Blood Supply
Fig. 9.1 The distance between the anterior and posterior branches of
the main cystic artery and the right hepatic artery was measured in the
3D model
Due to individual differences in patients, it is difcult to
obtain high quality submillimeter CT data by traditional
experience value scanning (traditional xed delay time
method). In this study, the experimental injection (low dose
pretest) was used to observe the dynamic changes of celiac
trunk artery enhancement by pre-injection of a low-dose
contrast agent with low mA scanning. The time–density
curve was used to determine the peak time of the arterial
phase enhancement. The optimal scanning delay time of the
artery is displayed, and the vasculature obtained by individu-
alization is well developed, and the imaging features of the
ne structure can be distinguished. The arterioles around the
extrahepatic bile duct can be well developed, and the small
branches can be developed more quickly than by the conventional method, thus satisfying the requirements of segmenting and 3D reconstruction of blood supply arteries of the
extrahepatic bile ducts.

188
Fig. 9.2 Submillimeter CT image, and the red arrow indicates the
peripheral artery of the bile duct
From the collected data, the outlines of blood vessels and
abdominal organs such as the pancreas, spleen, liver, and bile
duct are clearly displayed, and the cross-section angiography
agent is well lled.
9.3.1.1 Arterial Phase
The peripheral artery of the extrahepatic bile duct is displayed (Fig. 9.2), which includes not only thicker vessels
such as the common hepatic artery, the proper hepatic artery,
the left and right hepatic artery, the gastroduodenal artery,
the superior mesenteric artery, but also the ner vessels such
as gallbladder artery, superior pancreaticoduodenal artery,
and inferior pancreaticoduodenal artery.
9.3.1.2 Portal Venous Phase
The portal venous system is well displayed, almost reaching
the fourth-level branch of the portal vein. The contrast agent
in the portal vein is well lled, and the boundary between the
portal vein and hepatic parenchyma is clear.
9.3.2 Novel Interactive Segmentation
Method Based onVolume Rendering
Image segmentation is a critical technology in medical image
processing and analysis. A medical image usually composed
of region of interest (ROI) and backgrounds. The area of
interest contains signicant diagnostic information, which
provides reliable bases for clinical diagnosis and pathological research; the ROI occupies a very small proportion of the
total map area; however, the cost of misinterpretation is very
high. Relatively, the information of the background region is
less signicant. Thus, it is critical to segment the medical
image and extract the ROI.There are many traditional seg-
C. Fang et al.
mentation methods, which can be classied into three categories: threshold-based segmentation, edge-based
segmentation, and region-based segmentation. Segmentation
algorithms are generally based on two basic properties of
gray level values: discontinuity and similarity. The pixels
within the region usually have some similarities, while the
pixels at the boundary between the regions generally have
discontinuity. The most widely used segmentation method is
region growing. It involves the selection of initial seed points
on the CT tomographic image and determination of threshold values. The pixel values of the sequence maps within the
threshold and the regions are segmented, and the threedimensional reconstruction is performed. In image segmentation “dimensions” are not up down forward back type
dimensions, but mathematically similar pixel values. Region
growing uses formulae to decide similar pixels belong to one
group not the neighboring group and form a “segment”
(shape), you might have 5 types of tissue with denable
image properties, If you are trying to segment them you
could end up with very fractured images. The arteries that
supply the extrahepatic bile duct are all terminal vessels with
a small caliber. How to extract and segment them from CT
data is a difcult problem.
