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16 Digital Diagnosis andManagement ofCholangiocarcinoma
397
considered. The main portal vein was not invaded; the right hepatic artery was not invaded. The left lobe of the liver was signicantly atrophied with a compensatory proliferation of the right lobe (Figs.16.33 and 16.34). After admission, the patient underwent percutaneous transhepatic cholangial drainage (PTCD) of the right liver, with drainage time of 6 days, and the total serum bilirubin was reduced to
66.0mol/L by preoperative review.
3D Outcome Three-dimensional reconstruction showed that the middle hepatic artery was invaded, while the left and right hepatic arteries were not. The right hepatic artery originated from the superior mesenteric artery. The left branch, bifurca­tion, and right branch of the portal vein were invaded, and the main portal vein was not affected (Figs.16.35 and 16.36). The tumor was a Bismuth IVb type, and left hepatectomy com­bined with the right portal vein resection was initially planned.
Surgery and Pathology No metastasis of omentum or liver was found after surgical exploration. Noticeable hard
Fig. 16.33 Cross-sectional CT image shows a tumor (red arrow) with a majority to the left
Fig. 16.34 Coronal CT image shows invasion of the left portal vein and local wall stenosis in the initial segment of the right portal vein. Tumor invasion is considered. The left lobe of the liver is atrophic with compensatory hyperplasia of the right lobe. Note: 1. Left portal vein; 2. Main portal vein; 3. Right portal vein
Fig. 16.35 EDDA IQQA-Liver shows the spatial localization of the tumor
Fig. 16.36 EDDA IQQA-Liver shows the relationship of the tumor to the hepatic artery and portal vein
398
mass was found in the hilum, with extensive involvement on both sides, and atrophy of the left lobe of the liver. The hilar part of the liver had enlarged lymph nodes with a hard tex­ture. The common hepatic artery sheath was opened, and the enlarged lymph nodes around the common hepatic artery were dissected and separated. The gastroduodenal artery, proper hepatic artery, and left hepatic artery were dissected successively to the proximal end; the right hepatic artery was dissected along the right margin of the hepatic duodenal ligament, and the surrounding connective tissue was dis­sected from the main portal vein to the hepatic portal. The distal end of the common bile duct was cut off close to the pancreas, and the bile duct was pulled away to the hilum of liver. The tumor was mainly located in the left hepatic duct, invading the left branch of the portal vein, bifurcation, and main portal vein, which exceeded the evaluation results of preoperative imaging and three-dimensional reconstruction. However, the extent of invasion of the right portal vein branch was not clear. Due to the deep position of the right portal vein branch, the proximal invasion of the hepatic por­tal vein could not be determined by the anatomy of the hepatic portal vein. Combined with CT images, the splitting of the middle hepatic ssure and the opening of the hepatic portal plate were considered to determine the resectability after further exploration. Partial hepatic parenchyma was separated from the side of the hepatic portal, and the hepatic portal plate was opened. The right hepatic duct was sepa­rated from the normal texture of the bile duct, and two bile duct openings could be seen at the broken end, which were right anterior and right posterior bile duct openings, respec­tively. Under the immediate circumstance, it could be observed that the origin of the right branch of the portal vein, the bifurcation, the left branch, and main trunk of the right portal vein were invaded by tumors, but the resection and reconstruction could be completed. It was decided to combine left hepatectomy with portal vein resection and reconstruction (Figs.16.37, 16.38, 16.39, and 16.40). Postoperative pathological diagnosis: bile duct adenocarci­noma, grade II–III, mass size 1.8cm × 1.5cm × 1.5 cm, inltration of hepatic parenchyma and hepatic adipose brous connective tissue, invasion of the hepatic duct, nerve invasion, and intravascular tumor thrombus. No residual tumors were found in the incised margin of the liver. No tumor involvement was found at the cutting edge of the hepatic duct and right anterior bile duct. Tumor tissue can be seen at the portal vein pedicle. Tumor metastasis was found in lymph nodes (adjacent to the right hepatic artery and common hepatic artery). No metastasis was found in the lymph nodes of group 13 (0/1).
