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36. Lu D, Li Y, Yang Z, Zhao Z, Fang W, Chen L, Ma T, Wang N, Li X, Zhang T, Deng J.Application of the pressure cooker technique for transarterial embolization of brain arteriovenous malforma­tions: factors affecting obliteration and outcomes. Front Neurol. 2023;14:1133091. https://doi.org/10.3389/fneur.2023.1133091. PMID: 37122297; PMCID: PMC10133545.
37. Singh A, Kumar A, Kumar P, Kumar S, Gamanagatti S. “Beyond saving lives”: current perspectives of interventional radiology in trauma. World J Radiol. 2017;9(4):155–77. https://doi.org/10.4329/
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38. Lopera JE.Embolization in trauma: review of basic principles and techniques. Semin Intervent Radiol. 2021;38(1):18–33. https://
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33883798; PMCID: PMC8049768.
39. Hegde S, Sutphin PD, Zurkiya O, Kalva SP.Provocative mesen­teric angiography for occult gastrointestinal bleeding: a systematic review. CVIR Endovasc. 2023;6(1):42. https://doi.org/10.1186/
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42. Bandi R, Shetty PC, Sharma RP, Burke TH, Burke MW, Kastan D. Superselective arterial embolization for the treat­ment of lower gastrointestinal hemorrhage. J Vasc Interv Radiol. 2001;12(12):1399–405. https://doi.org/10.1016/s1051-
0443(07)61697- 2. PMID: 11742013.
43. Kwon JH, Han YH. Efcacy and safety of superselective trans­catheter arterial embolization of upper and lower gastrointes­tinal bleeding using N-butyl-2-cyanoacrylate. Emerg Radiol. 2018;25(2):111–20. https://doi.org/10.1007/s10140- 017- 1552- 0. Epub 2017 Oct 2. PMID: 28971259.
44. Tanaka Y, Kariya S, Nakatani M, Ueno Y, Ono Y, Maruyama T, Komemushi A, Tanigawa N.Percutaneous Transsplenic emboliza­tion of gastric varices in left-sided portal hypertension. Interv Radiol (Higashimatsuyama). 2022;7(2):58–62. https://doi.org/10.22575/
interventionalradiology.2021- 0019. PMID: 36196384; PMCID:
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45. Patel RK, Chandel K, Tripathy T, Choudhury A, Mukund A.Bleeding stomal varices and their interventional management— a series of three cases. J Clin Exp Hepatol. 2022;12(2):649–53.
https://doi.org/10.1016/j.jceh.2021.09.005. Epub 2021 Sep 10.
PMID: 35535115; PMCID: PMC9077216.
46. Heller DB, Beggin AE, Lam AH, Kohi MP, Heller MB.Geniculate artery embolization: role in knee Hemarthrosis and osteoarthri­tis. Radiographics. 2022;42(1):289–301. https://doi.org/10.1148/
rg.210159. Epub 2021 Dec 10. PMID: 34890274.
47. Taslakian B, Miller LE, Mabud TS, Macaulay W, Samuels J, Attur M, Alaia EF, Kijowski R, Hickey R, Sista AK.Genicular artery embolization for treatment of knee osteoarthritis pain: systematic review and meta-analysis. Osteoarthr Cartil Open. 2023;5(2):100342. https://doi.org/10.1016/j.ocarto.2023.100342. PMID: 36865988; PMCID: PMC9971280.
48. Okuno Y, Korchi AM, Shinjo T, Kato S, Kaneko T.Midterm clini­cal outcomes and MR imaging changes after Transcatheter arte-
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49. Lee SH, Hwang JH, Kim DH, So YH, Park J, Cho SB, Kim JE, Kim YJ, Hur S, Jae HJ.Clinical outcomes of Transcatheter arte­rial embolisation for chronic knee pain: mild-to-moderate ver­sus severe knee osteoarthritis. Cardiovasc Intervent Radiol. 2019;42(11):1530–6. https://doi.org/10.1007/s00270- 019- 02289- 4. Epub 2019 Jul 23. PMID: 31338552.
50. Padia SA, Genshaft S, Blumstein G, Plotnik A, Kim GHJ, Gilbert SJ, Lauko K, Stavrakis AI.Genicular artery embolization for the treatment of symptomatic knee osteoarthritis. JB JS Open Access. 2021;6(4):e21.00085. https://doi.org/10.2106/JBJS.OA.21.00085. PMID: 34703964; PMCID: PMC8542160.
51. Kishore S, Sheira D, Malin ML, Trost DW, Mandl LA.Transarterial embolization for the treatment of chronic Musculoskeletal pain: a systematic review of indications, safety, and efcacy. ACR Open Rheumatol. 2022;4(3):209–17. https://doi.org/10.1002/acr2.11383. Epub 2021 Nov 29. PMID: 34842365; PMCID: PMC8916547.
52. Okuno Y, Iwamoto W, Matsumura N, Oguro S, Yasumoto T, Kaneko T, Ikegami H. Clinical outcomes of Transcatheter arte­rial embolization for adhesive capsulitis resistant to conservative treatment. J Vasc Interv Radiol. 2017;28(2):161–167.e1. https://
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53. Padia SA, Okuno Y. Elbow artery embolization for lateral epi­condylitis. Tech Vasc Interv Radiol. 2023;26(1):100881. https://
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54. Wang B, Liang KW, Chen CH, Wang CK. Transcatheter arte­rial embolization for alleviating chronic musculoskeletal pain and improving physical function: a narrative review. Diagnostics (Basel). 2022;13(1):134. https://doi.org/10.3390/diagnos-
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55. Gandhi R, Banker M. Early outcomes of transcatheter arterial embolization using imipenem/cilastatin for plantar fasciitis refrac­tory to conservative therapy. Br J Radiol. 2024;97(1155):544–8.
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56. Weiss CR, Gunn AJ, Kim CY, Paxton BE, Kraitchman DL, Arepally A.Bariatric embolization of the gastric arteries for the treatment of obesity. J Vasc Interv Radiol. 2015;26(5):613–24.
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57. Weiss CR, Abiola GO, Fischman AM, Cheskin LJ, Vairavamurthy J, Holly BP, Akinwande O, Nwoke F, Paudel K, Belmustakov S, Hong K, Patel RS, Shin EJ, Steele KE, Moran TH, Thompson RE, Dunklin T, Ziessman H, Kraitchman DL, Arepally A. Bariatric embolization of arteries for the treatment of obesity (BEAT obesity) trial: results at 1 year. Radiology. 2019;291(3):792–800. https://
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Hardware forInterventions
VishnuPrasadPulappadi, AbhinavBansal, andS.H.Chandrashekhara
8
Key Messages
1. Interventional radiologists must be familiar with all the hardware available in the armamentarium.
2. Choosing the correct hardware is a paramount step in the technical success of the procedures.
3. The technical knowledge of hardware makes interven­tional radiology procedures less time-consuming with reduced complications.
4. The inadvertent complications can be addressed if you have essential hardware at our disposal.

