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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_585_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword I
- •Foreword II
- •Foreword III
- •Foreword IV
- •Contributors
- •Manuscripts Translation and Preparation
- •1.1 Introduction
- •Preface
- •Acknowledgments
- •Contents
- •Editors and Contributors
- •Deputy Editors
- •1.2.2.2 Gallbladder
- •1.2.2.3 Cystic Duct
- •1.2.2.4 Common Bile Duct
- •Supraduodenal Portion
- •Retroduodenal Portion
- •Pancreatic Portion
- •Intraduodenal Portion
- •1.3.2 Data Acquisition
- •1.3.2.2 Bile Duct Perfusion
- •1.3.2.3 Hepatic Artery Perfusion
- •1.3.2.4 Specimen Perfusion Fixation
- •1.4.1 Liver Dissection after Biliary Tract Perfusion
- •1.4.3.1 Image Registration After Bile Duct Perfusion
- •References
- •2.1 Introduction
- •2.2.1 Basic Principles
- •2.2.2.1 Methods
- •Preparation
- •Scanning Modalities
- •Contrast-Enhanced Scanning
- •Contrast-Enhanced Examination
- •Shaded Surface Display
- •Maximum Intensity Projection
- •Volume Rendering
- •2.3.1.1 MRI Devices
- •The Magnet
- •The Gradient System
- •The Radiofrequency System
- •Radiofrequency Coils
- •The Computer System
- •Other Auxiliary Equipment
- •2.3.2.1 MRI Preparations
- •Patient Preparation
- •2.3.2.2 Regular Scan Sequences
- •Single-Shot Turbo Spin-Echo Coronal Sequences
- •2D or 3D T2W1
- •Transaxial Single-Shot Turbo Spin-Echo Fat Suppression Sequences
- •Dynamic Enhancement Sequence
- •3D Volumetric Acquisitions
- •Advantages
- •Disadvantages
- •2D Continuous Thin-Slice Scanning
- •Advantages
- •Disadvantages
- •2D Thick-Slice Projection Imaging
- •Advantages
- •Disadvantages
- •References
- •3.1 Introduction
- •3.2 Congenital Biliary Diseases
- •3.2.1 Congenital Extrahepatic Biliary Atresia
- •3.2.1.1 CT Features
- •3.2.1.2 MRI Features
- •3.2.2 Biliary Dilatation
- •Type I
- •Type II
- •Type III
- •Type IV
- •Type V
- •3.2.2.2 Radiographic Features
- •CT Features
- •MRI Features
- •3.2.3 Bile Duct Hamartomas
- •3.2.3.1 CT Features
- •3.2.3.2 MRI Features
- •3.3 Common Gallbladder Diseases
- •3.3.1 Acute Cholecystitis
- •3.3.1.1 Radiographic Features
- •CT Features
- •MRI Features
- •Gangrenous Cholecystitis
- •Emphysematous Cholecystitis
- •Pediatric Cholecystitis
- •Pregnancy Cholecystitis
- •Gallbladder Empyema
- •Gallbladder Perforation
- •Hemorrhagic Cholecystitis
- •3.3.5 Other Gallbladder Tumors
- •3.3.5.3 Primary Gallbladder Lymphoma
- •3.3.5.4 Gallbladder Fibrosarcoma
- •3.3.6 Xanthogranulomatous Cholecystitis
- •3.3.6.1 CT Features
- •3.3.6.2 MRI Features
- •3.3.7 Gallbladder Adenomyomatosis
- •3.3.2 Chronic Cholecystitis
- •3.3.2.1 CT Features
- •3.3.2.2 MRI Features
- •3.3.3 Gallstones
- •3.3.3.1 CT Features
- •3.3.3.2 MRI Features
- •3.3.4 Gallbladder Cancer
- •3.3.4.1 CT Features
- •3.3.4.2 MRI Features
- •3.3.4.3 MRCP Features
- •3.3.7.1 CT Features
- •3.3.7.2 MRI Features
- •3.3.8.1 CT Features
- •3.3.9 Gallbladder Torsion
- •3.3.9.1 Type I
- •3.3.9.2 Type II
- •3.3.10.2 Gallbladder Sludge
- •3.3.11 Mirizzi’s Syndrome
- •3.3.11.1 CT Features
- •3.3.11.2 MRI Features
- •3.3.12 Post-Cholecystectomy Syndrome
- •3.4.1 Bile Duct Stones
- •CT Findings
- •MRI Findings
- •CT Findings
- •MRI Findings
- •3.4.2 Suppurative Cholangitis/Acute Cholangitis
- •3.4.3 Primary Sclerosing Cholangitis
- •3.4.3.1 CT Findings
- •3.4.3.2 MRI Findings
- •3.4.4 Secondary Sclerotic Cholangitis
- •3.4.5 Recurrent Pyogenic Cholangitis
- •3.4.5.1 CT Findings
- •3.4.6 Extrahepatic Cholangiocarcinoma
- •3.4.6.1 CT Findings
- •MRI Findings
- •MRCP Features
- •3.4.7 Intrahepatic Cholangiocarcinoma
- •3.4.7.3 Special Manifestations
- •3.4.8 Periampullary Carcinoma
- •3.4.8.1 Radiographic Findings
- •3.4.8.2 CT Findings
- •3.4.8.3 MRI Findings
- •3.4.9 Combined Hepatocellular-Cholangiocarcinoma
- •3.4.9.1 Imaging Findings
- •3.4.9.2 MRI Findings
- •3.5.1.1 Intrahepatic Biliary Dilatation
- •CT Findings
- •MRI Findings
- •3.5.1.2 Extrahepatic Bile Duct Dilatation
- •3.5.2.1 Hilar Obstruction
- •3.5.2.3 Pancreatic Obstruction
- •References
- •4.1 Introduction
- •4.1.2.1 CT Acquisition Protocols
- •4.1.2.2 Data Preprocessing
- •4.1.2.3 Medical Image Segmentation
- •4.1.2.4 3D Visualization
- •4.2.1 Image Registration
- •4.2.1.1 Template Matching Algorithm
- •4.2.1.2 Registration Steps
- •Step 1
- •Step 2
- •Step 3
- •4.2.2 Image Segmentation
- •Pixel Based Methods
- •Region Based Methods
- •Edge Based Methods
- •Model Based Methods
- •4.2.2.3 Serialized Segmentation Model
- •4.2.2.4 Adaptive Region Growing Algorithm
- •4.2.3 3D Reconstruction
- •References
- •5.1 Introduction
- •Fused Deposition Modeling
- •Stereolithography
- •Selected Laser Sintering
- •Direct Metal Laser Sintering
- •Laminated Object Manufacturing
- •Electron Beam Melting
- •Three-Dimensional Printing
- •High-Performance 3D Reconstruction Software
- •5.1.2.2 Medical Model Manufacturing
- •5.1.2.3 Tissue/Organ Regeneration
- •5.2.2 Digital Preparation
- •5.3.1.1 In Complex Liver Resection
