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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5196_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword
- •Preface
- •Goal of the textbook and accompanying ancillaries
- •Content
- •New to this edition
- •Chapter contents
- •Instructor materials
- •Using the book
- •About the authors
- •Acknowledgments
- •Learning enhancements
- •Ancillaries
- •Workbook.
- •1 Introduction to radiation protection
- •Objectives
- •Key terms
- •Team concept in the medical field
- •Control of radiant energy
- •Goals of radiation protection
- •Concept of radiation protection
- •Introduction to radiation quantities and units of measure
- •Absorbed dose (milligray [mGy]).
- •Effective dose (millisievert [mSv]).
- •Need to safeguard against adverse biologic effects of ionizing radiation
- •Justification and responsibility for imaging procedures: Benefit verses risk
- •As low as reasonably achievable (ALARA) principle
- •Cardinal rules of radiation protection
- •Responsibility for maintaining ALARA in the medical industry
- •Patient protection and patient education
- •Educating patients about imaging procedures
- •Background equivalent radiation time
- •Increased radiation sensitivity of children
- •Alliance for radiation safety in pediatric imaging
- •Image gently campaign
- •Pause and pulse: Image gently in fluoroscopy campaign.
- •Image wisely campaign
- •Monitoring and reporting radiation dose
- •The NEXT program and reference values
- •Protocols for dose alerts
- •Summary
- •General discussion questions
- •Review questions
- •2 Radiation: Types, sources, and doses received
- •Objectives
- •Key terms
- •Radiation
- •Types of radiation
- •The electromagnetic spectrum
- •Ionizing and nonionizing radiation
- •Particulate radiation
- •An introduction to the concept of radiation dose
- •Biologic damage potential
- •Sources of radiation
- •Natural radiation.
- •Terrestrial radiation.
- •Cosmic radiation.
- •Terrestrial and internal radiation.
- •Air travel.
- •Nuclear fuel for the generation of power.
- •Atmospheric fallout from nuclear weapons testing.
- •Nuclear power plant accidents.
- •Three mile Island unit 2.
- •Chernobyl.
- •Thyroid cancer, leukemia, and breast cancer as a result of the chernobyl disaster.
- •Fukushima Daiichi nuclear plant disaster.
- •Medical radiation.
- •Summary
- •General discussion questions
- •Review questions
- •3 Interaction of X-radiation with matter
- •Objectives
- •Key terms
- •Significance of X-ray absorption in biologic tissue
- •X-ray beam production and energy
- •Production of primary radiation
- •Energy of photons in a diagnostic X-ray beam
- •Attenuation
- •Direct and indirect transmission X-ray photons
- •Absorption vs. scatter.
- •Attenuation vs. transmission.
- •Direct transmission vs. indirect transmission.
- •Primary, exit, and attenuated photons
- •Probability of photon interaction with matter
- •Processes of interaction
- •Coherent scattering
- •Process of coherent scattering.
- •Photoelectric absorption
- •Process of photoelectric absorption.
- •Probability of occurrence of photoelectric absorption.
- •Mass density and effective atomic number of different body structures.
- •Body part thickness and density differences.
- •Effects of attenuation on radiographic images.
- •Impact of photoelectric absorption on radiographic contrast.
- •Photodisintegration
- •Process of photodisintegration.
- •Summary
- •General discussion questions
- •Review questions
- •4 Radiation quantities and units
- •Objectives
- •Key terms
- •Historical evolution of radiation quantities and units
- •Discovery of X-rays
- •First reports of injury
- •Use of contrast media to ensure visualization of anatomic structures.
- •Compton scattering
- •Process of compton scattering in a patient.
- •Pair production
- •Process of pair production.
- •Use of annihilation radiation in positron emission tomography.
- •Investigation of methods for reducing radiation exposure
- •Skin erythema dose
- •The modern era of radiation protection
- •Quantities and units in use today
- •Radiation quantities and their SI units of measure
- •Exposure
- •Air kerma
- •Absorbed dose
- •Equivalence of radiation-produced damage from different sources of ionizing radiation
- •Equivalent dose
- •Effective dose
- •Collective effective dose
- •Total effective dose equivalent
- •Summary
- •General discussion questions
- •Review questions
- •5 Radiation monitoring
- •Objectives
- •Key terms
- •Personnel monitoring
- •Requirement for personnel monitoring
- •Purpose of personnel dosimeters
- •Placement of personnel dosimeters
- •During routine radiographic procedures.
- •When a protective apron is worn.
- •As a second monitor when a protective apron is worn.
- •As a monitor for the embryo-fetus.
- •Extremity dosimeter
- •Advantages of the TLD ring dosimeter.
- •Disadvantages of the TLD ring dosimeter.
- •Record of radiation exposure
- •Personnel dosimeters for occupational monitoring
- •Characteristics
- •Types
- •Optically stimulated luminescence dosimeter.
- •Energy discrimination.
- •Control monitor.
- •Advantages of the OSL dosimeter.
- •Disadvantages of the OSL dosimeter.
- •Personnel monitoring report.
- •Change in employment by radiation worker.
- •Direct ion storage dosimeter.
- •Advantages of the direct ion storage dosimeter.
- •Disadvantages of the direct ion storage dosimeter.
- •Radiation survey instruments for area monitoring
- •Radiation detection and measurement
- •Types of instruments
- •Requirements
- •Gas-filled radiation survey instruments
- •Ionization chamber–type survey meter (cutie pie).
- •Sensitivity ranges and uses.
- •Advantages and disadvantages.
- •Proportional counter.
- •Geiger–Müller survey meter
- •Sensitivity and use.
- •Components.
- •Disadvantages.
