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38 Interventions oftheBiliary Tract
475
Patient preparation includes the following steps [15]:
• Adequate antibiotic coverage—usually a combination of Piperacillin and Tazobactam is administered intrave­nously as manipulations in an obstructed system carry a risk of cholangitis and venous reux of bile.
• Preferably fasting for at least 4 hours prior to the procedure.
• Intravenous analgesics for anxiety and pain alleviation.
38.4.2 Indications
• Provide adequate biliary drainage for:
– Relieving acute or recurrent cholangitis – Palliation of symptoms of jaundice, such as pruritus – Optimization of bilirubin level for chemotherapy
administration
• PTBD is preferred over endoscopic drainage in patients with:
– Unsuccessful endoscopic drainage – Obstruction in the proximal biliary tree – Surgically altered upper gastrointestinal tract anatomy
• Divert bile from site of leakage and permit placement of stent in bile duct defect
• Provide portal of access to biliary tract for therapeutic purposes:
– Dilation of biliary strictures – Removal of bile duct stones – Stent placement in malignant lesions – Brachytherapy/phototherapy – Endoluminal tissue sample or foreign body retrieval
38.4.3 Contraindications
Absolute contraindication for procedure is an uncorrected bleeding diathesis, while the presence of ascites is a relative contraindication [15].
38.4.4 Technique
PTBD is performed under ultrasound as well as uoroscopy guidance.
– The choice of duct for the puncture depends upon the
expertise level of the radiologist and whether it will drain at least one-sixth of the hepatic parenchyma or not.
– The targeted lobe should not be atrophic or have portal
vein involvement as it would not be effective enough in relieving the obstruction [16].
– If either the right or the left secondary conuence is
involved, drainage of the contralateral lobe is preferred to ensure that at least half of the functional liver paren­chyma is drained.
– Patients with involvement of both secondary conu-
ences are poor candidates for PTBD as they require placement of multiple catheters in both lobes for nor­malization of serum bilirubin. When such patients develop cholangitis, drainage is done for the segment that shows cholangitic abscesses on imaging. If there are no cholangitic abscesses on imaging, sequential drainage of multiple segments can be done until there is symptomatic improvement.
– The differences between right- and left-sided PTBD
are summarized in Table38.3.
• Puncture of the Biliary System – Under ultrasound guidance, the appropriately dilated
ductal system is punctured using an 18G puncture needle as peripheral as possible to reduce the risk of bleeding. Bile is aspirated to ensure proper position of the needle.
– Check cholangiogram is done using low osmolar
water-soluble contrast (Iohexol) and only 5–10ml of contrast is injected to avoid venous reux of bile, chol­angitis and sepsis.
– A 0.035 hydrophilic guide wire is then passed through
the needle and its position is monitored using uoroscopy.
– The needle is removed and angiographic catheter is
positioned over the guidewire and is manipulated across the obstruction. However, multiple attempts of manipulation should be avoided.
– If catheter is not manipulated beyond the obstruction,
external biliary drainage is done. Internalization can then be attempted after 3–4days once the biliary sys­tem is decompressed. However, if it passes beyond the site of obstruction, a Ring biliary catheter is used for ensuring both internal and external biliary drainage (Fig.38.1) [15].
• Selection of the Target Duct for Puncture – Site of obstruction is dened as high (involving the pri-
mary biliary conuence) and low (involving biliary duct below cystic duct insertion). PTBD is preferred for high obstruction, while endoscopic drainage is pre­ferred for low obstruction.
38.4.5 Post-Procedure Care
Major complications such as cholangitis, sepsis and bleeding can occur following PTBD.Hence, adequate post-procedure monitoring is necessary. Proper post-procedure care is also essential to increase the success rate of the procedure.
476
P. Garg et al.
Table 38.3 Differences between right- and left-sided PTBD
Right-sided PTBD Left-sided PTBD
Advantages Less radiation exposure to the radiologist
Larger segment of liver drained
Disadvantages Painful as intercostal nerves get stimulated
Increased risk of catheter slippage due to movement during respiration
Easier to perform Preferred in ascites Reduced risk of peri-catheter leak Better patient compliance
More radiation exposure to radiologist
Fig. 38.1 Steps of percutaneous transhepatic biliary drainage procedure. (a) USG-guided puncture of segment V hepatic duct using an 18G needle and needle position conrmed on cholangiogram. (b) Crossing the stenosis using an angled angiographic catheter and hydrophilic 0.035 guidewire (arrow). (c) Angled angiographic catheter advanced into the third part of the duodenum. (d) Angiographic catheter is exchanged for an 8.5F internal-external drainage catheter over an extra-stiff guidewire
a
c
d
b
• Patient should bekept admitted under observation for at
least 24hours.
