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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_585_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword I
- •Foreword II
- •Foreword III
- •Foreword IV
- •Contributors
- •Manuscripts Translation and Preparation
- •1.1 Introduction
- •Preface
- •Acknowledgments
- •Contents
- •Editors and Contributors
- •Deputy Editors
- •1.2.2.2 Gallbladder
- •1.2.2.3 Cystic Duct
- •1.2.2.4 Common Bile Duct
- •Supraduodenal Portion
- •Retroduodenal Portion
- •Pancreatic Portion
- •Intraduodenal Portion
- •1.3.2 Data Acquisition
- •1.3.2.2 Bile Duct Perfusion
- •1.3.2.3 Hepatic Artery Perfusion
- •1.3.2.4 Specimen Perfusion Fixation
- •1.4.1 Liver Dissection after Biliary Tract Perfusion
- •1.4.3.1 Image Registration After Bile Duct Perfusion
- •References
- •2.1 Introduction
- •2.2.1 Basic Principles
- •2.2.2.1 Methods
- •Preparation
- •Scanning Modalities
- •Contrast-Enhanced Scanning
- •Contrast-Enhanced Examination
- •Shaded Surface Display
- •Maximum Intensity Projection
- •Volume Rendering
- •2.3.1.1 MRI Devices
- •The Magnet
- •The Gradient System
- •The Radiofrequency System
- •Radiofrequency Coils
- •The Computer System
- •Other Auxiliary Equipment
- •2.3.2.1 MRI Preparations
- •Patient Preparation
- •2.3.2.2 Regular Scan Sequences
- •Single-Shot Turbo Spin-Echo Coronal Sequences
- •2D or 3D T2W1
- •Transaxial Single-Shot Turbo Spin-Echo Fat Suppression Sequences
- •Dynamic Enhancement Sequence
- •3D Volumetric Acquisitions
- •Advantages
- •Disadvantages
- •2D Continuous Thin-Slice Scanning
- •Advantages
- •Disadvantages
- •2D Thick-Slice Projection Imaging
- •Advantages
- •Disadvantages
- •References
- •3.1 Introduction
- •3.2 Congenital Biliary Diseases
- •3.2.1 Congenital Extrahepatic Biliary Atresia
- •3.2.1.1 CT Features
- •3.2.1.2 MRI Features
- •3.2.2 Biliary Dilatation
- •Type I
- •Type II
- •Type III
- •Type IV
- •Type V
- •3.2.2.2 Radiographic Features
- •CT Features
- •MRI Features
- •3.2.3 Bile Duct Hamartomas
- •3.2.3.1 CT Features
- •3.2.3.2 MRI Features
- •3.3 Common Gallbladder Diseases
- •3.3.1 Acute Cholecystitis
- •3.3.1.1 Radiographic Features
- •CT Features
- •MRI Features
- •Gangrenous Cholecystitis
- •Emphysematous Cholecystitis
- •Pediatric Cholecystitis
- •Pregnancy Cholecystitis
- •Gallbladder Empyema
- •Gallbladder Perforation
- •Hemorrhagic Cholecystitis
- •3.3.5 Other Gallbladder Tumors
- •3.3.5.3 Primary Gallbladder Lymphoma
- •3.3.5.4 Gallbladder Fibrosarcoma
- •3.3.6 Xanthogranulomatous Cholecystitis
- •3.3.6.1 CT Features
- •3.3.6.2 MRI Features
- •3.3.7 Gallbladder Adenomyomatosis
- •3.3.2 Chronic Cholecystitis
- •3.3.2.1 CT Features
- •3.3.2.2 MRI Features
- •3.3.3 Gallstones
- •3.3.3.1 CT Features
- •3.3.3.2 MRI Features
- •3.3.4 Gallbladder Cancer
- •3.3.4.1 CT Features
- •3.3.4.2 MRI Features
- •3.3.4.3 MRCP Features
- •3.3.7.1 CT Features
- •3.3.7.2 MRI Features
- •3.3.8.1 CT Features
- •3.3.9 Gallbladder Torsion
- •3.3.9.1 Type I
- •3.3.9.2 Type II
- •3.3.10.2 Gallbladder Sludge
- •3.3.11 Mirizzi’s Syndrome
- •3.3.11.1 CT Features
- •3.3.11.2 MRI Features
- •3.3.12 Post-Cholecystectomy Syndrome
- •3.4.1 Bile Duct Stones
- •CT Findings
- •MRI Findings
- •CT Findings
- •MRI Findings
- •3.4.2 Suppurative Cholangitis/Acute Cholangitis
- •3.4.3 Primary Sclerosing Cholangitis
- •3.4.3.1 CT Findings
- •3.4.3.2 MRI Findings
- •3.4.4 Secondary Sclerotic Cholangitis
- •3.4.5 Recurrent Pyogenic Cholangitis
- •3.4.5.1 CT Findings
- •3.4.6 Extrahepatic Cholangiocarcinoma
- •3.4.6.1 CT Findings
- •MRI Findings
- •MRCP Features
- •3.4.7 Intrahepatic Cholangiocarcinoma
- •3.4.7.3 Special Manifestations
- •3.4.8 Periampullary Carcinoma
- •3.4.8.1 Radiographic Findings
- •3.4.8.2 CT Findings