There are two existing methods for the reconstruction of
segmented 3D medical images: surface rendering (SR) and
volume rendering (VR). The VR technique involves several
rays passing through 3D volume data, without the need of
going through an intermediate surface extraction, and many
details of voxels can be preserved. VR can reproduce the real
structure of the human anatomy more effectively and improve
the delity of results. VR is superior to SR in terms of image
quality; however, SR is better than VR in terms of interaction
performance and algorithm efciency, at least on the current
hardware platform. Since the VR algorithm is computationally intensive, its interactive performance is not always optimum, even by using high-performance computers. This issue
can be addressed by using the segmentation method based on
volume rendering interaction. Firstly, the volume rendering
reconstruction is carried out. By adjusting the window width
and window position, the 3D image of the tissue of immediate
interest is obtained, the 3D seed points are obtained directly
on the volume rendering image, and the region growth algorithm is applied. The growth process is displayed on the volume rendering image; when growth stops, repairment can be
carried out on the volume rendering 3D image by human–
computer interaction. Especially for small blood vessels,
local small blood vessels can be extracted by magnifying the
ne blood vessels, extracting and segmenting the small blood
vessels. This project enables tissue segmentation, especially
more rened blood vessel segmentation, reaching the same
resolution level as volume rendering. When the user is satised with the current segmentation results, the results can be
saved immediately, and the 3D surface rendering and recon-

9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
struction can be carried out quickly, thus facilitating interactive operation of the subsequent 3D model.
The interactive segmentation method based on volume
rendering realizes the new concept of reconstruction rst and
then segmentation, which makes the segmentation process
“visible,” and achieves the purpose of improving the accuracy and integrity of segmentation. This method is satisfactory for segmenting and extracting the arterioles of the
extrahepatic bile duct in submillimeter CT images, which
lays a solid foundation for the construction of a 3D visualization model and provides a novel method for the segmentation
of ne human ducts.
Therefore, the advantages of interactive image segmentation method based on volume rendering in delicate blood
vessel segmentation extraction are as follows:
• The selection of seed points is directly performed on vol-
ume rendered images, which is intuitive and accurate.
• The segmentation process is controllable. The segmenta-
tion can be interrupted according to the growth process at
Fig. 9.3 Branches of the hepatic artery. 1. Cystic artery; 2. Right
hepatic artery; 3. Left hepatic artery; 4. Proper hepatic artery; 5.
Common hepatic artery; 6. Gastroduodenal artery; 7. Superior posterior
pancreaticoduodenal artery; 8. Anterior pancreaticoduodenal artery
any time.
• The segmentation results can be repaired. If errors occur,
seeds can be added or deleted to correct the results until
satised.
• The delicate parts can be amplied. The defect where the
original segmentation software cannot segment the micro
parts can be corrected. Make full use of the information
obtained by the imaging equipment.
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9.3.3 3D Modelling andDigital Classication
ofBlood Supply oftheExtrahepatic
Biliary Tract
9.3.3.1 3D Modelling ofBlood Supply
oftheExtrahepatic Biliary Tract
The 3D modelling of the extrahepatic bile duct and its supplying artery was performed by volume rendering with an
interactive segmentation algorithm. The reconstructed model
has a strong stereoscopic sense and truly reects the 3D anatomical structure of individual extrahepatic bile duct and
blood supply artery. The 3D model of the celiac artery can
accurately display the 4 to 5-grade branches of the hepatic
artery, the 2-grade branches of gallbladder artery (Fig.9.3),
pancreaticoduodenal artery arch (Fig.9.4) and posterior portal vein (Fig.9.5). The 3D model of the bile duct can clearly
show the intrahepatic bile duct, left and right hepatic duct,
gallbladder, common hepatic duct, choledochus and its dilatation, stricture, stone, or tumor. Meanwhile, the 3D model
can be fused, split, magnied, reduced, rotated, and distance
measured. Each part of the bile duct and its blood supply
structure can be displayed individually or in combination
through transparency and color settings.
Fig. 9.4 Pancreatic duodenal arterial arch
9.3.3.2 3D Characteristics ofExtrahepatic Bile
Duct Supplying Arteries
The extrahepatic bile duct can be divided into upper and
lower segments according to the region where the cystic duct
ows into the extrahepatic bile duct. By observing and analyzing the origin, course, and distribution of extrahepatic bile
duct blood supply arteries in the 3D model, the following
characteristics can be seen.
