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Wound Healing
New insights into Ancient Challenges
Edited by Vlad Adrian Alexandrescu
Wound Healing: New insights into Ancient Challenges
Edited by Vlad Adrian Alexandrescu
Published by ExLi4EvA
Copyright © 2016
All chapters are Open Access distributed under the Creative Commons Attribution
3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source.
As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications.
Notice
Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book.
Publishing Process Manager Technical Editor Cover Designer
ISBN-10: 953-51-2679-2 ISBN-13: 978-953-51-2679-9
Print ISBN-10: 953-51-2678-4 ISBN-13: 978-953-51-2678-2
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Contents

Preface
Chapter 1 The Role of MicroRNAs in Impaired Diabetic Wound Healing by Maggie M. Hodges, Carlos Zgheib, Junwang Xu and Kenneth W. Liechty
Chapter 2 The Physiological Roles of Leptin in Skin Wound Healing by Reiko Tokuyama-Toda and Kazuhito Satomura
Chapter 3 Roles of Matrix Metalloproteinases in Cutaneous Wound Healing by Trung T. Nguyen, Shahriar Mobashery and Mayland Chang
Chapter 4 Delivery Systems in Wound Healing and Nanomedicine by Lina Fu
Chapter 5 Cellular Therapy for Wounds: Applications of Mesenchymal Stem Cells in Wound Healing by Moyassar B. H. AlShaibani, Xiao Anne M. Dickinson
Chapter 6 The Role of Actin Remodelling Proteins in Wound Healing and Tissue Regeneration by Zlatko Kopecki and Allison J Cowin
Chapter 7 Regenerative Approaches in Wound Healing: New Alternatives for Older Tools by Michele R Colonna, Lupo Flavia, Delia Gabriele and Stagno d’Alcontres Francesco
Chapter 8 Polarisation of Macrophage and Immunotherapy in the Wound Healing by Yu-Sheng Wu, Fan-Hua Nan, Sherwin Chen and Shiu-Nan Chen
nong Wang, Penny E. Lovat and
VI Contents
Chapter 9 How Plasma Membrane and Cytoskeletal Dynamics Influence Single-Cell Wound Healing: Mechanotransduction, Tension and Tensegrity by Eric Boucher, Tatsuya Kato and Craig A. Mandato
Chapter 10 A Potential Mechanism for Diabetic Wound Healing: Cutaneous Environmental Disorders by Junna Ye, Ting Xie, Yiwen Niu, Liang Qiao, Ming Tian, Chun Qing and Shuliang Lu
Chapter 11 Ischemic Ulcer Healing: Does Appropriate Flow Reconstruction Stand for All That We Need? by Vlad-Adrian Alexandrescu and François Triffaux
Chapter 12 Venous Leg Ulceration by Aslı Aksu Çerman, İlknur Kıvanç Altunay and Ezgi Aktaş Karabay
Chapter 13 Topical Wound Oxygen Versus Conventional Compression Dressings in the Management of Refractory Venous Ulcers by Sherif Sultan, Wael Tawfick, Edel P Kavanagh and Niamh Hynes
Chapter 14 Pressure Ulcers by Jill M. Monfre
Chapter 15 Surgical Management of Wounds by Peter Mekhail, Shuchi Chaturvedi and Shailesh Chaturvedi
Chapter 16 Physical Modalities in the Management of Wound(s) by Amir Feily, Fatemeh Moeineddin and Shadi Mehraban
Chapter 17 Antimicrobial Dressings for Improving Wound Healing by Omar Sarheed, Asif Ahmed, Douha Shouqair and Joshua Boateng
Chapter 18 The Need for Increased Attention to Low
Level Laser Therapy as Treatment for Wounds and Ulcers by Mohammad Bayat
VII Contents
Chapter 19 The Use of Amniotic Membrane in the Management of Complex Chronic Wounds by Gregorio Castellanos, Ángel BernabéGarcía, Carmen García Insausti, Antonio Piñero, Jos
é M. Moraleda and Francisco J. Nicolás
Chapter 20 Progress and Perspectives in the Management of Wound Infections by Federica Paladini, Mauro Pollini, Alessandro Sannino and Luigi Ambrosio
Chapter 21 Alternative Approaches to Wound Healing by Anuradha Majumdar and Prajakta Sangole
Chapter 22 Medicinal Plants and Natural Products with Demonstrated Wound Healing Properties by Christian Agyare, Emelia Oppong Bekoe, Yaw Duah Boakye, Susanna Oteng Dapaah, Theresa Appiah and Samuel Oppong Bekoe

Preface

Outstanding scientific advances over the last decades unceasingly reveal real complexity of wound-healing process, astonishing in its staged progression, as life is unfolding itself. This natural course of tissue repair seems to bear thousands of overlapping molecular and macroscopic processes that nowadays only start to unfold to our knowledge. The present volume collecting recent scientific references proposes to readers a two-folded audacious goal. First, an updated design of intimate cellular mechanisms is entailed in tissue regeneration that emanates from the first section of the book. Next, a multidisciplinary therapeutic perspective that focuses on macroscopic healing throughout the second part of this work adds clinically integrated observation. Practical diagnostic and treatment information is appended in each chapter that may equally help experienced clinicians or dedicated students and researchers in broadening essential breaking points of their work. It is the wish of all multidisciplinary experts who gather prominent author's panel of this volume to incorporate latest medical reports and compel limits of current understanding for better tissue regeneration, limb salvage, and improved quality of life of our patients.