8.1 Introduction

Interventional radiology (IR) is an ever-expanding speciality that helps in the management of a wide range of diseases using minimally invasive procedures. The availability of proper hardware is crucial for performing such procedures. Interventional radiologists must be familiar with all the devices available in the armamentarium.

8.2 Puncture Needles

Needles may be either single piece bevel-tipped access needles, or a coaxial system in which there is an outer cannula with inner stylet. A single piece needle has a hollow core and a beveled tip that allows easy access to vessels. The bevel helps in steering the needle as it bends away from the bevel. The needle also has a small notch on the hub that corresponds to the position of the bevel. A trocar needle consists of a coax­ial system in which there is an outer cannula that can be bev­eled or non-beveled, and an inner removable sharp three-sided needle. The outer blunt cannula can be used for introducing guide wire after removing the inner stylet. Both the outer can­nula and inner stylet are beveled in the Chiba needle, which helps in better steering as compared to the trocar needle [1].
Micropuncture needle and dilator system are used in cases with difcult access (e.g., undilated biliary system, small ves­sel, antegrade femoral puncture) to decrease the rate of access site complications. The initial puncture is performed with a 21G needle which is then exchanged with a coaxial dilator over a 0.018-inch access guidewire. This can be further exchanged for a larger sheath over a 0.035-inch wire.

