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196
C. Fang et al.
a
Fig. 9.20 (a–b) The cystic artery originated from gastroduodenal artery supplies the lower extrahepatic bile duct (type III)
b
Table 9.1 Incidence of digital extrahepatic bile duct supplying artery (Yang 2017)
Types N Incidence (%) Right hepatic artery 35 85.4 Superior posterior pancreaticoduodenal
artery and its branches Cystic artery 27 65.9 Proper hepatic artery 12 29.3 Gastroduodenal artery and its main
branches Left hepatic artery 6 14.6 Posterior portal artery (from celiac trunk) 2 4.9 Posterior portal artery (from superior
mesenteric artery) Other arteries 1 2.4
a
The superior posterior pancreaticoduodenal artery is not included
a
30 73.2
7 17.1
2 4.9
Fig. 9.21 Anastomotic artery forming around the extrahepatic bile duct
three-dimensional visualization system (MI-3DVS). A total of 41 thin layer (0.625mm) DICOM images were collected from four stages of CT, including plain scan, arterial phase, portal phase, and venous phase, with excellent image quality, as well as a clear display of peripheral blood supply artery of the extrahepatic bile duct, cholelithiasis, pancreatic and peri­ampullary lesions, abdominal organs, and portal vein. The 3D model of extrahepatic bile duct blood supply established by MI-3DVS can obtain dynamic images of full dimension rotation, which can be arbitrarily scaled, displayed by any combination, and can be opacied or hidden from the target organ model, showing clearly the origin of extrahepatic bile
duct blood supply. Meanwhile, it can show the stereoscopic anatomical relationship between bile duct stones, tumors and surrounding organs and blood vessels.
9.4.1.1 Distribution ofExtrahepatic Bile Duct
Blood Supply
The right hepatic artery was involved in the blood supply in 35 cases (85.4%), the superior pancreaticoduodenal artery and its main branches in 30 cases (73.2%), the gallbladder artery in 27 cases (65.9%), the proper hepatic artery in 12 cases (29.3%), the gastroduodenum and its main branches in 7 cases (17.1%), the left hepatic artery in 6 cases (14.6%), the posterior portal vein artery in 4 cases (9.8%) and the other arteries in 1 case (2.4%) (Table9.1). It can be seen that the extrahepatic bile duct has a reticular blood supply formed by multiple arteries (Yang 2017).
9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
197
9.4.1.2 Digital Classication ofExtrahepatic Bile Duct Blood Supply
Among the 41 cases (Yang 2017) of the upper extrahepatic bile duct blood supply, there were 6 cases of type IA (14.6%) (Fig.9.22), 17 cases of type IB (41.5%) (Fig.9.23), 12 cases of type IC (29.3%) (Fig.9.24), and 6 cases of type II (14.6%) (Fig.9.25) (Table9.2).
In the lower extrahepatic bile duct blood supply, there were 13 cases of type IA (31.7%) (Fig.9.26), 13 cases of type IB (31.7%) (Fig. 9.27), 4 cases of type IC (9.8%)
a
(Fig.9.28), 7 cases of type II (170%) (Fig.9.29), 4 cases of type III (9.8%) (Fig.9.30) (Table9.3).
9.4.2 Surgical Management Based on3D Modelling ofExtrahepatic Bile Duct Blood Supply
All the 41 cases underwent surgical treatment, including choledocholithotomy in 15 cases (3 cases of left extrahepatic
b
Fig. 9.22 Blood supply to the upper extrahepatic bile duct (type IA). (a) The right hepatic artery supplies the upper extrahepatic bile duct. The blue arrow indicates the branch of the right hepatic artery accom-
a
Fig. 9.23 Blood supply to the upper extrahepatic bile duct (type IB). (a) The superior extrahepatic bile duct is supplied by the right hepatic artery and the gallbladder artery; (b) The superior extrahepatic bile duct is supplied by the right hepatic artery and the gallbladder artery
panying the extrahepatic bile duct; (b) The right hepatic artery supplies the upper extrahepatic bile duct. The blue arrow indicates the branch of the right hepatic artery accompanying the extrahepatic bile duct.
b
198
ab
Fig. 9.24 Blood supply to the upper extrahepatic bile duct (type IC). (a) The right hepatic artery and the proper hepatic artery supply the upper extrahepatic bile duct; (b) The right hepatic artery and the proper hepatic artery supply the upper extrahepatic bile duct
C. Fang et al.
biliary tract operation was in accordance with the preopera­tive planning, and the coincidence rate was 100%. The intra­operative morphology of extrahepatic bile duct, the blood ow of extrahepatic bile duct, the variation of the hepatic artery, the distribution of stones, and the relationship between tumor and blood vessel (Fig.9.31), were all consistent with the preoperative 3D model.