- •Instruments used to measure X-ray exposure
- •Summary
- •General discussion questions
- •Review questions
- •6 Overview of cell biology
- •Objectives
- •Key terms
- •The cell
- •Cell chemical composition
- •Protoplasm
- •Organic compounds
- •Proteins.
- •Structural and enzymatic proteins.
- •Repair enzymes.
- •Hormones and antibodies.
- •Carbohydrates.
- •Lipids.
- •Nucleic acids.
- •Deoxyribonucleic and ribonucleic acids.
- •Nitrogenous organic bases in DNA.
- •DNA: The master chemical substance.
- •Structural differences between DNA and RNA.
- •Messenger RNA.
- •Transfer RNA.
- •Ribosomal RNA.
- •Chromosomes and genes.
- •The human genome.
- •Inorganic compounds
- •Function of water within and outside of the cell.
- •Function of mineral salts within the cell.
- •Cell structure
- •Cell membrane—a “plastic storage bag” to contain the cell
- •Cytoplasm
- •Cytoplasmic organelles
- •Endoplasmic reticulum—the “highway” of the cell.
- •Golgi apparatus or complex—Hauls “Freight” within and out of the cell.
- •Mitochondria—the “power-generating station” of the cell.
- •Lysosomes—”garbage bags” with “poison pills.”
- •Ribosomes—”manufacturing facilities” of the cell.
- •Centrosomes—”weavers of the spindle.”
- •Nucleus—information-processing and administrative center
- •Cell division
- •Mitosis
- •The four phases of mitosis.
- •Prophase.
- •Metaphase.
- •Anaphase.
- •Telophase.
- •Meiosis
- •Multiple births.
- •Summary
- •General discussion questions
- •Review questions
- •7 Molecular and cellular radiation biology
- •Objectives
- •Key terms
- •Ionizing radiation
- •Radiation energy transfer determinants
- •Linear energy transfer
- •Radiation categories according to linear energy transfer.
- •Low–linear energy transfer radiation.
- •High–linear energy transfer radiation.
- •Risk of damage to DNA.
- •Probability of interaction with DNA.
- •Relative biologic effectiveness
- •Oxygen enhancement ratio
- •Molecular effects of irradiation
- •Effects of irradiation on somatic and genetic cells
- •Radiolysis of water
- •Ionization of water molecules.
- •Production of free radicals.
- •Production of cell-damaging substances.
- •Organic free radical formation.
- •Indirect action characteristics
- •Single-strand break.
- •Double-strand break.
- •Chromosome effect after a double-strand break in the same rung of DNA.
- •Mutation.
- •Covalent cross-links.
- •Effects of ionizing radiation on chromosomes
- •Radiation-induced chromosome breaks.
- •Chromosomal fragments.
- •Chromosome anomalies.
- •Summary of structural changes caused by ionizing radiation.
- •Consequences to the cell from structural changes within the nucleus
- •Target theory
- •Effects of irradiation on the entire cell
- •Instant death
- •Reproductive death
- •Apoptosis
- •Mitotic death
- •Mitotic delay
- •Interference with function
- •Survival curves for mammalian cells
- •Cell radiosensitivity
- •Cell maturity and specialization
- •Oxygen enhancement effects
- •Law of Bergonié and Tribondeau
- •Effects of ionizing radiation on human cells and tissues
- •Blood cells
- •Hematologic depression.
- •Depletion of immature blood cells.
- •Repopulation after a period of recovery.
- •Effects on stem cells of the hematopoietic system.
- •Effects of ionizing radiation on lymphocytes.
- •Effects of ionizing radiation on neutrophils.
- •Effects of ionizing radiation on thrombocytes (platelets).
- •Occupational radiation exposure monitoring.
- •Epithelial tissue.
- •Muscle tissue.
- •Nervous tissue.
- •Nerve tissue in the human adult.
- •Nerve tissue in the embryo-fetus.
- •Reproductive cells
- •Spermatogonia.
- •Ova.
- •Summary
- •General discussion questions
- •Review questions
- •Objectives
- •Key terms
- •Somatic and genetic effects
- •Somatic effects
- •Early tissue reactions
- •Acute radiation syndrome (ARS).
- •Symptoms of acute radiation syndrome.
- •Hematopoietic syndrome.
- •Gastrointestinal syndrome.
- •Cerebrovascular syndrome.
- •Lethal dose
- •LD 50/30.
- •LD 10/30, LD 50/60, and LD 100/60.
- •Repair and recovery
- •Local tissue damage
- •Effects on the skin
- •Effects on the reproductive system
- •Hematologic effects
- •Hematopoietic system.
- •Cytogenetic effects
- •Summary
- •General discussion questions
- •Review questions
- •Objectives
- •Key terms
- •Epidemiology
- •Carcinogenesis
- •Radiation dose–response relationship
- •Dose–response curves
- •Threshold and nonthreshold relationships
- •Risk models used to predict cancer risk and heritable damage in human populations
- •Risk models used to predict leukemia, breast cancer, and heritable damage
- •Risk model used to predict high-dose cellular response
- •The rationale for risk model selection
- •Somatic effects
- •Late somatic effects
- •Low-level effects summary
- •Major types of late effects
- •Risk estimates for cancer
- •Absolute risk and relative risk models.
- •Epidemiologic studies for determining the risk of cancer.
- •Radiation-induced cancer.
- •Radium watch-dial painters.
- •Uranium miners.
- •Early medical radiation workers.
- •Incidence of breast cancer in radiation treatment of benign postpartum mastitis.
- •Japanese atomic bomb survivors
- •Atomic bomb detonation on Hiroshima and Nagasaki.