8.3 Guidewires

Puncture needles are commonly used to gain access in to a vessel, cavity, or ductal system. Needle diameter is conven­tionally measured in Gauge (G) with lower Gauge represent­ing larger size needle. Guidewire is introduced through the lumen of the needle upon gaining access. In general, a 0.018­inch wire passes through 22G or larger needles whereas, a
0.035-inch wire requires a 19G or larger needle.
V. P. Pulappadi Kovai Medical Center and Hospital, Coimbatore, India
A. Bansal Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Delhi, India
S. H. Chandrashekhara ( Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, IRCH, Delhi, India
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024 S. H. Chandrashekhara (ed.), Textbook of Interventional Radiology, https://doi.org/10.1007/978-981-97-9601-4_8
*)
Guidewires are used to gain access into the vascular, biliary, or pelvicalyceal system and also for subsequent guidance. They also allow the exchange of various devices and cathe­ters. There are numerous types of wires based on properties such as diameter (measured in inches), stiffness, length, and hydrophilicity. Guidewires are available in sizes ranging from 0.007 to 0.038inches, with 0.014, 0.018, and 0.035­inch wires being the most commonly used ones. The appro­priate sized wire should be tightly matched to the end hole in the needle/catheter for smooth movement. Hydrophilic wires are slippery when wet and sticky when dry. They are less thrombogenic compared to non-hydrophilic wires and are useful in uid environment when less resistance is desired. They are easy to manipulate especially with the help of a torque device.
67
68
V. P. Pulappadi et al.
There are various kinds of wires used for specic
indications:
Access wires: These are short wires with atraumatic oppy tips used for vascular access. These are then quickly exchanged once the access is secured. An exam­ple is the Fixed Core Wire Guide (Cook Medical).
Maneuvre wires: These are hydrophilic wires with curved oppy tip, which helps in manipulating them into the blood vessel of interest. This helps in selective cannulation with catheters. Examples include Glidewire (Terumo) and Silverway (Asahi).
Rail wires: These are stiff wires that provide a plat- form for the exchange of dilators, catheters, and stents. Such stiff wires should not be steered through tortuous structures as it can cause injury. Examples include Amplatz (Boston Scientic) and Rosen (Cook Medical) wires.
Crossing wires: These are micro guidewires (0.014 or
0.018) that have soft tips that help in crossing chronic total occlusions in the lower limb arteries. They have stainless steel proximal shafts for support and are usually 300 cm long to facilitate catheter exchanges. Examples include Gladius & Gaia PV (Asahi) and Command (Abbott).
Good control is required to prevent guidewire dislodge-
ment while exchanging equipment over the guidewire. The length of the exchange guidewire should be longer than the sum of the length of the catheter and the distance from the puncture site to the target structure. For simplicity of calcula­tion, the wire length should be at least twice the length of the catheter to be exchanged [1].

