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30 Vascular Interventions inTrauma
379
Table 30.2 The hard and soft signs of peripheral arterial injury
HARD SIGN:
H : Expanding hematoma
A : Arterial pulsatile bleeding
R : Bruit and Thrill
D : Do not feel distal pulse
Evidence of regional ischemia: “6P” (Pallor, paresthesia, palsy, pain, pulseless ness, poikilothermia)
Table: Clinical sign of Arterial Injury :
ab
SOFT SIGN:
Non Expanding hematoma
Nonpulsatile bleeding
Proximity Injury
Unexplained hypotension
Injury to anatomically
related nerve
c
d
Fig. 30.5 Stent graft vascular reconstruction in a patient with a right lower limb hemorrhagic injury involving a non-sacricable artery (pop­liteal artery) following blunt trauma The coronal reformatted and volume rendering (VRT) CT angiography images of the bilateral lower limbs (a, b) depict a large, well-dened pseudoaneurysm arising from the distal supercial femoral artery. The
selective angiogram of the left common femoral artery (c, d) shows a large contrast blob (pseudoaneurysm) in the distal part of the supercial femoral artery. Post-vascular reconstruction (stent graft) images (d) demonstrate complete occlusion of the pseudoaneurysm with preserved forward ow
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Fig. 30.6 Coil embolization of a patient with a right lower limb hem­orrhagic injury involving a sacricable artery following a road trafc accident. Selective angiogram of the left common femoral artery (a, b) reveals a large contrast blob (pseudoaneurysm) in the distal part of the
artery-related injuries. USG guidance when available is pref­erable, especially in cases with hemodynamic instability. Heparin and heparin saline should be withheld in the setting of acute trauma. A selective angiogram is performed using a catheter like Picard or vertebral catheter. Cross-over sheath or long sheath is used when stent grafting is used, to stabilize the hardware if the injury is located distally. The long sheath is used for upper limb arterial injury, to stabilize the hard­ware and place stent graft.
Superselective catheterization of the targeted artery is usually done with a microcatheter. Depending upon the imaging and angiographic injury pattern, embolization or vascular reconstruction is done. In case of focal active bleed­ing or pseudoaneurysm or large AV stula, with an appropri­ate landing zone in the sacricable artery, proximal embolization is done using permanent embolizing agents like coils or coils with glue or plug, aimed to complete blockage of the forward ow of the targeted artery. In case of focal active bleeding or pseudoaneurysm or AV stula, with an appropriate landing zone in the main artery or non­sacricable artery, vascular reconstruction is done using a stent graft, aimed to salvage the limb and vessels, to achieve hemostasis.
deep femoral artery. Post-coil embolization images (c) demonstrate complete coil occlusion as close as possible to the culprit vessels with­out any further extravasation
30.4.5 Embolization Agent
The endovascular intervention aims to achieve hemostasis by occluding the injured artery or performing vascular recon­struction. The choice of endovascular treatment depends on the type of vessel, the nature of the injury, and the size of the artery. In case of injury to the main artery, vascular recon­struction using a covered stent graft is indicated for hemody­namically stable patients, to preserve patency for forward ow [23]. Conversely, in case of injury to the small to medium-sized or an end artery, feasible to sacrice or occlude the vessel, the preferred treatment is using an embo­lization agent or vascular plug [24]. Embolizing agents such as coil, glue, or a combination thereof, as well as, vascular plugs are selected depending on the specic characteristics of the landing zone.
30.4.6 Post-procedural Care
The immediate post-procedural care includes close observa­tion of vitals and access site care at least for 24hours to prevent complications. A routine post-procedural ultraso-
30 Vascular Interventions inTrauma
381
nography (USG) is recommended on the next day to look for residual pseudoaneurysm and to assess the puncture site complication. Low molecular weight heparin is advised for the next 24hours then tapered and shifted to oral antiplate­lets for at least 6months in a trauma setting to prevent stent thombosis.
30.4.7 Complications
Local site complications or rebleeding after embolization, reperfusion injury, embolization-related complications (coil migration, vessel perforation), and infection [25]. However, these complications are rare, and the benets of the emboli­zation procedure often outweigh the risks [26].