Case 3
A 65-year-old man was admitted to the hospital because of “upper abdominal pain with skin sclera yellowing for 10
F. Shen et al.
Fig. 16.37 Skeletonization of the hepatoduodenal ligament. Note: 1. Main portal vein; 2. The right hepatic artery originating from the supe­rior mesenteric artery; 3. Left hepatic artery
Fig. 16.38 After splitting and opening the hepatic portal plate, the tumor can be seen invading the left portal vein, main branch, and the starting part of the right portal vein
days.” On admission, total serum bilirubin and conjugated bilirubin were 152.9μmol/L and 116.8μmol/L, respectively. Tumor markers: CA 19-9 was signicantly elevated at
438.5 U/mL, and alpha-fetoprotein and carcinoembryonic
antigen were negative. Upper abdomen enhanced CT showed hilar bile duct space-occupying lesions with intrahepatic bile duct dilatation. The diagnosis was obstructive jaundice and hilar bile duct space-occupying lesions. Bilateral transder­mal hepatic puncture biliary drainage was performed after admission. The drainage time was 7days. The preoperative serum total bilirubin was reduced to 84.6μmol/L.
Imaging Assessment
Enhanced CT showed that the main
body of the lesion deviated to the right side, the tumor invaded the right main branch of the portal vein, the left bile duct system invaded more than the junction of B2 and B3
16 Digital Diagnosis andManagement ofCholangiocarcinoma
Fig. 16.39 Combined with left hemihepatectomy and portal vein resection and reconstruction. Note: 1. Middle hepatic vein; 2. The open­ing of the right posterior bile duct; 3. The opening of the right anterior bile duct; 4. Right hepatic artery; 5. Reconstructing anastomosis of the right portal vein
399
Fig. 16.41 Coronal CT image: tumor invasion of the right main portal vein (arrow)
Fig. 16.40 Portal venous phase of CT: low-density mass in the hilum (arrow) with intrahepatic bile duct dilatation
bile ducts. The left branch of the portal vein, bifurcation, and left hepatic artery were not involved (Figs.16.40, 16.41, and
16.42). Cholangiography showed that B4 merged into the
B3-bile duct, and the B2-bile duct did not develop. The tumors were Bismuth IV type a, and right trisectionectomy was proposed.
3D Outcome The spatial location of the tumor, the degree of bile duct invasion, and its relationship with the peripheral blood vessels were visually displayed. There was a variation of conuence mode in the left bile duct, that is, the fourth segment of the hepatic bile duct rst converged into the
Fig. 16.42 Cholangiography. Note: 1. Bile duct of segment IV; 2. Bile duct of segment III
third segment of the hepatic bile duct to form the trunk, and the second segment of the hepatic bile duct then converged. The whole liver volume was measured by three-dimensional
3
reconstruction software. Total liver volume was 1944cm
, the left lobe liver volume was 838cm3 (43.1%), and the left lateral lobe volume 449.3cm3 (23.1%). The residual left lat­eral lobe volume was insufcient after combined right tri­sectionectomy. Meanwhile, the distance between the boundary of the left tumor and the limit point of left hemi­hepatectomy (U point) was 15.2 mm on the three-dimen­sional reconstruction image. The simulation of a 10-mm surgical margin showed that a satisfactory negative margin could be obtained by combined right hemihepatectomy (Fig.16.43).
Surgery and Pathology The right branch of the portal vein was found to be invaded by tumor after the calcication of the hepatic duodenal ligament; the bifurcation of the portal
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third, and fourth segments of the hepatic duct, respectively (Fig.16.44). The rapid pathology of proximal and distal inci­sion margins of the bile duct was negative. The operation time was 450min, the intraoperative blood loss was 400ml, and no blood transfusion was performed. Routine pathology: bile duct adenocarcinoma, grade II–III, the mass invaded the whole layer of the bile duct to the surrounding adipose brous connective tissue, inltrating the liver parenchyma, and the tumor was observed to invade the nerve; Cancer metastasis was found in lymph nodes of group 12 (1/1), and no cancer metastasis was found in lymph nodes of group 8 and group 13 (0/1 and 0/2). Chronic inammation was found in both the distal bile duct margin and the left hepatic duct margin.