8.4 Sheath System

Sheaths are devices used to maintain access into a vessel and prevent access site injury from multiple exchanges during a procedure. The size of the sheath represents the inner diam­eter in French (F), unlike catheter size which is the outer diameter. Therefore, a 6F sheath allows the passage of a 6F catheter or dilator through it. The outer diameter of the sheath is 1–2F larger than the sheath size. Sheaths are color coded according to their inner diameters (Table 8.1). The size of the sheath for a particular procedure should be chosen according to the size of the catheters and stents that are required to be introduced through the sheath. A sheath is usu­ally introduced into a vessel over a dilator that is stiff and has a tapered edge that helps in seamless entry into a vessel. The dilator is subsequently removed upon entry into the target structure. Sheaths also have a hemostatic valve on the trail­ing end to prevent any bleeding or air embolism through the
Table 8.1 Color coding for vascular access sheaths according to their inner diameters
Color Inner diameter (F) Pink/red 4 Gray 5 Green 6 Orange 7 Blue 8 Black 9 Magenta 10
sheath while exchanging devices. The sheath has a side port for contrast injection and regular ushing of the sheath to prevent thrombus formation during a procedure [1].
There are various kinds of sheaths depending on their
lengths and shapes:
Short sheaths: These are the most commonly used ones for vascular access and are 10–15cm long. Short sheaths are used for initial access prior to insertion of other spe­cialty long sheaths. They are made of Teon and are non-braided.
Long sheaths: Their lengths vary from 20 to 90cm and have stainless steel braiding to provide support and pre­vent kinking. These sheaths are advanced up to the major branches of the aorta for maintaining access, for support while advancing devices into the target vessel, and for check angiograms during the procedure. Dedicated soft­tipped sheaths, such as the Flexor Ansel sheath (Cook), help to prevent vessel injury.
Cross over sheaths: These are 40–45cm braided long sheaths that are used for peripheral artery interventions via contralateral femoral access. They have curved tips that t into the curve at the aortic bifurcation, e.g., Flexor Balkin sheath (Cook).
Long sheaths for neuro intervention: Conventional long sheaths are not ideal for advancement into the inter­nal carotid artery due to their stiff ends. Dedicated sheaths with atraumatic oppy tips and stiff proximal end are therefore required for neurointerventions. A few exam­ples are Cerebase (Cerenovus), Neuron Max (Penumbra), AXS Innity (Stryker), and Ballast (Balt).
Radial access sheaths: These sheaths have a low prole that facilitates easy advancement into the relatively small caliber radial artery. They are longer than the conven­tional short sheath, usually 23cm in length, e.g., Prelude Radial Sheath (Merit Medical). The long length helps to reduce the occurrence of vasospasm in the radial artery during catheter exchanges.
Pedal access sheaths: These are low prole short sheaths used for securing access in below knee run-off arteries, e.g., Glidesheath Slender (Terumo). They are used with micropuncture access needle and 0.018 guidewire.
8 Hardware forInter ventions
69
Peel away sheath: It is a modication of the regular sheath and has two plastic wings at the extravascular end that help in peeling apart the sheath without the need for exchanging it over the guidewire. It is used for insertion of mediports and tunneled lines that have bulky hubs.