- •3.4.8.3 MRI Findings
- •3.4.9 Combined Hepatocellular-Cholangiocarcinoma
- •3.4.9.1 Imaging Findings
- •3.4.9.2 MRI Findings
- •3.5.1.1 Intrahepatic Biliary Dilatation
- •CT Findings
- •MRI Findings
- •3.5.1.2 Extrahepatic Bile Duct Dilatation
- •3.5.2.1 Hilar Obstruction
- •3.5.2.3 Pancreatic Obstruction
- •References
- •4.1 Introduction
- •4.1.2.1 CT Acquisition Protocols
- •4.1.2.2 Data Preprocessing
- •4.1.2.3 Medical Image Segmentation
- •4.1.2.4 3D Visualization
- •4.2.1 Image Registration
- •4.2.1.1 Template Matching Algorithm
- •4.2.1.2 Registration Steps
- •Step 1
- •Step 2
- •Step 3
- •4.2.2 Image Segmentation
- •Pixel Based Methods
- •Region Based Methods
- •Edge Based Methods
- •Model Based Methods
- •4.2.2.3 Serialized Segmentation Model
- •4.2.2.4 Adaptive Region Growing Algorithm
- •4.2.3 3D Reconstruction
- •References
- •5.1 Introduction
- •Fused Deposition Modeling
- •Stereolithography
- •Selected Laser Sintering
- •Direct Metal Laser Sintering
- •Laminated Object Manufacturing
- •Electron Beam Melting
- •Three-Dimensional Printing
- •High-Performance 3D Reconstruction Software
- •5.1.2.2 Medical Model Manufacturing
- •5.1.2.3 Tissue/Organ Regeneration
- •5.2.2 Digital Preparation
- •5.3.1.1 In Complex Liver Resection
- •5.3.1.2 In Liver Transplantation
- •5.3.2.1 In Cholangiocarcinoma Surgery
- •5.3.4 Prospects
- •References
- •6.1 Introduction
- •6.1.1 Virtual Anatomy
- •6.1.2 Surgical Simulation
- •Improved Doctor–Patient Relationship
- •Reduced Surgical Costs
- •Remote Intervention
- •6.2 Virtual Surgical Instruments
- •6.2.1 Geometric Modeling
- •6.2.2 Motion Modeling
- •6.2.3 Physical Modeling
- •6.3 Surgical Simulation
- •6.3.1 The Hardware System
- •6.3.2 Software System
- •6.3.2.1 FreeForm Modeling System
- •6.3.2.2 Open Graphics Library
- •6.3.2.3 Tactile Development Kit
- •6.4.4 Discussion
- •References
- •7.1 Introduction
- •References
- •8.1 Introduction
- •8.2 Duodenoscopy
- •8.3 Choledochoscopy
- •8.3.1 Preoperative Application
- •8.3.2 Intraoperative Application
- •8.3.3 Postoperative Application
- •8.4 Capsule Endoscopy
- •8.5 Laparoscope
- •8.6 Endoscopic Ultrasound
- •8.7 3D Visualization-Assisted Endoscopic Technology
- •References
- •9.1 Introduction
- •9.3.1.1 Arterial Phase
- •9.3.1.2 Portal Venous Phase
- •References
- •10.1 Introduction
- •10.2.1.2 Image Segmentation
- •10.2.1.3 3D Reconstruction
- •10.2.1.4 Surgical Simulation
- •Surgical Procedure
- •References
- •11.1 Introduction
- •11.2.2 Image Registration
- •References
- •12.1 Introduction
- •12.2.1 Imaging
- •12.2.2 Other Auxiliary Examinations
- •12.2.2.1 Biliary Manometry
- •12.2.2.2 Cholescintigraphy
- •12.2.2.3 Selective Celiac Arteriography
- •12.3.1 Collection Equipment
- •12.3.3 Plain Scan
- •12.3.4 Dynamic Enhanced CT Scan
- •12.4.1 Image Registration
- •12.6.1 Semiautomatic Liver Segmentation
- •Surgical Procedures
- •Surgical Procedures
- •12.10.2 Anatomical or Regular Hepatectomy Guided by 3D Visualization
- •12.10.2.1 Indications
- •12.10.2.2 Contraindications
- •12.10.2.4 Surgical Procedures
- •For Anatomical Right Hemihepatectomy
- •For Anatomical Left Hemihepatectomy
- •12.10.3.1 Contraindication
- •12.10.3.3 Surgical Procedures
- •Case 1
- •Case 2
- •12.10.4.1 Indications
- •12.10.4.2 Contraindication
- •12.10.4.4 Surgical Procedures
- •12.10.4.5 Attention
- •12.10.5.1 Indications
- •12.10.5.2 Contraindications
- •12.10.5.3 Surgical Procedures
- •12.10.5.4 Attention
- •12.10.6.1 Indications
- •12.10.6.2 Contraindications
- •12.10.6.3 Preoperative Imaging Evaluation
- •12.10.6.4 Surgical Procedures
- •12.10.6.5 Attention
- •12.10.7.1 Indications
- •12.10.7.2 Contraindications
- •12.10.7.3 Surgical procedures
- •12.10.7.4 Attention
- •12.10.8.1 Preoperative Evaluation