• Vitals (heart rate and blood pressure) should be carefully
evaluated for detection of sepsis.
• Presence of severe abdominal pain or distension suggests
intraperitoneal bleed or biliary leak.
• Patient is to be evaluated for drain output, perihepatic
uid as well as relief of biliary dilatation using USG.
• Prophylactic intravenous antibiotics should be adminis-
tered for at least 1week.
• Adequate analgesia and tube care to avoid dislodgement
of tube.
• Adequate skin care and dressing to avoid peri-catheter
skin excoriation.
• After discharge, patient should be followed up on outpa-
tient basis.
38.4.6 Complications
Since PTBD is a challenging and invasive procedure, post­procedure complications are a common occurrence [16].
Minor complications:
• Pain
• Peri-catheter leak leading to excoriation
• Catheter dislodgement
Major complications:
• Cholangitis
• Biliary sepsis
• Haemorrhage and haemophilia
• Biliary peritonitis
38 Interventions oftheBiliary Tract
477
• Iatrogenic pancreatitis
• Pleural effusion/pneumothorax due to inadvertent pleural
puncture
Peri-catheter leak is common and usually occurs due to catheter dislodgement. A check cholangiogram helps in ascertaining the position of the catheter and its side holes. If displaced, the catheter should be positioned in such a way that side holes are located both distal and proximal to the obstruction and do not extend into the parenchymal tract. Persistent peri-catheter leak even after proper positioning requires upsizing of the catheter.
In the immediate post-procedure period, if the patient becomes hemodynamically unstable, haemorrhage or sepsis should be suspected. The incidence rate of sepsis is 5% after PTBD [17]. Cholangitis presents with Charcot’s triad (fever, jaundice and pain) and biliary stasis (persistent dilatation), peribiliary hypoechogenicity and cholangiolar peribiliary abscess on USG.It is managed with administration of appro­priate antibiotics and image-guided drainage of cholangiolar abscess [18]. Broad-spectrum antibiotics should be usedto cover gram-negative bacteria as well. The prevention strat­egy for cholangitis is to avoid repeated manipulations and use minimal amount of iodinated contrast media as cholangi­tis is a potentially life-threatening entity.
The rate of haemorrhage during the procedure varies from
0.6 to 12% [19]. The major source of bleeding is hepatic artery and portal vein branches because of their close vicin­ity to the biliary tract [17]. It can lead to localized haema­toma, haemoperitoneum as well as haemobilia. Haemobilia can occur secondary to iatrogenic stula between hepatic artery and portal vein. There is anincreased risk of bleeding in patients with advanced age, cirrhosis, non-dilated system and multiple manipulations [20]. The source of bleeding can be determined as hepatic artery bleeding would cause signi­cant hemodynamic instability along with pulsatile and con­tinuous bleeding as compared to portal vein bleeding [17]. Minor oozing can be controlled by capping the drainage catheter for 48 hours or by upsizing the catheter. Major bleeding due to hepatic arterial injury or stula needs percu­taneous transhepatic or transarterial embolization.

38.5 Biliary Stenting

Stenting across the obstruction facilitates biliary drainage into the duodenum. The two broad types of biliary stents are plastic and metallic stents. Plastic stents are retrievable stents that are typically inserted through endoscopic route as they require a large bore access. They can be used in both benign and malignant obstructions. Metallic stents require smaller calibre access than plastic stents and thus can be inserted through percutaneous access. They are not retrievable once
placed within the biliary system and are therefore used only as palliative treatment in unresectable cancers.
38.5.1 Indications
Provide biliary drainage in unresectable malignancies involving the biliary tract for:
• Relieving acute or recurrent cholangitis
• Palliation of symptoms of jaundice, such as pruritus
• Optimization of bilirubin level for chemotherapy administration
The contraindications and complications of biliary stent-
ing are similar to that of PTBD.
