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13 Digital Surgical Diagnosis andManagement ofBiliary Dilatation
317

13.3.6 Radionuclide Hepatobiliary Scan

Although radionuclide hepatobiliary imaging is useful in the diagnosis of bile duct cysts, its clinical value is lim­ited because the information provided is functional rather than anatomical, which can only supplement cholangiog­raphy or stereoscopic imaging. Therefore, it can be used only when the symptoms are similar and difficult to identify.

13.3.7 Digital Medicine Technology

With the rapid development of digital medicine technology, digitalization has become one of the developing directions of surgical medicine, and its application in biliary surgery has become more and more extensive. Three-dimensional visualization technology utilizes modern photoconductive technology and imaging technology to overcome the limita­tion that human eyes cannot see through or see directly. Thus, the spatial structure of the liver and its vascular sys­tem can be viewed panoramically and stereoscopically. The liver, surrounding organs, celiac vessels, and different vas­cular systems in the liver can be displayed three-dimension­ally; with the aid of transparency modulation techniques and local magnication of the liver, the shape and distribu­tion of the diseased bile duct are clearly dened through rotating stereoscopic observation of different angles and directions. The extent of the affected bile duct, the degree of dilation, as well as the relationship between the bile duct and hepatic artery, hepatic vein, and portal vein are shown. 3D printing technology can also be used to reconstruct the individual hepatobiliary system accurately, to determine and measure the distribution of the diseased bile duct and its spatial relationship with adjacent vascular structures. Meanwhile, visual virtual simulated operation on the model can help to make the operation plan, determine the best pro­cedural path, guide the actual surgery, and improve accuracy and safety.
13.4.1 The Dierential Diagnosis ofBiliary
Dilatation
13.4.1.1 Dierentiation ofDiseases
Characterized by Jaundice
Periampullary Tumor
Periampullary tumor predominantly occurs in the middle­aged or above, with a relatively short course; jaundice is aggravated progressively, often accompanied by itchy skin. The patient’s condition deteriorates rapidly and symptoms such as weight loss and anemia may occur; larger tumors may be palpable on the surface of the body and felt hard and nodular; imaging exams such as CT and MRI reveal a solid mass in the distal ampulla of the common bile duct, while no such imaging ndings are demonstrated in the case of BD.
Biliary Atresia
Biliary atresia is a rare disease that occurs in infants; symp­toms usually appear between 1 and 2 weeks after birth. Infants with biliary atresia develop cholestatic jaundice, dark brown urine, light yellow feces, and later developing into clay-colored stools, yellow staining of skin and sclera, and cholestatic portal hypertension or ascites in the later stages of the disease. B-ultrasound cannot detect the common bile duct, absence of gallbladder or atrophied gallbladder only, while BD is characterized by expansion of extrahepatic bile duct.
13.4.1.2 Dierentiation ofDiseases
Characterized by Acute EpigastricPain
Acute Pancreatitis
Mostly in adults, and causes such as overeating, calculus, or drinking may induce this disease; severe abdominal pain can involve the left back and left shoulder; the biochemical examination shows a signicant increase in blood and urine amylase. B-ultrasound and CT show enlarged pancreas but normal choledochus.
13.4 Dierential Diagnosis andManagement ofBiliary Dilatation
The clinical differential diagnosis of this disease is of great signicance. With the deepening understanding of the etiol­ogy and pathology of BD, clinical diagnosis of it has become clearer. Targeted treatment can be carried out promptly, to achieve better clinical efcacy.
Acute Cholecystitis
Mostly in adults, symptoms such as fever, pain in the right upper abdomen, tenderness, and muscle tension are obvious. Murphy’s sign is positive; real-time examination with B-ultrasound can clearly differentiate.
Ascariasis ofBiliary Tract
Sudden pain in the right epigastric or epigastric cavity can be alleviated or restored to normal after attack; no mass in the
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right epigastric or epigastric abdomen exists; ultrasonic examination shows worm-like echo in the common bile duct and mild dilatation in the common bile duct, while no worm­like echo in BD.
13.4.1.3 Dierentiation ofDiseases
Characterized by Abdominal Cystic Mass
Hepatic Cyst
Normal liver function. Patients with polycystic liver disease may be complicated with polycystic lesions of the kidney, pancreas, or spleen. Imaging methods such as CT or B-ultrasound can present the intrahepatic location of the cyst and a normal extrahepatic bile duct.