- •12.10.8.2 Preoperative Preparation
- •12.10.8.3 Contraindications
- •12.10.8.4 Operation Methods
- •12.10.8.5 Attention
- •12.10.9.1 Biliary Injury
- •Causes
- •Preventive Measures
- •12.10.9.2 Biliary Bleeding
- •12.10.9.3 Gastrointestinal Water Retention
- •Reasons
- •12.10.9.4 Biliary Leakage
- •12.11.1.1 Reasons
- •Main Reasons
- •Iatrogenic Biliary Tract Injury
- •Other Reasons
- •12.11.1.3 Surgical Procedures
- •Roux-en-Y Choledochojejunostomy
- •Hepatectomy
- •Intrahepatic Lithotripsy Through Sinus Tract or PTCS
- •Severe Symptomatic Patients
- •References
- •13.1 Introduction
- •13.3.1 Ultrasonography
- •13.3.2 Multi-Slice CT
- •13.3.5 Intraoperative Cholangiography
- •13.3.6 Radionuclide Hepatobiliary Scan
- •13.3.7 Digital Medicine Technology
- •Periampullary Tumor
- •Biliary Atresia
- •Acute Pancreatitis
- •Acute Cholecystitis
- •Hepatic Cyst
- •Hepatic Echinococcosis
- •Retroperitoneal Cystic Masses
- •13.4.2.1 Biliary Drainage
- •13.4.2.3 Liver Resection
- •13.4.2.4 Pancreaticoduodenectomy
- •13.4.2.5 Liver Transplantation
- •13.4.2.6 Laparoscopic Surgery
- •13.4.2.7 Reoperation
- •References
- •14.1 Introduction
- •14.1.1.1 Etiology
- •Anatomical Factors
- •Pathological Factors
- •Surgeon Factors
- •14.1.2.2 End-to-End Cholangiostomy
- •14.1.2.3 Choledochoduodenostomy
- •14.1.2.4 Roux-en-Y Cholangiojejunostomy
- •14.1.2.7 Liver Transplantation
- •14.2.2.1 Patient Information
- •14.2.2.2 Diagnosis
- •14.2.2.3 Complaint
- •14.2.2.4 History
- •14.2.2.5 Signs
- •14.2.2.6 Previous History
- •14.2.2.7 Laboratory Examination
- •Blood Routine
- •Coagulation Function
- •Liver Function
- •Renal Function
- •Tumor Markers
- •14.2.2.8 General Condition Assessment
- •Nutritional Status Evaluation
- •Liver Function Evaluation
- •Important Organ Function Evaluation
- •14.2.2.9 Imaging Evaluation
- •Evaluation by 3D Visualization
- •14.2.2.10 Surgical Planning
- •14.2.2.11 Surgical Procedures
- •Step 1
- •Step 2
- •Step 3
- •14.2.3.1 Patient Information
- •14.2.3.2 Diagnosis
- •14.2.3.3 Complaint
- •14.2.3.4 History
- •14.2.3.5 Signs
- •14.2.3.6 Previous History
- •14.2.3.7 Laboratory Examination
- •Blood Routine
- •Coagulation Function
- •Liver Function
- •Renal Function
- •Tumor Markers
- •14.2.3.8 General Condition Assessment
- •Nutritional Status Evaluation
- •Liver Function Evaluation
- •Important Organ Function Evaluation
- •14.2.3.9 Imaging Evaluation
- •Evaluation by 3D Visualization
- •14.2.3.10 Surgical Planning
- •14.2.3.11 Surgical Procedure
- •Step 1
- •Step 2
- •Step 3
- •References
- •15.1 Introduction
- •15.2 Clinical Stages
- •15.2.2 Surgical Strategy
- •Tis/T1a Stage
- •T1b Stage
- •Stage T2
- •Stage T3
- •Stage T4
- •15.2.2.2 Lymph Node Dissection Range
- •Stage Tis/T1a
- •Stage T1b
- •Stage T2
- •Stage T3
- •Stage T4
- •15.2.2.3 Extrahepatic Bile Duct Management
- •Stage Tis/T1a
- •Stage T1b
- •Stage T2
- •Stage T3
- •Stage T4
- •15.3.1 T Staging Assessment
- •15.3.1.1 Stage T2
- •MDCT
- •15.3.1.2 Stage T3
- •MDCT
- •15.3.1.3 Stage T4
- •15.3.3 Resectability Assessment
- •15.3.3.1 General Assessment
- •15.3.3.2 Liver Function Assessment
- •15.3.3.3 Virtual Surgery Assessment
- •15.4.1 Surgical Indications
- •15.4.2 Preoperative Preparation
- •15.4.2.3 Preoperative 3D Visualization Evaluation
- •15.4.3 Surgical Procedures
- •15.4.3.1 Resection Range
- •Radical Pancreaticoduodenectomy
- •15.4.4 Surgical Prognosis
- •References
- •16.1 Introduction
- •16.2.2.2 Imaging Diagnosis
- •16.2.2.3 Pathological Diagnosis
- •16.2.2.4 Clinical Staging
- •16.2.3.1 Preoperative Assessment
- •Liver Function Assessment
- •Resectability Assessment
- •3D Visualization Assessment
- •16.2.3.2 Surgical Approach
- •16.2.3.3 Controversial Point
- •Lymphadenectomy