- •5.3.1.2 In Liver Transplantation
- •5.3.2.1 In Cholangiocarcinoma Surgery
- •5.3.4 Prospects
- •References
- •6.1 Introduction
- •6.1.1 Virtual Anatomy
- •6.1.2 Surgical Simulation
- •Improved Doctor–Patient Relationship
- •Reduced Surgical Costs
- •Remote Intervention
- •6.2 Virtual Surgical Instruments
- •6.2.1 Geometric Modeling
- •6.2.2 Motion Modeling
- •6.2.3 Physical Modeling
- •6.3 Surgical Simulation
- •6.3.1 The Hardware System
- •6.3.2 Software System
- •6.3.2.1 FreeForm Modeling System
- •6.3.2.2 Open Graphics Library
- •6.3.2.3 Tactile Development Kit
- •6.4.4 Discussion
- •References
- •7.1 Introduction
- •References
- •8.1 Introduction
- •8.2 Duodenoscopy
- •8.3 Choledochoscopy
- •8.3.1 Preoperative Application
- •8.3.2 Intraoperative Application
- •8.3.3 Postoperative Application
- •8.4 Capsule Endoscopy
- •8.5 Laparoscope
- •8.6 Endoscopic Ultrasound
- •8.7 3D Visualization-Assisted Endoscopic Technology
- •References
- •9.1 Introduction
- •9.3.1.1 Arterial Phase
- •9.3.1.2 Portal Venous Phase
- •References
- •10.1 Introduction
- •10.2.1.2 Image Segmentation
- •10.2.1.3 3D Reconstruction
- •10.2.1.4 Surgical Simulation
- •Surgical Procedure
- •References
- •11.1 Introduction
- •11.2.2 Image Registration
- •References
- •12.1 Introduction
- •12.2.1 Imaging
- •12.2.2 Other Auxiliary Examinations
- •12.2.2.1 Biliary Manometry
- •12.2.2.2 Cholescintigraphy
- •12.2.2.3 Selective Celiac Arteriography
- •12.3.1 Collection Equipment
- •12.3.3 Plain Scan
- •12.3.4 Dynamic Enhanced CT Scan
- •12.4.1 Image Registration
- •12.6.1 Semiautomatic Liver Segmentation
- •Surgical Procedures
- •Surgical Procedures
- •12.10.2 Anatomical or Regular Hepatectomy Guided by 3D Visualization
- •12.10.2.1 Indications
- •12.10.2.2 Contraindications
- •12.10.2.4 Surgical Procedures
- •For Anatomical Right Hemihepatectomy
- •For Anatomical Left Hemihepatectomy
- •12.10.3.1 Contraindication
- •12.10.3.3 Surgical Procedures
- •Case 1
- •Case 2
- •12.10.4.1 Indications
- •12.10.4.2 Contraindication
- •12.10.4.4 Surgical Procedures
- •12.10.4.5 Attention
- •12.10.5.1 Indications
- •12.10.5.2 Contraindications
- •12.10.5.3 Surgical Procedures
- •12.10.5.4 Attention
- •12.10.6.1 Indications
- •12.10.6.2 Contraindications
- •12.10.6.3 Preoperative Imaging Evaluation
- •12.10.6.4 Surgical Procedures
- •12.10.6.5 Attention
- •12.10.7.1 Indications
- •12.10.7.2 Contraindications
- •12.10.7.3 Surgical procedures
- •12.10.7.4 Attention
- •12.10.8.1 Preoperative Evaluation
- •12.10.8.2 Preoperative Preparation
- •12.10.8.3 Contraindications
- •12.10.8.4 Operation Methods
- •12.10.8.5 Attention
- •12.10.9.1 Biliary Injury
- •Causes
- •Preventive Measures
- •12.10.9.2 Biliary Bleeding
- •12.10.9.3 Gastrointestinal Water Retention
- •Reasons
- •12.10.9.4 Biliary Leakage
- •12.11.1.1 Reasons
- •Main Reasons
- •Iatrogenic Biliary Tract Injury
- •Other Reasons
- •12.11.1.3 Surgical Procedures
- •Roux-en-Y Choledochojejunostomy
- •Hepatectomy
- •Intrahepatic Lithotripsy Through Sinus Tract or PTCS
- •Severe Symptomatic Patients
- •References
- •13.1 Introduction
- •13.3.1 Ultrasonography
- •13.3.2 Multi-Slice CT
- •13.3.5 Intraoperative Cholangiography
- •13.3.6 Radionuclide Hepatobiliary Scan
- •13.3.7 Digital Medicine Technology
- •Periampullary Tumor
- •Biliary Atresia
- •Acute Pancreatitis
- •Acute Cholecystitis
- •Hepatic Cyst
- •Hepatic Echinococcosis
- •Retroperitoneal Cystic Masses
- •13.4.2.1 Biliary Drainage
- •13.4.2.3 Liver Resection
- •13.4.2.4 Pancreaticoduodenectomy
- •13.4.2.5 Liver Transplantation
- •13.4.2.6 Laparoscopic Surgery
- •13.4.2.7 Reoperation
- •References
- •14.1 Introduction
- •14.1.1.1 Etiology
- •Anatomical Factors
- •Pathological Factors
- •Surgeon Factors
- •14.1.2.2 End-to-End Cholangiostomy
- •14.1.2.3 Choledochoduodenostomy
- •14.1.2.4 Roux-en-Y Cholangiojejunostomy
- •14.1.2.7 Liver Transplantation
- •14.2.2.1 Patient Information
- •14.2.2.2 Diagnosis
- •14.2.2.3 Complaint
- •14.2.2.4 History
- •14.2.2.5 Signs
- •14.2.2.6 Previous History
- •14.2.2.7 Laboratory Examination
- •Blood Routine
- •Coagulation Function
- •Liver Function
- •Renal Function
- •Tumor Markers
- •14.2.2.8 General Condition Assessment
- •Nutritional Status Evaluation
- •Liver Function Evaluation
- •Important Organ Function Evaluation
- •14.2.2.9 Imaging Evaluation
- •Evaluation by 3D Visualization
- •14.2.2.10 Surgical Planning
- •14.2.2.11 Surgical Procedures
- •Step 1
- •Step 2
- •Step 3
- •14.2.3.1 Patient Information
- •14.2.3.2 Diagnosis
- •14.2.3.3 Complaint
- •14.2.3.4 History
- •14.2.3.5 Signs
- •14.2.3.6 Previous History
- •14.2.3.7 Laboratory Examination
- •Blood Routine
- •Coagulation Function
- •Liver Function
- •Renal Function
- •Tumor Markers
- •14.2.3.8 General Condition Assessment
- •Nutritional Status Evaluation
- •Liver Function Evaluation
- •Important Organ Function Evaluation
- •14.2.3.9 Imaging Evaluation
- •Evaluation by 3D Visualization
- •14.2.3.10 Surgical Planning
- •14.2.3.11 Surgical Procedure
- •Step 1
- •Step 2
