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9 Tree-in-Bud Sign

 

 

CT Findings

CT manifestations of cellulose granulomatosis consist of diffuse centrilobular small nodules and a tree-in-bud pattern [11] (Fig. 9.2).

CT–Pathology Comparisons

Tree-in-bud pattern seen on HRCT in patients with cellulose granulomatosis represents intra-arteriolar accumulation of microcrystalline cellulose with associated adjacent granulomatous reaction (Fig. 9.2).

Patient Prognosis

There are no established treatments for talc granulomatosis. Patients must stop the intravenous drug use. Success with steroids has been reported [12], but most believe that there is no benefit from corticosteroid therapy. Lung transplantation is considered a last option for patients with end-stage disease.

References

1. Im JG, Itoh H, Shim YS, et al. Pulmonary tuberculosis: CT find- ings–early active disease and sequential change with antituberculous therapy. Radiology. 1993;186:653–60.

2. Lee KS, Kim TS, Han J, et al. Diffuse micronodular lung disease: HRCT and pathologic findings. J Comput Assist Tomogr. 1999;23:99–106.

3. Han D, Lee KS, Franquet T, et al. Thrombotic and nonthrombotic pulmonary arterial embolism: spectrum of imaging findings. Radiographics. 2003;23:1521–39.

4. Chung MP, Yi CA, Lee HY, Han J, Lee KS. Imaging of pulmonary vasculitis. Radiology. 2010;255:322–41.

5. Moon JW, Lee HY, Han J, Lee KS. Tree-in-bud sign as a manifestation of localized pulmonary lymphatic metastasis from a pancreas cancer. Intern Med. 2011;50:3027–9.

6. Shiley KT, Van Deerlin VM, Miller Jr WT. Chest CT features of community-acquired respiratory viral infections in adult in patients with lower respiratory tract infections. J Thorac Imaging. 2010;25:68–75.

7. Rossi SE, Franquet T, Volpacchio M, Gimenez A, Aguilar G. Tree- in-bud pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics. 2005;25:789–801.

8. Marik PE. Pulmonary aspiration syndromes. Curr Opin Pulm Med. 2011;17:148–54.

9. Franquet T, Gimenez A, Roson N, Torrubia S, Sabate JM, Perez C. Aspiration diseases: findings, pitfalls, and differential diagnosis. Radiographics. 2000;20:673–85.

10. Marchiori E, Lourenco S, Gasparetto TD, Zanetti G, Mano CM, Nobre LF. Pulmonary talcosis: imaging findings. Lung. 2010;188:165–71.

11.Bendeck SE, Leung AN, Berry GJ, Daniel D, Ruoss SJ. Cellulose granulomatosis presenting as centrilobular nodules: CT and histologic findings. AJR Am J Roentgenol. 2001;177:1151–3.

12.Chau CH, Yew WW, Lee J. Inhaled budesonide in the treatment of talc-induced pulmonary granulomatosis. Respiration. 2003;70:439.