Hepatic Echinococcosis
The patients had contact with animals such as dogs and sheep in livestock areas. The cysts gradually increase; B-ultrasound and CT show intrahepatic space-occupying lesions and a normal extrahepatic common bile duct; eosino­phils increased; Casoni test (hydatid intradermal test) posi­tive rate reaches as high as 80%–95%.
Retroperitoneal Cystic Masses
Cystic teratoma or lymphangioma, for example, retroperito­neal cystic and BD can be differentiated basically by using B-ultrasound or CT, and the possibility of BD can be excluded by ERCP.Right hydronephrosis is not easily distin­guished from BD by physical examination; however, the incidence of hydronephrosis is more common on the right side and the lumbar triangle is usually full, so B-ultrasound, intravenous pyelography (IVP), or endoscopic retrograde cholangiopancreatography (ERCP) can help determine right hydronephrosis and BD.
13.4.2 Treatment ofBD
BD has a high canceration rate, which increases gradually with age, specically, 0.7% under the age of 10years, 6.8% between 10 and 20years, and 14.3% over 20years (Chijiiwa and Koga 1993). Therefore, surgical treatment should be per­formed as soon as possible once BD is diagnosed regardless of clinical symptoms.
ary drainage under the guidance of ultrasound should be performed. The operation of biliary drainage can help to alleviate critical conditions such as acute obstruction and infectious shock caused by infection. After the patient’s general condition is improved, resection of the diseased bile duct and reconstruction of the biliary tract should be performed.
13.4.2.2 Cholecystectomy, Resection oftheDiseased Bile Duct + Roux-en-Y Anastomosis ofBile Duct andJejunum
This procedure can completely eliminate the cyst, improve drainage, signicantly reduce the complications of the sur­gery, and prevent canceration, and thus, it is generally con­sidered suitable for the management of Todani type I, II, and IVb. Because of repeated attacks of cholangitis in adults, there is visible inammation around the cyst, and it is some­times more challenging to remove the cyst entirely. In such cases, intracapsular resection can be performed, as proposed by Lily in 1978. Intracapsular resection means resection of the remaining part of the posterior wall adjacent to the portal vein, which was named the Lily procedure. The theoretical basis of this procedure is that the damage of the cyst itself is a potential canceration and the canceration only originates from the mucosa. Therefore, the purpose of preventing can­ceration can be achieved as long as the mucosal layer is elim­inated. Cholangioduodenostomy and cholangiojejunostomy should be abandoned.
13.4.2.3 Liver Resection
BD involving intrahepatic bile duct should be treated with drainage or lobectomy. The specic approach of liver resec­tion depends on the distribution and extent of dilated hepa­tobiliary duct, the complication of hepatic lesion and residual liver function. The residual functional liver volume should be fully evaluated before liver resection. If the resid­ual liver function is insufcient, the columnar dilated hepatic duct and its drainage segments should be properly preserved.
13.4.2.4 Pancreaticoduodenectomy
Pancreaticoduodenectomy is feasible when the lesions are associated with carcinogenesis of the lower common bile duct or obstructive jaundice caused by chronic pancreatitis.
13.4.2.1 Biliary Drainage
For patients with acute suppurative inammation, severe obstructive jaundice, and perforation of the biliary duct who cannot tolerate complex surgery, it is recommended that percutaneous transhepatic bile duct drainage and extra-bili-
13.4.2.5 Liver Transplantation
Liver transplantation is a practical and nal choice for dif­fuse BD with extensive lesions in bilateral hepatic lobes. Type A2 BD (Caroli’s disease involving the whole liver), complicated with severe hepatic brosis and portal hyper-
13 Digital Surgical Diagnosis andManagement ofBiliary Dilatation
319
tension, is feasible for liver transplantation. It is also feasi­ble for types A, B, C, and D2 BD complicated with intrahepatic or hilar cholangiocarcinoma which cannot be cured by regular operation and has no extrahepatic metasta­sis. Some patients with Caroli’s disease even need liver and kidney transplantation.