- •Step 3
- •References
- •15.1 Introduction
- •15.2 Clinical Stages
- •15.2.2 Surgical Strategy
- •Tis/T1a Stage
- •T1b Stage
- •Stage T2
- •Stage T3
- •Stage T4
- •15.2.2.2 Lymph Node Dissection Range
- •Stage Tis/T1a
- •Stage T1b
- •Stage T2
- •Stage T3
- •Stage T4
- •15.2.2.3 Extrahepatic Bile Duct Management
- •Stage Tis/T1a
- •Stage T1b
- •Stage T2
- •Stage T3
- •Stage T4
- •15.3.1 T Staging Assessment
- •15.3.1.1 Stage T2
- •MDCT
- •15.3.1.2 Stage T3
- •MDCT
- •15.3.1.3 Stage T4
- •15.3.3 Resectability Assessment
- •15.3.3.1 General Assessment
- •15.3.3.2 Liver Function Assessment
- •15.3.3.3 Virtual Surgery Assessment
- •15.4.1 Surgical Indications
- •15.4.2 Preoperative Preparation
- •15.4.2.3 Preoperative 3D Visualization Evaluation
- •15.4.3 Surgical Procedures
- •15.4.3.1 Resection Range
- •Radical Pancreaticoduodenectomy
- •15.4.4 Surgical Prognosis
- •References
- •16.1 Introduction
- •16.2.2.2 Imaging Diagnosis
- •16.2.2.3 Pathological Diagnosis
- •16.2.2.4 Clinical Staging
- •16.2.3.1 Preoperative Assessment
- •Liver Function Assessment
- •Resectability Assessment
- •3D Visualization Assessment
- •16.2.3.2 Surgical Approach
- •16.2.3.3 Controversial Point
- •Lymphadenectomy
- •Extended Hepatectomy
- •Liver Transplantation
- •Operative Prognosis
- •16.2.4 Multidisciplinary Team
- •16.2.5 Conclusion
- •Notes
- •16.3.4 Surgical Planning Guided by 3D Visualization
- •Type I
- •Type II
- •Type IIIa
- •Type IIIb
- •Type IVa
- •Type IVb
- •Type V
- •16.3.6.2 Typical Case
- •Case 1
- •Case 2
- •Case 3
- •Case 4
- •Case 5
- •16.3.6.4 Lymphadenectomy
- •16.3.6.6 Laparoscopic Exploration
- •16.3.6.7 Intraoperative Frozen Section Consultation
- •16.3.6.8 Liver Transplantation
- •Common Type
- •Type II Variation
- •Type III Variation
- •16.3.10 Other Comprehensive Treatment
- •16.3.11 Other Perioperative Management
- •16.3.11.2 Postoperative Follow-Up
- •References
- •17.1 Introduction
- •17.2.2.1 Perihilar Tumor
- •17.2.2.2 High Biliary Stricture
- •Hepatic Arterial Variation
- •Portal Vein Variations
- •Bile Duct Variations
- •17.3.2 Complex Pathophysiology
- •17.4.1.3 Preoperative Biliary Drainage
- •17.4.2.3 Cholangiojejunostomy
- •17.6 3D Visualization Imaging
- •Viscera Reconstruction
- •Lesion Reconstruction
- •Vascular Reconstruction
- •References

16 Digital Diagnosis andManagement ofCholangiocarcinoma
397
considered. The main portal vein was not invaded; the right
hepatic artery was not invaded. The left lobe of the liver was
signicantly atrophied with a compensatory proliferation of
the right lobe (Figs.16.33 and 16.34). After admission, the
patient underwent percutaneous transhepatic cholangial
drainage (PTCD) of the right liver, with drainage time of
6 days, and the total serum bilirubin was reduced to
66.0mol/L by preoperative review.
3D Outcome Three-dimensional reconstruction showed that
the middle hepatic artery was invaded, while the left and right
hepatic arteries were not. The right hepatic artery originated
from the superior mesenteric artery. The left branch, bifurcation, and right branch of the portal vein were invaded, and the
main portal vein was not affected (Figs.16.35 and 16.36). The
tumor was a Bismuth IVb type, and left hepatectomy combined with the right portal vein resection was initially planned.
Surgery and Pathology No metastasis of omentum or
liver was found after surgical exploration. Noticeable hard
Fig. 16.33 Cross-sectional CT image shows a tumor (red arrow) with
a majority to the left
Fig. 16.34 Coronal CT image shows invasion of the left portal vein
and local wall stenosis in the initial segment of the right portal vein.
Tumor invasion is considered. The left lobe of the liver is atrophic with
compensatory hyperplasia of the right lobe. Note: 1. Left portal vein; 2.
Main portal vein; 3. Right portal vein
Fig. 16.35 EDDA IQQA-Liver shows the spatial localization of the
tumor
Fig. 16.36 EDDA IQQA-Liver shows the relationship of the tumor to
the hepatic artery and portal vein

398
mass was found in the hilum, with extensive involvement on
both sides, and atrophy of the left lobe of the liver. The hilar
part of the liver had enlarged lymph nodes with a hard texture. The common hepatic artery sheath was opened, and the
enlarged lymph nodes around the common hepatic artery
were dissected and separated. The gastroduodenal artery,
proper hepatic artery, and left hepatic artery were dissected
successively to the proximal end; the right hepatic artery
was dissected along the right margin of the hepatic duodenal
ligament, and the surrounding connective tissue was dissected from the main portal vein to the hepatic portal. The
distal end of the common bile duct was cut off close to the
pancreas, and the bile duct was pulled away to the hilum of
liver. The tumor was mainly located in the left hepatic duct,
invading the left branch of the portal vein, bifurcation, and
main portal vein, which exceeded the evaluation results of
preoperative imaging and three-dimensional reconstruction.