30.5 Pelvic Trauma

30.5.1 Background
Traumatic pelvic injuries are associated with signicant morbidity and mortality, with a mortality rate of ~16%, which is the highest mortality rate of any skeletal injury [27]. Hemorrhage is the most common treatable cause of death in pelvic trauma and the source of the massive pelvic bleed are rupture of the vein or venous plexus, bleeding from cancel­lous bone, rupture of arteries, or a combination [28]. The majority are the result of venous injury, which accounts for 80–90% of bleeding, while arterial injury accounts for 10–20% [29]. Hence timely identication and control of bleeding is pivotal in reducing mortality.
The rst line of management is the pelvic xation with binder or pelvic packing, and after that further assessment depends on the hemodynamic status of the patient. Intervention radiology serves at the forefront of pelvic trauma management and has several advantages over surgi­cal intervention. First, the relatively conned space makes surgical access difcult; second, surgery may release the tamponade effect, which can be catastrophic; and nally, the rich vasculature and collaterals network may make arterial ligation difcult [30].
30.5.2 Indication
screening to exclude pelvic hemorrhage, predict the type (arterial vs venous), and site of injury, and tailor the emboli­zation accordingly [31]. The ideal candidates for angioem­bolization are pelvic trauma with the following:
1. CT evidence of focal arterial or diffuse arterial micro­bleeds, in patients with stable hemodynamics.
2. In transient responders, where vitals remain unstable even after >1.5L of IV uid or after pelvic packing, and represents slow and continuous bleeding, TAE is war­ranted even without preceding CT.
3. Ongoing bleeding despite the surgical intervention or pel­vic packing, even though the patient is hemodynamically unstable.
4. Delayed vascular complications like pseudoaneurysm formation in follow-up cases, managed conservatively initially.
30.5.3 Technique
Includes patient preparation, procedure steps, approaches, the embolizing agent used, and post-procedural care. The planning is based on ndings on CECT ndings, which not only delineate the characteristics of the injury but also fur­nish a roadmap for localizing the site of hemorrhage and any concomitant anatomical variations of the artery, particularly “corona mortis,” to circumvent unnecessary time expendi­ture in identifying or localizing vessel origins.
30.5.4 Patient Preparation
Patient preparation is an essential aspect of trauma care and encompasses ongoing resuscitation, securing the airway, ensuring effective breathing, and maintaining circulation. Establishing and maintaining adequate IV access with a large bore IV line is crucial to facilitate the administration of life-saving uids and medications. In cases of trauma, basic laboratory parameters are not essential prerequisites, as the primary goal is to achieve hemostasis and stabilize the patient rapidly. In instances of pelvic trauma, it is important to ensure that the urinary bladder is empty, as a full bladder may obscure the eld of view and complicate assessment.
According to ATLS guidelines, the assessment starts with the pelvic binder, pelvic packing, and after fracture stabilization in case of pelvic trauma, and then is followed by computed tomography angiography (CECT) torso, which is also an independent predictor for survival. CT is an excellent tool for
30.5.5 Procedure (Fig.30.7)
The arterial access is gained via puncturing the common femoral artery. The ipsilateral or contralateral site can be used for a puncture, depending upon the choice of IR radi-
382
Fig. 30.7 Bilateral internal iliac artery angioembolization in a transient responder patient with multiple pelvic fractures following a road trafc accident Selective angiogram of the right internal iliac artery (a, b, c) demonstrates multifocal contrast blush consistent with extravasa­tion from the superior, inferior gluteal, and internal pudendal artery branches of the anterior division of the internal iliac artery on either side. Post-coil embolization images (d) show complete occlusion of the anterior division of the bilateral internal iliac artery using Nester coils without further extravasations
R. Yadav et al.
a
b
cd
ologist. However, the contralateral site or site opposite of pelvic fracture is used for puncture, for ease, and to allow more secure seating of the catheter. USG guidance when available is preferable, especially in cases with hemody­namic instability and given pelvic binder, that can be cut away to create a sufcient window. Heparin and hep saline should be withheld in the setting of acute trauma. A selective external iliac and common femoral artery angiogram is per­formed using appropriately shaped catheters like Picard or Simmons reverse curve (SIM1) depending on the angle of aortic bifurcation, and usually contralateral angiogram is preferred (if suspected), followed by ipsilateral. Superselective catheterization of the targeted artery is done with a microcatheter. The angiographic evidence of arterial injury is spasm, truncation of the artery (cut-off sign), extrav­asation, pseudoaneurysm, and AV stula formation. Oblique view and delayed images are taken until venous return. Always look for multiple bleeder sites and the primary aim is to manage the massive bleeder site rst and embolize as selectively as time permits. A tailored approach is essential for optimizing patient outcomes and minimizing potential complications. Selective embolization is the preferred method if patient hemodynamics are stable as it minimizes damage to the noninjured vessel, but this can be technically
challenging in hemodynamic instability, vasoconstriction, and vascular spasm. Nonselective embolization where gel­foam is delivered to the main internal iliac artery or its divi­sions, either unilaterally or bilaterally depending on the severity of fracture and bleeding. Nonselective embolization is the preferred method when the patient is unstable and time is of the essence and in the presence of multiple arterial bleeding points and when active extravasation is not demon­strated, but there is a high index of suspicion that arterial bleeding is the cause of ongoing instability.
30.5.6 Embolization Agent
The selection of an embolization material is meticulously tailored to the specic requirements of each individual case, taking into consideration the imaging characteristics of the injury and the preferences of the interventional radiologist [32]. Embolization can be performed in a selective or nonse­lective manner. In the context of pelvic trauma, embolization should be as selective as time permits. However, bilateral nonselective embolization of the internal iliac artery is justi­ed in cases of transient responders. The embolizing agent of choice for nonselective embolization or in the presence of
30 Vascular Interventions inTrauma
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diffuse bleeding is gelfoam (in the form of a slurry), whereas coils are utilized for selective focal arterial bleeds [33]. Furthermore, other embolization agents that can be utilized include glue and onyx [34].
30.5.7 Complications
Complications are rare and associated with access site com­plications or embolization-related issues, with an incidence of 5–6% [35]. Short-term complications commonly observed with nonselective embolization encompass infection, gluteal necrosis, skin breakdown, bladder necrosis, urinary reten­tion, and rhabdomyolysis. Long-term complications, while very rare, may include sciatic or sacral plexus palsies, gluteal claudication, or impotence [36].