13.4.2.6 Laparoscopic Surgery
Since Farello rst applied laparoscopic treatment of this dis­ease in 1995, many scholars have begun to explore laparo­scopic techniques. Because of the magnifying effect provided by laparoscopy, the operation is more precise, which is conducive to radical resection and correction of hepatic bile duct stricture. With the promotion of laparoscopic techniques and the accumulation of surgical experience, this technology has become one of the important techniques for the treatment of this disease.
13.4.2.7 Reoperation
It is not uncommon for patients with bile duct cysts to be reoperated. The leading cause of reoperation is the mis­management of various complications or the discovery of carcinogenesis. Removal of the duodenal or jejunal anasto­mosis of the original cyst, as well as the cystectomy and reconstruction of the biliary tract, are the main methods of reoperation. For those who have resected cyst, the critical point is to solve the stricture of choledochojejunostomy. At the time of reoperation, it should be noted that because the recurrence causes the cyst and the surrounding tissue to densely adhere, it is more difcult to separate and excise the cyst. The anterior wall and the bilateral wall can be excised, while the posterior wall can be removed only by removing the intima; leaving an outer layer to prevent the portal vein, hepatic artery, and even inferior vena cava from being damaged. For those with particularly dense adhe­sions, part of the wall can remain, and this remaining part may be damaged with iodine tincture, alcohol, or phenol after scratching. The anastomotic site should be enlarged to the left or right hepatic duct when there is too much resec­tion near the hilar bile duct in the rst operation, which results in the stricture of the anastomotic stoma. In order to avoid biliary stricture and stone formation, the condition of grade 2 or 3 bile duct in the liver should be fully explored. Liver lobectomy should be performed when intrahepatic lesions are found.
13.4.2.8 3D Visualization Technology toAssist Surgical Planning
The majority of BD patients have experienced a long pro­cess of chronic cholangitis and chronic obstruction of the biliary tract. Their biliary tract structure has been distorted,
deformed, dilated, or narrowed. Even adjacent liver tissues are affected, and pathophysiological changes occur, which makes the original complex intrahepatic conduit system more challenging to identify. Additionally, it brings uncer­tainty to the accurate determination of the anatomical rela­tionship between blood vessels and bile duct before an operation. The 3D reconstruction images from CT and MRCP have a single color for the biliary tract and can only display different axial sections. It is impossible to simulta­neously visualize the spatial relationship between the bili­ary system and the three sets of vascular systems in the liver and the whole liver. They are not real three-dimen­sional images, making it difcult for the operator to make a more accurate judgment on the variation of individual anatomy.
In recent years, the rise of digital medical technology and the clinical application of three-dimensional visualization of human organs has brought new ideas for the diagnosis and treatment of BD.Many domestic scholars use proprietary 3D software to reconstruct, and assist in 3D reconstruction and operation planning for BD. 3D models of individualized liver, biliary tract, and blood vessel based on CT or MR data can be used to determine the shape and movement of intrahe­patic and extrahepatic bile ducts, and whether they are accompanied by dilation, strictures, and stones; as well as to observe the anatomical relationship of the bile duct, the sur­rounding portal vein and hepatic vein at any angle. The risk of hemorrhage during operation can be avoided through judgment and evaluation of pathological changes, pre­planning, and treatment of possible complications such as intrahepatic bile duct dilatation, stenosis, or other complex biliary malformations and management of important periph­eral vessels. Thus, reasonable, and quantitative surgical plans can be formulated, and individualized, precise biliary sur­gery can be performed.
Fang Chihua’s research group has reconstructed the sub­millimeter CT data of 10 children with BD through the self­developed proprietary 3D visualization system for abdominal medical images and virtual surgical instrument simulation. The 3D images can be rotated and observed at will. A stereoscopic display of the shape and scope of the huge bile duct cyst and its relationship with the surrounding structures, as well as that of the stricture of the bile duct outlet and the conuence of the biliary duct at the lower end of the bile duct cyst, played a guiding role in the develop­ment of the surgical plan (Figs.13.7 and 13.8). It is believed that in the near future, with the development and integration of computer technology, physics, and medical equipment technology, digital medicine will be further improved and become one of the essential auxiliary diagnostic and thera­peutic means of BD.