- •Data obtained from epidemiologic studies.
- •Incidence of breast cancer in japanese women.
- •Radiation dose and radiation-induced leukemia.
- •Conclusions from the Chernobyl nuclear disaster
- •Need for follow-up studies.
- •Worldwide effects of the accident.
- •Thyroid cancer from the accident.
- •Life span shortening
- •Animal studies.
- •Human studies
- •American radiologists.
- •American radiologic technologists.
- •Embryologic effects (birth defects)
- •Stages of gestation in humans.
- •Embryonic cell radiosensitivity during the first trimester of pregnancy.
- •Embryonic cell radiosensitivity during the second and third trimesters of pregnancy.
- •Embryonic effects resulting from the chernobyl nuclear power plant accident.
- •Review of fetal effects by UNSCEAR.
- •Effects of low-level ionizing radiation on the embryo-fetus.
- •Genetic (hereditary) effects
- •Irradiation mutations
- •Natural mutations
- •Other agents of genetic mutations
- •Incapacities of mutant genes
- •Dominant or recessive point mutations
- •Ionizing radiation as a possible cause of genetic (hereditary) effects
- •Doubling dose concept
- •Summary
- •General discussion questions
- •Review questions
- •Objectives
- •Key terms
- •Basis of effective dose limiting system
- •Radiation protection standards organizations
- •International commission on radiological protection
- •National council on radiation protection and measurements
- •National academy of sciences/National research council committee on the biological effects of ionizing radiation (NAS/NRC-BEIR)
- •US regulatory agencies
- •Nuclear regulatory commission
- •Agreement states
- •Environmental protection agency (EPA)
- •US food and drug administration (FDA)
- •Occupational safety and health administration (OSHA)
- •Radiation safety program
- •Requirement
- •Radiation for health and safety act of 1968
- •Code of standards for diagnostic X-ray equipment
- •ALARA concept
- •Model for the ALARA concept
- •Food and drug administration white paper
- •Consumer-patient radiation health and safety act of 1981
- •Radiation-induced responses of concern in radiation protection
- •Categories for radiation-induced responses
- •Changes in terminology from the 1970s to the present
- •Tissue reactions.
- •Early and late tissue reactions.
- •Stochastic effects.
- •Current radiation protection philosophy
- •Occupational risk
- •The vulnerability of the embryo-fetus to radiation exposure
- •Basis for the effective dose limiting system
- •Concept underlying radiation protection
- •Tissue weighting factor
- •Current national council on radiation protection and measurements recommendations
- •National council on radiation protection and measurements reports
- •International commission on radiological protection recommendation for downward revision of the annual effective dose limit.
- •Limits for nonoccupationally exposed individuals.
- •Limits for pregnant radiation workers.
- •Limits for education and training purposes.
- •Limits for tissues and organs exposed selectively or together with other organs.
- •Negligible individual dose.
- •Action limits
- •Radiation hormesis
- •Occupational and nonoccupational dose limits
- •Effective dose limits for radiation workers and the population as a whole
- •Special limits for selected areas
- •Summary
- •General discussion questions
- •11 Equipment design for radiation protection
- •Objectives
- •Key terms
- •Radiation safety features of radiographic equipment, devices, and accessories
- •Diagnostic-type protective tube housing and functions
- •Control panel, or console
- •Radiographic examination table
- •Source-to-image receptor distance indicator
- •X-ray beam limitation devices for fixed and mobile radiographic equipment
- •Light-localizing variable-aperture rectangular collimators.
- •Construction.
- •Skin sparing.
- •Luminance.
- •Coincidence between the radiographic beam and the localizing light beam.
- •Positive beam limitation.
- •Filtration
- •Purpose and effects of radiographic beam filtration.
- •Types of filtration.
- •Requirement for total filtration.
- •Filtration for general diagnostic radiology.
- •Compensating filters
- •Required radiation exposure characteristics
- •Exposure reproducibility.
- •Exposure linearity.
- •Automatic exposure control (AEC) and phototiming
- •Radiographic grids
- •Grid ratio and patient dose.
- •Effect of source-skin distance on patient entrance exposure.
- •Mobile, or portable, radiographic units
- •General information and radiation safety features of digital imaging equipment and accessories
- •Digital processed radiography imaging modes
- •Digital imaging overview
- •Computed radiography (CR)
- •Kilovoltage.
- •X-ray beam collimation.
- •Use of radiographic grids.
- •Digital radiography (DR)
- •Digital radiography systems advantages and disadvantages.
- •Repeat rates in digital imaging
- •Radiation safety features of fluoroscopic equipment, devices, and accessories
- •Fluoroscopic procedures and patient irradiation rates
- •Fluoroscopic imaging systems: Non-digital
- •Brightness of the fluoroscopic image and patient absorbed dose.
- •Pulsed fluoroscopy.
- •Limiting fluoroscopic field size.
- •Radiation delivery factors
- •Selection of technique exposure factors for adult patients.
- •Selection of technique factors for children.
- •Filtration.
- •Cumulative timing device.
- •Entrance irradiation rate limitations.
- •Primary protective barrier.
- •Fluoroscopic exposure control switch.
- •Mobile fluoroscopic systems
- •Radiation safety features of mobile C-arm fluoroscopy.
- •Radiation safety features of digital fluoroscopic equipment
- •Digital fluoroscopy (DF)
- •Pulsed progressive systems.
- •Last image hold.
- •Digital subtraction angiography (DSA) and interventional systems
- •Interventional procedures.
- •Digital subtraction angiography.
- •Roadmapping.