Fig. 16.43 EDDA IQQA-Liver 3D reconstruction: a direct view of the tumor (yellow mass) and the conuence pattern of the left biliary tract system; set the 10-mm simulated surgical resection margin, and it can be seen that the limit of the left biliary tract system is within the limit point (U point) of the right liver resection. Note: 1. The bile duct in hepatic segment II; 2. The bile duct in hepatic segment III; 3. The bile duct in hepatic segment IV
Case 4
A 66-year-old man was admitted to the hospital because of “half a month of hilar space found by physical examina­tion.” On admission, total serum bilirubin and conjugated bilirubin were 14.6 μmol/L and 5.9 μmol/L, respectively. Tumor markers: CA 19-9 was 33.4U/mL, and alpha-feto­protein and carcinoembryonic antigen were negative. MRCP showed hilar space-occupying and right anterior bile duct dilatation (Fig. 16.45). Upper abdomen enhanced CT showed hilar bile duct wall thickening and intrahepatic bile duct dilatation. The diagnosis was a hilar bile duct space­occupying lesion.
Imaging Assessment
Cross-sectional CT images showed
that the main body of the tumor was in the right anterior bile duct with signicant dilatation of the right anterior bile duct
Fig. 16.44 Hepatic cross section after right hepatectomy with total caudate lobectomy. Note: 1. Bile duct in hepatic segment II; 2. Bile duct in hepatic segments II and III; 3. Left hepatic artery; 4. Main portal vein; 5. Left portal vein; 6. Middle hepatic vein
vein, the left branch, and the hepatic artery were not involved. The right margin of the sagittal portion of the portal vein was touching a segment of the soft bile duct; right hemihepatec­tomy was performed as scheduled. Intraoperative ultraso­nography was used to locate the route of the middle hepatic vein, and the dissociation plane of liver parenchyma was marked with an electric knife. The left hepatic duct was amputated about 5mm from the tumor boundary. Two bile duct openings were observed in the hepatic section. Biliary duct probes were used to identify movement in the second,
Fig. 16.45 MRCP indicates that the bile duct at the hilar region is truncated and the right anterior bile duct is signicantly dilated
16 Digital Diagnosis andManagement ofCholangiocarcinoma
401
and mild dilatation of the left hepatic duct. The tumor surrounded the right anterior branch of the portal vein, and the transverse part of the left branch of the portal vein might be invaded (Figs. 16.46 and 16.47). The right posterior branch of the portal vein, main trunk, and hepatic artery were not involved by tumors. The tumor was of Bismuth IIIa type, and the right hepatectomy combined with resection and reconstruction of the left branch of the portal vein was pre­liminarily proposed.
3D Outcome The whole liver volume was measured by three-dimensional reconstruction software. Total liver vol­ume was 768cm 3, the left lobe liver volume was 146cm3 (19.0%), and the left lateral lobe volume 417cm3 (54.3%). Since the reserved left hepatic volume after right hepatec­tomy is only 19.0%, and the possibility of postoperative liver failure is extremely high, it is proposed to switch to right
Fig. 16.46 Contrast-enhanced CT suggests that a tumor (yellow arrow) may have invaded the left portal vein (blue arrow)
Fig. 16.47 Contrast-enhanced CT suggests the tumor (yellow arrow) invading the right anterior portal vein (blue arrow)
anterior lobectomy + caudate lobectomy + left portal vein branch resection and reconstruction, the reserved liver vol­ume can reach 73.3%. However, should this procedure be performed, there would be two liver transections, bilateral choledochointestinal anastomosis, more frequent intraopera­tive bleeding, and a higher incidence of postoperative com­plications, all of which would increase the difculty of surgery. Through three-dimensional visualization, it was shown that the patient had an anatomic variation of the portal vein, that is, the right anterior portal vein was originated from the left portal vein; the bifurcation and course of right hepatic were lower and farther away from the tumor; the middle hepatic vein was slender, the right hepatic vein was thick and there were branches of the right posterior inferior hepatic vein. Thanks to the identication of the above­mentioned anatomical variations and the measurement of liver volume, we believed that the combined resection of hepatic SIII could simplify the surgical procedures to the greatest extent and conform to the principle of complete tumor resection while retaining sufcient functional liver volume.