30.6 Maxillofacial Injury (MFI)

30.6.1 Background
Blunt trauma is the predominant mechanism responsible for maxillofacial injuries, often resulting in copious oronasal bleeding. Among traumatic maxillofacial injuries, the inter­nal maxillary artery emerges as the most frequently impli­cated artery, followed by the facial and lingual arteries [37]. The primary objective in managing maxillofacial injuries lies in ensuring the patency of the airway, as bleeding into the oral cavity, particularly posterior epistaxis, can swiftly compromise respiratory function. Therefore, securing the airway constitutes the foremost priority in such cases. The second is to halt the hemorrhage through various methods such as nasal packing with gauze, Foley’s catheter insertion, fracture reduction, arterial ligation, and selective angioem­bolization. Conventional approaches like surgical arterial ligation may be ineffective in cases involving injury to mul­tiple vessels and a well-established collateral vascular net­work in complex facial trauma scenarios. Furthermore, the nonselective nature and associated high morbidity of surgi­cal ligation of external carotid arteries underscore the neces­sity for alternative strategies to achieve effective and safe hemostasis [38].
Transarterial embolization (TAE) emerges as a highly efcient and clinically signicant treatment modality for cases of intractable refractory hemorrhage associated with maxillofacial injuries [39]. This minimally invasive tech­nique offers precise and targeted occlusion of bleeding ves­sels using embolic agents, thereby overcoming the limitations of conventional surgical approaches. The conservative treat­ment consisting of packing of the nares, compression, and blood transfusion should always precede TAE as the primary protocol.
30.6.2 Indication
The decision to pursue IR angioembolization in the maxil­lofacial injury is made in collaboration with a multidisci­plinary team, including interventional radiologists, trauma surgeons, and maxillofacial specialists, taking into account the specic clinical presentation and imaging ndings of the individual patient. The indications are:
1. Refractory or intractable bleeding (microhemorrhages) from Lefort or non-Lefort maxillofacial injury evident on CTA.
2. In transient responders, where bleeding persists or vitals remain unstable even after conservative treatment or the need for continued blood product replacement exceeding 1500mL and a systolic blood pressure<90mm Hg, TAE intervention is warranted even without CT or before other surgical interventions.
3. Presence of CT evidence of direct focal vascular injury (pseudoaneurysm, AV stula, or focal contrast extravasa­tion in MFI with stable hemodynamic status.
4. Delayed vascular injury like pseudoaneurysm in the fol­low- up cases of MFI, managed earlier nonoperatively.
30.6.3 Technique
Includes patient preparation, procedure steps, approaches, the embolizing agent used, and post-procedural care. The planning is based on CT angiography ndings, which not only delineate the characteristics of the injury but also fur­nish a roadmap for localizing the site of hemorrhage and any concomitant injury.
30.6.4 Patient Preparation
Patient preparation is an essential aspect of trauma care and encompasses ongoing resuscitation, securing the airway, ensuring effective breathing, and maintaining circulation. Establishing and maintaining adequate IV access with a large bore IV line is crucial to facilitate the administration of life-saving uids and medications. In cases of trauma, basic laboratory parameters are not essential prerequisites, as the primary goal is to achieve hemostasis and stabilize the patient rapidly.
30.6.5 Procedure (Figs.30.8 and30.9)
The arterial access is gained via puncturing the common femoral artery. After getting arterial access the carotid arter­ies are cannulated using a 4F or 5F diagnostic catheter
384
R. Yadav et al.
a
c
Fig. 30.8 Gelfoam angioembolization in a patient with multiple maxil­lofacial injuries following a road trafc accident, experiencing uctuat­ing blood pressure and persistent tachycardia (transient responder), despite nasal packing, Foley catheter placement, and blood transfusion Axial (a) with sagittal reformatted (b) contrast- enhanced CT images of the face reveal extensive maxillofacial injuries with Foley bulbs in the nasopharynx
b
d