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Fig. 13.7 In the MI-3DVS, the 3D image (liver and pancreas semi­transparent substance) displays the size, shape, and scope of the cyst, as well as the relation of the cyst with peripheral vascular space stereo­scopically; the 3D image also shows the distal bile duct opening of a bile duct cyst. With the guidance of this information, complete excision of the cyst during the operation was avoided without damaging the bil­iopancreatic junction
J. Yang et al.

References

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literature. Saudi J Gastroenterol. 2012;18:230–6. Chijiiwa K, Koga A.Surgical management and long-term follow-up of
patients with choledochal cysts. Am J Surg. 1993;165(1):238–43. Dong J, Zhang X, Xia H, et al. Cystic dilation of bile duct: new
clinical classication and treatment strategy. Chin J Dig Sur.
2013;12(5):370–7. Lee HK, Park SJ, Yi BH, Lee AL, Moon JH, Chang YW.Imaging fea-
tures of adult choledochal cysts: a pictorial review. Korean J Radiol.
2009a;10:71–80. Lee HK, Park SJ, Yi BH, etal. Imaging features of adult choledochal
cysts: a pictorial review. J Korean J Radiol. 2009b;10(1):71–80. Liu Y-B, Wang J-W, Devkota KR, et al. Congenital choledochal
cysts in adults: twenty-ve-year experience. J Chin Med J.
2007;120(16):1404–7. Miyano T, Yamataka A, Li L.Congenital biliary dilatation. J Semin
Pediatr Surg. 2000;9(4):187–95. Park DH, Kim MH, Lee SK, etal. Can MRCP replace the diagnostic
role or ERCP for patients with choledochal cysts? J Gastrointest
Endosc. 2005;62(3):360–6. Soares KC, Arnaoutakis DJ, Kamel I, Rastegar N, Anders R, Maithel S,
etal. Choledochal cysts: presentation, clinical differentiation, and
management. J Am Coll Surg. 2014;219(6):1167–80. Yu ZL, Zhang LJ, Fu JZ, etal. Anomalous pancreaticobiliary junction:
image analysis and treatment principles. J Hepatobiliary Pancreat
Dis Int. 2004;3(1):136–9.
Fig. 13.8 Intraoperative exploration conrmed the presence of stric­ture in the distal bile duct opening of the choledochal cyst (on the right biliary duct probe)
3D Visual Diagnosis andManagement ofBile Duct Injuries
NingZeng, SilveZeng, JianWang, JiayanYan, andChihuaFang
14

14.1 Introduction

Bile duct injuries refer to any damages to the original struc­ture of the biliary system and abdominal changes in the ow of bile caused by traumatic or iatrogenic factors. Iatrogenic bile duct injuries are attributed to iatrogenic factors such as surgery or invasive diagnosis and treatment. Traumatic biliary strictures refer to the stricture or occlusion of bile ducts due to the injury of the biliary system, which is mainly divided into primary biliary stricture and secondary biliary stricture. The critical cause of benign stricture of the bile duct is inamma­tory reaction and excessive collagen synthesis caused by bile leakage into the wall of the bile duct after bile duct injury. Typical clinical manifestations are obstructive jaundice, bile leakage, or biliary peritonitis. The management of bile duct injuries remains one of the most complex problems in abdom­inal surgery. At present, the diagnosis of bile duct injuries is assisted by cholangiography, ultrasound, and CT. Surgical repair and biliary drainage are the main methods for the treat­ment of bile duct injuries, but partial hepatectomy or liver transplantation is perhaps the most appropriate treatment for patients with partial or complete liver atrophy.
14.1.1 Etiology andClassication of Bile Duct Injury
14.1.1.1 Etiology
Anatomical Factors
Variation of Cystic Duct Typical anatomy of the cystic duct accounts for only 65%. The mode of conuence between
N. Zeng · S. Zeng · C. Fang (*) Zhujiang Hospital, Southern Medical University, Guangzhou, China
J. Wang · J. Yan Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
the cystic duct and the common hepatic duct may be angular, parallel, and spiral. Generally, there are two types of varia­tions, including variation in the course of the cystic duct (The cystic duct is parallel to the common hepatic duct or right hepatic duct) and variations of conuence (The cystic duct obliquely crosses the front or rear of the common bile duct and converges into the left wall of the common bile duct; the cystic duct conuences into the back of the com­mon hepatic duct, with high opening of the cystic duct in the right hepatic duct, the left hepatic duct, or the lower segment of the common bile duct; the cystic duct ows into the right common bile duct after encircling the common bile duct for one turn). In case of unusual type of cystic duct variation, bile duct injuries are easy to occur in an emergency operation.