Surgery and Pathology
Intraoperative exploration revealed
no cholestasis in the liver, small left lobe, and atrophy of right anterior lobe. Hard masses were palpable in the right anterior portal area; the Rouviere groove was soft on palpa­tion with the left hilum. No enlarged lymph nodes or meta­static lesions were found in the hepatoduodenal ligament, the common hepatic artery, the peritoneal trunk, or the pelvic cavity. An intraoperative ultrasound examination revealed no intrahepatic metastases. It was decided that the resection of hepatic SIII should be carried out according to the scheduled plan. First, the regional lymph nodes were cleared, and the following were freed, including the trunk of right posterior branch and the initial segment of the left branch of the portal vein, the trunk, the right anterior and the right posterior branch of the right hepatic artery, and the initial segment of the left hepatic artery; the left hepatic artery, the right ante­rior hepatic artery and the left portal vein branches were separately ligated and severed. The liver parenchyma was isolated along the ischemia-dividing line between the right anterior lobe and the right posterior lobe. The resection mar­gin between the distal bile duct and the right posterior bile duct was conrmed to be free of tumor residue by rapid intraoperative pathological examination. The operation time was 270min, with 600ml intraoperative blood loss and no blood transfusion. Conventional pathology results: bile duct adenocarcinoma, grade II~III, mass size 2.0cm × 1.5cm ×
1.0cm, involving the liver parenchyma, visible focal neural invasion; no cancer metastasis were found in lymph nodes of group 12, group 8, and group 13 (0/4, 0/3, 0/2). The distal bile duct and the cutting edge of the right posterior bile duct were chronically inamed.
402
Case 5
A 74-year-old male was admitted to the hospital for “yellow skin and sclera for 2 months.” There was a history of hepati­tis B for 20 years and hypertension for 10 years. Cholecystectomy was performed in 1988. Routine examina­tion after admission: ALT 61.7IU/L, AST 57.4IU/L, TBIL
31.8 μmol/L, DBIL 15.8 μmol/L. Tumor markers: CA19-9 > 1000 U/mL, AFP 4.4 ng/mL, CEA 3.8 ng/ mL.Enhanced CT examination of the upper abdomen: the hilar was occupied with a diameter of about 1.2cm, accom­panied by signicant ICC expansion, which was considered as a possibility of hilar cholangiocarcinoma.
Imaging Assessment Enhanced CT showed that the main
body of the tumor deviated to the left, involving the right hepatic duct and the opening of the hepatic IV bile duct. Portal vein and hepatic artery were not invaded. MRCP images showed the presence of accessory right hepatic duct (Figs.16.48, 16.49, 16.50, and 16.51). Due to tumor invasion to the opening of the left secondary bile duct branch, the classication and staging were: Bismuth IIIb, MSKCC T1. Surgical planning: left hemihepatectomy + caudate lobec­tomy + hilar lymph node dissection + right hepatic duct­jejunum Roux-en-Y anastomosis.
F. Shen et al.
Fig. 16.49 Arterial phase: the right hepatic artery is not invaded. Note:
1. Tumor; 2. Right hepatic artery
3D Outcome 3D reconstruction images suggested that the patient’s bile duct in hepatic segment VI was the Infraportal type, that is, the segment VI bile duct ran under the right branch of the portal vein and directly entered the common bile duct; it was invaded by the tumor at the opening of the segment VI bile duct. Bile duct in hepatic SVII converged into the right anterior bile duct to form the right hepatic duct;
Fig. 16.50 Venous phase: the opening of IV segmental bile duct (black arrow) is invaded by the tumor
meanwhile, the bile duct of the hepatic S IV was merged into the left hepatic duct near the hepatic hilum. The involvement of the left and right bile ducts of the tumor was a long dis­tance from the corresponding limit points (U and P points) (Fig. 16.52). Based on the identication of the anatomical structure and the re-judgment of the extent of bile duct inva­sion by 3D reconstructed images, a satisfactory tumor-free cutting margin could be achieved free of extensive hepatec­tomy, and simple extrahepatic bile duct resection was proposed.