8.5 Catheters

The catheter is a exible hollow tube that can be inserted into a vessel, duct, or cavity. It consists of a tubular shaft with a hub at the rear end and a tapered or non-tapered tip. Various kinds of catheters are available for performing interventions in different blood vessels. The distal tip of the catheter can be straight or curved (with primary, secondary, and tertiary curves). Catheters are introduced through the arterial sheath and manipulated over guidewires to reach the target site. Subsequently, they can be used for angiograms or adminis­tration of drugs.
Catheters are generally made of polytetrauoroethylene
(PTFE), polyethylene, nylon, silicone, polyvinyl chloride, or a combination of these materials. Catheters intended for different purposes may vary with respect to the material used, diameter, length, tip shape, and side hole congura­tion. Selective catheters have different tip shapes and sin­gle-end hole to seek branches of the main vessel. They have tapered tips to advance smoothly into a vessel with single­or double- wire braiding for extra torquability. The size of the catheter is denoted using its outer diameter. It is mea­sured in F (1F = 1/3 mm). A catheter is wider at the hub than at the tip, and the diameter at the tip represents the maximum diameter of the guidewire it can accommodate. Most angiographic catheters are 4 or 5 F in size and are passed over a 0.035 or 0.038-inch guidewire. The torsional strength of a catheter refers to the ability to steer the cath­eter tip in various directions by rotating its hub. It depends on catheter size and material and is proportional to the dif­ference between the fourth powers of the outer and inner diameter.
Catheter tips can have various shapes. There are straight
catheters with no curve, pigtail catheters with multiple side holes near the catheter tip for ush aortograms, sin­gle-curve catheters, e.g., multipurpose angiographic cath­eters (MPAs), and complex curve catheters. Complex curve catheters have secondary, and in some cases, tertiary curves in addition to the primary curves and can be subdi­vided into double curve catheters (e.g., renal double curve catheter, cobra catheter) and reverse curve catheters (e.g., Simmons, Roberts Uterine catheter). Both pigtail and straight catheters have multiple side holes, which help in injecting a large volume of contrast at a high rate. Commonly used angiographic catheters and their uses are listed in Table8.2 [1, 2].
Catheters have various technical properties:
Table 8.2 Various angiographic catheter shapes and their common uses
Catheter shape Common indications Representative image Pigtail –Flush aortogram
Marker pigtail –Measurement of
required length of stent during transjugular intrahepatic portosystemic shunt (TIPS) creation
Angled pigtail –Pulmonary angiogram;
the shallow angle helps in maneuvering the catheter through the right atrium and right ventricle into the pulmonary artery
(continued)
70
V. P. Pulappadi et al.
Table 8.2 (continued)
Catheter shape Common indications Representative image Multipurpose –Catheterization of
Berenstein/ Picard
hepatic vein from jugular approach –Catheterization of superior mesenteric artery from radial artery access
–Catheterization of branches of the aortic arch –Selective catheterization of branches of medium­sized vessels such as the renal artery and superior mesenteric artery –Crossing over the aortic bifurcation
Table 8.2 (continued)
Catheter shape Common indications Representative image Cobra –Catheterization of
visceral arteries and side branches of the aorta such as the bronchial, intercostal, and lumbar arteries
Head hunter –Catheterization of
aortic arch branches
Rosch Celiac –Catheterization of
visceral branches of aorta, i.e., celiac axis and superior and inferior mesenteric artery
(continued)
Vertebral –Catheterization of
aortic arch branches
(continued)
8 Hardware forInter ventions
71
Table 8.2 (continued)
Catheter shape Common indications Representative image Renal double
curve
Simmons –Catheterization of the
–Catheterization of renal arteries and side branches of aorta
renal artery, superior mesenteric artery, and celiac axis with steep downward course –Catheterization of aortic arch branches through radial access
Table 8.2 (continued)
Catheter shape Common indications Representative image Shepherd hook –Catheterization of side
Roberts uterine artery
branches of the aorta such as the bronchial, intercostal, and lumbar arteries
–A long secondary curve that enables cannulation of bilateral internal iliac arteries and their branches through single femoral artery access
Sos –Catheterization of
internal iliac artery from ipsilateral femoral access
(continued)
Judkin’s –Judkin’s right and
Judkin’s left catheters are used for cannulation of right and left coronary arteries, respectively
(continued)
72
V. P. Pulappadi et al.
Table 8.2 (continued)
Catheter shape Common indications Representative image Yashiro –It has a 3D curve that
helps in the cannulation of the celiac axis and its branches
Trackability is the ability of the catheter to follow the guidewire over which it is advanced.
Pushability is the forward push transmitted at the tip of the catheter due to the force applied by the operator at the hub.
Crossability is dened as the ability of a catheter to navi­gate across a tortuous segment of the artery.
Steerability/torquability refers to the steering move­ment of the catheter tip in response to handling maneu­vers performed at the hub.
neuromicrocatheters used for specic indications are enu­merated as follows:
Flow-directed microcatheters: As opposed to other microcatheters, these microcatheters have non-braided tapered tips. They are used for super-selective distal cath­eterization of arterial feeders in high ow arteriovenous malformations (AVMs). Examples include Marathon (Medtronic), Apollo (Medtronic), Magic (Balt), and Sonic (Balt).
Dimethyl sulfoxide (DMSO) compatible: DMSO is the solvent used during embolization using ethylene vinyl alcohol copolymer (EVOH). As it is a highly potent sol­vent, microcatheters made of DMSO resistant material must be used during for injection of EVOH.Examples include Headway Duo (Microvention), Echelon (Medtronic), Marathon (Medtronic), Apollo (Medtronic), and Sonic (Balt).
Detachable tip microcatheters: These catheters have a detachable distal tip and are used during embolization using liquid embolic agents. The detachable tip helps in retrieving the microcatheter even if the tip gets stuck within the EVOH cast [3, 4]. Examples are Apollo (Medtronic), and Sonic (Balt).