However, the extent of invasion of the right portal vein
branch was not clear. Due to the deep position of the right
portal vein branch, the proximal invasion of the hepatic portal vein could not be determined by the anatomy of the
hepatic portal vein. Combined with CT images, the splitting
of the middle hepatic ssure and the opening of the hepatic
portal plate were considered to determine the resectability
after further exploration. Partial hepatic parenchyma was
separated from the side of the hepatic portal, and the hepatic
portal plate was opened. The right hepatic duct was separated from the normal texture of the bile duct, and two bile
duct openings could be seen at the broken end, which were
right anterior and right posterior bile duct openings, respectively. Under the immediate circumstance, it could be
observed that the origin of the right branch of the portal
vein, the bifurcation, the left branch, and main trunk of the
right portal vein were invaded by tumors, but the resection
and reconstruction could be completed. It was decided to
combine left hepatectomy with portal vein resection and
reconstruction (Figs.16.37, 16.38, 16.39, and 16.40).
Postoperative pathological diagnosis: bile duct adenocarcinoma, grade II–III, mass size 1.8cm × 1.5cm × 1.5 cm,
inltration of hepatic parenchyma and hepatic adipose
brous connective tissue, invasion of the hepatic duct, nerve
invasion, and intravascular tumor thrombus. No residual
tumors were found in the incised margin of the liver. No
tumor involvement was found at the cutting edge of the
hepatic duct and right anterior bile duct. Tumor tissue can
be seen at the portal vein pedicle. Tumor metastasis was
found in lymph nodes (adjacent to the right hepatic artery
and common hepatic artery). No metastasis was found in the
lymph nodes of group 13 (0/1).
Case 3
A 65-year-old man was admitted to the hospital because of
“upper abdominal pain with skin sclera yellowing for 10
F. Shen et al.
Fig. 16.37 Skeletonization of the hepatoduodenal ligament. Note: 1.
Main portal vein; 2. The right hepatic artery originating from the superior mesenteric artery; 3. Left hepatic artery
Fig. 16.38 After splitting and opening the hepatic portal plate, the
tumor can be seen invading the left portal vein, main branch, and the
starting part of the right portal vein
days.” On admission, total serum bilirubin and conjugated
bilirubin were 152.9μmol/L and 116.8μmol/L, respectively.
Tumor markers: CA 19-9 was signicantly elevated at
438.5 U/mL, and alpha-fetoprotein and carcinoembryonic
antigen were negative. Upper abdomen enhanced CT showed
hilar bile duct space-occupying lesions with intrahepatic bile
duct dilatation. The diagnosis was obstructive jaundice and
hilar bile duct space-occupying lesions. Bilateral transdermal hepatic puncture biliary drainage was performed after
admission. The drainage time was 7days. The preoperative
serum total bilirubin was reduced to 84.6μmol/L.
Imaging Assessment
Enhanced CT showed that the main
body of the lesion deviated to the right side, the tumor
invaded the right main branch of the portal vein, the left bile
duct system invaded more than the junction of B2 and B3

16 Digital Diagnosis andManagement ofCholangiocarcinoma
Fig. 16.39 Combined with left hemihepatectomy and portal vein
resection and reconstruction. Note: 1. Middle hepatic vein; 2. The opening of the right posterior bile duct; 3. The opening of the right anterior
bile duct; 4. Right hepatic artery; 5. Reconstructing anastomosis of the
right portal vein
399
Fig. 16.41 Coronal CT image: tumor invasion of the right main portal
vein (arrow)
Fig. 16.40 Portal venous phase of CT: low-density mass in the hilum
(arrow) with intrahepatic bile duct dilatation
bile ducts. The left branch of the portal vein, bifurcation, and
left hepatic artery were not involved (Figs.16.40, 16.41, and
16.42). Cholangiography showed that B4 merged into the
B3-bile duct, and the B2-bile duct did not develop. The
tumors were Bismuth IV type a, and right trisectionectomy
was proposed.
3D Outcome The spatial location of the tumor, the degree
of bile duct invasion, and its relationship with the peripheral
blood vessels were visually displayed. There was a variation
of conuence mode in the left bile duct, that is, the fourth
segment of the hepatic bile duct rst converged into the
Fig. 16.42 Cholangiography. Note: 1. Bile duct of segment IV; 2. Bile
duct of segment III
third segment of the hepatic bile duct to form the trunk, and
the second segment of the hepatic bile duct then converged.
The whole liver volume was measured by three-dimensional
3
reconstruction software. Total liver volume was 1944cm
,
the left lobe liver volume was 838cm3 (43.1%), and the left
lateral lobe volume 449.3cm3 (23.1%). The residual left lateral lobe volume was insufcient after combined right trisectionectomy. Meanwhile, the distance between the
boundary of the left tumor and the limit point of left hemihepatectomy (U point) was 15.2 mm on the three-dimensional reconstruction image. The simulation of a 10-mm
surgical margin showed that a satisfactory negative margin
could be obtained by combined right hemihepatectomy
(Fig.16.43).
Surgery and Pathology The right branch of the portal vein
was found to be invaded by tumor after the calcication of
the hepatic duodenal ligament; the bifurcation of the portal

400
F. Shen et al.
third, and fourth segments of the hepatic duct, respectively
(Fig.16.44). The rapid pathology of proximal and distal incision margins of the bile duct was negative. The operation
time was 450min, the intraoperative blood loss was 400ml,
and no blood transfusion was performed. Routine pathology:
bile duct adenocarcinoma, grade II–III, the mass invaded the
whole layer of the bile duct to the surrounding adipose
brous connective tissue, inltrating the liver parenchyma,
and the tumor was observed to invade the nerve; Cancer
metastasis was found in lymph nodes of group 12 (1/1), and
no cancer metastasis was found in lymph nodes of group 8
and group 13 (0/1 and 0/2). Chronic inammation was found
in both the distal bile duct margin and the left hepatic duct
margin.