Fig. 16.48 CT multi-plane reconstruction shows that the tumor body is skewed to the left
Surgery and Pathology
The rst hepatic hilum was dis-
sected, and lymph nodes in groups 8, 12, and 13 were cleared. The main portal vein and hepatic artery were not invaded by the tumor, which was consistent with the 3D imaging evalu-
16 Digital Diagnosis andManagement ofCholangiocarcinoma
403
Fig. 16.51 The MRCP image shows the accessory right hepatic duct (arrow)
Fig. 16.52 EDDA IQQA-Liver 3D image shows tumor spatial loca­tion, relative relationship between tumor boundaries and the limit point, and hepatic hilar anatomic variation. Note: 1. VII segmental bile duct;
2. VI segmental bile duct; 3. IV segmental bile duct. U-point: The turn­ing point between the transverse part of the left portal vein and the sagittal part; P-point: The starting part of the right posterior portal vein
Fig. 16.53 Post simple extrahepatic cholangiectomy. Note: 1. Right hepatic duct; 2.2. VI segmental bile duct; 3. Right hepatic artery; 4. Left hepatic artery; 5. Left hepatic duct
duct and the right hepatic duct were cut off 5mm away from the tumor boundary. Five bile duct openings were observed on the hepatic section, namely: the hepatic duct, the left hepatic duct, the left caudate lobe bile duct (about 2mm in diameter), the right hepatic duct in the segment IV of the liver, and the hepatic duct in segment VI of the liver. The results of the rapid pathological examination were all nega­tive. The caudate lobe bile duct was sutured and closed. The left hepatic duct and the bile duct and right hepatic duct in segment IV of the liver were formed into one opening. Together with segment VI of the liver, Roux-en-Y cholangio­jejunostomy were performed separately (Fig.16.53). Routine pathological examination results: grade II–III cholangioade­nocarcinoma with a mass size of 3cm × 1.5cm × 1cm inl­trated the whole wall of the duct, and nerve invasion could be observed. No tumors were found in the incision margins of bile ducts (distal bile duct, left lateral lobe bile duct, bile duct in segment IV of the liver, left caudate lobe bile duct, bile duct in segment VI of the liver, and right hepatic duct). No metastasis was found in lymph nodes of groups 8, 12, and 13 (0/1, 0/4, 0/2).
ation. The bile duct was separated from the superior margin of the pancreas, and the incision margin was used for rapid postoperative pathology: (distal margin) chronic inamma­tion of the mucosa. The bile duct was pulled upward, and it was removed from the posterior part of the bile duct and lymphatic connective tissue around the portal vein to the bifurcation of the portal vein. It was found that the bifurca­tion of the portal vein and the initial part of the left and right branches were not invaded by the tumor. The left hepatic
16.3.6.3 The Extent ofParenchyma Resection
Combined hepatectomy can signicantly improve the surgi­cal resection rate of hilar cholangiocarcinoma, reduce tumor recurrence, and prolong patient survival. Since the upper caudate lobe is located behind the rst hepatic hilum and the bile duct of the caudate lobe is often directly merged into the conuence of the left and right hepatic ducts, the caudate lobe is prone to tumor invasion. For tumors involving the conuence of the left and right hepatic ducts, total caudate
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lobectomy should be performed routinely to improve the radical resection rate.
Simple extrahepatic bile duct resection is mainly suitable for Bismuth-Corlette type I and papillary tumors. Anatomically, the left hepatic duct is longer than the right hepatic duct, and the right hepatic artery runs behind the com­mon bile duct. In order to obtain a satisfactory negative mar­gin, based on the above-mentioned anatomical factors, some scholars have proposed the combination of right hemihepa­tectomy and total caudate lobectomy as a surgical strategy for Bismuth-Corlette type I and II tumors. Studies suggest it can improve the radical resection rate of the Bismuth-Corlette type I and II cancers and reduce the postoperative local recur­rence rate. However, in previous studies, the main indication of combined lobectomy in the treatment of early hilar cholan­giocarcinoma was when combined with vascular invasion, especially of the right hepatic artery. Therefore, a clear pic­ture of the resection rate and survival rate of this surgery method itself remains to be further conrmed.