38.5.2 Technique
Self-expanding metallic stents are used for percutaneous biliary stenting. Uncovered stents are more commonly used than covered stents, although both have similar patency rates [21]. While uncovered stents are more prone to obstruction due to tissue ingrowth, covered stents are more prone to migration. Single stent is placed if the site of obstruction is distal to the primary conuence (Fig. 38.2). Stents with diameter of 10mm and length of 100 mm are usually used and they are deployed such that the proximal end is at least 2–3cm proximal to the obstruction and the distal end is at least 1cm into the duodenum. Balloon angioplasty is avoided in malignant strictures due to risk of bleeding from the tumour.If the primary conuence is involved by the tumour, two separate stents are placed into the right and the left hepatic ducts. Drainage of at least 50% of the liver paren­chyma is essential for a favourable clinical outcome. Bilobar stenting can be performed in two different congurations:
• T-type: One stent is deployed from the right or the left hepatic duct into the CBD.Subsequently, the second stent is deployed through the struts of the rst stent across the primary conuence into the contralateral duct. The advan­tage of this technique is that only one lobe needs to be accessed percutaneously for deploying both stents.
• Y-type: In this technique, bilobar biliary access is obtained and stents are deployed from both the right and the left hepatic duct into the common bile duct. As compared to the Y-type, the T-type stenting has a higher technical suc­cess rate and lower complication rate. However, the stent patency rates are higher with Y-type stenting [22]. The Y-type stenting technique has two variations:
– Side-by-side stenting: The two stents are deployed par-
allel to each other in the common bile duct (Fig.38.3).
478
P. Garg et al.
a
b
a
b
Fig. 38.2 Metallic stent placement for malignant biliary obstruction. (a) Coronal reformatted contrast-enhanced CT image of a 68-year-old man shows a heterogeneously enhancing mass (asterisk) in the pylorus of the stomach inltrating into the hepatic hilum and causing intrahe­patic biliary radical dilation (arrow). Endoscopic biopsy revealed carci­noma of the pylorus. (b) A self-expanding metallic stent (10×100 mm) was placed in the common bile duct as a palliative treatment for biliary obstruction
– Stent-in-stent: One stent is rst deployed fully, follow-
ing which the second stent is deployed from the con­tralateral hepatic duct through the struts of the rst stent into its lumen. Various studies have shown that side-by-side stenting has longer duration of patency as compared to the stent-in-stent technique [23, 24].
In patients with benign strictures of the common bile duct or operable malignant strictures in whom permanent metallic stent placement is not desirable, a rendezvous procedure can be done if the stricture cannot be crossed by the endoscopic route. In this technique, the stricture is crossed through per­cutaneous access and a guidewire is placed across the steno­sis into the duodenum. The guidewire can then be retrieved
Fig. 38.3 Parallel biliary stent placement for hilar obstruction. (a) Axial contrast-enhanced CT image of a 45-year-old lady with jaundice shows a heterogeneously enhancing mass (black arrow) in the hepatic hilum, suggestive of hilar cholangiocarcinoma, causing bilobar intrahe­patic biliary radical dilation (white arrows) with involvement of the primary conuence. (b) Parallel Y-stenting done from both right and left lobe access for relieving the biliary obstruction
endoscopically and a plastic stent placed across the stricture.
38.6 Management ofBenign Biliary Stricture
Benign biliary strictures occur usually due to iatrogenic injury during hepatobiliary surgeries. CBD strictures are managed surgically. Percutaneous transhepatic dilatation is the mainstay of treatment for anastomotic site strictures that develop after hepaticojejunostomy as they cannot be accessed
38 Interventions oftheBiliary Tract
479
through the endoscopic route and revision surgery is often difcult (Fig.38.4).
Intrahepatic biliary radical dilation is often mild in benign strictures as compared to malignant obstruction. Therefore, micropuncture set may be required to obtain access to the biliary duct. The stricture is crossed using a guidewire and a 10-12F internal-external drainage catheter is placed across the stricture. Subsequently, serial catheter upsizing is performed every 2–4 weeks up to 16-18F depending upon the duct diameter. Balloon angioplasty of the stricture using 8–10mm balloons is performed during each upsizing to facilitate catheter placement. The large bore catheter is kept in situ for at least 6months, following which the catheter is removed if the cholangiogram shows good antegrade ow across the anastomotic site. An external drainage catheter is placed proximal to the stricture and capped. This catheter is then removed after one week to check if cholangiogram shows good antegrade ow and there is no elevation of serum bilirubin. Follow-up for any recurrent symptoms or elevation in serum bilirubin is done 1, 3, 6 and 12months after catheter removal and then yearly thereafter. A study by DePietro etal. showed that the patency rate using this technique is 84% one year after catheter removal [25]. In case of recurrent stricture, the procedure is repeated and large bore catheter is placed for a longer dura­tion of up to 12months.