- •Extended Hepatectomy
- •Liver Transplantation
- •Operative Prognosis
- •16.2.4 Multidisciplinary Team
- •16.2.5 Conclusion
- •Notes
- •16.3.4 Surgical Planning Guided by 3D Visualization
- •Type I
- •Type II
- •Type IIIa
- •Type IIIb
- •Type IVa
- •Type IVb
- •Type V
- •16.3.6.2 Typical Case
- •Case 1
- •Case 2
- •Case 3
- •Case 4
- •Case 5
- •16.3.6.4 Lymphadenectomy
- •16.3.6.6 Laparoscopic Exploration
- •16.3.6.7 Intraoperative Frozen Section Consultation
- •16.3.6.8 Liver Transplantation
- •Common Type
- •Type II Variation
- •Type III Variation
- •16.3.10 Other Comprehensive Treatment
- •16.3.11 Other Perioperative Management
- •16.3.11.2 Postoperative Follow-Up
- •References
- •17.1 Introduction
- •17.2.2.1 Perihilar Tumor
- •17.2.2.2 High Biliary Stricture
- •Hepatic Arterial Variation
- •Portal Vein Variations
- •Bile Duct Variations
- •17.3.2 Complex Pathophysiology
- •17.4.1.3 Preoperative Biliary Drainage
- •17.4.2.3 Cholangiojejunostomy
- •17.6 3D Visualization Imaging
- •Viscera Reconstruction
- •Lesion Reconstruction
- •Vascular Reconstruction
- •References

196
C. Fang et al.
a
Fig. 9.20 (a–b) The cystic artery originated from gastroduodenal artery supplies the lower extrahepatic bile duct (type III)
b
Table 9.1 Incidence of digital extrahepatic bile duct supplying artery
(Yang 2017)
Types N Incidence (%)
Right hepatic artery 35 85.4
Superior posterior pancreaticoduodenal
artery and its branches
Cystic artery 27 65.9
Proper hepatic artery 12 29.3
Gastroduodenal artery and its main
branches
Left hepatic artery 6 14.6
Posterior portal artery (from celiac trunk) 2 4.9
Posterior portal artery (from superior
mesenteric artery)
Other arteries 1 2.4
a
The superior posterior pancreaticoduodenal artery is not included
a
30 73.2
7 17.1
2 4.9
Fig. 9.21 Anastomotic artery forming around the extrahepatic bile
duct
three-dimensional visualization system (MI-3DVS). A total
of 41 thin layer (0.625mm) DICOM images were collected
from four stages of CT, including plain scan, arterial phase,
portal phase, and venous phase, with excellent image quality,
as well as a clear display of peripheral blood supply artery of
the extrahepatic bile duct, cholelithiasis, pancreatic and periampullary lesions, abdominal organs, and portal vein. The
3D model of extrahepatic bile duct blood supply established
by MI-3DVS can obtain dynamic images of full dimension
rotation, which can be arbitrarily scaled, displayed by any
combination, and can be opacied or hidden from the target
organ model, showing clearly the origin of extrahepatic bile
duct blood supply. Meanwhile, it can show the stereoscopic
anatomical relationship between bile duct stones, tumors and
surrounding organs and blood vessels.
9.4.1.1 Distribution ofExtrahepatic Bile Duct
Blood Supply
The right hepatic artery was involved in the blood supply in
35 cases (85.4%), the superior pancreaticoduodenal artery
and its main branches in 30 cases (73.2%), the gallbladder
artery in 27 cases (65.9%), the proper hepatic artery in 12
cases (29.3%), the gastroduodenum and its main branches in
7 cases (17.1%), the left hepatic artery in 6 cases (14.6%),
the posterior portal vein artery in 4 cases (9.8%) and the
other arteries in 1 case (2.4%) (Table9.1). It can be seen that
the extrahepatic bile duct has a reticular blood supply formed
by multiple arteries (Yang 2017).

9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
197
9.4.1.2 Digital Classication ofExtrahepatic Bile
Duct Blood Supply
Among the 41 cases (Yang 2017) of the upper extrahepatic
bile duct blood supply, there were 6 cases of type IA (14.6%)
(Fig.9.22), 17 cases of type IB (41.5%) (Fig.9.23), 12 cases
of type IC (29.3%) (Fig.9.24), and 6 cases of type II (14.6%)
(Fig.9.25) (Table9.2).