For Bismuth-Corlette type III and IV hilar cholangiocar­cinoma, large-scale hepatectomy is a common surgical pro­cedure. In most cases, the extent of hepatic parenchyma resection is determined by the main site of the lesion. Combined right hepatectomy is suitable for Bismuth-Corlette type IIIa and IVa tumor and combined left hepatectomy is suitable for Bismuth-Corlette type IIIb and IVb tumors. Combined hemihepatectomy was performed in cases where negative margins were expected to be obtained within the limit point of hemihepatectomy retaining the lateral biliary tract system. Images indicated that combined trisectionec­tomy should be performed to achieve radical resection when the tumor boundary is close to or beyond the reserved hemi­hepatectomy limit. Also, combined right trisectionectomy is suitable for Bismuth-Corlette type IIIb or IV tumors with right hepatic artery invasion or right hepatic atrophy. Combined trisectionectomy is mainly suitable for cases where combined hemihepatectomy fails to obtain negative margins. It has not been widely used in China due to the small size of the residual liver, long perioperative treatment time, and a high incidence of postoperative liver failure. For Bismuth-Corlette type IV tumors with primary invasion of the bile duct in hepatic segment IV and right anterior hepatic duct, combined resection of the middle lobe (hepatic seg­ment IV, V, VII) and total caudate lobe can preserve more liver parenchyma based on radical treatment and reduce the possibility of postoperative liver failure. However, mid­lobectomy is difcult and has a high incidence of complica­tions. It can only be implemented selectively.
Although expanding the scope of liver parenchyma resec­tion can improve the rate of radical resection, the incidence of postoperative complications and mortality is higher. Also, in the case of hilar cholangiocarcinoma without microvascu­lar invasion, some scholars advocate small-scale hepatec-
tomy, which includes segment IVb+V+I of the liver. The advantage of this method lies in that it can fully expose the left and right hepatic pedicles and retain more functional liver parenchyma based on the maximization of the biliary tract cutting edge. However, due to the limitations of the sur­gical approach and the complex process of choledochointes­tinal reconstruction, the treatment of hilar cholangiocarcinoma with small-scale hepatectomy has not been widely used. Many factors, such as biliary tract involvement, vascular invasion, anatomical variation, and residual liver volume, should be considered in the selection of the specic extent of hepatectomy. With the advance of hepatectomy instruments and the maturity of vascular reconstruction technology, seg­mental hepatectomy based on accurate image evaluation is a surgical strategy for hilar cholangiocarcinoma. It is based on the actual extent of tumor involvement and anatomical varia­tion, guided by segmental hepatic duct orice, and combined with the cut-off limit point to design an individualized and precise surgical scheme. However, only selective implemen­tation is available at present. There are no relevant results of clinical research. The specic approach of surgical explora­tion should be based on the diagnosis and treatment experi­ence of each center. For those who lack experience in hepatic artery reconstruction, the arterial approach is preferred. The right hepatic artery should be explored rst to determine the extent of resectability or hepatic parenchyma resection. For the centers with rich experience in vascular reconstruction, a transhepatic-portal approach can be adopted. The procedure is described as follows: the partial hepatic parenchyma is separated from the side of the hepatic portal, the hepatic por­tal plate is opened, the lateral vascular structure is dissected and preserved, the proximal bile duct is separated, and the proximal bile duct and hepatic duodenal ligament are sepa­rated after no tumor cutting edge is dened, and then the distal bile duct and hepatic duodenal ligament are skeletal. Separate partial hepatic parenchyma from the side of the hepatic portal rst, open the portal plate, dissect and preserve the structure of the lateral vessels, cut off the proximal bile duct, separate the proximal bile duct and hepatic duodenal ligament after the tumor-free cutting edge is conrmed, and then cut off the distal bile duct and achieve the skeletaliza­tion of the hepatoduodenal ligament.
16.3.6.4 Lymphadenectomy
Lymph node dissection in the hilar region is an important part of radical surgery, and the peripheral nerve connective tissue should be stripped away close to the outer membrane of the blood vessel to prevent residual nerve tissue inltrated by the tumor. The principle of artery priority is often adopted in the clearance of the hilar area; that is, the sheath of the artery is peeled along the proper hepatic artery and gradually cleaned to the proximal end, until the bifurcation of the left and right hepatic artery is exposed. The common bile duct
16 Digital Diagnosis andManagement ofCholangiocarcinoma
405
was pulled laterally to expose the portal vein behind the bile duct, and the surrounding tissue was cleaned proximally to the bifurcation of the portal vein. Through careful anatomy to form the skeletal area of the hilar area during operation, the actual invasion range of the tumor was further deter­mined, and the resectability was claried. If the bile duct cannot be clearly separated from the breakpoint outside the liver, the liver parenchyma can be cut along the median s­sure, and the hepatic portal plate can be opened to explore the extent of proximal tumor invasion fully.