Retrievable covered stents that can be deployed and retrieved through percutaneous route have recently come up as an alternative to serial dilatation and catheter upsizing. All retrievable stents are covered stents to prevent tissue ingrowth
that may hamper the retrieval. The covered stent is placed across the stricture for a duration of 3–6months along with a pigtail catheter in the biliary system to maintain the percuta­neous access. This technique has been shown to have reduced catheter indwelling time and lower recurrence rate than the catheter upsizing technique, due to the larger diameter of the stent as compared to the internal-external drainage catheter and chronic outward force exerted by the stent on the stric­ture [26].

38.7 Intraluminal Procedures Through Percutaneous Biliary Access

38.7.1 Endobiliary Biopsy
Various techniques of endobiliary sampling include brush cytology and forceps biopsy. Percutaneous endoluminal sampling is performed if endoscopic sampling is not feasi­ble. Once the percutaneous biliary access is obtained, sam­pling is done under either uoroscopic or cholangioscopic guidance. Brush cytology is obtained by repeatedly passing the cytology brush across the site of stenosis. Forceps biopsy yields better samples than brush cytology.
38.7.2 Intraluminal Brachytherapy
Intraluminal brachytherapy delivers a high dose of radiother­apy to the tumour while not exceeding the normal tissue tol­erance of surrounding organs.
Indications
Fig. 38.4 Schematic representation of percutaneous transhepatic dila­tation of anastomotic site stricture that develops after hepaticojejunostomy
• Radical treatment: stand-alone treatment in small inoper-
able tumours, or in combination with external beam radiotherapy and/or chemotherapy in advanced disease for unresectable patients
• Adjuvant treatment: after non-radical excision, possibly
combined with external beam radiotherapy
• Palliative treatment: to facilitate the outow of bile (irre-
spective of the size of the tumour, including large inoper­able tumours with signicant extraductal disease)
Through the PTBD access, Iridium-192 applicator is introduced into the site of the tumour and high-dose rate radiotherapy is administered [27].
38.7.3 Gallstone Extraction
Percutaneous extraction can be performed for gallstones that are located in the gall bladder, intrahepatic biliary radicals or CBD.However, it requires a large bore access and is indi-
480
cated only in patients who are poor candidates for surgery and endoscopic removal is not feasible, such as after hepati­cojejunostomy. The most commonly used technique is push­ing the stones into the duodenum using a partially inated angioplasty balloon. Angioplasty of the sphincter of Oddi is done prior to this manoeuvre using 8–14mm balloon cathe­ters, depending upon the diameter of the largest stone. Stones can also be extracted using a Dormia basket with or without intraluminal lithotripsy to fragment the stones [27].

38.8 Percutaneous Cholecystostomy

Percutaneous cholecystostomy involves obtaining percuta­neous access into the gall bladder for drainage of its contents (Fig.38.5).
P. Garg et al.
38.8.1 Indications
• Acute cholecystitissecondary to gall stones: Percutaneous cholecystostomy may be used as a temporizing measure in patients of acute cholecystitis who are critically ill and therefore cannot undergo surgery. After the patient’s con­dition is stabilized, cholecystectomy will still be requiredas the denitive treatment.
• Acalculous cholecystitis: It may occur in critically ill patients and percutaneous drainage is the denitive treat­ment option.
• Relief of biliary obstruction: Cholecystostomy can pro­vide a means of accessing the biliary tree in patients with obstructive jaundice in whom the bile ducts are minimally dilated and the level of obstruction is distal to the inser­tion of the cystic duct. This is done in critically ill patients with biliaryobstruction as a bedside procedure.
38.8.2 Technique
The gallbladder is punctured under USG guidance. There are two approach routes available for puncturing the gallbladder.
Fig. 38.5 Schematic diagram demonstrating transhepatic percutane­ous cystostomy
– It has a higher risk of bleeding complications as the
liver parenchyma is traversed.