3D Characteristics ofBlood Supply totheUpper
Extrahepatic Bile Duct
Blood Supply of Right Hepatic Artery The 3D model
showed that the right hepatic artery originated from the

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Fig. 9.5 Yellow arrowhead points to the posterior portal artery (posterior view)
Fig. 9.6 Superior extrahepatic bile duct is supplied by right hepatic
artery
proper hepatic artery and ascended along the left posterior
part of the upper extrahepatic bile duct, then turned to the
right posterior part of the common hepatic duct to enter the
liver. Along the way, branches were issued in front of the
bile duct to supply the upper extrahepatic bile duct
(Fig.9.6).
Cystic Artery Supply The 3D model showed that after the
cystic artery was issued from the right hepatic artery, its
main trunk closely followed the right side of the common
hepatic duct and became a part of the 9 o’clock artery supplying the upper extrahepatic bile duct. Then, the anterior
and posterior branches of the cystic artery emanated from the
neck of the gallbladder.
Fig. 9.7 Extrahepatic bile duct is supplied by the upper segment of left
hepatic artery
Fig. 9.8 Superior extrahepatic bile duct is supplied by the proper
hepatic artery
Left Hepatic Artery Supply The 3D model showed that
the left hepatic artery originated from the proper hepatic
artery issued a branch in front of the bile duct and became
the upper extrahepatic bile duct supplying artery (Fig.9.7).
Proper Hepatic Artery Supply The 3D model showed that
the proper hepatic artery was close to the left wall of the
extrahepatic bile duct and became the middle and upper
extrahepatic bile duct supplying artery (Fig.9.8).
3D Characteristics ofBlood Supply totheLower
Extrahepatic Bile Duct
Superior Pancreaticoduodenal Artery Supply
The 3D
model showed that the superior and posterior pancreatico-

9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
191
duodenal artery originated from the gastroduodenal artery,
and then coursed along the left upper anterior direction of the
lower extrahepatic bile duct; afterward, it becomes the inferior extrahepatic bile duct blood supplying artery (Fig.9.9a).
The posterior pancreaticoduodenal artery arch was formed
behind the bile duct (Fig.9.9b).
Cystic Artery Supply The 3D model showed that the vari-
ant cystic artery was originated from the gastroduodenal
artery and ran close to the right wall of the extrahepatic bile
duct. It accompanied the cystic duct running under the duct
and entered the gallbladder, forming the ascending 9 o’clock
artery, which became the blood supply artery of the lower
extrahepatic bile duct.
Gastroduodenal Artery Supply The 3D model showed
that the gastroduodenal artery was close to the left wall of
the lower segment of the extrahepatic bile duct and
descended. Close to the wall of the bile duct, it issued the
superior and posterior pancreaticoduodenal arteries and
course down to right posterior inferior part of the bile duct
to form the blood supply arteries of the lower extrahepatic
bile duct (Fig.9.10).
9.3.3.3 3D Digital Classication ofBlood Supply
totheExtrahepatic Bile Duct
The 3D digital classication of extrahepatic bile duct blood
supply was established according to the characteristics of the
source and distribution of extrahepatic bile duct blood supply in the 3D visualization model.
Posterior Portal Vein Arterial Supply
After the posterior
portal vein artery is originated from the superior mesenteric
artery, it runs to the right along the direction of the portal
vein and the back of the pancreatic head, and then up to the
right posterior wall of the bile duct. After the combination
with the posterior duodenal artery, it continues to adhere to
the lower bile duct and runs upward, and mainly becomes the
signicant blood supply artery of the lower extrahepatic bile
duct (Fig.9.11).
a
Fig. 9.10 The lower segment of extrahepatic bile duct is supplied by
gastroduodenal artery. 1. Cystic artery; 2. Gastroduodenal artery; 3.