Selective angiogram of the right maxillary artery (c) shows contrast blush (extravasation) from the facial branch of the right internal maxil­lary artery in the distalmost part, which could not be reached due to the small caliber of the vessel. Therefore, gelfoam embolization was per­formed. Post-coil embolization images (d) demonstrate complete occlusion without further extravasation
(VERT slip-cath or Picard), and selective angiograms of common carotid arteries (CCAs), internal carotid arteries (ICAs), and external carotid artery (ECAs) are obtained. If the bleeding is from a single nostril or predominantly from one side, the ipsilateral arteries should be interrogated rst. Initially, angiography of ICAs is done to rule out an ICA source of bleed, to see the supply of ophthalmic artery (cho­roidal blush), and to rule out communication between branches of ICA and ECAs. In such cases, surgery is pre­ferred over embolization due to the higher risk of complica­tions from accidental nontarget embolization. Selective angiography of ECAs is then done to look for the source of the bleed and to rule out potentially dangerous collaterals, followed by super selective cannulation of ECA branches using microcatheters in selective cases with active bleeding in distal branches or with tortuous anatomy of the parent ves­sel. The most commonly seen angiographic patterns of arte­rial injury in MFI are active contrast extravasation or micro blushes from branches of the internal maxillary artery. The most commonly injured artery is the internal maxillary artery followed by the facial, lingual, and supercial temporal artery. Gelfoam pledgets and bered coils are used as embo­lizing agents [40]. Gelfoam pledget/slurry is the most com­monly used agent. In cases when angiography does not
reveal any active contrast leak, the internal maxillary arteries on either side can be empirically embolized using gelfoam injection. To avoid nontarget embolization the catheter tip is placed distal to meningeal and deep temporal branches.
30.6.6 Embolization Agent
The selection of an embolization material is meticulously tailored to the specic requirements of each case, consider­ing the imaging characteristics of the injury. Gelfoam and coil are commonly used embolizing agents for oronasal bleeding, with gelfoam being the most frequently used. Gelfoam is preferred in cases where there is diffuse blush from small distal vessels on angiography or when superse­lective catheterization or reaching the site of active contrast extravasation by microcatheter is not feasible [41]. In selected cases, gelfoam embolization may be performed prophylactically to reduce the perfusion pressure to manage venous bleeding [42]. Before gelfoam injection, it is essen­tial to carefully assess and rule out the communicating channels between the branches of the external and internal carotid arteries. In cases where communicating channels are evident on angiography, coils are preferred over gelfoam to
bc
30 Vascular Interventions inTrauma
a
385
de
Fig. 30.9 Coil angioembolization in a patient with maxillofacial inju­ries following a road trafc accident The sagittal reformatted (a) and volume- rendering (VRT) (b) contrast­enhanced CT images of the face reveal a left hemimandible fracture with a pseudoaneurysm arising from the supercial temporal artery.
The selective angiogram of the right external carotid artery (c) shows a contrast blob (pseudoaneurysm) from a branch of the left supercial temporal artery. Post-coil embolization images (d, e, f) demonstrate complete proximal coil occlusion without further extravasation
f
mitigate the risk of nontarget embolization. Coils are also a preferred choice for the presence of focal active contrast extravasation observed on angiography and when superse­lective catheterization allows reaching near the site using a microcatheter. A combined embolization approach using both gelfoam and coil, known as the sandwich technique, can be done to reinforce the embolization and achieve immediate hemostasis [43].
30.6.7 Complications
Complications are rare and primarily associated with access sites, as well as complications secondary to embolization­related issues, such as nontarget embolization and local isch­emic changes or soft tissue swelling [44]. Other uncommon complications include cerebrovascular accidents, blindness, lip-tongue necrosis, facial nerve palsy, and trismus [45].
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30.7 Conclusion