Of the 41 cases, 3 had mild pancreatic leakage, 4 had a pulmonary infection, 2 had incision fat liquefaction. They recovered after active conservative treatment. No intraoperative or postoperative biliary bleeding or biliary fistula occurred in any patient. Patients were followed up between 3 and 15months. No extrahepatic biliary stric­ture or biliary–intestinal anastomotic stricture occurred (Fig.9.32).
Fig. 9.25 Blood supply to the upper extrahepatic bile duct (type II). The left hepatic artery and the cystic artery supply the upper extrahe­patic bile duct
Table 9.2 Digital classication of the blood supply of the upper extra­hepatic bile duct in 41 patients with biliary obstruction (Yang 2017)
Types N Incidence (%) Type IA 6 14.6 Type IB 17 41.5 Type IC 12 29.3 Type II 6 14.6
9.4.3 Clinical Signicance of3D Modelling
ofExtrahepatic Bile Duct Blood Supply inPatients withBiliary Obstruction
9.4.3.1 Digital Classication andClinical
Signicance ofExtrahepatic Bile Duct Blood Supply inPatients withBiliary Obstruction
Digital classication of extrahepatic bile duct blood supply based on the distribution characteristics of blood supply to the upper and lower extrahepatic bile ducts, is helpful for
lobectomy), end-to-side cholangiojejunostomy in 22 cases (20 cases of pancreaticoduodenectomy), side-to-side Cholangiojejunostomy in 3 cases, and excision of solid pseu­dopapilloma in the head of the pancreas with duodenal pres­ervation in 1 case (Yang 2017). The method of intraoperative
clinicians to correctly diagnose the blood supply type of the extrahepatic bile duct in the upper and lower segments. Preoperative evaluation is performed according to the posi­tion of the extrahepatic bile duct, which guides the rationale for selecting the surgical method.
9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
199
a
Fig. 9.26 Blood supply of the lower extrahepatic bile duct (Type IA). (a) The posterior superior pancreaticoduodenal artery supplies the lower extrahepatic bile duct; (b) The posterior superior pancreaticoduodenal artery supplies the lower extrahepatic bile duct
b
the digital classication of extrahepatic bile duct blood sup­ply can be performed before operation, the operative method can be selected according to the type of classication. When the blood supply of the lower extrahepatic bile duct is classi­ed as type I, it is mainly supplied by the superior posterior pancreaticoduodenal artery, whose arch should be preserved during operation. For type II, the main supply of bile duct was the gastroduodenal artery and pancreaticoduodenal anterior artery. It was often suggested that the posterior pan­creaticoduodenal artery arch was small, and the anterior pan­creaticoduodenal artery arch should be preserved to ensure the blood supply of duodenum and bile duct. If type III, the cholecystic artery originated from the gastroduodenal artery, goes up to the upper right, and supplies blood to the bile duct. It is necessary to avoid the destruction of the ascending
Fig. 9.27 Blood supply of the lower extrahepatic bile duct (Type IB). The posterior superior pancreaticoduodenal artery and the gastroduode­nal artery supply the lower extrahepatic bile duct
gallbladder artery while preserving the head of the pancre­atic artery arch; if the posterior pancreaticoduodenal artery arch is preserved only according to experience, it may lead to complications such as postoperative biliary ischemic steno-
For example, in pancreatectomy with duodenal preserva­tion, the site of operation is mainly in the lower part of the common bile duct, and the surgeon protects the duodenum and the lower extrahepatic bile duct blood supply by retain­ing the posterior pancreaticoduodenal arterial arch based on experience from autopsy. After complete resection of the lesions, the common bile duct is examined for ischemia. If the blood supply of the common bile duct is inadequate, the common bile duct should be cut off, and choledochoduode­nal anastomosis should be performed. However, delayed postoperative biliary ischemia is often unnoticed, thus increasing the occurrence of biliary stula and stricture. If
sis and biliary stula.