Variation of Cystic Artery Generally, cystic artery is in the cystic triangle, arising from the right hepatic artery and then coursing to the gallbladder. About 20% of the cystic artery variations originate from arteries other than the right hepatic artery. Variations of bilateral cystic arteries and variations in the origin of gallbladder are common.
Variation of Right Hepatic Artery Caterpillar hump right hepatic artery, right hepatic artery, or gallbladder artery ows to the gallbladder before passing through the common bile duct.
Anatomical Variant oftheGallbladder
• Congenital absence of gallbladder.
• Bilateral gallbladder.
• Intrahepatic gallbladder.
• Transverse gallbladder.
• Left gallbladder.
• Inversion of the gallbladder fundus (Phrygian cap).
• Gallbladder in the left hepatic falciform ligament.
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021 C. Fang, W. Y. Lau (eds.), Biliary Tract Surgery, https://doi.org/10.1007/978-981-33-6769-2_14
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Pathological Factors
Stone incarceration in the neck of the gallbladder and gall­bladder atrophy are high-risk factors for transection and defect of bile ducts caused by laparoscopic cholecystectomy (LC). Stones in the junction of the cystic duct and common hepatic duct, as well as right hepatic atrophy in cirrhosis can cause anomaly in bile duct movement and it can easily lead to bile duct injuries; local adhesion and dense inltration caused by gastric neoplasms can alter the normal anatomy of the bile duct, and even that of the hepatic artery and portal vein. Forced transection, resection, or improper operation can easily damage the bile duct.
Surgeon Factors
In a large-scale study of 125,000 patients undergoing laparo­scopic cholecystectomy, the incidence of biliary tract injury was 0.85%, which was three to four times higher than that of conventional laparotomy. Therefore, LC has always been listed as an important factor of biliary injury. Besides, factors such as the improper selection of incision, insufcient relax­ation of anesthetic, inadequate timing of operation, surgeon’s incomplete knowledge of anatomical structures, lack of understanding of biliary tract variation, nonstandard opera­tion, and rough surgical techniques would lead to clamping, excessive traction, and excessive dissection of common bile duct, and in blood pools. During the bile duct exploration, the mucous membrane of the lower part of the bile duct or papilla would be damaged due to rough operation; the place­ment of excessively thick T-tube and tight suture would also affect the blood supply of the common bile duct wall.
In addition, the ischemic biliary disease caused by biliary dysfunction is another factor of bile duct injury and trau­matic biliary stricture, which is elaborated in Chap. 9.
14.1.1.2 Classication ofBile Duct Injury
At present, there is still a lack of comprehensive coverage in the international community, which can accurately summa­rize all the pathological characteristics of the various types of bile duct injuries and provide guidance for the prevention, treatment, and prognosis evaluation of various types of bile duct injuries.
The commonly used international classication methods for bile duct injury include Bismuth-Corlette classication, Strasburg modication, and Stewart-Way classication (Mercado and Dominguez 2011). Some classications are mainly established in the period of cholecystectomy, some by biliary stenosis, and others by biliary tract injuries caused by laparoscopic cholecystectomy. Therefore, there is no uni­ed classication of bile duct injury at present.
Bismuth-Corlette Classication
Type I Low common hepatic duct (CHD) stricture, with a length of the CHD stump of >2cm.
Type II Middle stricture: length of CHD <2cm. Type III Hilar stricture, without CHD available but pre-
served conuence.
Type IV Hilar stricture, with involvement of conuence and loss of communication between right and left hepatic ducts.
Type V Combined CHD and aberrant right hepatic duct (RHD) injury, separating from the distal common bile duct (CBD) (Renz etal. 2017).
Strasberg Classication
Type A Bile leak from the cystic duct or liver bed without further injury.
Type B Partial Occlusion of the biliary tree, commonly aberrant right hepatic duct(s).
Type C Bile leak from aberrant right hepatic duct(s) that is not communicating with the CBD.
Type D Lateral injury of biliary system, without loss of continuity.
Type E1 Injury >2cm from the conuence.
Type E2 Injury <2cm from the conuence.