Fig. 16.43 EDDA IQQA-Liver 3D reconstruction: a direct view of the
tumor (yellow mass) and the conuence pattern of the left biliary tract
system; set the 10-mm simulated surgical resection margin, and it can
be seen that the limit of the left biliary tract system is within the limit
point (U point) of the right liver resection. Note: 1. The bile duct in
hepatic segment II; 2. The bile duct in hepatic segment III; 3. The bile
duct in hepatic segment IV
Case 4
A 66-year-old man was admitted to the hospital because of
“half a month of hilar space found by physical examination.” On admission, total serum bilirubin and conjugated
bilirubin were 14.6 μmol/L and 5.9 μmol/L, respectively.
Tumor markers: CA 19-9 was 33.4U/mL, and alpha-fetoprotein and carcinoembryonic antigen were negative. MRCP
showed hilar space-occupying and right anterior bile duct
dilatation (Fig. 16.45). Upper abdomen enhanced CT
showed hilar bile duct wall thickening and intrahepatic bile
duct dilatation. The diagnosis was a hilar bile duct spaceoccupying lesion.
Imaging Assessment
Cross-sectional CT images showed
that the main body of the tumor was in the right anterior bile
duct with signicant dilatation of the right anterior bile duct
Fig. 16.44 Hepatic cross section after right hepatectomy with total
caudate lobectomy. Note: 1. Bile duct in hepatic segment II; 2. Bile duct
in hepatic segments II and III; 3. Left hepatic artery; 4. Main portal
vein; 5. Left portal vein; 6. Middle hepatic vein
vein, the left branch, and the hepatic artery were not involved.
The right margin of the sagittal portion of the portal vein was
touching a segment of the soft bile duct; right hemihepatectomy was performed as scheduled. Intraoperative ultrasonography was used to locate the route of the middle hepatic
vein, and the dissociation plane of liver parenchyma was
marked with an electric knife. The left hepatic duct was
amputated about 5mm from the tumor boundary. Two bile
duct openings were observed in the hepatic section. Biliary
duct probes were used to identify movement in the second,
Fig. 16.45 MRCP indicates that the bile duct at the hilar region is
truncated and the right anterior bile duct is signicantly dilated

16 Digital Diagnosis andManagement ofCholangiocarcinoma
401
and mild dilatation of the left hepatic duct. The tumor
surrounded the right anterior branch of the portal vein, and
the transverse part of the left branch of the portal vein might
be invaded (Figs. 16.46 and 16.47). The right posterior
branch of the portal vein, main trunk, and hepatic artery were
not involved by tumors. The tumor was of Bismuth IIIa type,
and the right hepatectomy combined with resection and
reconstruction of the left branch of the portal vein was preliminarily proposed.
3D Outcome The whole liver volume was measured by
three-dimensional reconstruction software. Total liver volume was 768cm 3, the left lobe liver volume was 146cm3
(19.0%), and the left lateral lobe volume 417cm3 (54.3%).
Since the reserved left hepatic volume after right hepatectomy is only 19.0%, and the possibility of postoperative liver
failure is extremely high, it is proposed to switch to right
Fig. 16.46 Contrast-enhanced CT suggests that a tumor (yellow
arrow) may have invaded the left portal vein (blue arrow)
Fig. 16.47 Contrast-enhanced CT suggests the tumor (yellow arrow)
invading the right anterior portal vein (blue arrow)
anterior lobectomy + caudate lobectomy + left portal vein
branch resection and reconstruction, the reserved liver volume can reach 73.3%. However, should this procedure be
performed, there would be two liver transections, bilateral
choledochointestinal anastomosis, more frequent intraoperative bleeding, and a higher incidence of postoperative complications, all of which would increase the difculty of
surgery. Through three-dimensional visualization, it was
shown that the patient had an anatomic variation of the portal
vein, that is, the right anterior portal vein was originated
from the left portal vein; the bifurcation and course of right
hepatic were lower and farther away from the tumor; the
middle hepatic vein was slender, the right hepatic vein was
thick and there were branches of the right posterior inferior
hepatic vein. Thanks to the identication of the abovementioned anatomical variations and the measurement of
liver volume, we believed that the combined resection of
hepatic SIII could simplify the surgical procedures to the
greatest extent and conform to the principle of complete
tumor resection while retaining sufcient functional liver
volume.
Surgery and Pathology
Intraoperative exploration revealed
no cholestasis in the liver, small left lobe, and atrophy of
right anterior lobe. Hard masses were palpable in the right
anterior portal area; the Rouviere groove was soft on palpation with the left hilum. No enlarged lymph nodes or metastatic lesions were found in the hepatoduodenal ligament, the
common hepatic artery, the peritoneal trunk, or the pelvic
cavity. An intraoperative ultrasound examination revealed no
intrahepatic metastases. It was decided that the resection of
hepatic SIII should be carried out according to the scheduled
plan. First, the regional lymph nodes were cleared, and the
following were freed, including the trunk of right posterior
branch and the initial segment of the left branch of the portal
vein, the trunk, the right anterior and the right posterior
branch of the right hepatic artery, and the initial segment of
the left hepatic artery; the left hepatic artery, the right anterior hepatic artery and the left portal vein branches were
separately ligated and severed. The liver parenchyma was
isolated along the ischemia-dividing line between the right
anterior lobe and the right posterior lobe. The resection margin between the distal bile duct and the right posterior bile
duct was conrmed to be free of tumor residue by rapid
intraoperative pathological examination. The operation time
was 270min, with 600ml intraoperative blood loss and no
blood transfusion. Conventional pathology results: bile duct
adenocarcinoma, grade II~III, mass size 2.0cm × 1.5cm ×
1.0cm, involving the liver parenchyma, visible focal neural
invasion; no cancer metastasis were found in lymph nodes of
group 12, group 8, and group 13 (0/4, 0/3, 0/2). The distal
bile duct and the cutting edge of the right posterior bile duct
were chronically inamed.

402
Case 5
A 74-year-old male was admitted to the hospital for “yellow
skin and sclera for 2 months.” There was a history of hepatitis B for 20 years and hypertension for 10 years.
Cholecystectomy was performed in 1988. Routine examination after admission: ALT 61.7IU/L, AST 57.4IU/L, TBIL
31.8 μmol/L, DBIL 15.8 μmol/L. Tumor markers:
CA19-9 > 1000 U/mL, AFP 4.4 ng/mL, CEA 3.8 ng/
mL.Enhanced CT examination of the upper abdomen: the
hilar was occupied with a diameter of about 1.2cm, accompanied by signicant ICC expansion, which was considered
as a possibility of hilar cholangiocarcinoma.
Imaging Assessment Enhanced CT showed that the main
body of the tumor deviated to the left, involving the right
hepatic duct and the opening of the hepatic IV bile duct.