A 3D model of extrahepatic bile duct blood supply in a patient undergoing duodenum-preserving pancreatectomy showed that the lower part of the common bile duct was mainly supplied by the gastroduodenal artery and the pancre­aticoduodenal anterior artery. The anterior pancreaticoduode­nal artery arch was formed to supply duodenal blood, and the lower extrahepatic bile duct blood supply was digitally classi­ed as type II.According to the 3D model, the anterior pancre­aticoduodenal artery arch was successfully preserved during the operation without biliary stula or duodenal stula. No stricture of bile duct occurred after a 1-year follow-up.
200
C. Fang et al.
a
Fig. 9.28 Blood supply of the lower extrahepatic bile duct (Type IC). (a) The posterior superior pancreaticoduodenal artery and the posterior portal artery supply the lower extrahepatic bile duct; (b) The posterior
Fig. 9.29 The gastroduodenal artery and its branches (the anterior pancreaticoduodenal artery) supply the lower extrahepatic bile duct and form the anterior pancreaticoduodenal arch
b
9.4.3.2 Signicance of3D Visualization ofExtrahepatic Bile Duct Blood Supply inSurgical Decision Making ofExtrahepatic Bile Duct Obstructive Diseases
In patients with extrahepatic bile duct obstructive disease, the bile duct is dilated, and the blood supply to the bile duct is bound to increase. The artery supplying blood to the bile
superior pancreaticoduodenal artery and the posterior portal artery sup­ply the lower extrahepatic bile duct
duct will increase in diameter and increase the branch com­pensation mechanism to meet the increase in bile duct blood supply. Moreover, the main blood supply to extrahepatic bile ducts, that is, the right hepatic artery and gallbladder artery, vary considerably. If the source and distribution of extrahe­patic bile duct blood supply cannot be recognized before the operation, it may be damaged during operation, which may lead to complications such as biliary bleeding, postoperative biliary stula, stricture of extrahepatic bile duct, or cholan­gio–intestinal anastomosis.
The 3D model of extrahepatic bile duct blood supply based on submillimeter CT data can provide three­dimensional visual distribution characteristics of individual extrahepatic bile duct blood supply and become a “digital uoroscopic eye” helping biliary surgeons to understand the internal structure of living human body. A 3D model of extrahepatic bile duct blood supply clearly showed that the variant right hepatic artery originated from the superior mes­enteric artery and passed through part of the pancreatic tissue during the course of the operation. In pancreaticoduodenec­tomy, the injury of the right hepatic artery was avoided, and the right hepatic artery was dissected thoroughly, thus pre­serving the arterial blood supply of the right half liver and the upper extrahepatic bile duct (Fig.9.33).
Biliary stula and bile duct stenosis after extrahepatic cholangiostomy are strongly related to injury to the anterior wall of the bile duct during the operation. The 3D model of extrahepatic bile duct blood supply can be used to under­stand the distribution of arteries attached to the anterior wall of the extrahepatic bile duct before operation and thus guide the location of the longitudinal incision of the extrahepatic
ab
9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
201
a
Fig. 9.30 Blood supply of the lower extrahepatic bile duct (Type III). (a) The cystic artery arising from the gastroduodenal artery supplies the lower segment of the extrahepatic bile duct; (b) The cystic artery arising
Table 9.3 Digital classication of blood supply of the lower extrahepatic bile duct in 41 patients with biliary obstruction (Yang 2017)
b
from the gastroduodenal artery supplies the lower segment of the extra­hepatic bile duct
Types N Incidence (%) Type IA 13 31.7 Type IB 13 31.7 Type IC 4 9.8 Type II 7 17.0 Type III 0.4 9.8
Fig. 9.31 Intraoperative picture of blood supply to extrahepatic bile duct. (a) The supercial vascular network and bile duct of the 9 o’clock artery (blue arrow); (b) 3 o’clock artery (indicated by vascular forceps)
202
Fig. 9.32 Postoperative cholangiography and MRCP results: typical case 3, The MRCP examination 1year after the operation showed no extrahepatic bile duct stricture
Fig. 9.33 Variation of hepatic artery passing through pancreatic parenchyma
bile duct. A patient with lower choledocholithiasis was scanned and a 3D model constructed (Fig.9.34). The model showed the right hepatic artery and the proper hepatic artery supplying the anterior wall of the extrahepatic bile duct (Fig.9.34). The location of the incision was selected accord­ing to the model so as to avoid complications such as biliary stula or late biliary stricture, injury to the anterior wall of the blood supply artery was avoided when the extrahepatic bile duct was cut open, sutured, and closed.