- •Radiation safety for high-level control interventional procedures
- •Public health advisory about the dangers of overexposure of patients and exposure rate limits
- •Use of fluoroscopic equipment by non-radiologist physicians
- •Summary
- •General discussion questions
- •Review questions
- •Objectives
- •Key terms
- •Effective communication
- •Verbal messages and body language
- •Importance of patient instructions
- •Appropriate communication for procedures that will cause pain or discomfort
- •Repeat radiographic exposures resulting from poor communication
- •Immobilization
- •Need for patient immobilization
- •Types of patient motion
- •Protective shielding
- •Need for protective shielding
- •Gonadal shielding
- •CARES committee.
- •Technical exposure factors
- •Appropriate selection
- •Use of standardized technique charts
- •Use of high-kVp and low-mAs exposure factors to reduce dose to the patient
- •Postprocessing of the radiographic image
- •Quality control program
- •Air gap technique
- •Reduction of scattered radiation
- •High peak kilovoltage radiography
- •Repeat images
- •Consequences of repeat images
- •Increase in repeat rates
- •Concern about risk of exposure during diagnostic imaging procedures
- •Nonessential radiologic examinations
- •Specifying the amount of radiation received by a patient during a diagnostic imaging procedure
- •Skin dose.
- •Gonadal dose
- •Difference in gonadal dose received by male and female patients.
- •Bone marrow dose.
- •Fluoroscopically guided positioning
- •Protecting the pregnant or potentially pregnant patient
- •Position of the american college of radiology on abdominal radiologic examinations of female patients
- •Determining the possibility of pregnancy
- •Irradiation during an unknown pregnancy
- •Procedure to follow and responsibility for absorbed dose determination to the patient’s embryo-fetus
- •Sample cases to estimate approximate equivalent dose to the embryo-fetus
- •Sample cases to obtain an approximate estimate of the fetal equivalent dose
- •Irradiating a known pregnant patient
- •Pediatric considerations during radiographic imaging
- •Vulnerability of children to radiation exposure
- •Children require smaller radiation doses than do adults
- •Patient motion and motion reduction methods
- •Gaining cooperation during the procedure
- •Collimation
- •Patient protection in computed tomography for adults and children: Similarities and necessary changes
- •Image gently campaign
- •Image wisely campaign
- •Summary
- •General discussion questions
- •Review questions
- •13 Special considerations on safety in computed tomography
- •Objectives
- •Key terms
- •Patient dose in computed tomography
- •Radiation exposure
- •Concerns related to patient dose: Skin dose and dose distribution
- •Direct patient shielding
- •Helical, or spiral, computed tomography
- •Methods for reduction of patient dose in CT
- •Tube current modulation
- •Iterative reconstruction
- •Optimization of tube voltage
- •Patient centering
- •Computed tomography dose parameters
- •Effective computed tomography dose
- •Multidetector computed tomography scanning (MDCT)
- •MDCT collimation, slice width, and slice number
- •MDCT advantages
- •Slice thickness and reconstruction interval
- •Computed tomography cardiovascular imaging (CT CVI)
- •Basic heart anatomy and processes
- •Phases of the cardiac cycle
- •CT cardiovascular imaging (CT CVI)
- •ECG gated imaging.
- •Heart beat rate.
- •CT CVI imaging metrics
- •Temporal resolution (TR).
- •Spatial resolution (SR).
- •Contrast resolution (CR).
- •Metrics summary.
- •CT CVI and radiation doses
- •Patient radiation doses and volume scanning
- •Radiation dose and image noise
- •Summary
- •General discussion questions
- •Review questions
- •Objectives
- •Key terms
- •Mammography and breast compression
- •Patient dose in mammography
- •Mammography screening
- •Dose reduction in mammography
- •Filtration for mammographic equipment
- •Digital breast tomosynthesis/3D mammography
- •Tomography
- •Digital breast tomosynthesis (DBT)
- •Effects of tomographic angular scan range
- •On the depth resolution of structures.
- •On in-plane image quality.
- •Effects summary.
- •Image reconstruction (IR)
- •Advantages of DBT
- •Reduce the need for follow-up imaging.
- •Detect more cancers than a standard mammogram alone.
- •Improve breast cancer detection in dense breast tissue.
- •Artifacts in digital breast tomography
- •Artifacts due to motion.
- •Artifacts due to method of acquisition.
- •Artifacts due to reconstruction process.
- •Properties of DBT summarized
- •Expanding the angular sweep of the X-ray tube.
- •Increasing the number of projections for a given angular range.
- •Number of projections required depends on:
- •DBT imaging unit characteristics
- •DBT procedure: Steps and details
- •Radiation dosage
- •DBT summary
- •Summary
- •Discussion questions
- •Review questions
- •Objectives
- •Key terms
- •Annual limit for occupationally exposed personnel
- •Effective dose limits
- •Annual occupational and nonoccupational effective dose limits
- •Allowance for a larger equivalent dose for radiation workers
- •ALARA concept
- •Dose-reduction methods and techniques
- •Repeats in digital imaging
- •The patient as a source of scattered radiation
- •Scattered radiation—occupational hazard
- •Filtration of the diagnostic X-ray beam
- •Protective apparel
- •Technical exposure factors
- •Patient restraint
- •Protection for pregnant personnel
- •Imaging department protocol
- •Acknowledgment of counseling and understanding of radiation safety measures
- •Protective maternity apparel
- •Work schedule alteration
- •Basic principles of radiation protection for personnel exposure reduction
- •Time
- •Distance
- •Application of the inverse square law.
- •Shielding
- •Protective structural shielding.
- •Primary protective barrier.
- •Secondary protective barrier.
- •Control-booth barrier.
- •Clear lead–acrylic secondary protective barrier.
- •Clear lead–acrylic overhead protective barrier.