Lymph node metastasis is one of the important factors suggesting a poor prognosis of hilar cholangiocarcinoma, with an incidence of 30%–50%. There is still some contro­versy about the extent and number of lymph node dissec­tions, and whether enlarged lymph node dissection can more accurately indicate prognosis or improve survival. A multi­center study in Italy suggests that the number of lymph nodes to be cleaned is at least 5 but cleaning more than 6 enlarged nodes fails to improve long-term survival signi­cantly (Giuliante etal. 2016). Some scholars believe that for patients with regional negative lymph nodes, enlarged dis­section is necessary to clarify the status of these lymph nodes, but it is impossible to improve the survival time of patients with positive lymph nodes. In the latest AJCC eighth edition cancer staging system, the standard for strati­cation of lymph node metastasis was changed from the lymph node metastasis in the seventh edition to the number of regional positive lymph nodes, that is, the number of pos­itive lymph nodes in N1 was 1–3, and the number of positive lymph nodes in N2 was at least 4. However, the minimum number of lymph nodes detected was not clearly dened. Currently, regional lymph nodes to be routinely dissected for hilar cholangiocarcinoma include the hepatic duodenal ligament (group 12), the common hepatic artery (group 8), and the lateral and upper pancreatic head lymph nodes (group 13a). When a regional lymph node is negative or dis­tant lymph node metastasis such as para-aortic metastasis is detected, the extent of dissection can be expanded to pro­vide more accurate staging information and guide further postoperative treatment. Since the 3D visualization technol­ogy cannot determine the nature of the lymph node, the intraoperative guidance of 3D visualization for lymph node is not elaborated in this book.
16.3.6.5 Combined Vascular Resection
andReconstruction
Due to the biological characteristics of multi-polarization inltration of hilar cholangiocarcinoma and its anatomic proximity to important blood vessels in the hilar area, vascu­lar invasion is prone to occur. It is difcult to accurately determine the invasion or adhesion between tumor and blood vessels by imaging examination. Moreover, actual surgical
exploration is still the gold standard. If it is found that the blood vessel wall is partially grayish-white, hard, and cannot be easily peeled off from the tumor during the operation, it is regarded as a vascular invasion. Advanced hilar cholangio­carcinoma complicated with vascular invasion is no longer a taboo for radical surgery. It is necessary to completely dis­sociate the uninvolved vessels in the upper and lower seg­ments during the operation. The reconstruction methods after segmental vascular resection, including end-to-end anastomosis, articial blood vessel, or autologous blood ves­sel reconstruction, are determined according to the actual degree of invasion.
Combined resection and reconstruction of the affected portal vein can improve the radical resection rate and long­term survival rate of locally advanced hilar cholangiocarci­noma. However, when it refers to that of the involved hepatic arteries, controversy still exists. Due to the limitation of arte­rial reconstruction techniques, most surgeons believe that the tumor cannot be resected when the retained hepatic artery is found to be invaded. Despite poor overall prognosis and higher incidence of postoperative complications, prognosis for patients with hepatic artery reconstruction is signicantly better than those with unresectable hepatic artery. Therefore, when hepatic artery invasion becomes the only hindrance to radical resection, hepatic artery reconstruction should be considered when technical conditions permit. The key to improve the quality of arterial anastomosis and reduce the occurrence of related complications is to construct a 3D visualization model of the hepatic artery before the opera­tion, to determine the length and extent of invasion, and to apply careful vascular anatomy and microsurgical techniques.
16.3.6.6 Laparoscopic Exploration
Compared with gallbladder carcinoma and ICC, hilar bile duct carcinoma is less likely to have distant metastasis. For patients with resectable primary lesions, the signicance of laparoscopic exploration is to nd small lesions in the abdominal wall and omentum that cannot be recognized by images, to avoid unnecessary laparotomy. However, the con­ventional application of laparoscopic exploration before a laparotomy is controversial in clinical practice. With the advance of imaging technology, the positive ndings of lapa­roscopy will be signicantly reduced. Laparoscopic ultra­sound examination is greatly inuenced by the experience and manipulation of the operator. Therefore, it is unneces­sary to perform routine laparoscopic exploration for patients with hilar cholangiocarcinoma. If there are suspected metas­tases on imaging, but they cannot be clearly identied, lapa­roscopic exploration and biopsy can be conducted in advance to clarify the nature of the lesions and determine the next treatment plan.
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F. Shen et al.