8.7 Embolizing Agents

8.6 Microcatheters

Microcatheters are small caliber catheters with an outer diameter 3F.They are used along with microguidewires for super-selective cannulation of small vessels that cannot be cannulated using an angiographic catheter. Like angio­graphic catheters, microcatheters are braided to enhance their pushability. They have a specialized PTFE inner lining, which is hydrophobic and allows smooth passage of the microcatheter over hydrophilic guidewires.
The outer diameter of microcatheters ranges from 1.2 to
2.7F and lengths range from 130 to 167cm. The choice of microcatheter depends upon the size of target vessel and the planned procedure. Microcatheters of the range 2–2.7F are used for peripheral and visceral artery interventions, and commonly used ones are Progreat (Terumo) and Master Parkway Soft (Asahi). Dedicated microcatheters are avail­able for neuro-interventions. While microcatheters with an inner diameter of 0.017 are used for aneurysm coiling, those with an inner diameter of 0.021 or 0.027 are used for the deployment of stent retrievers and ow diverters. Special
A variety of embolizing agents are used in interventional radiology practice. The type of agent to be used depends upon the indication—whether it is for attaining tissue necro­sis or to control active bleeding, the size of the vessel to be occluded, and whether the target organ has collateral supply from other arteries. Embolizing agents are broadly classied as permanent or temporary (Table8.3). Various commonly used embolizing agents are described below.
Table 8.3 Classication of embolizing agents
Temporary agents Permanent agents Gelatin foam
Autologous blood clot Thrombin
Coils Vascular plugs Particulate agents –polyvinyl alcohol –tris-acryl gelatin microspheres Liquid embolic agents –n-butyl cyanoacrylate –ethylene vinyl alcohol copolymer Detachable balloons
8 Hardware forInter ventions
73
8.7.1 Gelatin Foam
Gelatin foam is the most commonly used temporary emboli­zing agent. It is derived from porcine skin and is commonly available as sheets. These sheets are cut into smaller pieces and used for embolization. When proximal embolization is desirable, it is cut into large pieces called torpedoes, which mechanically occlude the blood vessel. Alternatively, gel­foam pledgets, which are made by cutting the sheet into smaller pieces and agitating them in diluted contrast medium, can be used for proximal embolization. Slurry made of gel­foam scrapings is used when distal embolization is required. It is commonly used for cases of active bleeding. Gelfoam being a temporary agent, the embolized blood vessel is recanalized in 4–6 weeks. Its major advantages are cost effectiveness and ease of use [5]. However, the occurrence of infection is a potential concern with its use because the air trapped within it may contain infectious bacteria [6].
8.7.2 Autologous Blood Clot
It is one of the rst agents to be used as an embolizing agent. In current practice, it is used during percutaneous needle biop­sies to seal off the puncture tract. Once the biopsy is com­pleted, the clot formed from a small quantity of blood taken from the patient’s peripheral vein is injected through the coax­ial needle. Alternatively, the clot may be allowed to form within the lumen of the coaxial needle once the biopsy needle is taken out, and it is then pushed into the biopsy tract using a blunt needle while withdrawing the coaxial needle. The advan­tage is that there is no added cost or additional hardware requirement. The disadvantage is that the clot gets lysed within a short period of time by the circulating plasmin.
8.7.3 Thrombin
for embolization, different types of coils have been developed for use in specic situations. Coils are usually made of plati­num and are available in various diameters, lengths, and stiffness. They can be classied on the basis of their proper­ties as follows:
• Deployment mechanism.
1. Pushable: These coils are deployed by pushing out of
the catheter using a pusher wire. They cannot be retrieved back into the catheter once deployed. They are used for embolization in blood vessels other than in the intracranial circulation.
2. Detachable: These coils stay attached to the pusher
wire till they are deployed electrolytically or mechani­cally. This allows the coil to be retracted and reposi­tioned until the intended coil position is attained. They are used predominantly for coiling of intracranial aneurysms where precise placement of the coils is of utmost importance. They are costlier than pushable coils.