Type E3 Injury at the conuence; conuence intact.
Type E4 Destruction of the biliary conuence.
Type E5 Injury to the aberrant right hepatic duct or with
concomitant stricture of the common hepatic duct (Strasberg etal. 1995).
Lau Classication
Academician Wan-Yee and Junxiong (2008) introduced a simple classication method for iatrogenic bile duct injury:
Type 1 Bile leaks from cystic duct stump or small ducts in the liver bed.
Type 2 Partial CBD/CHD wall injuries with or without tissue loss.
Type 3 CBD/CHD transection with or without tissue loss.
Type 4 Left/right hepatic duct or sectoral duct injuries
with or without tissue loss.
Type 5 Bile duct injury complicated with vascular injuries.
14.1.2 Repair ofBile Duct Injury
14.1.2.1 Repair oftheBile Duct InSitu
The intraoperatively discovered small laceration or avulsion of the bile duct wall can only be repaired by direct suture at the injured place, but the indication of this method is rela­tively strict. Normally, repair of the bile duct in situ can be considered when the defect of bile duct wall is <0.5cm and the following four conditions are required:
• The anatomical structure of intra- and extrahepatic bile
duct is normal, and no pathological changes can be found.
14 3D Visual Diagnosis andManagement ofBile Duct Injuries
323
• The diameter of the injured bile duct is >0.5cm.
• No tension when repairing or stitching.
• The diameter of the bile duct cavity has not changed obvi­ously after repair and suture.
Therefore, this method is only suitable for patients with
small biliary tract trauma and a better prognosis.
14.1.2.2 End-to-End Cholangiostomy
Theoretically, this method is most consistent with the physi­ological anatomy of the human body, which not only retains the function of the biliary sphincter but also helps prevent retrograde biliary tract infection. However, practical studies have shown that after the resection of bile duct injury or ste­nosis site, the difference of defect or diameter of the entire bile duct and the distance between the two fractures often make anastomosis difcult and increase the incidence of bili­ary leakage. Moreover, the rate of reoperation for patients undergoing this procedure is as high as 16%–20%.
14.1.2.3 Choledochoduodenostomy
It is safe and easy to perform direct anastomosis of the site of bile duct injury with duodenum by this method. However, it is difcult to avoid postoperative biliary reux and recurrent retrograde cholangitis; moreover, the diameter of the injured bile duct is often thin and the anastomotic stoma is prone to narrow. When stricture of high bile duct occurs, the chyme often reuxes to the intrahepatic bile duct after choledocho­duodenostomy, which easily results in sclerosing cholangi­tis. Therefore, this method is not widely used in the clinic. However, Aikawa et al. (2010) have made progress in the anti-reux effect compared with end-to-side choledochoduo­denal anastomosis by improving the method and using end­to- side choledochoduodenal anastomosis to encapsulate the distal end of the articial bile duct into the serosa layer of the duodenum.
14.1.2.4 Roux-en-Y Cholangiojejunostomy
The jejunum is cut off, and the distal segment is lifted to anastomose with the bile duct. The proximal end of the jeju­num is anastomosed end to side with the lifted jejunum. An open jejunum can be designed in this method as a mecha­nism to prevent the reux of intestinal contents, which is the most common method of bile duct reconstruction after bile duct injury or resection of biliary and pancreatic tumors. However, research and clinical follow-up showed that the incidence of reux cholangitis is still high due to the loss of function of Oddi sphincter. Moreover, with the prolongation of the jejunal loop, the peristalsis of the intestine is relatively weakened, the pressure of the intestine is increased, and the number of bacteria increases signicantly. Anaerobes are the dominant bacteria, which increase the incidence of counter­current cholangitis and choledochostomy infection and also
increase the risk of cholangiocarcinoma. Also, the incidence of gastrointestinal endocrine dysfunction, increased gastric acid, and duodenal ulcers will increase accordingly.
14.1.2.5 Biliary Duct Repair withPedicled Autologous Biovalve
Due to complications such as bile leakage and reux in the direct repair of the bile duct or intestinal anastomosis of the bile duct, clinicians have begun to use autologous tissue for bile duct repairs, such as pedicled gastric wall valve, gastric serosal valve, and umbilical vein of the hepatic round liga­ment. Although these autologous tissues have the advantages of proximity to the bile duct, convenient material taking, and easy trimming and shaping: this method can easily lead to brosis not only because of the difference between tissue structure and bile duct, but because it does not have the unique morphological structure of the biliary epithelium, such as regulatory vesicles and microvilli, and the alkaline environment in the bile duct is different from the growth environment of the autogenous tissue. Reasons also include the difculty of bile duct repair surgery as well as postopera­tive near- and long-term complications.