16.3.6.7 Intraoperative Frozen Section Consultation
Because cholangiocarcinoma has the characteristic of inl­trating along the mucosa or submucosa, it is difcult to accu­rately determine the extension of the tumor along the axis of the bile duct tree by imaging. Intraoperative frozen section is of great signicance for judging the state of incision margin and dening the radical treatment of tumors during operation and should be routinely carried out. The incidence of posi­tive margin (R1 resection) in hilar cholangiocarcinoma was about 25%. Whether further resection is necessary for patients undergoing R1 resection is still uncertain. The pri­mary method to reduce R1 resection is based on an accurate imaging assessment and a suitable range of liver resection. For patients with a positive distal incision margin, it is often necessary to combine pancreaticoduodenectomy for radical treatment.
16.3.6.8 Liver Transplantation
For unresectable hilar cholangiocarcinoma, the only hope for a cure is liver transplantation. However, there have been very few reports on liver transplantation in China due to the short­age of donor liver resources, the poor effect of transplanta­tion in the early years, and the differences in the standard of unresectable liver cancer among various centers. In the past decades, the Mayo clinic has performed liver transplantation for unresectable hilar cholangiocarcinoma with rigorous selection criteria combined with multi-modality neoadjuvant therapy, with encouraging results. Recent clinical studies at 12 transplant centers in the United States, including the Mayo Clinic, have demonstrated that neoadjuvant chemora­diotherapy improves the efcacy of liver transplantation in treating hilar cholangiocarcinoma, with a 5-year tumor-free survival rate of 65% (Darwish Murad etal. 2012). The strict control of the indications of liver transplantation for hilar cholangiocarcinoma is the key to reduce tumor recurrence and to achieving long-term survival after transplantation. For patients with tumor >3cm and lymph node metastasis, the risk of recurrence and death after transplantation increased three times.
16.3.7 Surgical Planning forIntrahepatic
Biliary Variations inHilar Cholangiocarcinoma Guided by 3D Visualization
16.3.7.1 Surgical Planning ofPortal Vein Variation Guided by 3D Visualization
(Fig.16.54)
Limit point of the normal portal vein, and bile duct separa­tion (U point: the angle between the horizontal and sagittal part of the left portal vein; P point: the bifurcation of the
right anterior branch and the right posterior branch of the portal vein) refers to the limit point where bile duct can be separated from the parallel portal vein and hepatic artery during hepatectomy. The upstream bile duct at this limit point cannot be separated and cut off alone. Through 3D visualization analysis of the limit points (P points and U points), and liver 3D printing, the normal portal vein and various variations of portal vein P points and U points can be observed in a three-dimensional and all-round way, thus guiding the formulation of surgical plans and accurate surgery.
Common Type
Under this situation, the limit point (U point) of left-sided biliary ducts is located on the reverse turn between horizon­tal part and sagittal part of left branch of portal vein in the right hepatectomy. Limit point (P point) of right-sided bili­ary ducts is located on the bifurcate portion of portal vein between the right anterior branch and right posterior branch.
Type IVariation
Right-anterior branch, right posterior branch, and left branch of portal vein emerge as trifurcation because the trunk of left branch still exists, the U point is determined, and P point moves toward porta hepatis.
Type II Variation
The trunk of portal vein branches off right posterior branch rst, and in its way upward, it branches off right anterior and left branches. In this situation, the P point is determined the and U point moves toward the porta hepatis.
Type III Variation
The trunk of the portal vein divides the right posterior branch directly, and the right anterior branch originates from the trunk of portal vein left branch. In this situation, the P point moves toward porta hepatis.
Thus, when types I, II, and III variations happen, the U point is xed, and the P point moves toward porta hepatis. In this situation, when hilar cholangiocarcinoma requires right hemihepatectomy, we should isolate the trunk of the portal vein, right anterior branch, and left branch, respectively. We then resect the right anterior branch of the portal vein when we have protected the trunk and left branch of the portal vein. On the other hand, when patients undergo left hemi­hepatectomy, we should isolate the left branch and right anterior branch of the portal vein, and then resect the left branch of the portal vein when we have protected the right anterior branch of the portal vein. At the same time, based on liver 3D printing and intraoperative pathological exami­nation, we correct the clinical classication of hilar cholan­giocarcinoma in real time to select related types of operation.