Transperitoneal Approach. – The gallbladder is punctured at the point where it lies
closest to the anterior abdominal wall.
– It is less commonly done as it is associated with a
higher risk of bile leak into the peritoneum.
– The trocar technique is generally used for the insertion
of the catheter.
If surgery is not considered as in acalculous cholecystitis, the catheter can be removed once the patient’s signs and symptoms resolve and sufcient time has elapsed for the tract to mature. This is said to be at least two weeks when the transhepatic route is used and three weeks when the trans­peritoneal approach is used. Removal of the catheter before tract maturation may result in leakage of bile and peritonitis.

References

Transhepatic Route. – Using the transhepatic route, the gallbladder is punc-
tured where it is xed to the liver, generally at the junc­tion between the cephalic and middle third of the body.
– It is usually preferred as it is associated with lower risk
of bile leak and biliary peritonitis.
– It is usually done using the Seldinger technique, in
which the access is obtained using a puncture needle and secured using a guidewire. 10F pigtail catheter is inserted over the guidewire following serial dilatation.
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2. Moghimi M, Marashi SA, Salehian MT, Sheikhvatan M.Obstructive jaundice in Iran: factors affecting early outcome. Hepatobiliary Pancreat Dis Int. 2008;7:515–9.
3. Fekaj E, Jankulovski N, Matveeva N.Obstructive jaundice. Austin Dig Syst. 2017;2(1):1006.
4. Gupta P, Gupta J, Kumar-M P.Imaging in obstructive jaundice: what a radiologist needs to know before doing a percutane­ous transhepatic biliary drainage. J Clin Interven Radiol ISVIR. 2020;4(01):31–7.
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5. Le CC. foie: etudes anatomiques et chirurgicales. Paris: Masson & Cie; 1957. p.530.
6. Gazelle GS, Lee MJ, Mueller PR. Cholangiographic segmental anatomy of the liver. Radiographics. 1994;14:1005–13.
7. Puente SG, Bannura GC. Radiological anatomy of the bili­ary tract: variations and congenital abnormalities. World J Surg. 1983;7:271–6.
8. Brink JA, Borrello JA. MR imaging of the biliary system. Magn Reson Imaging Clin N Am. 1995;3:143–60.
9. Low RN, Sigeti JS, Francis IR, etal. Evaluation of malignant biliary obstruction: efcacy of fast multiplanar spoiled gradient-recalled MR imaging vs spin-echo MR imaging, CT, and cholangiography. AJR Am J Roentgenol. 1994;162:315–23.
10. De Cobelli F, Marra P, Diana P, Brembilla G, Venturini M.Therapeutic EUS: biliary drainage– the interventional radiolo­gist’s perspective. Endosc Ultrasound. 2017;6:S127–31.
11. Soto JA, Alvarez O, Lopera JE, Múnera F, Restrepo JC, Correa G.Biliary obstruction: ndings at MR cholangiography and cross­sectional MR imaging. Radiographics. 2000;20(2):353–66.
12. Saad WE, Wallace MJ, Wojak JC, Kundu S, Cardella JF.Quality improvement guidelines for percutaneous transhepatic cholangi­ography, biliary drainage, and percutaneous cholecystostomy. J Vasc Interv Radiol. 2010;21:789–95. https://doi.org/10.1016/j.
jvir.2010.01.012.
13. Patel IJ, Davidson JC, Nikolic B, Salazar GM, Schwartzberg MS, Walker TG, Saad WA. Consensus guidelines for periproce­dural management of coagulation status and hemostasis risk in percutaneous image-guided interventions. J Vasc Interv Radiol. 2012;23:727–36. https://doi.org/10.1016/j.jvir.2012.02.012.
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20. Weber A, Gaa J, Rosca B, Born P, Neu B, Schmid RM, Prinz C. Complications of percutaneous transhepatic biliary drain­age in patients with dilated and nondilated intrahepatic bile ducts. Eur J Radiol. 2009;72:412–7. https://doi.org/10.1016/j.
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22. Chen L, Gao GM, Li DL, Chen ZK. Side-by-side versus stent­in- stent bilateral stenting for malignant hilar biliary obstruc­tion: a meta-analysis. Wideochir Inne Tech Maloinwazyjne. 2022;17(2):279–88.