In the lower extrahepatic bile duct blood supply, there
were 13 cases of type IA (31.7%) (Fig.9.26), 13 cases of
type IB (31.7%) (Fig. 9.27), 4 cases of type IC (9.8%)
a
(Fig.9.28), 7 cases of type II (170%) (Fig.9.29), 4 cases of
type III (9.8%) (Fig.9.30) (Table9.3).
9.4.2 Surgical Management Based on3D
Modelling ofExtrahepatic Bile Duct
Blood Supply
All the 41 cases underwent surgical treatment, including
choledocholithotomy in 15 cases (3 cases of left extrahepatic
b
Fig. 9.22 Blood supply to the upper extrahepatic bile duct (type IA).
(a) The right hepatic artery supplies the upper extrahepatic bile duct.
The blue arrow indicates the branch of the right hepatic artery accom-
a
Fig. 9.23 Blood supply to the upper extrahepatic bile duct (type IB). (a) The superior extrahepatic bile duct is supplied by the right hepatic artery
and the gallbladder artery; (b) The superior extrahepatic bile duct is supplied by the right hepatic artery and the gallbladder artery
panying the extrahepatic bile duct; (b) The right hepatic artery supplies
the upper extrahepatic bile duct. The blue arrow indicates the branch of
the right hepatic artery accompanying the extrahepatic bile duct.
b

198
ab
Fig. 9.24 Blood supply to the upper extrahepatic bile duct (type IC). (a) The right hepatic artery and the proper hepatic artery supply the upper
extrahepatic bile duct; (b) The right hepatic artery and the proper hepatic artery supply the upper extrahepatic bile duct
C. Fang et al.
biliary tract operation was in accordance with the preoperative planning, and the coincidence rate was 100%. The intraoperative morphology of extrahepatic bile duct, the blood
ow of extrahepatic bile duct, the variation of the hepatic
artery, the distribution of stones, and the relationship between
tumor and blood vessel (Fig.9.31), were all consistent with
the preoperative 3D model.
Of the 41 cases, 3 had mild pancreatic leakage, 4 had
a pulmonary infection, 2 had incision fat liquefaction.
They recovered after active conservative treatment. No
intraoperative or postoperative biliary bleeding or biliary
fistula occurred in any patient. Patients were followed up
between 3 and 15months. No extrahepatic biliary stricture or biliary–intestinal anastomotic stricture occurred
(Fig.9.32).
Fig. 9.25 Blood supply to the upper extrahepatic bile duct (type II).
The left hepatic artery and the cystic artery supply the upper extrahepatic bile duct
Table 9.2 Digital classication of the blood supply of the upper extrahepatic bile duct in 41 patients with biliary obstruction (Yang 2017)
Types N Incidence (%)
Type IA 6 14.6
Type IB 17 41.5
Type IC 12 29.3
Type II 6 14.6
9.4.3 Clinical Signicance of3D Modelling
ofExtrahepatic Bile Duct Blood Supply
inPatients withBiliary Obstruction
9.4.3.1 Digital Classication andClinical
Signicance ofExtrahepatic Bile Duct
Blood Supply inPatients withBiliary
Obstruction
Digital classication of extrahepatic bile duct blood supply
based on the distribution characteristics of blood supply to
the upper and lower extrahepatic bile ducts, is helpful for
lobectomy), end-to-side cholangiojejunostomy in 22 cases
(20 cases of pancreaticoduodenectomy), side-to-side
Cholangiojejunostomy in 3 cases, and excision of solid pseudopapilloma in the head of the pancreas with duodenal preservation in 1 case (Yang 2017). The method of intraoperative
clinicians to correctly diagnose the blood supply type of the
extrahepatic bile duct in the upper and lower segments.
Preoperative evaluation is performed according to the position of the extrahepatic bile duct, which guides the rationale
for selecting the surgical method.

9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
199
a
Fig. 9.26 Blood supply of the lower extrahepatic bile duct (Type IA). (a) The posterior superior pancreaticoduodenal artery supplies the lower
extrahepatic bile duct; (b) The posterior superior pancreaticoduodenal artery supplies the lower extrahepatic bile duct
b
the digital classication of extrahepatic bile duct blood supply can be performed before operation, the operative method
can be selected according to the type of classication. When
the blood supply of the lower extrahepatic bile duct is classied as type I, it is mainly supplied by the superior posterior
pancreaticoduodenal artery, whose arch should be preserved
during operation. For type II, the main supply of bile duct
was the gastroduodenal artery and pancreaticoduodenal
anterior artery. It was often suggested that the posterior pancreaticoduodenal artery arch was small, and the anterior pancreaticoduodenal artery arch should be preserved to ensure
the blood supply of duodenum and bile duct. If type III, the
cholecystic artery originated from the gastroduodenal artery,
goes up to the upper right, and supplies blood to the bile
duct. It is necessary to avoid the destruction of the ascending
Fig. 9.27 Blood supply of the lower extrahepatic bile duct (Type IB).
