Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5320_Библиотеки_им_академика_М_И_Перельмана
.pdf
https://t.me/med1917
266
Pharmaceutical Dosage Forms and Drug Delivery
3. Nanoparticles and liposomes
4. Intraocular implants
triamcinolone acetonide, and recombinant tissue plasminogen activator.
Hydrogels:
N
15.6.2 Brain- Targeted Drug Delivery
15.6.2.1 Blood– Brain Barrier
BBB is a term
and lipophilic molecules that can diffuse through the cell membranes (paracellular route) and active
transport (through the transcellular route) of certain molecules that are important to neuronal function,
such as glucose and amino acids (
15.6.2.2 Drug Delivery Strategies to the Brain
1. Drug encapsulation in liposomes or nanoparticles
• -
https://t.me/med1917
Organ-Specic Drug Delivery
FIGURE 15.3
267
•
nanoparticles (Aurimmune) and gold- coated silica nanoparticles (AuroShell).
2.
•
3.
transport
•
drugs and nanoparticles the brain.
4.
•
to the brain through the nasal route.
•
implanted catheter.
•
https://t.me/med1917
268
15.6.3 Liver- Targeted Drug Delivery
Pharmaceutical Dosage Forms and Drug Delivery
15.6.3.1 Cellular Components of the Liver
hepatocytes
the liver mass and are involved in various liver activities including the formation and secretion of bile.
Kupffer cells
colloids.
and endothelial cells (
15.6.3.2 Common Diseases of the Liver
liver function.
1. Hepatocellular carcinoma
2. Cirrhosis
3. Hepatitis
prevalent, lead to chronic diseases, and are the most common cause of liver cirrhosis and cancer.
https://t.me/med1917
Organ-Specic Drug Delivery
FIGURE 15.4
J. Biol. Chem
269
15.6.3.3 Natural Mechanisms of Hepatic Drug Uptake
1. Hepatic rst- pass effect
a.
b. Prolonging the circulation time of compounds targeted for the liver provides passive targeting to
®®) have been
2. Enhanced permeation and retention effect
larger particulate drug carriers being able to concentrate in the tumor tissue more than the normal
https://t.me/med1917
270
15.6.3.4 Cellular Targets for Disease Therapy
Pharmaceutical Dosage Forms and Drug Delivery
1. Hepatocytes
a.
b.
c.
d.
2. Kupffer cells
a.
b.
c.
1.
2.
3.
https://t.me/med1917
Organ-Specic Drug Delivery
271
15.6.4 Colon- Targeted Drug Delivery
15.6.4.1 Utilization of the Unique Colonic Microflora
proteins and amino acids.
bond ().
https://t.me/med1917
272
Pharmaceutical Dosage Forms and Drug Delivery
FIGURE 15.5
product performance.
https://t.me/med1917
Organ-Specic Drug Delivery
15.6.4.2 pH- Dependent Dosage Forms
273
®
®
Eudragit®®
®
budesonide.
location of Eudragit®
15.6.4.3 Time- Dependent Drug Release
®
®®
https://t.me/med1917
274
Pharmaceutical Dosage Forms and Drug Delivery
15.6.4.4 Osmotically Controlled Drug Delivery Systems
®
for drug release.
-
ation in the colon to use it as an osmotic agent and a pore- forming agent in the impermeable cellulose
®a, on reaching
in vitro drug- release characteristics that demonstrated its potential
for colon targeting.
15.7 Combination and Other Strategies for Colon Targeting
https://t.me/med1917
Organ-Specic Drug Delivery
FIGURE 15.6
enteric coating of Eudragit®
cellulose acetate coating in the colon and (b) in vitro
, 1:1; , 1:1.6; , 1:2; and , 1:2.6), amount of chitosan in the
, 60 mg; , 40 mg),
, 10%;
, 12%; Int. J. Pharm
release and prolonged residence in the colonic environment.
authors observed colon targeting in mouse and rat models for the treatment of colon cancer. After oral
®
Соседние файлы в папке Библиотека им академика М.И. Перельмана