Portal vein and hepatic artery were not invaded. MRCP
images showed the presence of accessory right hepatic duct
(Figs.16.48, 16.49, 16.50, and 16.51). Due to tumor invasion
to the opening of the left secondary bile duct branch, the
classication and staging were: Bismuth IIIb, MSKCC T1.
Surgical planning: left hemihepatectomy + caudate lobectomy + hilar lymph node dissection + right hepatic ductjejunum Roux-en-Y anastomosis.
F. Shen et al.
Fig. 16.49 Arterial phase: the right hepatic artery is not invaded. Note:
1. Tumor; 2. Right hepatic artery
3D Outcome 3D reconstruction images suggested that the
patient’s bile duct in hepatic segment VI was the Infraportal
type, that is, the segment VI bile duct ran under the right
branch of the portal vein and directly entered the common
bile duct; it was invaded by the tumor at the opening of the
segment VI bile duct. Bile duct in hepatic SVII converged
into the right anterior bile duct to form the right hepatic duct;
Fig. 16.50 Venous phase: the opening of IV segmental bile duct (black
arrow) is invaded by the tumor
meanwhile, the bile duct of the hepatic S IV was merged into
the left hepatic duct near the hepatic hilum. The involvement
of the left and right bile ducts of the tumor was a long distance from the corresponding limit points (U and P points)
(Fig. 16.52). Based on the identication of the anatomical
structure and the re-judgment of the extent of bile duct invasion by 3D reconstructed images, a satisfactory tumor-free
cutting margin could be achieved free of extensive hepatectomy, and simple extrahepatic bile duct resection was
proposed.
Fig. 16.48 CT multi-plane reconstruction shows that the tumor body
is skewed to the left
Surgery and Pathology
The rst hepatic hilum was dis-
sected, and lymph nodes in groups 8, 12, and 13 were cleared.
The main portal vein and hepatic artery were not invaded by
the tumor, which was consistent with the 3D imaging evalu-

16 Digital Diagnosis andManagement ofCholangiocarcinoma
403
Fig. 16.51 The MRCP image shows the accessory right hepatic duct
(arrow)
Fig. 16.52 EDDA IQQA-Liver 3D image shows tumor spatial location, relative relationship between tumor boundaries and the limit point,
and hepatic hilar anatomic variation. Note: 1. VII segmental bile duct;
2. VI segmental bile duct; 3. IV segmental bile duct. U-point: The turning point between the transverse part of the left portal vein and the
sagittal part; P-point: The starting part of the right posterior portal vein
Fig. 16.53 Post simple extrahepatic cholangiectomy. Note: 1. Right
hepatic duct; 2.2. VI segmental bile duct; 3. Right hepatic artery; 4. Left
hepatic artery; 5. Left hepatic duct
duct and the right hepatic duct were cut off 5mm away from
the tumor boundary. Five bile duct openings were observed
on the hepatic section, namely: the hepatic duct, the left
hepatic duct, the left caudate lobe bile duct (about 2mm in
diameter), the right hepatic duct in the segment IV of the
liver, and the hepatic duct in segment VI of the liver. The
results of the rapid pathological examination were all negative. The caudate lobe bile duct was sutured and closed. The
left hepatic duct and the bile duct and right hepatic duct in
segment IV of the liver were formed into one opening.
Together with segment VI of the liver, Roux-en-Y cholangiojejunostomy were performed separately (Fig.16.53). Routine
pathological examination results: grade II–III cholangioadenocarcinoma with a mass size of 3cm × 1.5cm × 1cm inltrated the whole wall of the duct, and nerve invasion could be
observed. No tumors were found in the incision margins of
bile ducts (distal bile duct, left lateral lobe bile duct, bile duct
in segment IV of the liver, left caudate lobe bile duct, bile
duct in segment VI of the liver, and right hepatic duct). No
metastasis was found in lymph nodes of groups 8, 12, and 13
(0/1, 0/4, 0/2).
ation. The bile duct was separated from the superior margin
of the pancreas, and the incision margin was used for rapid
postoperative pathology: (distal margin) chronic inammation of the mucosa. The bile duct was pulled upward, and it
was removed from the posterior part of the bile duct and
lymphatic connective tissue around the portal vein to the
bifurcation of the portal vein. It was found that the bifurcation of the portal vein and the initial part of the left and right
branches were not invaded by the tumor. The left hepatic
16.3.6.3 The Extent ofParenchyma Resection
Combined hepatectomy can signicantly improve the surgical resection rate of hilar cholangiocarcinoma, reduce tumor
recurrence, and prolong patient survival. Since the upper
caudate lobe is located behind the rst hepatic hilum and the
bile duct of the caudate lobe is often directly merged into the
conuence of the left and right hepatic ducts, the caudate
lobe is prone to tumor invasion. For tumors involving the
conuence of the left and right hepatic ducts, total caudate

404
F. Shen et al.
lobectomy should be performed routinely to improve the
radical resection rate.
Simple extrahepatic bile duct resection is mainly suitable
for Bismuth-Corlette type I and papillary tumors.
Anatomically, the left hepatic duct is longer than the right
hepatic duct, and the right hepatic artery runs behind the common bile duct. In order to obtain a satisfactory negative margin, based on the above-mentioned anatomical factors, some
scholars have proposed the combination of right hemihepatectomy and total caudate lobectomy as a surgical strategy for
Bismuth-Corlette type I and II tumors. Studies suggest it can
improve the radical resection rate of the Bismuth-Corlette
type I and II cancers and reduce the postoperative local recurrence rate. However, in previous studies, the main indication
of combined lobectomy in the treatment of early hilar cholangiocarcinoma was when combined with vascular invasion,
especially of the right hepatic artery. Therefore, a clear picture of the resection rate and survival rate of this surgery
method itself remains to be further conrmed.
For Bismuth-Corlette type III and IV hilar cholangiocarcinoma, large-scale hepatectomy is a common surgical procedure. In most cases, the extent of hepatic parenchyma
resection is determined by the main site of the lesion.
Combined right hepatectomy is suitable for Bismuth-Corlette
type IIIa and IVa tumor and combined left hepatectomy is
suitable for Bismuth-Corlette type IIIb and IVb tumors.
Combined hemihepatectomy was performed in cases where
negative margins were expected to be obtained within the
limit point of hemihepatectomy retaining the lateral biliary
tract system. Images indicated that combined trisectionectomy should be performed to achieve radical resection when
the tumor boundary is close to or beyond the reserved hemihepatectomy limit. Also, combined right trisectionectomy is
suitable for Bismuth-Corlette type IIIb or IV tumors with
right hepatic artery invasion or right hepatic atrophy.