The three-dimensional visualization model of extrahe-
patic bile duct blood supply can assist in the decision-
C. Fang et al.
Fig. 9.34 The 3D model suggests that the right hepatic artery and the proper hepatic artery send out large branches on the anterior wall of the extrahepatic bile duct to supply the bile duct
making of cholangioenterostomy and the location of the biliary anastomosis. Typical case 1 (Resource 9.1: case 1): The patient was diagnosed with inammatory stenosis of the lower common bile duct. Conservative treatment and endoscopic duodenal papilla incision were ineffective, and bile drainage was needed through choledochojejunostomy. The preoperative 3D model of the extrahepatic bile duct supply suggested that the common hepatic bile duct blood supply was composed of “9 o’clock” artery and right hepatic artery formed by the main gallbladder artery. The lower part of the common bile duct blood supply was sup­plied by the superior and posterior pancreaticoduodenal artery, but no obvious arterial blood supply was found in the upper part of the common bile duct and duodenum. Above all, the extrahepatic bile duct was cut off at the level of the common bile duct with abundant blood supply, and end-to-side cholangiojejunostomy was performed. Typical case two (Resource 9.1: case 2) was also diagnosed with inammatory stenosis in the lower common bile duct, but the individual 3D model suggested that the extrahepatic bile duct blood supply of the patient was variable, and the cholecystic artery originated from the gastroduodenal artery. The intestinal artery, which is close to the right-side wall of the extrahepatic bile duct, enters the gallbladder and forms a “9 o’clock” artery for ascending blood supply. If the patient receives an extrahepatic bile duct transection and end-to-side cholangiojejunostomy, the arterial blood supply may be destroyed at 9 o’clock. Therefore, side- to­side cholangiojejunostomy was selected as the operative method.
9 Application of3D Visualization forBlood Supply ofExtrahepatic Bile Ducts
203
The extrahepatic bile duct blood supply artery is accom­panied by the biliary tract along its course, and inammatory ulceration of the bile duct may be caused by the incarcera­tion of the extrahepatic bile duct stone.
If the distribution of the blood supply of the extrahepatic bile duct and the adjacent relationship between the stone and the blood supply of the extrahepatic bile duct are not fully understood before the lithotomy, misguided lithotomy can cause extrahepatic bile duct hemorrhage. It is impossible to deal with the anatomic characteristics of individual bile duct blood supply accurately and properly when extrahepatic bile duct hemorrhage occurs. In cases of massive hemorrhage of the posterior wall of the common bile duct, the ligation of the proper hepatic artery and the gastroduodenal artery is not effective. The blood vessels of the posterior wall of the bile duct were sutured in a wide range of upper and lower areas before the bleeding was stopped. These facts suggest that blood ow from the posterior portal vein plays a vital role in the blood supply of the bile duct. The 3D model of the extra­hepatic bile duct in one patient clearly showed that the pos-
Fig. 9.35 The 3D model suggests that the posterior portal artery sup­plies extrahepatic bile duct blood close to the posterior wall of the com­mon bile duct, and abundant arteries can be seen interlacing into a network in the bile duct wall behind incarcerated stones (posterior view)
terior portal vein artery originated from the superior mesenteric artery converged with the posterior pancreatico­duodenal artery at the posterior end of the bile duct and con­tinued to supply blood to the bile duct along the posterior wall of the extrahepatic bile duct, and the posterior wall of the bile duct at the lower end of the common bile duct incar­cerated with stones forms a rich supply arterial network (Fig.9.35) (Yang 2017). Guided by the 3D model, the stone was removed gently under the direct view with a choledo­choscope during the operation, and the procedure of stone extraction was smooth. Even if biliary bleeding occurs during lithotomy, the bleeding artery can be accurately deter­mined based on a three-dimensional visual model of extrahe­patic bile duct blood supply without blindly and experimentally ligating the peripheral artery, avoiding greater body damage or complications.