- •Accessory protective devices.
- •Requirements for lead aprons and gloves.
- •Neck and thyroid shield.
- •Protective eyeglasses.
- •X-ray tube housing cables
- •Protection during fluoroscopic procedures
- •Personnel protection
- •Dose-reduction techniques
- •Remote-control fluoroscopic systems
- •Protective curtain
- •Bucky slot shielding device
- •Rotational scheduling of personnel
- •Protection during mobile X-ray examinations
- •Use of protective garments
- •Distance as a means of protection
- •Protection during C-arm fluoroscopy
- •Personnel exposure resulting from scattered radiation
- •Need for protective apparel for all personnel and monitoring of imaging personnel
- •Positioning of the C-arm fluoroscope
- •Exposure reduction for personnel
- •Protection during high-level control interventional procedures
- •Increased importance of radiation safety techniques
- •Knowledge of dose-reduction techniques required by the radiographer
- •How the radiologist or other interventional physician can reduce radiation exposure
- •Extremity monitoring
- •Diagnostic X-ray suite protection design
- •Requirement for radiation-absorbent barriers
- •Reason for overshielding
- •Radiation shielding categories
- •Primary radiation.
- •Scatter radiation.
- •Leakage radiation.
- •Calculation considerations
- •Workload.
- •Inverse square law.
- •Use factor.
- •Occupancy factor.
- •Controlled and uncontrolled areas.
- •Calculating barrier shielding requirements
- •Primary barrier calculation.
- •Secondary barrier calculation.
- •Scatter radiation.
- •Leakage radiation.
- •Current approaches to shielding
- •Radiation caution signs
- •Beam-on indicator sign
- •General posting
- •Summary
- •General discussion questions
- •Review questions
- •16 Radioisotopes and radiation protection
- •Objectives
- •Key terms
- •Medical usage
- •Radiation therapy
- •Iodine-125.
- •Iodine-131.
- •Proper handling and disposal of radioactive materials
- •Nuclear medicine
- •Iodine-123.
- •Technetium-99m.
- •Positron emission tomography and computed tomography
- •Imaging.
- •Fluorine-18.
- •Radiation protection and the PET-CT scanner
- •Radioimmunotherapy (RIT)
- •The immune system
- •Monoclonal antibodies
- •Agents of RIT and their destructive capabilities
- •How RIT is performed
- •Radiation safety considerations
- •Imaging for RIT proper treatment delivery
- •Summary of RIT
- •Radiation emergencies: Use of radiation as a terrorist weapon
- •Contamination
- •Cleanup of a contaminated Urban Area
- •Medical management of persons experiencing radiation bioeffects
- •Summary
- •General discussion questions
- •Review questions
- •Image gently pledge
- •Image wisely pledge
- •Pledge for imaging professionals
- •Electron volt common energy designations
- •Common frequency spectrum designations
- •§ 35.50 training for radiation safety officer and associate radiation safety officer
- •Subtitle I—consumer-patient radiation health and safety act of 1981
- •Short title
- •Statement of findings
- •Statement of purpose
- •Promulgation of standards
- •Model statute
- •Compliance
- •Federal radiation guidelines
- •Applicability to federal agencies
- •References
- •Chapter 1
- •Chapter 2
- •Chapter 3
- •Chapter 4
- •Chapter 5
- •Chapter 6
- •Chapter 7
- •Chapter 8
- •Chapter 9
- •Chapter 10
- •Chapter 11
- •Chapter 12
- •Chapter 13
- •Chapter 14
- •Chapter 15
- •Chapter 16
- •GLOSSARY
- •Index

ACKNOWLEDGMENTS
xix
this textbook, it is my hope that the material contained
within this edition will greatly contribute to providing
you with a foundation in radiation protection/safety
and radiation biology and the means to enhance your
knowledge in this subject matter. Education is an ongoing process; each person who enters into radiation
sciences profession assumes a responsibility to continue
learning to enhance their skills and overall knowledge.
This growth will enable imaging professionals including
American registered radiologic technologists, radiologists, medical physicists, and referring physicians to
better serve patients entrusted to their care.
Finally, as I have stated in previous editions of this
text, a very special remembrance is given to my parents,
the late Felix and Elizabeth (Markovitch) Krohn, for
all they did for me. Their many words of wisdom and
lifelong encouragement remain with me. The education
in my chosen profession they made possible helped
me gain the knowledge and motivation necessary to
prepare this new and previous editions. My personal
accomplishments in the field of medical imaging serve
as a tribute to them.
Mary Alice Statkiewicz Sherer, AS, RT(R), FASRT

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C O N T E N T S
1 Introduction to Radiation Protection, 1
2 Radiation: Types, Sources, and Doses
Received, 16
3 Interaction of X-Radiation With Matter, 34
4 Radiation Quantities and Units, 54
5 Radiation Monitoring, 72
6 Overview of Cell Biology, 88
7 Molecular and Cellular Radiation Biology, 111
8 Early Tissue Reactions and Their
Effects on Organ Systems, 137
9 Stochastic Effects and Late Tissue
Reactions of Radiation in Organ Systems, 153
10 Dose Limits for Exposure to Ionizing
Radiation, 173
11 Equipment Design for Radiation Protection, 194
12 Management of Patient Radiation Dose During
X-Ray Procedures, 227
13 Special Considerations on Safety in Computed
Tomography, 252
Appendix A: Relationships Between Systems
of Units, 343
Appendix B: Image Gently Pledge and Image Wisely
Pledge, 345
Appendix C: Standard Designations for Metric
System Lengths, Electron Volt Energy
Levels, and Frequency Spectrum
Ranges, 347
Appendix D: Periodic Table of Elements, 349
Appendix E: Relationship Among Photons,
Electromagnetic Waves, Wavelength,
and Energy, 351
Appendix F: Electron Shell Structure of the Atom, 352
Appendix G: Compton Interaction, 354
Appendix H: NCRP 10CFR Part 35.50 Training for
Radiation Safety Officer and Associate
Radiation Safety Officer, 356
Appendix I: Consumer-Patient Radiation Health
and Safety Act of 1981, 358
References, 362
Glossary, 370
Index, 392
14 X-Ray Breast Imaging: Methods and Radiation
Safety Aspects, 275
15 Management of Imaging Personnel Radiation
Dose During Diagnostic X-Ray Procedures, 293
16 Radioisotopes and Radiation Protection, 319
xxi

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Introduction to Radiation Protection
O B J E C T I V E S
After completing this chapter, the reader will be able to
perform the following:
• Define all key terms.