The posterior superior pancreaticoduodenal artery and the gastroduodenal artery supply the lower extrahepatic bile duct
gallbladder artery while preserving the head of the pancreatic artery arch; if the posterior pancreaticoduodenal artery
arch is preserved only according to experience, it may lead to
complications such as postoperative biliary ischemic steno-
For example, in pancreatectomy with duodenal preservation, the site of operation is mainly in the lower part of the
common bile duct, and the surgeon protects the duodenum
and the lower extrahepatic bile duct blood supply by retaining the posterior pancreaticoduodenal arterial arch based on
experience from autopsy. After complete resection of the
lesions, the common bile duct is examined for ischemia. If
the blood supply of the common bile duct is inadequate, the
common bile duct should be cut off, and choledochoduodenal anastomosis should be performed. However, delayed
postoperative biliary ischemia is often unnoticed, thus
increasing the occurrence of biliary stula and stricture. If
sis and biliary stula.
A 3D model of extrahepatic bile duct blood supply in a
patient undergoing duodenum-preserving pancreatectomy
showed that the lower part of the common bile duct was
mainly supplied by the gastroduodenal artery and the pancreaticoduodenal anterior artery. The anterior pancreaticoduodenal artery arch was formed to supply duodenal blood, and the
lower extrahepatic bile duct blood supply was digitally classied as type II.According to the 3D model, the anterior pancreaticoduodenal artery arch was successfully preserved during
the operation without biliary stula or duodenal stula. No
stricture of bile duct occurred after a 1-year follow-up.

200
C. Fang et al.
a
Fig. 9.28 Blood supply of the lower extrahepatic bile duct (Type IC).
(a) The posterior superior pancreaticoduodenal artery and the posterior
portal artery supply the lower extrahepatic bile duct; (b) The posterior
Fig. 9.29 The gastroduodenal artery and its branches (the anterior
pancreaticoduodenal artery) supply the lower extrahepatic bile duct and
form the anterior pancreaticoduodenal arch
b
9.4.3.2 Signicance of3D Visualization
ofExtrahepatic Bile Duct Blood Supply
inSurgical Decision Making
ofExtrahepatic Bile Duct Obstructive
Diseases
In patients with extrahepatic bile duct obstructive disease,
the bile duct is dilated, and the blood supply to the bile duct
is bound to increase. The artery supplying blood to the bile
superior pancreaticoduodenal artery and the posterior portal artery supply the lower extrahepatic bile duct
duct will increase in diameter and increase the branch compensation mechanism to meet the increase in bile duct blood
supply. Moreover, the main blood supply to extrahepatic bile
ducts, that is, the right hepatic artery and gallbladder artery,
vary considerably. If the source and distribution of extrahepatic bile duct blood supply cannot be recognized before the
operation, it may be damaged during operation, which may
lead to complications such as biliary bleeding, postoperative
biliary stula, stricture of extrahepatic bile duct, or cholangio–intestinal anastomosis.
The 3D model of extrahepatic bile duct blood supply
based on submillimeter CT data can provide threedimensional visual distribution characteristics of individual
extrahepatic bile duct blood supply and become a “digital
uoroscopic eye” helping biliary surgeons to understand the
internal structure of living human body. A 3D model of
extrahepatic bile duct blood supply clearly showed that the
variant right hepatic artery originated from the superior mesenteric artery and passed through part of the pancreatic tissue
during the course of the operation. In pancreaticoduodenectomy, the injury of the right hepatic artery was avoided, and
the right hepatic artery was dissected thoroughly, thus preserving the arterial blood supply of the right half liver and
the upper extrahepatic bile duct (Fig.9.33).
Biliary stula and bile duct stenosis after extrahepatic
cholangiostomy are strongly related to injury to the anterior
wall of the bile duct during the operation. The 3D model of
extrahepatic bile duct blood supply can be used to understand the distribution of arteries attached to the anterior wall
of the extrahepatic bile duct before operation and thus guide
the location of the longitudinal incision of the extrahepatic

ab
9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
201
a
Fig. 9.30 Blood supply of the lower extrahepatic bile duct (Type III).
(a) The cystic artery arising from the gastroduodenal artery supplies the
lower segment of the extrahepatic bile duct; (b) The cystic artery arising
Table 9.3 Digital classication of blood supply of the lower
extrahepatic bile duct in 41 patients with biliary obstruction
(Yang 2017)
b
from the gastroduodenal artery supplies the lower segment of the extrahepatic bile duct
Types N Incidence (%)
Type IA 13 31.7
Type IB 13 31.7
Type IC 4 9.8
Type II 7 17.0
Type III 0.4 9.8
Fig. 9.31 Intraoperative picture of blood supply to extrahepatic bile duct. (a) The supercial vascular network and bile duct of the 9 o’clock artery
(blue arrow); (b) 3 o’clock artery (indicated by vascular forceps)

202
Fig. 9.32 Postoperative cholangiography and MRCP results: typical
case 3, The MRCP examination 1year after the operation showed no
extrahepatic bile duct stricture
Fig. 9.33 Variation of hepatic artery passing through pancreatic
parenchyma
bile duct. A patient with lower choledocholithiasis was
scanned and a 3D model constructed (Fig.9.34). The model
showed the right hepatic artery and the proper hepatic artery
supplying the anterior wall of the extrahepatic bile duct
(Fig.9.34). The location of the incision was selected according to the model so as to avoid complications such as biliary
stula or late biliary stricture, injury to the anterior wall of
the blood supply artery was avoided when the extrahepatic
bile duct was cut open, sutured, and closed.