Typical cases of extrahepatic biliary tract obstruction with
3D visualization are attached.

References

Ayoub WS, Esquivel CO, Martin P. Biliary complications following
liver transplantation. Dig Dis Sci. 2010;55(6):1540–6. https://doi.
org/10.1007/s10620- 010- 1217- 2.
Balderramo D, Navasa M, Cardenas A.Current management of biliary
complications after liver transplantation: emphasis on endoscopic therapy. Gastroenterol Hepatol. 2011;34(2):107–15. https://doi.
org/10.1016/j.gastrohep.2010.05.008.
Cameron GR, Hou CT. An experimental study of stricture of the
common bile-duct in the guinea-pig.[J]. Journal of Pathology & Bacteriology, 1962, 83:265.
Fang C.Digital hepatic surgery[M]. Beijing: People’s Military Medical
Press; 2014. p.139–62.
Northover JM, Williams ED, Terblanche J.The investigation of small
vessel anatomy by scanning electron microscopy of resin casts. A description of the technique and examples of its use in the study of the microvasculature of the peritoneum and bile duct wall. J Anat. 1980;130:43–54.
Park KM, Lee SG, Lee YJ, etal. Adult-to-adult living donor liver trans-
plantation at Asian Medical Center, Seoul, Korea. Transplant Proc. 1999;31(1–2):456–8.
Shapiro AL, Robillard GL.The arterial blood supply of the common
and hepatic bile ducts with reference to problems of common duct injury and repair: based on a series of 23 dissections. Surgery. 1948;23:1–4.
Terblanche J, Allison HF, Northover JMA.An ischemic basis for bili-
ary strictures. Surgery. 1983;94:56.
Yang J, Tao H, Fang C, et al. Clinical Applications of Three-
Dimensional Visualization Model of Arteries Supplying the Extrahepatic Bile Duct for Patients with Biliary Obstruction[J]. Am Surg. 2017.
Digital Surgical Diagnosis andManagement ofCholecystolithiasis
NanXiang, SongshengHe, andChihuaFang
10

10.1 Introduction

The majority of cholecystolithiasis presents predominantly with cholesterol stones, whereas the remainder consists of mixed cholesterol and black pigment stones. Females have a higher prevalence of cholecystolithiasis than males, and the frequency of this disease increases with age, escalating sig­nicantly in their 40s.
The causes of cholecystolithiasis are very complicated and are associated with various factors. Risk factors that affect the change in the ratio of cholesterol to bile acid con­centration and cause cholestasis, can lead to stone forma­tion, such as race, gender, obesity, pregnancy, high-fat diet, long- term parenteral nutrition, diabetes, hyperlipidemia, and cirrhosis. In China, the incidence of cholecystolithiasis in the northwest is high, which may be related to dietary habits.
Most patients are asymptomatic, with stones only discov­ered accidentally during physical examination, surgery and autopsy, and become stationary gallstones. With the popu­larization of health examination, the discovery of asymp­tomatic gallstones has increased signicantly. Only a few patients present with biliary colic symptoms typical of cho­lecystolithiasis. The majority manifest as acute or chronic cholecystitis. Jaundice rarely occurs. Small stones can enter through the cystic duct and stay in the common bile duct to become common bile duct stones, which can induce biliary pancreatitis. Chronic perforation of cholecystitis caused by stone compression can result in Mirizzi syndrome, cholecys­toduodenal stula, or cholecystocolonic stula. Long-term stimulation by stones, and inammation, can induce gall­bladder cancer.