Superior posterior pancreaticoduodenal artery; 4. Posterior pancreaticoduodenal arch
b
Fig. 9.9 The lower extrahepatic bile duct is supplied by the superior posterior pancreaticoduodenal artery. (a) The front view; (b) The back view

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C. Fang et al.
The Blood Supply oftheUpper Extrahepatic
BileDuct
Type I Right hepatic artery blood supply. Three subtypes
were subdivided according to its combination with other
arteries:
Type IA Right hepatic artery only (Fig.9.12).
Type IB Right hepatic artery combined with gallbladder
artery (Fig.9.13).
Type IC Right hepatic artery combined with the proper
hepatic artery (Fig.9.14).
Type II Left hepatic artery combined with gallbladder
artery blood supply (Fig.9.15).
Fig. 9.11 Extrahepatic bile duct at lower segment of blood supply is
supplied by the posterior portal artery (yellow arrows indicate posterior
portal artery)
Blood Supply oftheLower Extrahepatic Bile Duct
Type I Superior and posterior pancreaticoduodenal artery
blood supply. Three subtypes were subdivided according to
their combination with other arteries:
Type IA Superior and posterior pancreaticoduodenal
artery only (Fig.9.16).
Type IB Superior and posterior pancreaticoduodenal
artery combined with gastroduodenal artery (Fig.9.17).
Type IC Superior and posterior pancreaticoduodenal
artery combined with posterior portal vein artery (Fig.9.18).
Type II Gastroduodenal artery and the blood supply type
of its main branches (except the superior and posterior pancreaticoduodenal artery) (Fig.9.19).
Type III Blood supply of the gallbladder artery originated from the gastroduodenal artery (Fig.9.20).
9.3.3.4 3D Modelling ofAnastomotic Artery
Around theExtrahepatic Bile Duct
The incidence of hepatic artery variation is high, and the
right hepatic artery is an important source of extrahepatic
bile duct blood supply. It is of great clinical signicance to
identify and protect the variant hepatic artery during the
operation. For example, the 3D model of extrahepatic bile
duct blood supply showed that the variant right hepatic artery
originated from the superior mesenteric artery; the posterior
superior pancreaticoduodenal artery issued branches, and its
branches were close to the common bile duct, and the left
edge of the common hepatic duct and ran upward. Finally,
they converged with the variant right hepatic artery to form
the left marginal artery of the extrahepatic bile duct (3
o’clock artery) and supplied the extrahepatic bile duct
throughout (Fig. 9.21). The signicance of analyzing the
variant extrahepatic blood supply artery by 3D technique lies
a
Fig. 9.12 The superior extrahepatic bile duct is supplied by the right hepatic artery. The blue arrow indicates the branch of the right hepatic artery
accompanying the extrahepatic bile duct. (a) Lateral, type IA; (b) Dorsal, type IA
b

9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
193
a
Fig. 9.13 The superior extrahepatic bile duct is supplied by the right hepatic artery and the gallbladder artery. (a) Ventral, type IB; (b) Dorsal,
type IB
a
b
b
Fig. 9.14 The superior extrahepatic bile duct is supplied by the right hepatic artery and proper hepatic artery. (a) Ventral, type IC; (b) Lateral, type IC
Fig. 9.15 The superior extrahepatic bile duct is supplied by the
left hepatic artery and cystic artery (type II)

194
ab
Fig. 9.16 The lower extrahepatic bile duct is supplied by the superior posterior pancreaticoduodenal artery. (a) Ventral, type IA; (b)
Lateral, type IA
C. Fang et al.
9.4 3D Modelling ofExtrahepatic Bile
Duct Blood Supply inExtrahepatic
Biliary Obstructive Diseases
Extrahepatic biliary obstructive diseases are common in hepatobiliary surgery, including cholelithiasis, pancreatic head
tumor or periampullary tumor, and inammatory stenosis of
the lower common bile duct. Surgical treatment is often
required, such as common bile duct exploration, end-to-side
or side-to-side anastomosis of the bile duct, and jejunum.