The three-dimensional visualization model of extrahe-
patic bile duct blood supply can assist in the decision-
C. Fang et al.
Fig. 9.34 The 3D model suggests that the right hepatic artery and the
proper hepatic artery send out large branches on the anterior wall of the
extrahepatic bile duct to supply the bile duct
making of cholangioenterostomy and the location of the
biliary anastomosis. Typical case 1 (Resource 9.1: case 1):
The patient was diagnosed with inammatory stenosis of
the lower common bile duct. Conservative treatment and
endoscopic duodenal papilla incision were ineffective, and
bile drainage was needed through choledochojejunostomy.
The preoperative 3D model of the extrahepatic bile duct
supply suggested that the common hepatic bile duct blood
supply was composed of “9 o’clock” artery and right
hepatic artery formed by the main gallbladder artery. The
lower part of the common bile duct blood supply was supplied by the superior and posterior pancreaticoduodenal
artery, but no obvious arterial blood supply was found in
the upper part of the common bile duct and duodenum.
Above all, the extrahepatic bile duct was cut off at the level
of the common bile duct with abundant blood supply, and
end-to-side cholangiojejunostomy was performed. Typical
case two (Resource 9.1: case 2) was also diagnosed with
inammatory stenosis in the lower common bile duct, but
the individual 3D model suggested that the extrahepatic
bile duct blood supply of the patient was variable, and the
cholecystic artery originated from the gastroduodenal
artery. The intestinal artery, which is close to the right-side
wall of the extrahepatic bile duct, enters the gallbladder
and forms a “9 o’clock” artery for ascending blood supply.
If the patient receives an extrahepatic bile duct transection
and end-to-side cholangiojejunostomy, the arterial blood
supply may be destroyed at 9 o’clock. Therefore, side- toside cholangiojejunostomy was selected as the operative
method.

9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
203
The extrahepatic bile duct blood supply artery is accompanied by the biliary tract along its course, and inammatory
ulceration of the bile duct may be caused by the incarceration of the extrahepatic bile duct stone.
If the distribution of the blood supply of the extrahepatic
bile duct and the adjacent relationship between the stone and
the blood supply of the extrahepatic bile duct are not fully
understood before the lithotomy, misguided lithotomy can
cause extrahepatic bile duct hemorrhage. It is impossible to
deal with the anatomic characteristics of individual bile duct
blood supply accurately and properly when extrahepatic bile
duct hemorrhage occurs. In cases of massive hemorrhage of
the posterior wall of the common bile duct, the ligation of the
proper hepatic artery and the gastroduodenal artery is not
effective. The blood vessels of the posterior wall of the bile
duct were sutured in a wide range of upper and lower areas
before the bleeding was stopped. These facts suggest that
blood ow from the posterior portal vein plays a vital role in
the blood supply of the bile duct. The 3D model of the extrahepatic bile duct in one patient clearly showed that the pos-
Fig. 9.35 The 3D model suggests that the posterior portal artery supplies extrahepatic bile duct blood close to the posterior wall of the common bile duct, and abundant arteries can be seen interlacing into a
network in the bile duct wall behind incarcerated stones (posterior
view)
terior portal vein artery originated from the superior
mesenteric artery converged with the posterior pancreaticoduodenal artery at the posterior end of the bile duct and continued to supply blood to the bile duct along the posterior
wall of the extrahepatic bile duct, and the posterior wall of
the bile duct at the lower end of the common bile duct incarcerated with stones forms a rich supply arterial network
(Fig.9.35) (Yang 2017). Guided by the 3D model, the stone
was removed gently under the direct view with a choledochoscope during the operation, and the procedure of stone
extraction was smooth. Even if biliary bleeding occurs
during lithotomy, the bleeding artery can be accurately determined based on a three-dimensional visual model of extrahepatic bile duct blood supply without blindly and
experimentally ligating the peripheral artery, avoiding
greater body damage or complications.
Typical cases of extrahepatic biliary tract obstruction with
3D visualization are attached.
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Am Surg. 2017.

Digital Surgical Diagnosis
andManagement ofCholecystolithiasis
NanXiang, SongshengHe, andChihuaFang
10
10.1 Introduction
The majority of cholecystolithiasis presents predominantly
with cholesterol stones, whereas the remainder consists of
mixed cholesterol and black pigment stones. Females have a
higher prevalence of cholecystolithiasis than males, and the
frequency of this disease increases with age, escalating signicantly in their 40s.
The causes of cholecystolithiasis are very complicated
and are associated with various factors. Risk factors that
affect the change in the ratio of cholesterol to bile acid concentration and cause cholestasis, can lead to stone formation, such as race, gender, obesity, pregnancy, high-fat diet,
long- term parenteral nutrition, diabetes, hyperlipidemia, and
cirrhosis. In China, the incidence of cholecystolithiasis in the
northwest is high, which may be related to dietary habits.