• Presence of bers.
1. Fibered: Coils with bers made of nylon and polyester
promote thrombus formation adjacent to the coil mass. These coils are used for embolization in the peripheral circulation.
2. Non-bered: These are used in intracranial circulation
where bered coils may promote thrombus propaga­tion into the parent artery and distal embolism.
• Shape.
1. Framing coils: These are three dimensional coils that
are used to create the initial frame within an aneurysm. Once the rst framing coil is deployed, further space within the aneurysm is lled with packing coils that are helical in shape.
2. Helical coils: They are general-purpose coils used for
embolization of blood vessels and for packing inside an aneurysm after placing a framing coil.
Thrombin is a component of the coagulation cascade and is involved in the conversion of brinogen into brin, which is necessary for clot formation. Human thrombin is widely used as a hemostatic agent during various surgeries. In interven­tional radiology practice, the use of thrombin is limited to the treatment of supercial narrow neck pseudoaneurysms, such as those that develop at the femoral artery puncture site. Thrombin is rst mixed with calcium chloride for its activation and then injected into the pseudoaneurysm under USG guidance.
8.7.4 Coils
Coils are the most commonly used agents when proximal embolization is desired. After its introduction by Gianturco
The diameter of the coil to be used depends upon the tar-
get vessel diameter. The coil has to be oversized by 20% more than the target vessel diameter for effective occlusion. Use of larger coils will prevent the coil from forming its shape while smaller coils may embolize distally [5].
8.7.5 Vascular Plugs
Vascular plugs are large embolization devices used for proxi­mal occlusion when the vessel diameter is too large for coil placement. Amplatzer plugs (Abbott) are the most com­monly used vascular plugs. It is a nitinol mesh that is detached from the delivery wire by screw-release mecha­nism. This detachment mechanism allows for resheathing
74
Amplatzer plugs, of which Amplatzer II and IV are the most commonly used ones. Amplatzer II is a trilobed device with a diameter range of 3–22 mm and a sheath compatibility range of 4–7 F. Amplatzer IV is a smaller prole bilobed device that can be deployed through any diagnostic catheter and has a diameter range of 4–8mm. The most common uses of plugs are embolization of pulmonary AVMs, plug-assisted transvenous retrograde obliteration of varices (PARTO), and embolization of visceral arteries to prevent endoleak after endovascular aneurysm repair. Plugs are oversized by 30–50% greater than the target vessel diameter to ensure complete occlusion [5].
8.7.6 Particulate Agents
These are used for distal embolization of small vessels. Commonly used particulate agents are polyvinyl alcohol (PVA) particles and trisacryl gelatin microspheres (TAGM) (Embospheres, Merit Medical). They block vessels by physi­cally occluding them, inducing slow ow, thrombus forma­tion, and inammation in the vessel wall.
PVA particle size ranges from 100 to 1100μm, and par­ticles of various sizes are separated from each other by pass­ing the particles through appropriately sized lters. The rst generation PVA particles are made by scraping PVA foam sheets and are irregular in shape with non-uniform sizes. These non-spherical PVA particles have a tendency to clump together, resulting in more proximal embolization. Despite this drawback, they are commonly used due to their low cost. To overcome the issue of clumping of particles, second­generation spherical PVA particles were developed (Contour, Boston Scientic). Hydrogel microspheres are newer third­generation PVA particle agents that are made of hydrophilic or amphiphilic polymers (Bead Block, Boston Scientic).
TAGMs are particles that are calibrated to a more uniform size than PVA particles and are available in size ranges vary­ing from 40 to 1200μm. They do not get clumped due to their uniform spherical shape. This property, in addition to their ability to get compressed, facilitates more distal embolization as compared to PVA particles. Therefore, if TAGMs were to be used instead of PVA particles for a spe­cic indication, the size of TAGMs has to be larger than that of PVA particles to avoid organ ischemia due to distal embo­lization [5].