14.1.2.6 Patch Repair ofBile Duct Defect
Under normal physiological conditions, the bile duct epithe­lium is surrounded by highly cytotoxic bile acids and patho­gens, while the monolayer columnar epithelium protects it from injury. As a substitute for the biliary tract system, arti­cial bile duct should possess not only excellent mechanical properties and biocompatibility, but also possess high strength joint ability as well as stability, elasticity, and corro­sion resistance. Its exibility should be similar to that of bile duct tissue structure and have a surface roughness favorable for cell adhesion and growth. Also, articial bile ducts should also minimize the possibility of biodegradation. Aikawa etal. (2010) have used polycaprolactone, polylactic acid, and polyglycolic acid ber to construct articial bile duct, recon­struct bile duct by the bypass, and compare the repair effect of transplanted bone marrow before and after cell transplan­tation. Aikawa concluded that the addition of bone marrow stem cells had no apparent effect on the results of the experi­ment, and it was suggested that the articial bile duct mate­rial could be applied in the clinic. Based on the above factors, the clinical application of articial bile duct is rare, and its therapeutic effect needs further research and conrmation. However, recently, there are some reports on the successful restoration of the narrow bile duct with biodegradable syn­thetic materials.
14.1.2.7 Liver Transplantation
The incidence of portal hypertension and biliary cirrhosis after bile duct injury is 8%. Some foreign scholars have found that hepatic brosis is related to the delayed treatment
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of biliary stricture through liver biopsy. Therefore, liver transplantation may be the only way to treat biliary system injury when cirrhosis and portal hypertension are caused by biliary system injury. However, intrahepatic bile duct steno­sis is a common complication after liver transplantation, which is an important factor hindering the improvement of liver transplantation efcacy. Therefore, the treatment of bile duct injury through liver transplantation needs further clini­cal exploration.
14.2 Application of3D Visualization inBiliary Tract Injury
The hepatobiliary system is the only way for bile to descend. Once damaged, it will affect liver function and endanger life. Because of the particularity of extrahepatic biliary system anatomical variation and the new problems brought about by the development of laparoscopic technology, iatrogenic bile duct injury is still an unavoidable technical problem in hepa­tobiliary surgery. Though hepatobiliary surgery has been developing for more than a hundred years, the incidence of bile duct injury is reported as 0.5–0.8% after laparoscopic cholecystectomy (Bektas et al. 2011). Also, trauma, war injury, and pathological injury caused by tumor can lead to severe bile duct injury. The repair of hepatic biliary system injury is still one of the most challenging in hepatobiliary surgery. Mastering the type, and location of bile duct injury before the operation is of great importance in the treatment of biliary tract injury. Abdominal ultrasonography has a high diagnostic rate for suspected bile duct injury. Up to 10%– 14% of patients produce intrafossa uid after cholecystec­tomy can produce a small amount of subhepatic effusion, while only 10% of patients with biliary obstruction will have bile duct dilatation early after an operation (Frilling et al.
2004), therefore, the results of ultrasonography should be
carefully interpreted. The exact diagnosis needs the support of ERCP, PTC, or MRCP.PTC is an invasive diagnostic tech­nique with the risk of bleeding, secondary infection, and puncture failure. PTC is often difcult to perform in the case of recent bile duct injury with bile leakage without apparent dilation of the bile duct. In patients with complete transec­tion or stricture of the bile duct; with ERCP it is difcult to show the structure of the injured proximal bile duct tree. As a noninvasive biliary imaging technique, MRC can display the anatomical structure of various types of bile duct tree in many directions. It can provide accurate information about the location, range, and extent of bile duct stricture and the degree of proximal bile duct dilatation; so as to provide a reliable basis for the design of the surgical plan. However, it cannot be used to observe the adjacent relationship of the injured bile duct from multi-directions and multi-angles. Three-dimensional visualization technology can be used to
acquire submillimeter thin-layer anatomical image data of the living human body, by advanced MSCT acquisition; and use of computer image processing technology to transform 2D to 3D, which can be used to guide clinical practice. The location of biliary tract injury and its relationship to its sur­roundings can be observed from multiple directions and angles. Preoperative planning and surgical guidance can be carried out to minimize the reinjury of the biliary tract in patients.