B-mode ultrasound is the rst-line imaging modality in evaluating cholecystolithiasis, with a reported sensitivity of approximately 100% (Hwang et al. 2014); approximately 10–20% of gallstone contain enough calcium to be visible by
N. Xiang · S. He · C. Fang (*) Zhujiang Hospital, Southern Medical University, Guangzhou, China
abdominal X-ray (Zeman 1994; Bortoff etal. 2000; Chuah etal. 2017); CT and MRI can also display gallstones, but not as a routine examination.
With the development of digital medicine, 3D visual­ization has been widely used in preoperative evaluation of hepatobiliary and pancreatic diseases as well as in the intra­operative navigation of surgery. Laparoscopic cholecys­tectomy is preferred for gallstones with symptoms and/or complications. Preoperatively, 3D visualization can be used to evaluate cholecystolithiasis more accurately, to guide sur­geons to perform more precise operations, and to reduce the incidence of surgical complications (Fan etal. 2013; Zeng etal. 2016).
10.2 Application of3D Visualization
inCholecystolithiasis
Currently, for most patients with cholecystolithiasis with simple conditions and no anatomic variation, the diagnosis can be conrmed by preoperative B-ultrasound. However, for some complicated diseases, such as repeated acute calculous cholecystitis, severe adhesion in the triangle area, unclear or variable anatomical relationship, patients with portal hyper­tension, complex vasculature in the portal area; surgeons need to perform cholecystectomy according to the specic conditions encountered during the operation. It is impossible to know in advance all the patient’s individual anatomical characteristics (such as variations of gallbladder and right hepatic arteries), and the lack of foresight for potential risks of surgery, especially for beginners, may result in iatrogenic injury during operation.
In recent years, with the rapid development of digital medicine, 3D visualization has been widely applied clini­cally. Through preoperative 3D modeling by MI-3DVS software, the anatomical structure of abdominal parenchy­mal organs and celiac vessels, as well as their spatial rela­tionships, can be accurately displayed stereoscopically; this helps surgeons to understand (a) the shape of the gallbladder,
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021 C. Fang, W. Y. Lau (eds.), Biliary Tract Surgery, https://doi.org/10.1007/978-981-33-6769-2_10
205
206
ab
N. Xiang et al.
(b) the distribution, shape, and size of the gallstones, and (c) the spatial relationship between the gallbladder and the surrounding organs, blood vessels and tissue preoperatively. Moreover, 3D reconstructed models can help foresee situ­ations that may arise during the operation due to anatomic variations. In order to improve the safety of the operation and promote the recovery of patients after surgery, surgical preoperative planning can be trialed with the aid of a surgical simulation system. Surgical plans can be rehearsed repeat­edly and the optimal individualized surgical procedures can be selected, thereby improving the safety of operation and promoting postoperative recovery.
10.2.1 3D Visualization Workow
10.2.1.1 Acquisition ofThin-Slice CT Data
Multiphase images (plain scan, arterial, hepatic venous, and portal venous phase) should be obtained rst, and then these images [with a slice thickness of 5mm] should be imported into a Mxview workstation and sliced into 0.625 mm, using the digital imaging and communications in medicine (DICOM) 3.0. format. These processed images should be
subsequently transmitted to the terminal server for 3D imag­ing through the internal network and exported to obtain the available thin-layer original CT image data (Fig.10.1).
10.2.1.2 Image Segmentation
CT image was imported into MI-3DVS for automated image segmentation (Fig.10.2).
MI-3DVS was used to segment the CT data of each phase quickly and the results were satisfactory. Data were obtained from the gallbladder, gallstone, liver, portal vein, and hepatic artery. A few unsatisfactory segmentation can be corrected by adjusting the threshold value for further 3D reconstruc­tion (Fig.10.3).
10.2.1.3 3D Reconstruction
3D Reconstruction ofBlood Vessels
3D Reconstruction of Arteries Conventional enhanced
CT data in the arterial phase was segmented and recon-
structed by surface rendering (Fig.10.4a); CTA data were
reconstructed by volume rendering, with the advantage of
high speed and high quality. During the reconstruction
process, it may not be possible to reconstruct some arte-
c
Fig. 10.1 Thin-layer original CT image data. (a) Plain scan phase; (b) Arterial phase; (c) Venous phase