Further advancements in technology have enabled the development of even more tightly calibrated microspheres. An example is Embozene (Boston Scientic), which has 95% of the particles calibrated to a specic diameter instead of a size range. It has a core made of polymethyl methacry­late and a coating made of Polyzene-F. Particles that are capable of carrying chemotherapeutic agents are used for trans-arterial chemoembolization (DC beads, Boston
V. P. Pulappadi et al.
Scientic). Biodegradable hydrogel microspheres are avail­able that resorb over a period of time and act as temporary embolizing agents. Gel-bead (Teleex) is a bioresorbable microsphere made of gelatin and can be used in place of gelatin foam as a temporary embolizing agent.
Embolization of bronchial, uterine, prostate and genicu­late arteries, tumor embolization, and embolization for epi­staxis are the most common indications for the use of particulate agents.
8.7.7 Liquid Embolic Agents
N-butyl cyanoacrylate (NBCA) and ethylene vinyl alcohol copolymer (EVOH) are the two commonly used liquid embolic agents.
NBCA (Histoacryl, Braun; Trull, Cordis) polymerizes instantly upon coming in contact with an anionic medium such as blood. Solidied NBCA glue cast causes mechanical occlusion of the blood vessel. Unlike other embolizing agents such as coils, NBCA is not dependent on additional thrombus formation for complete occlusion of the vessel. Due to this reason, it is the preferred agent in patients with coagulopathy. It is used in combination with ethiodized oil (Lipiodol, Guerbet) in various concentrations ranging from 1:5 (~16% NBCA) to 3:1 (75% NBCA). Highly concentrated NBCA is used in high-ow lesions such as AVMs and arteriovenous stulas, where NBCA has to polymerize instantly without distal embolization into the pulmonary circulation. A more dilute NBCA mixture is used during embolization of AVM nidus or vascular tumors where it has to penetrate deep into the lesion. In addition to delaying the polymerization of NBCA, ethiodized oil, being radio- opaque, facilitates visual­ization of the mixture during injection. Prior to injection, the catheter and the vascular bed are primed with dextrose, which is a non-ionic solvent. Advantages of NBCA are that it is cheap, causes instant occlusion of the blood vessel, and can be used as a proximal or distal embolizing agent by varying its concentration. The disadvantages include the need for expertise for its injection, risk of catheter occlusion during injection, and catheter getting stuck within the NBCA glue cast. Common uses of NBCA are embolization of high-ow AVMs, tumor embolization, and portal vein embolization. It is also used for embolization of pseudoaneurysms by transar­terial route, if the microcatheter cannot be advanced till the pseudoaneurysm for coil placement, or by percutaneous route under USG guidance.
EVOH (Onyx, Medtronic; Menox, Meril) takes longer time to polymerize than NBCA, enabling slow and more controlled embolization. EVOH comes pre-mixed with tan­talum powder, which is radio-opaque. EVOH vial is placed in a shaker for at least 20min prior to using it to ensure uni­form mixing of EVOH with tantalum powder. Prior to inject­ing EVOH, the catheter is primed with DMSO to prevent
8 Hardware forInter ventions
75
polymerization within the catheter. Because DMSO is a potent solvent, specialized DMSO-compatible microcathe­ters are to be used for embolization using EVOH.It is com­monly used for embolization of intracranial AVMs. Although it can also be used in peripheral AVMs as well, there is a risk of skin pigmentation secondary to tantalum deposition when used in supercial lesions. Onyx (Medtronic) is an EVOH agent that comes in two different preparations of varying vis­cosities: 18 and 34centiStokes (cSt). While the low viscosity preparation is used for embolization of the nidus as it has deep penetration, the high viscosity one is used for emboli­zation of high ow stulous components. Squid (Balt) is another EVOH agent that is available in 12 and 18cSt prepa­rations. The major disadvantage of EVOH is its high cost.

8.8 Detachable Balloons

These were once popular for embolization of carotico­cavernous stulas. These balloons are made of latex or sili­con and are deployed across the stula through transarterial
access. They are not popular nowadays due to the high inci­dence of balloon deation and migration [5].

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