14.2.1 Application of3D Visualization Technique inBiliary Tract Injury (Case1)
A 40-year-old man was admitted postoperatively for conver­sion from laparoscopic cholecystectomy to open surgery nearly 4 months ago in another hospital. The patient reported that he received conversion from laparoscopic cholecystec­tomy to open surgery on June 24, 2013. Postoperative jaun­dice was progressively aggravated. The TBil was 203.0 μmol/L, and DBil was 119.3 μmol/L; after admission, biliru­bin was still progressively elevated; the upper abdomen enhanced CT was performed and “after cholecystectomy, intrahepatic bile duct dilatation was more obvious than before, considering the possibility of common hepatic duct stenosis.” Diagnosis: obstructive jaundice, portal hyperten­sion, splenectomy, posthepatitic cirrhosis, chronic viral hep­atitis B (active phase), conversion from laparoscopic cholecystectomy to open surgery, anemia. On July 10, TBil was 571 μmol/L, and DBil was 334 μmol/L.The bilirubin was signicantly decreased after percutaneous transhepatic right lobe biliary drainage under local anesthesia on July 10, 2013, and discharged from hospital on July 16, 2013. After discharge, the patient had no apparent discomfort, no chills, fever, no abdominal pain, no abdominal distension, no nau­sea, vomiting, no chest tightness, no palpitations, no dif­culty breathing, no black spots, clay-like stools, etc. PTCD drained 500 to 800 ml of golden yellow bile daily. He returned to the hospital on August 25, 2013, for review. Jaundice had subsided, and the symptoms improved slightly. On August 26, “TBil was 28.1 μmol/L, DBil was 22.4 μmol/L.” On August 27, enhanced CT of the upper abdomen showed that “after cholecystectomy + PTCD, the extent of intrahepatic bile duct dilatation did not change signicantly compared with the previous CT lms on 2013-07-16; effu­sion and pneumatosis in cholecystectomy area had decreased; right pleural effusion and a small amount of ascites were basically absorbed.”
After 3 months of PTCD drainage, the yellow scleral staining subsided. Specialist examination: at abdomen, no exposure of abdominal wall vein, oblique operation scar about 8cm along the right costal margin, an operation scar of
14 3D Visual Diagnosis andManagement ofBile Duct Injuries
about 0.5cm under the xiphoid process, a scar of about 1cm under the navel, and a scar of about 1cm under the right mid­abdomen; no peristaltic wave and no abnormal pulsation; soft abdominal wall; no abdominal tenderness, no rebound pain, no palpable abdominal mass. The subcostal parts of liver, spleen, and gallbladder were not touched. The liver neck reux sign was negative, and the upper boundary of liver turbidity was located in the fth intercostal area of the middle line of the right clavicle. The bowel sounds were about 4/min. A PTCD drainage tube can be seen in the right upper abdomen (Fig.14.1). Preliminary diagnosis: (a) The laparoscopic operation conversion to open cholecystectomy; (b) Portal hypertension, splenomegaly; (c) Posthepatitic cir­rhosis; (d) Hepatitis B virus carrier; (e) Right hepatic punc­ture after biliary drainage (Figs.14.2, 14.3, 14.4, 14.5, 14.6,
14.7, 14.8, 14.9, 14.10, 14.11, 14.12, 14.13, 14.14, 14.15,
14.16, 14.17, 14.18 and 14.19).
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Fig. 14.3 CT scan obtained during arterial phase
Fig. 14.1 Broken end of bile duct injury found by MRCP
Fig. 14.2 Dilated bile duct and PTCD tube displayed by Plain CT scan
Fig. 14.4 CT scan obtained during portal venous phase
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Fig. 14.5 Biliary tract angiography via a PTCD drainage tube
Fig. 14.6 The 3D reconstructed model showing the plane of the dilated
bile duct
Fig. 14.7 The front view of the 3D reconstructed model
Fig. 14.8 The back view of the 3D reconstructed model