• Identify the consequences of ionization in human
cells.
• List the properties, or characteristics, of x-rays.
• Describe the concept of teamwork in the medical
field, and state the potential benefit that such an
organized collaborative approach can have on
radiation safety.
• Give examples of how radiologic technologists and
radiologists can exercise control of radiant energy
while performing imaging procedures.
• State the goals and discuss the concept of radiation
protection.
• List the three main types of radiation quantities
and identify the unit(s) of measure in which each
quantity is specified.
• Explain the justification and responsibility for
imaging procedures.
• Explain how diagnostic efficacy of an imaging
procedure can be maximized.
1
• State the As Low As Reasonably Achievable
(ALARA) principle and discuss its significance in
diagnostic imaging.
• List the three basic principles of radiation protection.
• List employer requirements for implementing and
maintaining an effective radiation safety program
in a facility that provides imaging services and
identify the responsibilities that radiation workers
must fulfill.
• Describe the importance of patient education as it
relates to medical imaging.
• Explain how radiographers should answer patients’
questions about the risk of radiation exposure from
an imaging procedure and give some examples.
• Compare radiation sensitivity of children with
radiosensitivity of adults.
• Explain the difference between the Image Gently
Campaign and the Image Wisely Campaign.
• Discuss the Pause and Pulse: Image Gently in
Fluoroscopy Campaign.
• Discuss the reasons for monitoring and reporting
radiation dose.
C H A P T E R O U T L I N E
Team Concept in the Medical Field
Control of Radiant Energy
Goals of Radiation Protection
Concept of Radiation Protection
Introduction to Radiation Quantities and Units of
Measure
Need to Safeguard Against Adverse Biologic Effects
of Ionizing Radiation
Justification and Responsibility for Imaging
Procedures: Benefit Verses Risk
Diagnostic Efficacy
As Low As Reasonably Achievable (ALARA) Principle
Cardinal Rules for Radiation Protection
Responsibility for Maintaining ALARA in the
Medical Industry
Patient Protection and Patient Education
Educating Patients About Imaging Procedures
Risk of Imaging Procedures Verses Potential Benefit
Background Equivalent Radiation Time
Increased Radiation Sensitivity of Children
Alliance for Radiation Safety in Pediatric Imaging
Image Gently Campaign
1

2
CHAPTER 1 Introduction to Radiation Protection
Image Wisely Campaign
Monitoring and Reporting Radiation Dose
The NEXT Program and Reference Values
K E Y T E R M S
absorbed dose
ALARA
alert levels
Alliance for Radiation Safety in
Pediatric Imaging
background equivalent radiation
time
biologic effects
coulomb per kilogram (C/kg)
diagnostic efficacy
The transfer of energy from one location to another is
called radiation. It has been present on this planet in
all of its various manifestations since the beginning of
time. The use of radiation within the healing arts did
not occur until after the discovery of an energetic form
of radiation called x-rays in 1895. Since the early
1900s, both their beneficial and destructive potentials
have been known. When passing through normal matter, x-rays were observed to produce electrically
charged particles along their path. The altered atoms
or molecules comprising these charged particles were
called ions. Because of this effect the x-rays were classified as ionizing radiation. The production of these
ions, as well as the electrons ejected in the process, is
the event that may cause injury in normal biologic tissue. Consequences of ionization in human cells are
listed in Box 1.1.
In the years following their discovery, most of the
fundamental properties of x-rays were discovered by
experiment. Briefly, they can be described as follows:
• X-rays are invisible.
• X-rays can have varying degrees of penetration in
normal tissue, ranging from very superficial (skin
surface) to much deeper (5 cm or greater) depending
on their energy.
• X-rays are not deflected from their paths by either
electric or magnetic fields and so are classified as
electrically neutral.
• Although visible light may be focused with a lens,
x-rays cannot.
effective dose
exposure
gray (Gy)
Image Gently Campaign
Image Wisely Campaign
ionizing radiation
milligray (mGy)
milliroentgens (mR)
millisievert (mSv)
Protocols for Dose Alerts
Summary
optimization for radiation
protection (ORP)
Pause and Pulse: Image Gently in
Fluoroscopy Campaign
radiation
radiation protection
reference values
risk
Sievert (Sv)
BOX 1.1 Consequences of Ionization in
Human Cells*
• Creation of unstable atoms
• Production of free electrons
• Production of low-energy x-ray photons
• Creation of highly reactive free molecules (called free
radicals) capable of producing substances poisonous
to the cell
• Creation of new biologic molecules detrimental to
the living cell
• Injury to the cell that may manifest itself as abnormal
function or loss of function
*Each of these consequences is fully discussed in subsequent
chapters.
• X-rays travel in straight lines and at the speed of light
(300 million meters per second) until they interact
with atoms.