Combined trisectionectomy is mainly suitable for cases
where combined hemihepatectomy fails to obtain negative
margins. It has not been widely used in China due to the
small size of the residual liver, long perioperative treatment
time, and a high incidence of postoperative liver failure. For
Bismuth-Corlette type IV tumors with primary invasion of
the bile duct in hepatic segment IV and right anterior hepatic
duct, combined resection of the middle lobe (hepatic segment IV, V, VII) and total caudate lobe can preserve more
liver parenchyma based on radical treatment and reduce the
possibility of postoperative liver failure. However, midlobectomy is difcult and has a high incidence of complications. It can only be implemented selectively.
Although expanding the scope of liver parenchyma resection can improve the rate of radical resection, the incidence
of postoperative complications and mortality is higher. Also,
in the case of hilar cholangiocarcinoma without microvascular invasion, some scholars advocate small-scale hepatec-
tomy, which includes segment IVb+V+I of the liver. The
advantage of this method lies in that it can fully expose the
left and right hepatic pedicles and retain more functional
liver parenchyma based on the maximization of the biliary
tract cutting edge. However, due to the limitations of the surgical approach and the complex process of choledochointestinal reconstruction, the treatment of hilar cholangiocarcinoma
with small-scale hepatectomy has not been widely used.
Many factors, such as biliary tract involvement, vascular
invasion, anatomical variation, and residual liver volume,
should be considered in the selection of the specic extent of
hepatectomy. With the advance of hepatectomy instruments
and the maturity of vascular reconstruction technology, segmental hepatectomy based on accurate image evaluation is a
surgical strategy for hilar cholangiocarcinoma. It is based on
the actual extent of tumor involvement and anatomical variation, guided by segmental hepatic duct orice, and combined
with the cut-off limit point to design an individualized and
precise surgical scheme. However, only selective implementation is available at present. There are no relevant results of
clinical research. The specic approach of surgical exploration should be based on the diagnosis and treatment experience of each center. For those who lack experience in hepatic
artery reconstruction, the arterial approach is preferred. The
right hepatic artery should be explored rst to determine the
extent of resectability or hepatic parenchyma resection. For
the centers with rich experience in vascular reconstruction, a
transhepatic-portal approach can be adopted. The procedure
is described as follows: the partial hepatic parenchyma is
separated from the side of the hepatic portal, the hepatic portal plate is opened, the lateral vascular structure is dissected
and preserved, the proximal bile duct is separated, and the
proximal bile duct and hepatic duodenal ligament are separated after no tumor cutting edge is dened, and then the
distal bile duct and hepatic duodenal ligament are skeletal.
Separate partial hepatic parenchyma from the side of the
hepatic portal rst, open the portal plate, dissect and preserve
the structure of the lateral vessels, cut off the proximal bile
duct, separate the proximal bile duct and hepatic duodenal
ligament after the tumor-free cutting edge is conrmed, and
then cut off the distal bile duct and achieve the skeletalization of the hepatoduodenal ligament.
16.3.6.4 Lymphadenectomy
Lymph node dissection in the hilar region is an important
part of radical surgery, and the peripheral nerve connective
tissue should be stripped away close to the outer membrane
of the blood vessel to prevent residual nerve tissue inltrated
by the tumor. The principle of artery priority is often adopted
in the clearance of the hilar area; that is, the sheath of the
artery is peeled along the proper hepatic artery and gradually
cleaned to the proximal end, until the bifurcation of the left
and right hepatic artery is exposed. The common bile duct

16 Digital Diagnosis andManagement ofCholangiocarcinoma
405
was pulled laterally to expose the portal vein behind the bile
duct, and the surrounding tissue was cleaned proximally to
the bifurcation of the portal vein. Through careful anatomy
to form the skeletal area of the hilar area during operation,
the actual invasion range of the tumor was further determined, and the resectability was claried. If the bile duct
cannot be clearly separated from the breakpoint outside the
liver, the liver parenchyma can be cut along the median ssure, and the hepatic portal plate can be opened to explore
the extent of proximal tumor invasion fully.
Lymph node metastasis is one of the important factors
suggesting a poor prognosis of hilar cholangiocarcinoma,
with an incidence of 30%–50%. There is still some controversy about the extent and number of lymph node dissections, and whether enlarged lymph node dissection can more
accurately indicate prognosis or improve survival. A multicenter study in Italy suggests that the number of lymph
nodes to be cleaned is at least 5 but cleaning more than 6
enlarged nodes fails to improve long-term survival signicantly (Giuliante etal. 2016). Some scholars believe that for
patients with regional negative lymph nodes, enlarged dissection is necessary to clarify the status of these lymph
nodes, but it is impossible to improve the survival time of
patients with positive lymph nodes. In the latest AJCC
eighth edition cancer staging system, the standard for stratication of lymph node metastasis was changed from the
lymph node metastasis in the seventh edition to the number
of regional positive lymph nodes, that is, the number of positive lymph nodes in N1 was 1–3, and the number of positive
lymph nodes in N2 was at least 4. However, the minimum
number of lymph nodes detected was not clearly dened.
Currently, regional lymph nodes to be routinely dissected
for hilar cholangiocarcinoma include the hepatic duodenal
ligament (group 12), the common hepatic artery (group 8),
and the lateral and upper pancreatic head lymph nodes
(group 13a). When a regional lymph node is negative or distant lymph node metastasis such as para-aortic metastasis is
detected, the extent of dissection can be expanded to provide more accurate staging information and guide further
postoperative treatment. Since the 3D visualization technology cannot determine the nature of the lymph node, the
intraoperative guidance of 3D visualization for lymph node
is not elaborated in this book.
16.3.6.5 Combined Vascular Resection
andReconstruction
Due to the biological characteristics of multi-polarization
inltration of hilar cholangiocarcinoma and its anatomic
proximity to important blood vessels in the hilar area, vascular invasion is prone to occur. It is difcult to accurately
determine the invasion or adhesion between tumor and blood
vessels by imaging examination. Moreover, actual surgical
exploration is still the gold standard. If it is found that the
blood vessel wall is partially grayish-white, hard, and cannot
be easily peeled off from the tumor during the operation, it is
regarded as a vascular invasion. Advanced hilar cholangiocarcinoma complicated with vascular invasion is no longer a
taboo for radical surgery. It is necessary to completely dissociate the uninvolved vessels in the upper and lower segments during the operation. The reconstruction methods
after segmental vascular resection, including end-to-end
anastomosis, articial blood vessel, or autologous blood vessel reconstruction, are determined according to the actual
degree of invasion.
