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Wound Healing
New insights into Ancient Challenges
Edited by Vlad Adrian Alexandrescu

Wound Healing: New insights into Ancient Challenges
Edited by Vlad Adrian Alexandrescu
Published by ExLi4EvA
Copyright © 2016
All chapters are Open Access distributed under the Creative Commons Attribution
3.0 license, which allows users to download, copy and build upon published articles
even for commercial purposes, as long as the author and publisher are
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As for readers, this license allows users to download, copy and build upon
published chapters even for commercial purposes, as long as the author and publisher
are properly credited, which ensures maximum dissemination and a wider impact of
our publications.
Notice
Statements and opinions expressed in the chapters are these of the individual
contributors and not necessarily those of the editors or publisher. No responsibility is
accepted for the accuracy of information contained in the published chapters. The
publisher assumes no responsibility for any damage or injury to persons or property
arising out of the use of any materials, instructions, methods or ideas contained in the
book.
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ISBN-10: 953-51-2679-2
ISBN-13: 978-953-51-2679-9
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ISBN-10: 953-51-2678-4
ISBN-13: 978-953-51-2678-2
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Contents
Preface
Chapter 1 The Role of MicroRNAs in Impaired Diabetic Wound
Healing
by Maggie M. Hodges, Carlos Zgheib, Junwang Xu and Kenneth W.
Liechty
Chapter 2 The Physiological Roles of Leptin in Skin Wound
Healing
by Reiko Tokuyama-Toda and Kazuhito Satomura
Chapter 3 Roles of Matrix Metalloproteinases in Cutaneous
Wound Healing
by Trung T. Nguyen, Shahriar Mobashery and Mayland Chang
Chapter 4 Delivery Systems in Wound Healing and Nanomedicine
by Lina Fu
Chapter 5 Cellular Therapy for Wounds: Applications of
Mesenchymal Stem Cells in Wound Healing
by Moyassar B. H. Al‐Shaibani, Xiao‐
Anne M. Dickinson
Chapter 6 The Role of Actin Remodelling Proteins in Wound
Healing and Tissue Regeneration
by Zlatko Kopecki and Allison J Cowin
Chapter 7 Regenerative Approaches in Wound Healing: New
Alternatives for Older Tools
by Michele R Colonna, Lupo Flavia, Delia Gabriele and Stagno
d’Alcontres Francesco
Chapter 8 Polarisation of Macrophage and Immunotherapy in the
Wound Healing
by Yu-Sheng Wu, Fan-Hua Nan, Sherwin Chen and Shiu-Nan Chen
nong Wang, Penny E. Lovat and

VI Contents
Chapter 9 How Plasma Membrane and Cytoskeletal Dynamics
Influence Single-Cell Wound Healing: Mechanotransduction, Tension and
Tensegrity
by Eric Boucher, Tatsuya Kato and Craig A. Mandato
Chapter 10 A Potential Mechanism for Diabetic Wound Healing:
Cutaneous Environmental Disorders
by Junna Ye, Ting Xie, Yiwen Niu, Liang Qiao, Ming Tian, Chun Qing and
Shuliang Lu
Chapter 11 Ischemic Ulcer Healing: Does Appropriate Flow
Reconstruction Stand for All That We Need?
by Vlad-Adrian Alexandrescu and François Triffaux
Chapter 12 Venous Leg Ulceration
by Aslı Aksu Çerman, İlknur Kıvanç Altunay and Ezgi Aktaş Karabay
Chapter 13 Topical Wound Oxygen Versus Conventional
Compression Dressings in the Management of Refractory Venous Ulcers
by Sherif Sultan, Wael Tawfick, Edel P Kavanagh and Niamh Hynes
Chapter 14 Pressure Ulcers
by Jill M. Monfre
Chapter 15 Surgical Management of Wounds
by Peter Mekhail, Shuchi Chaturvedi and Shailesh Chaturvedi
Chapter 16 Physical Modalities in the Management of Wound(s)
by Amir Feily, Fatemeh Moeineddin and Shadi Mehraban
Chapter 17 Antimicrobial Dressings for Improving Wound Healing
by Omar Sarheed, Asif Ahmed, Douha Shouqair and Joshua Boateng
Chapter 18 The Need for Increased Attention to Low‐
Level Laser
Therapy as Treatment for Wounds and Ulcers
by Mohammad Bayat

VII Contents
Chapter 19 The Use of Amniotic Membrane in the Management of
Complex Chronic Wounds
by Gregorio Castellanos, Ángel Bernabé‐García, Carmen García
Insausti, Antonio Piñero, Jos
é M. Moraleda and Francisco J. Nicolás
Chapter 20 Progress and Perspectives in the Management of
Wound Infections
by Federica Paladini, Mauro Pollini, Alessandro Sannino and Luigi
Ambrosio
Chapter 21 Alternative Approaches to Wound Healing
by Anuradha Majumdar and Prajakta Sangole
Chapter 22 Medicinal Plants and Natural Products with
Demonstrated Wound Healing Properties
by Christian Agyare, Emelia Oppong Bekoe, Yaw Duah Boakye, Susanna
Oteng Dapaah, Theresa Appiah and Samuel Oppong Bekoe


Preface
Outstanding scientific advances over the last decades unceasingly
reveal real complexity of wound-healing process, astonishing in its
staged progression, as life is unfolding itself. This natural course of
tissue repair seems to bear thousands of overlapping molecular and
macroscopic processes that nowadays only start to unfold to our
knowledge. The present volume collecting recent scientific references
proposes to readers a two-folded audacious goal.
First, an updated design of intimate cellular mechanisms is entailed in
tissue regeneration that emanates from the first section of the book.
Next, a multidisciplinary therapeutic perspective that focuses on
macroscopic healing throughout the second part of this work adds
clinically integrated observation.
Practical diagnostic and treatment information is appended in each
chapter that may equally help experienced clinicians or dedicated
students and researchers in broadening essential breaking points of
their work.
It is the wish of all multidisciplinary experts who gather prominent
author's panel of this volume to incorporate latest medical reports and
compel limits of current understanding for better tissue regeneration,
limb salvage, and improved quality of life of our patients.

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