Although the technique of surgical anastomosis is improving
continuously, postoperative biliary mucus deposition, biliary
tract or bile intestinal anastomotic stricture, and biliary
stula have been thorny complications of biliary surgery. In
Fig. 9.17 The lower extrahepatic bile duct is supplied by superior posterior pancreaticoduodenal artery and gastroduodenal artery (type IB)
in this: If no variant right hepatic artery originated from a
superior mesenteric artery is identied before pancreaticoduodenectomy, the common hepatic artery and branches of
the hepatoduodenal ligament exist normally. It is easier to be
neglected during intrahepatic exploration. If it is accidentally
disconnected, it may cause extrahepatic bile duct ischemia in
addition to hepatic complications, which may lead to the
occurrence of cholangiointestinal anastomotic stula,
because right hepatic artery becomes the main blood supply
artery of the residual extrahepatic bile duct after the gastroduodenal artery is disconnected.
recent years, with the development of liver transplantation
and anatomy as well as understanding of hepatic bile duct
nutrient vessels, it is noted that the destruction of extrahepatic bile duct blood supply is closely related to the occurrence of these complications. By discussing the pathological
relationship between biliary blood supply and biliary stricture and bile duct anastomotic stula, some scholars have
found that local ischemia caused by blocked blood supply
can damage the bile mucosa and make it susceptible to inltration of bile. The effect of bile on ischemic tissue in the
wall leads to inammation, edema, and brosis, resulting in
the closure of the capillary plexus in the wall, further exacerbating the local ischemia and brosis of the wall. Both
Cameron and Chung have conrmed through animal experiments that the destruction of biliary tract blood transport is

9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
195
ab
Fig. 9.18 (a–b) The lower extrahepatic bile duct is supplied by the superior posterior pancreaticoduodenal artery and the posterior portal artery.
Yellow arrow indicates the posterior portal vein artery, and the white indicates the superior posterior pancreaticoduodenal artery (type IC)
Fig. 9.19 The gastroduodenal artery and its branch, anterior superior
pancreaticoduodenal artery supply the lower extrahepatic bile duct, and
form the anterior arch of the pancreaticoduodenal artery (type II)
the leading cause of postoperative biliary stricture and bile
leakage. There is a consensus that delayed biliary stricture
occurring in some patients after extrahepatic bile duct exploration is related to local compressive ischemic injury caused
by T-tube coarsening and tight suture.
Based on the 3D model, information such as the source,
course, and distribution of extrahepatic bile duct blood sup-
ply in patients with extrahepatic bile duct obstructive diseases, can be obtained to help carry out individualized
preoperative planning and surgical design. This provides
individualized anatomical guidance for the rational selection
of clinical biliary surgical plans.
9.4.1 Digital Classication ofExtrahepatic
Bile Duct Blood Supply forObstructive
Biliary Disease
Three-dimensional visualization and digital typing of extrahepatic bile duct blood supply were carried out in 41 patients
with extrahepatic bile duct obstructive disease (Yang 2017).
Inclusion criteria: extrahepatic bile duct dilatation (diameter
larger than 10mm), the indication of biliary tract operation,
common bile duct exploration, choledochojejunostomy, etc.
Exclusion criteria: previous abdominal surgery history,
changes in the extrahepatic bile duct and its adjacent anatomical structures.
The mean diameter of the extrahepatic bile duct
24.3 ± 5.1 mm (range 16–34 mm). Clinical diagnosis: 15
cases of choledocholithiasis (including lower common bile
duct stones, intrahepatic and extrahepatic bile duct stones), 5
cases of lower biliary tract inammatory stenosis, 21 cases
of pancreatic head or periampullary tumor. All patients
underwent 64-slice spiral CT angiography (CTA) scan of the
upper abdomen before the operation, and the extrahepatic
bile duct blood supply and its adjacent organs and blood vessels were reconstructed by the abdominal medical image
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