23. Zhou WZ, Liu S, Yang ZQ, Xian YT, Dou XH, Zheng WJ, et al. Percutaneous stent placement for malignant hilar biliary obstruction: side-by-side versus stent-in-stent technique. BMC Gastroenterol. 2020;20(1):174.
24. Lee TH, Moon JH, Park SH.Biliary stenting for hilar malignant biliary obstruction. Dig Endosc. 2020;32(2):275–86.
25. DePietro DM, Shlansky-Goldberg RD, Soulen MC, Stavropoulos SW, Mondschein JI, Dagli MS, et al. Long-term outcomes of a benign biliary stricture protocol. J Vasc Interv Radiol. 2015 Jul;26(7):1032–9.
26. Ye P, Zeng Q, Miao H, Pang H, Chen Y.Percutaneous treatment of benign biliary anastomotic strictures: retrievable covered self­expandable metal stent with xation string versus large-bore cath­eters. J Vasc Interv Radiol. 2021;32:113–20.
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Non-vascular Interventions oftheGastrointestinal Tract
RishabhJain andS.H.Chandrashekhara
39
Key Messages
1. Percutaneous radiological gastrostomy (PRG), in the absence of bowel obstruction/perforation, superiorly displaced stomach, and immunosuppression, can be considered for nutrition in patients with high risk of pro­longed malnutrition and aspiration.
2. Push technique in PRG is associated with more peri­intervention complications than the pull-through technique.
3. Percutaneous jejunostomy has the same indication as PRG and is considered where gastrostomy tube is not suitable or has been ineffective in preventing aspiration.
4. Specic complications that can be catastrophic in percu­taneous jejunostomy are small bowel and colonic perfo­ration which can be avoided by using CT for guidance instead of uoroscopy.
5. Percutaneous cecostomy can be used in cases of impend­ing perforation due to cecal dilatation and is of particular use when colonic decompression is unsuccessful.
6. Percutaneous cecostomy looks particularly promising in cases of Ogilvie’s Syndrome.
7. Cecopexy is an integral part of percutaneous cecostomy and must be done using T-fasteners in order to prevent leakage into the peritoneal cavity.
8. Fluoroscopy-guided balloon dilatation of esophageal strictures is preferred to endoscopic bougienage as it causes less tears.
9. Plastic stents for dilatation of esophageal strictures are associated with a higher complication rate and are being gradually replaced by retrievable metallic stents.
R. Jain Department of Interventional Radiology, Institute of Liver and Biliary Sciences, Delhi, India
S. H. Chandrashekhara ( Department of Radiodiagnosis and Interventional Radiology, IRCH, All India Institute of Medical Sciences, Delhi, India
*)
10. Evolution of stents for esophageal dilation like self­expanding stents, conical wall stents, and stents with ared ends has reduced the rates of migration.
11. Development of covered metallic prostheses has shown promise in the management of esophageal strictures with coexisting tracheoesophageal stula.

39.1 Introduction

The development of minimally invasive interventions of the gastrointestinal tract has been a game changer, be it for thera­peutic purposes, prophylaxis against life-threatening events like aspiration or bowel perforation, or end-of-life palliative care. By obviating the need for extensive surgeries, they have also contributed to a decrease in surgery and anesthesia­related morbidity.
In this chapter, we discuss the commonly performed interventions of the gastrointestinal tract, their indications, the techniques, and complications.

39.2 Percutaneous Gastrostomy

Gastrostomy provides an alternative method for nutritional support in individuals who have difculty with prolonged oral intake. Maintaining gastrointestinal function is vital for nutritional supplementation and maintaining the quality of life. Gastrostomy tubes can be placed via surgical, endo­scopic, or radiological methods. Among these, surgical gas­trostomy has the highest overall complication rate at 29%, whereas percutaneous endoscopic gastrostomy (PEG) and radiological gastrostomy each have a complication rate of about 15%. Of the radiological methods, percutaneous radio­logical gastrostomy (PRG) is the safest and least invasive.
Two approaches are available for radiologically guided gas­trostomy: the “push-type gastrostomy,” which is the traditional percutaneous approach involving access through the abdomi­nal wall to the stomach, and the “pull-type gastrostomy,”
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024 S. H. Chandrashekhara (ed.), Textbook of Interventional Radiology, https://doi.org/10.1007/978-981-97-9601-4_39
483
484
R. Jain and S. H. Chandrashekhara
adapted from the PEG technique, which involves placing the gastrostomy catheter through an internal/external approach.