Hemodynamically stable patients with splenic and hepatic injuries are the candidates for embolization. The choice of proximal vs distal coil embolization relies on the imaging pattern of injury and the aim to achieve. Endovascular man­agement is used only in hemorrhagic type of peripheral arte­rial injury. A multidisciplinary approach is preferred for managing pelvic, head, and neck trauma patients with arte­rial injury.

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Vascular Interventions inEndocrinopathies
DevasenathipathyKandasamy andKavirajanKabilan
31
Key Messages
1. Venous sampling plays an important role in management wherever the ndings on diagnostic modalities are equivocal.
2. In certain situations, they are considered the gold standard.
3. Bilateral inferior petrosal sinus sampling and adrenal vein sampling are the most commonly performed procedures.
4. Inferior petrosal sinus sampling can reliably differentiate the central source from the ectopic source in patients with ACTH-dependent Cushing’s disease.
5. Adrenal vein sampling can reliably differentiate unilat­eral from bilateral secretion in patients with primary hyperaldosteronism.
6. Selective arterial calcium stimulation test (SACST) can help in localizing the source of insulin in patients with hypoglycemic hyperinsulinoma where diagnostic imag­ing is either not helpful or equivocal.
7. Whole-body venous sampling is generally performed in patients with tumor-induced osteomalacia where diag­nostic imaging fails to localize the source with certainty.
8. The venous sampling procedures are safe and well toler­ated by the patients.
9. Meticulous planning of these procedures is equally important to the procedure itself.
The interventional radiologist should be well versed in the basic hormonal pathways, actions, and the appropri­ate methods to transport the samples for accurate analysis.

31.1 Introduction

Endocrinopathies are a group of disorders resulting from pathological sources of hormone production. Cross-sectional imaging techniques such as CT and MRI are good morpho­logical modalities but lack functional information which is important for deciding the management of patients with vari­ous endocrinopathies. Venous sampling should be consid­ered in patients with high suspicion of endocrine abnormalities with normal or doubtful cross-sectional imag­ing ndings; in some situations, it has a role in patients with unequivocal imaging ndings. Venous sampling plays an important role in endocrinopathies such as endogenous adre­nocorticotropic hormone (ACTH)-dependent Cushing syn­drome (CS) to differentiate pituitary versus ectopic source; in primary hyperaldosteronism to differentiate unilateral dis­ease from bilateral disease; in small pancreatic neuroendo­crine tumors (panNETs) presenting with hyper insulinemic hypoglycemia and Zollinger-Ellison syndrome; in hyperan­drogenism to identify the androgen-producing ovarian or adrenal tumors; renal vein renin sampling in renovascular hypertension to identify unilateral or bilateral secretion; and tumor-induced osteomalacia (TIO) to help in preoperative localization.

31.2 Inferior Petrosal Sinus Sampling

31.2.1 The Pituitary Gland andInferior Petrosal Sinus Anatomy
The pituitary gland is situated in the sella and consists of the anterior (adenohypophysis) and posterior lobes (neurohy­pophysis). The anterior lobe comprises pars tuberalis, pars intermedia, and pars distalis. The majority of the pituitary hormone production occurs in pars distalis.
D. Kandasamy (*) · K. Kabilan Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Delhi, India
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024 S. H. Chandrashekhara (ed.), Textbook of Interventional Radiology, https://doi.org/10.1007/978-981-97-9601-4_31
Adrenocorticotropic hormone (ACTH), prolactin (PRL), luteinizing hormone (LH), follicle stimulating hormone (FSH), growth hormone (GH), and thyroid-stimulating hor-
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