• When passing through matter, x-rays will produce
charged particles by interaction with atoms composing that matter, as well as cause an emission of light
known as fluorescence in certain crystals.
• X-rays will darken photographic film, with the degree
of darkening on portions of the film being associated
with the intensity (amount or quantity) of the x-rays
striking those portions.
• X-ray beams generally have within them a wide
range of energies; that is, x-ray beams are normally
heterogeneous instead of monoenergetic.

CHAPTER 1 Introduction to Radiation Protection
TEAM CONCEPT IN THE MEDICAL FIELD
In recent years, there has been an increasing awareness
of the value of a “team approach” to patient care. In
a team approach, various participants assume responsibility for their areas of expertise, and the importance
of communication throughout the team is emphasized.
The composition of the team will vary with the circumstances of the patient. It will include the physician of
record, nursing and other medical assistants, and any
specialty care physicians, including radiologists and
their support group. This support group consists of
radiologic technologists, radiologist assistants, and
medical physicists. The team may also include physical
therapists, respiratory therapists, dietary consultants,
language interpreters, and others. It is recognized that
each member of the team brings their own unique
contributions to a successful medical interaction with
the patient and that teamwork reduces the rate of
occurrence of medical errors. Such an organized
collaborative approach can also have the benefit of
increased radiation safety, both to patients and directly
involved members of the imaging team. This model is
becoming a standard part of the curriculum at all levels
of training for medical schools, residencies, and medical
professional training programs.
1–5
Organizations such
as The American Registry of Radiologic Technologists
(ARRT), The American Society of Radiologic Technologists (ASRT), and The Joint Commission encourage
health care providers to function as effective team members while establishing a culture of quality, patient
safety, and high reliability.
CONTROL OF RADIANT ENERGY
Target
(anode +)
Glass
envelope
X-ray beam
(electromagnetic
waves)
Fig. 1.1 Radiant energy is emitted from the x-ray tube in the
form of waves (or particles). This energy made by humans can
be controlled by the selection of equipment components and
devices made for this purpose and by the selection of appropriate technical settings.
High-speed
electron
stream
Filament
(cathode −)
By adhering to these good practices, technologists
and radiologists minimize the possibility of causing
damage to healthy biologic tissue.
3
By using the knowledge of radiation-induced hazards
that has been gained over many years and by employing
effective methods to limit or eliminate those hazards,
humans can safely control the use of “radiant energy.”
An example of controllable radiant energy is the radiation produced from an x-ray tube (Fig. 1.1).
Radiologic technologists and radiologists:
• Are educated in the safe operation of x-ray–producing
imaging equipment.
• Use protective devices whenever appropriate.
• Follow established procedures.
• Select technical settings that significantly reduce radiation exposure to patients and to themselves.
GOALS OF RADIATION PROTECTION
The goal of modern radiation protection programs is
twofold: to protect persons from both short-term and
long-term effects of radiation. Some of these effects
occur in just specific organs and organ systems. Others,
such as cancer and genetic changes, may affect the
whole body and future generations.
CONCEPT OF RADIATION PROTECTION
Diagnostic imaging professionals have an ongoing responsibility to ensure radiation safety during all medical

4
CHAPTER 1 Introduction to Radiation Protection
radiation procedures. They fulfill this obligation by
following an established radiation protection program.
Radiation protection may be defined simply as effective
measures employed by radiation workers to safeguard
patients, personnel, and the general public from unneces-
sary exposure to ionizing radiation. This refers to any
radiation exposure that does not benefit a person in
terms of diagnostic information obtained from images
for the clinical management of medical needs. Effective
protective actions take into consideration both human
and environmental physical determinants, technical
elements, and procedural factors. To comprehend that
process more fully, this textbook has been designed
to introduce its readers at appropriate times in the following chapters to the relevant scientific principles that
underlie the tools and techniques of these measures.
Scientific application of tools and techniques requires
a common usage of quantities and units. Important
examples of this are length and time with their corresponding metrics: meters, and seconds. Unfortunately,
there is not just one unique set or system of these units
for ionizing radiation. Rather, three such systems are
currently in existence, and each one has a significant area
of usage. Appendix A contains detailed lists of all the
major components comprising each of the three systems
and furthermore gives the numeric relationships among
the corresponding units of each system.
Introduction to Radiation Quantities and Units of Measure
The science of radiation quantities and units is complex.
An introduction is provided to allow the reader to
appreciate the relative magnitudes of sources of radiation exposure of humans to radiation. There are three
main types of quantities to consider:
• Exposure
• Absorbed dose
• Effective dose
A brief explanation of these quantities and the units
in which they are most commonly specified follows.
Exposure (coulomb per kilogram [C/kg] or milliroentgen [mR]). The terms exposure and exposed are used in
everyday speech to refer to any situation in which radiation is in contact with humans, as in “The patient was
exposed to radiation to obtain a medical image.” But
there is a specific scientific meaning to the term expo-
sure. Exposure is the amount of ionization produced in
air when ionizing radiation is present. The air at the
surface of an x-ray room tabletop or the interior of a
computed tomography (CT) scanner becomes ionized
when the x-ray tube is energized. Devices called ioniza-
tion chambers can measure this quantity directly and are
used to determine the amount of radiation
produced by x-ray equipment. Exposure is measured
in coulomb per kilogram (C/kg) in the metric International System of Units (SI), or historically and still quite
commonly in milliroentgens (mR), a subunit of the
roentgen, a nonmetric unit likewise used for measuring
the ionizing capability of radiation. A milliroentgen is
equal to 1/1000 of a roentgen.