39.2.1 Indications
It is recommended for patients at high risk of malnutrition who are unlikely to regain their ability to eat orally in the near future. Additionally, it is used for patients needing long­term gastric decompression. Examples include:
• Neurogenic cause of abnormal swallowing reex— patients with high risk of aspiration—cerebrovascular event, traumatic brain injury, cerebral palsy, etc.
• Malignancy of the head and neck region.
• Surgery of the oral cavity/larynx.
• Systemic sclerosis.
• Severe burns.
39.2.2 Contraindications
Absolute Contraindications
• Uncorrected coagulopathy.
• Active peritonitis.
• Bowel ischemia.
• Patients with portal hypertension and high-risk gastric varices—potential for catastrophic bleeding.
Relative Contraindications
• Ascites.
• Partial gastrectomy.
• Surgeries with risk of aspiration—large hiatus hernia, gastric volvulus, esophagostomy with gastric pull­through, colonic interposition.
• Diaphragmatic denervation with superiorly displaced stomach.
• Prolonged immunosuppression.
39.2.3 Pre-procedural Work-Up
• Platelets >50,000/μL, PT INR <1.5, aPTT <40.
• CT to rule out ascites and anatomical variations like hia­tus hernia, interposition of colon, enlarged liver, and situs inversus.
• Antiseptic mouth rise on the day of procedure in pull type.
• Local preparation of abdomen (shaving and betadine scrub).
• Broad-spectrum IV antibiotic on the day of the procedure.
39.2.4 Technique
Push-Type PRG
Push-type technique uses the Seldinger technique to insert the gastrostomy tube into the stomach, bypassing the phar­ynx. The rst step requires gastropexy to securely fasten the gastric and abdominal walls together.
The stomach is insufated with air via the nasogastric tune after navigating past any neoplastic mass or stricture with a combination of angiographic catheters and wires. An ultrasound (USG) is used to outline the left lobe of the liver on the skin, after which the epigastric area is cleaned and prepared. Two to three access sites are marked on the skin in a small triangular formation directly above the stomach, positioned equidistant from each curvature and between the left hepatic lobe outline and the palpable left costal margin. T fasteners are then inserted into the stomach at these marked sites under uoroscopic guidance, using a con­trolled, brisk push.
The intragastric conrmation of the T-fasteners is veried by aspirating air into a syringe partially lled with contrast and then injecting a small amount of contrast to visualize the dependent gastric rugal folds. After performing the gastro­pexy of the stomach, an 18-G needle is inserted at the center of the marked triangle, and the intragastric conrmation pro­cess is repeated. Following this, an extra-stiff Amplatz guide­wire is inserted, coiling within the fundus and body of the stomach to ensure a secure placement within the stomach lumen. Sequential dilatation of the tract is done with the larg­est being 2-4F wider than the expected size of the gastros­tomy tube followed by placement of the gastrostomy tube into the stomach.
Once the catheter tip is conrmed to be beyond the outer sheath, the gastrostomy balloon is inated with dilute iodin­ated contrast, up to 6–10mL depending on the catheter size. The outer sheath is then peeled away and the gastrostomy catheter is pulled until the inner balloon is ush with the gas­tric wall. The external retainer on the catheter is advanced until it is ush with the skin around the stoma.
In the situation where the upper aerodigestive tract is obstructed, preventing the passage of an NG tube for insuf­ation, direct puncture of the stomach wall is done under USG and uoroscopy guidance after identifying the borders of the left lobe of the liver and colon. A linear high-frequency USG probe is employed to locate the collapsed stomach. The anterior wall of the stomach is then targeted using an 18-G needle and tip conrmed by injecting contrast. Subsequently, 600–800mL of room air is pushed via the needle to inate the stomach. Gastropexy is subsequently to oppose the ante­rior abdominal wall with the stomach wall using three T-fasteners as described previously. A stiff guidewire is introduced into the gastric lumen through the 18-G needle and serial tract dilatation is done.
39 Non-vascular Inter ventions oftheGastrointestinal Tract
485
The peel-away sheath is advanced to the gastric lumen over the stiff guidewire, the trocar of the sheath along with the stiff guidewire is removed, and the gastrostomy tube is inserted through the peel-away sheath. Once the tip of the tube is beyond the sheath (as seen on uoroscopy), the sheath is peeled away and the tube is adjusted as described above.