Most patients are asymptomatic, with stones only discovered accidentally during physical examination, surgery and
autopsy, and become stationary gallstones. With the popularization of health examination, the discovery of asymptomatic gallstones has increased signicantly. Only a few
patients present with biliary colic symptoms typical of cholecystolithiasis. The majority manifest as acute or chronic
cholecystitis. Jaundice rarely occurs. Small stones can enter
through the cystic duct and stay in the common bile duct to
become common bile duct stones, which can induce biliary
pancreatitis. Chronic perforation of cholecystitis caused by
stone compression can result in Mirizzi syndrome, cholecystoduodenal stula, or cholecystocolonic stula. Long-term
stimulation by stones, and inammation, can induce gallbladder cancer.
B-mode ultrasound is the rst-line imaging modality in
evaluating cholecystolithiasis, with a reported sensitivity of
approximately 100% (Hwang et al. 2014); approximately
10–20% of gallstone contain enough calcium to be visible by
N. Xiang · S. He · C. Fang (*)
Zhujiang Hospital, Southern Medical University,
Guangzhou, China
abdominal X-ray (Zeman 1994; Bortoff etal. 2000; Chuah
etal. 2017); CT and MRI can also display gallstones, but not
as a routine examination.
With the development of digital medicine, 3D visualization has been widely used in preoperative evaluation of
hepatobiliary and pancreatic diseases as well as in the intraoperative navigation of surgery. Laparoscopic cholecystectomy is preferred for gallstones with symptoms and/or
complications. Preoperatively, 3D visualization can be used
to evaluate cholecystolithiasis more accurately, to guide surgeons to perform more precise operations, and to reduce the
incidence of surgical complications (Fan etal. 2013; Zeng
etal. 2016).
10.2 Application of3D Visualization
inCholecystolithiasis
Currently, for most patients with cholecystolithiasis with
simple conditions and no anatomic variation, the diagnosis
can be conrmed by preoperative B-ultrasound. However, for
some complicated diseases, such as repeated acute calculous
cholecystitis, severe adhesion in the triangle area, unclear or
variable anatomical relationship, patients with portal hypertension, complex vasculature in the portal area; surgeons
need to perform cholecystectomy according to the specic
conditions encountered during the operation. It is impossible
to know in advance all the patient’s individual anatomical
characteristics (such as variations of gallbladder and right
hepatic arteries), and the lack of foresight for potential risks
of surgery, especially for beginners, may result in iatrogenic
injury during operation.
In recent years, with the rapid development of digital
medicine, 3D visualization has been widely applied clinically. Through preoperative 3D modeling by MI-3DVS
software, the anatomical structure of abdominal parenchymal organs and celiac vessels, as well as their spatial relationships, can be accurately displayed stereoscopically; this
helps surgeons to understand (a) the shape of the gallbladder,
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021
C. Fang, W. Y. Lau (eds.), Biliary Tract Surgery, https://doi.org/10.1007/978-981-33-6769-2_10
205

206
ab
N. Xiang et al.
(b) the distribution, shape, and size of the gallstones, and
(c) the spatial relationship between the gallbladder and the
surrounding organs, blood vessels and tissue preoperatively.
Moreover, 3D reconstructed models can help foresee situations that may arise during the operation due to anatomic
variations. In order to improve the safety of the operation
and promote the recovery of patients after surgery, surgical
preoperative planning can be trialed with the aid of a surgical
simulation system. Surgical plans can be rehearsed repeatedly and the optimal individualized surgical procedures can
be selected, thereby improving the safety of operation and
promoting postoperative recovery.
10.2.1 3D Visualization Workow
10.2.1.1 Acquisition ofThin-Slice CT Data
Multiphase images (plain scan, arterial, hepatic venous, and
portal venous phase) should be obtained rst, and then these
images [with a slice thickness of 5mm] should be imported
into a Mxview workstation and sliced into 0.625 mm,
using the digital imaging and communications in medicine
(DICOM) 3.0. format. These processed images should be
subsequently transmitted to the terminal server for 3D imaging through the internal network and exported to obtain the
available thin-layer original CT image data (Fig.10.1).
10.2.1.2 Image Segmentation
CT image was imported into MI-3DVS for automated image
segmentation (Fig.10.2).
MI-3DVS was used to segment the CT data of each phase
quickly and the results were satisfactory. Data were obtained
from the gallbladder, gallstone, liver, portal vein, and hepatic
artery. A few unsatisfactory segmentation can be corrected
by adjusting the threshold value for further 3D reconstruction (Fig.10.3).
10.2.1.3 3D Reconstruction
3D Reconstruction ofBlood Vessels
• 3D Reconstruction of Arteries Conventional enhanced
CT data in the arterial phase was segmented and recon-
structed by surface rendering (Fig.10.4a); CTA data were
reconstructed by volume rendering, with the advantage of
high speed and high quality. During the reconstruction
process, it may not be possible to reconstruct some arte-
c
Fig. 10.1 Thin-layer original CT image data. (a) Plain scan phase; (b) Arterial phase; (c) Venous phase
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