Absorbed Dose (milligray [mGy]). The term dose
is also employed in everyday speech, as in “Everyone
receives a dose of radiation from sources in the environment.” The exact meaning of absorbed dose is the
amount of energy that is deposited in a material per
unit mass of the material. For living tissue more energy
deposited is usually related to more disruption of biomolecules. Less energy received is related to less disruption. Absorbed dose is measured in milligray (mGy), a
subunit of the gray (Gy) in the SI. The milligray is equal
to 1/1000 of a gray.
Effective Dose (millisievert [mSv]). The term effec-
tive dose is an attempt to provide a quantity that is
a measure of general harm in humans. It takes into
account the amount of absorbed dose that is received
by a human, the exact type of radiation (the effects
of alpha particles, beta particles, protons, and neutrons
are all somewhat different at the same absorbed dose
levels), and the specific organs or organ systems irradiated. The effective dose is the best overall measure of
the biologic effects of ionizing radiation. In SI units,
effective dose is specified in millisievert (mSv), a sub-
unit of the sievert (Sv). The millisievert is equal to
1/1000 of a sievert.
Need to Safeguard Against Adverse Biologic Effects of Ionizing Radiation
The need to safeguard against unnecessary radiation
exposure is based on strong evidence that living tissue
of animals and humans can be damaged by exposure to
ionizing radiation. This type of harm is referred to as
adverse biologic effects. In medicine, when radiation
safety principles are correctly applied during imaging

CHAPTER 1 Introduction to Radiation Protection
5
procedures, the energy deposited in living tissue by
radiation can be limited, thereby reducing the potential
for adverse biologic effects. This textbook focuses on
radiation protection for patients, diagnostic imaging
personnel, and the general public.
JUSTIFICATION AND RESPONSIBILITY FOR IMAGING PROCEDURES: BENEFIT VERSES RISK
Radiation exposure should always be kept at the lowest
possible level for the general public. However, when
illness or injury occurs or when a specific imaging
procedure for health screening purposes is called for,
a patient may choose to assume a relatively small statistical risk for a physician to obtain essential diagnostic
medical information. A prime example of such a voluntary assumption of risk occurs when women elect
to undergo screening mammography to enable detection of breast cancer in its early stages (Fig. 1.2). Highquality mammography continues to be the most
effective tool for diagnosing breast cancer early, when
the disease can best be treated.6 Its use contributes
significantly to improving the life expectancy for women
at risk. The potential benefits of this exposure to radiant
energy far outweigh any slight chance of inducing a radiogenic malignancy or any genetic defects.
Diagnostic Efficacy
Diagnostic efficacy is the degree to which the diagnos-
tic study accurately reveals the presence or absence
of disease in the patient, while adhering to radiation
safety guidelines. It is maximized when essential images
are produced with the least radiation exposure to the
patient. Thus this concept of efficacy is a vital part of
radiation protection in the healing arts, providing
the basis for deciding whether an imaging procedure
or practice is justified (Box 1.2). Ultimately, the referring physician, however, carries the responsibility for
determining this medical necessity for the patient. After
ordering an x-ray examination or procedure, the referring physician must accept basic responsibility for protecting the patient from nonuseful radiation exposure.
As health care professionals, radiographers also accept a
Fig. 1.2 High-quality mammography continues to be the most effective tool for diagnosing breast cancer.
It can be used as a screening tool or a diagnostic procedure. In either instance, the potential benefits of
exposure to radiant energy, in terms of medical information obtained, far outweigh any slight chance of inducing a radiogenic malignancy or any genetic defects. (From Long BW, Rollins JH, Smith BJ Merrill’s atlas of
radiographic positioning and procedures, ed 14, St. Louis: Elsevier; 2019.)

6
CHAPTER 1 Introduction to Radiation Protection
BOX 1.2 Achievement of Diagnostic
Efficacy
Imaging procedure
orpractice justified
by referring
physician
n
Minimal
radian ttion
exposure
P
rresence
orabsence
ofdisease
revealed
n
Optimal
image(s)
produced
Diagn5oostic
efficacy
portion of the responsibility for the patient’s welfare
by providing high-quality imaging services. Both the radiographer and the involved radiologist share in the
task of keeping the patient’s medical radiation exposure
at the lowest level possible. This can best be accomplished by producing optimal images with the first
exposure. Repeated examinations made necessary by
technical error or carelessness (Fig. 1.3) must be avoided.
AS LOW AS REASONABLY ACHIEVABLE (ALARA) PRINCIPLE
ALARA is an acronym for “as low as reasonably achiev-
able.” This term is synonymous with the term optimiza-
tion for radiation protection (ORP). The rationale
for ALARA or ORP comes from evidence compiled by
scientists over the past century.7 At the time of this publication, radiation protection guidelines remain rooted
in the philosophy of ALARA. Therefore this dictum, as
low as reasonably achievable, should be a main part of
every health care facility’s personnel radiation control
program. In addition, because at this time no firm dose
limits have been established for the amount of radiation
that patients may receive for each individual imaging
procedure, the ALARA philosophy should be maintained and must show that all reasonable actions that
will reduce doses to patients and personnel to levels that
are below those strictly required by regulations have
been employed (Fig. 1.4). Radiation-induced cancer
A B
Fig. 1.3 (A) Posteroanterior chest projection requiring repeat examination because of multiple external
foreign bodies (several necklaces and an underwire bra) that should have been removed before the x-ray
examination. (B) Anteroposterior projection of a right hip requiring a repeat examination because of poor collimation and the presence of an external foreign body (a cigarette lighter) overlying the anatomy of concern.
The patient’s slacks with the pocket containing the lighter should have been removed before the x-ray
examination.
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