39.2.5 Post-procedures Advice Following
theProcedure
The gastrostomy tube is advised to be used for feeding after 24 h. Till then, feeding can be given through the already­inserted NG tube. After 24h, diluted milk followed by saline infusion is done. The patient is observed for 2h. If there are no features of peritonitis and the patient tolerates feeding well, then a proper diet can be started. A liquid diet, prefer­ably 200ml 6 times a day or as suggested by a dietician, is started. After every feed, 50ml of saline ush is given from the same tube for cleaning. Hot uids should be avoided via a gastrostomy tube.
39.2.6 Pull-Type PRG
The stomach is inated with approximately 1000ml of air using a three-way stopcock through an indwelling nasogas­tric tube. Under uoroscopic guidance, an 18G puncture needle is used to create a gastric puncture in the lower third of the stomach, positioned centrally to avoid damaging the gastroepiploic artery. The puncture site is selected to be equi­distant from the greater and lesser curvatures, and lateral to the rectus muscle or in the midline to avoid puncturing the epigastric arteries. Gastric puncture is conrmed either by aspirating air into a syringe or ushing with contrast media. The needle is then exchanged over a wire (J wire/Terumo hydrophilic wire) for a 5F sheath.
A 65cm, 4 or 5F catheter is introduced over the guide­wire. Usually, this allows for direct retrograde access to the esophageal lumen with the guiding catheter. The catheter- guidewire combination is then either exited through the mouth or withdrawn with forceps when the guidewire reaches the nasopharynx. If needed, an 18 G needle directed toward the gastroesophageal junction and manipulation of the hydrophilic guidewire may success­fully advance the guidewire into the esophagus. The hydrophilic guidewire is then replaced with a super stiff guidewire, and a 9F, 65cm long sheath is inserted and exited through the mouth.
An extra-long, super-stiff Amplatz guidewire is folded and doubled at its midpoint. This guidewire is introduced ret-
rogradely through the 9F sheath, from the stomach end to exit through the tip of the sheath at the mouth end. After applying a water-soluble lubricant, the feeding tube wire and the folded end of the guidewire are connected with a square knot. The entire assembly is then pulled through the anterior abdominal wall under uoroscopic guidance until the mush­room end of the feeding tube is felt to contact the gastric wall. Finally, the outer bolster of the feeding tube is secured and fastened.
39.2.7 Comparison Between Push-Type andPull-Type Gastrostomy Tubes
Overall, periprocedural complications are more frequent with push-type gastrostomy tubes compared to pull-type tubes. Minor complications occur in 10.2% of push-type and
22.4% of pull-type gastrostomy tube placements. These
complications include dislodgement, pericatheter leakage, tube occlusion, supercial stomal infections, and minor bleeding related to the tube [1]. If a push-type tube becomes dislodged, it can be easily reinserted because the T-fasteners remain in place for 2weeks, providing gastropexy for tube reinsertion. The anchor sutures resorb spontaneously over 2weeks, and the tract is typically well-matured by then [2]. Major complications occur in 1–5% of pull-type versus 5–10% of push-type gastrostomy tubes and include peripro­cedural hemorrhage, aspiration pneumonia, pneumoperito­neum due to bowel perforation, and deep abscesses (Figs.39.1 and 39.2).
Pull-type percutaneous radiological gastrostomy (PRG) is considered more secure than the conventional push-type tubes because the retention device in the pull-type does not deate, unlock, or become displaced during feeding. Pull­type gastrostomy is generally preferred for patients with nonobstructive neuromuscular esophageal dysmotility disorders.
In patients with advanced head, neck, and upper aerodi­gestive tract cancers, the push-type technique is often pre­ferred due to the luminal compromise that complicates the per-oral passage of a pull-type tube. PRG has demonstrated safety and efcacy for enteral access, with a success rate of up to 98% in patients who previously had failed endoscopic gastrostomy placements [3, 4]. Kumar etal. reported techni­cal success in 29 out of 31 patients with head and neck squa­mous cell carcinoma and esophageal cancers [2]. An advantage of the push-type PRG is that it can be placed without stomach air insufation; direct stomach puncture can be performed with a 22 G percutaneous needle, fol­lowed by air insufation, gastropexy, and tube placement (Figs.39.3, 39.4 and 39.5).