Combined resection and reconstruction of the affected
portal vein can improve the radical resection rate and longterm survival rate of locally advanced hilar cholangiocarcinoma. However, when it refers to that of the involved hepatic
arteries, controversy still exists. Due to the limitation of arterial reconstruction techniques, most surgeons believe that the
tumor cannot be resected when the retained hepatic artery is
found to be invaded. Despite poor overall prognosis and
higher incidence of postoperative complications, prognosis
for patients with hepatic artery reconstruction is signicantly
better than those with unresectable hepatic artery. Therefore,
when hepatic artery invasion becomes the only hindrance to
radical resection, hepatic artery reconstruction should be
considered when technical conditions permit. The key to
improve the quality of arterial anastomosis and reduce the
occurrence of related complications is to construct a 3D
visualization model of the hepatic artery before the operation, to determine the length and extent of invasion, and to
apply careful vascular anatomy and microsurgical
techniques.
16.3.6.6 Laparoscopic Exploration
Compared with gallbladder carcinoma and ICC, hilar bile
duct carcinoma is less likely to have distant metastasis. For
patients with resectable primary lesions, the signicance of
laparoscopic exploration is to nd small lesions in the
abdominal wall and omentum that cannot be recognized by
images, to avoid unnecessary laparotomy. However, the conventional application of laparoscopic exploration before a
laparotomy is controversial in clinical practice. With the
advance of imaging technology, the positive ndings of laparoscopy will be signicantly reduced. Laparoscopic ultrasound examination is greatly inuenced by the experience
and manipulation of the operator. Therefore, it is unnecessary to perform routine laparoscopic exploration for patients
with hilar cholangiocarcinoma. If there are suspected metastases on imaging, but they cannot be clearly identied, laparoscopic exploration and biopsy can be conducted in advance
to clarify the nature of the lesions and determine the next
treatment plan.

406
F. Shen et al.
16.3.6.7 Intraoperative Frozen Section Consultation
Because cholangiocarcinoma has the characteristic of inltrating along the mucosa or submucosa, it is difcult to accurately determine the extension of the tumor along the axis of
the bile duct tree by imaging. Intraoperative frozen section is
of great signicance for judging the state of incision margin
and dening the radical treatment of tumors during operation
and should be routinely carried out. The incidence of positive margin (R1 resection) in hilar cholangiocarcinoma was
about 25%. Whether further resection is necessary for
patients undergoing R1 resection is still uncertain. The primary method to reduce R1 resection is based on an accurate
imaging assessment and a suitable range of liver resection.
For patients with a positive distal incision margin, it is often
necessary to combine pancreaticoduodenectomy for radical
treatment.
16.3.6.8 Liver Transplantation
For unresectable hilar cholangiocarcinoma, the only hope for
a cure is liver transplantation. However, there have been very
few reports on liver transplantation in China due to the shortage of donor liver resources, the poor effect of transplantation in the early years, and the differences in the standard of
unresectable liver cancer among various centers. In the past
decades, the Mayo clinic has performed liver transplantation
for unresectable hilar cholangiocarcinoma with rigorous
selection criteria combined with multi-modality neoadjuvant
therapy, with encouraging results. Recent clinical studies at
12 transplant centers in the United States, including the
Mayo Clinic, have demonstrated that neoadjuvant chemoradiotherapy improves the efcacy of liver transplantation in
treating hilar cholangiocarcinoma, with a 5-year tumor-free
survival rate of 65% (Darwish Murad etal. 2012). The strict
control of the indications of liver transplantation for hilar
cholangiocarcinoma is the key to reduce tumor recurrence
and to achieving long-term survival after transplantation. For
patients with tumor >3cm and lymph node metastasis, the
risk of recurrence and death after transplantation increased
three times.
16.3.7 Surgical Planning forIntrahepatic
Biliary Variations inHilar
Cholangiocarcinoma Guided by 3D
Visualization
16.3.7.1 Surgical Planning ofPortal Vein
Variation Guided by 3D Visualization
(Fig.16.54)
Limit point of the normal portal vein, and bile duct separation (U point: the angle between the horizontal and sagittal
part of the left portal vein; P point: the bifurcation of the
right anterior branch and the right posterior branch of the
portal vein) refers to the limit point where bile duct can be
separated from the parallel portal vein and hepatic artery
during hepatectomy. The upstream bile duct at this limit
point cannot be separated and cut off alone. Through 3D
visualization analysis of the limit points (P points and U
points), and liver 3D printing, the normal portal vein and
various variations of portal vein P points and U points can be
observed in a three-dimensional and all-round way, thus
guiding the formulation of surgical plans and accurate
surgery.
Common Type
Under this situation, the limit point (U point) of left-sided
biliary ducts is located on the reverse turn between horizontal part and sagittal part of left branch of portal vein in the
right hepatectomy. Limit point (P point) of right-sided biliary ducts is located on the bifurcate portion of portal vein
between the right anterior branch and right posterior branch.
Type IVariation
Right-anterior branch, right posterior branch, and left branch
of portal vein emerge as trifurcation because the trunk of left
branch still exists, the U point is determined, and P point
moves toward porta hepatis.
Type II Variation
The trunk of portal vein branches off right posterior branch
rst, and in its way upward, it branches off right anterior and
left branches. In this situation, the P point is determined the
and U point moves toward the porta hepatis.
Type III Variation
The trunk of the portal vein divides the right posterior branch
directly, and the right anterior branch originates from the
trunk of portal vein left branch. In this situation, the P point
moves toward porta hepatis.
Thus, when types I, II, and III variations happen, the U
point is xed, and the P point moves toward porta hepatis. In
this situation, when hilar cholangiocarcinoma requires right
hemihepatectomy, we should isolate the trunk of the portal
vein, right anterior branch, and left branch, respectively. We
then resect the right anterior branch of the portal vein when
we have protected the trunk and left branch of the portal
vein. On the other hand, when patients undergo left hemihepatectomy, we should isolate the left branch and right
anterior branch of the portal vein, and then resect the left
branch of the portal vein when we have protected the right
anterior branch of the portal vein. At the same time, based
on liver 3D printing and intraoperative pathological examination, we correct the clinical classication of hilar cholangiocarcinoma in real time to select related types of
operation.
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