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CHAPTER 16 Radioisotopes and Radiation Protection
337
After an explosion of a dirty bomb, some individu­als would be contaminated with dust and debris, some of which could contain radioactive materials. The pro­cedure for decontamination is surprisingly simple. Removal of contaminated clothing and immersion in a shower comprise the best method. If a wound con­tains radioactive material, a simple rinse of the area is usually sufficient to allow medical personnel to pro­vide medical attention. Most hospitals are stocked with Geiger–Müller (GM) detectors (described in Chapter 5), and emergency personnel are trained to provide guidance concerning contamination levels. The facility’s radiation safety officer would also be available to assess contamination levels.
It is unlikely that a dirty bomb would cause con­tamination with so much radioactive material that a victim could not receive medical attention. The key here is that the same personnel need not be near patients for any length of time. Most emergency room treatments do not require the staff to be near patients for as long as an hour. Even if a GM detector shows readings of two to five times natural background radiation, this means an effective dose rate of only 0.03 to 0.15 mSv/hr would be experienced by a physician who is in direct contact with the patient. Therefore, a physician could treat this pa­tient under these circumstances without exceeding nor­mal dose limits. Normal dose limits do not apply in ra­diation crisis situations.
The Environmental Protection Agency (EPA) sug- gests that during such an emergency, individuals en­gaged in non-lifesaving activities work under a dose limit of 50 mSv (5 rem) per event. For individuals en­gaged in lifesaving activities, the dose limit is permitted to rise to 250 mSv per event.9 Because it may be difficult to monitor all workers involved in a radiation emer­gency, a dose rate criterion is often used. In this case, if the dose rate in the area is less than 0.1 mSv/hr, emer­gency personnel may enter an area to perform critical tasks. If the dose rate exceeds 0.1 mSv/hr, emergency personnel should await specific instructions from radia­tion experts on how to proceed.
10

Cleanup of a Contaminated Urban Area

The EPA sets limits for radioactive contamination that assume that a 1 in 10,000 risk of causing a fatal cancer is unacceptable. This type of regulation requires hospitals, educational facilities, and industries to control accidental exposures so that the health of the population cannot be
measurably affected. It also assumes that many other carcinogens are present and that all are regulated to a similarly low level.
However, if radioactive contamination were to result from a dirty bomb, it is hoped that a more realistic evaluation of actual risk would be used. Unnecessary use of resources to clean a large inhabitable area (e.g., at the heart of a major city) to unreasonably stringent standards would be an unfortunate outcome requiring the expenditure of vast resources that could be used to benefit the public elsewhere. For example, a 1 in
10,000 probability of causing a fatal cancer corresponds approximately to a 2 mSv (200 mrem) effective dose.
Recall from Chapter 2 that the annual effective dose resulting from average natural background radiation is approximately 3 mSv. Therefore, cleanup of a contami­nated site to levels associated with normal radiation protection standards would require heroic measures, such as:
• Removal of topsoil
• Digging up of roadways
A practical compromise should be made to allow land use after a reasonable cleanup.

Medical Management of Persons Experiencing Radiation Bioeffects

If surface contamination is suspected, personnel should wear gowns, masks, and gloves when working with the patient. The same procedures that control the spread of infection are useful to prevent the spread of radioactive contamination. The clothing of individuals who have been contaminated should be placed in plas­tic containers and set aside for later evaluation. Re­moval of surface contamination involves removal of the patient’s clothing and the use of a shower to cleanse the skin.
The various stages of ARS were discussed in Chapter
8. A complete discussion of procedures for handling ARS is beyond the scope of this text. The interested reader is referred to recent publications on this sub-
11,12
ject.
In dealing with patients with ARS, some esti­mate of the amount of exposure they have received helps predict the clinical course of the syndrome (Table
16.2). There are many methods other than ARS symp-
toms that may be used to determine the amount of radiation dose received during acute exposure. Biodo­simetry is a general term used to refer to analysis of bio­logical fluids such as blood and urine to look for actual
338
TABLE 16.2 Dose Effect Relation After Acute Whole-Body Radiation From Gamma Rays
CHAPTER 16 Radioisotopes and Radiation Protection
or X-Rays
Whole-Body (Gyt) Absorbed Dose Effect
0.05 No symptoms
0.15 No symptoms but possible chromosomal aberrations in cultured peripheral blood lymphocytes
0.5 No symptoms (minor decreases in white blood cell and platelet counts in a few persons)
1 Nausea and vomiting in approximately 10% of patients within 48 hr after exposure 2 Nausea and vomiting in approximately 50% of persons within 24 hr, with marked decreases
in white blood cell and platelet counts
4 Nausea and vomiting in 90% of persons within 12 hr and diarrhea in 10% within 8 hr; 50%
mortality in the absence of treatment
6 100% mortality within 30 days because of bone marrow failure in the absence of treatment 10 Approximate dose that is survivable with the best medical therapy available .10–30 Nausea and vomiting in all persons in less than 5 minutes; severe gastrointestinal damage;
death likely in 2 to 3 weeks in the absence of treatment
.30 Cardiovascular collapse and central nervous system damage, with death in 24 to 72 hr
Data from Gusev I, Guskova AK, Mettler FA Jr, eds: Medical management of radiation accidents, ed 2, Boca Raton, FL, 2001, CRC Press.
internal contamination, changes in blood components, and for genetic analysis. Physical dosimetry methods include analysis of physical components of the body and surroundings. These include optically stimulated luminescence of teeth, implanted ceramics, plastic cards, and even fabric samples. These techniques may be used to provide information to aid in triage immedi­ately after an accident or to modify treatment by refin­ing dosimetry estimates at a later time. They have been compiled recently by the International Council on Ra­diation Protection and Units.13 For exposures localized to specific regions of the body, medical management involves the prevention of infection and control of pain and potential skin grafts. If beta-emitting radioactive material settles on a patient’s skin, the dose is superfi­cial, and skin grafts may be successful. Gamma-emitting materials can produce a deeper dose that could interfere with healing.
During the first 48 hours of ARS, symptoms such as nausea and vomiting occur. Medical management at this time is simply to treat the symptoms and try to prevent dehydration. The bone marrow becomes de­pleted (leukopenia and thrombocytopenia) after a few weeks. Bone marrow transplants (such as hematopoietic stem cell transplants) may be effective in replacing the
function of damaged bone marrow. Such activities re­quire special expertise and, in the event of a radiation emergency, would be coordinated by the Radiation Injury Treatment Network.
14
In the event of internal contamination, various strategies are used, depending on the clinical and radio­logic form of contamination. Some of these methods include:
• Dilution (forcing fluids)
• Blocking absorption in the gastrointestinal tract
(administration of emetics, charcoal, laxatives)
If the radionuclide is iodine, administration of po­tassium iodide to block further uptake in the thyroid is possible if no more than a few hours have elapsed since the contamination.
The National Library of Medicine and the National Institutes of Health (NIH) maintain a website that con­tains a wealth of information on dealing with radiation emergencies. It contains:
• Both basic and advanced methods for decontamination
• Methods to reduce exposure
• Specific medical emergency procedures for various
situations
The website may be found at www.nlm.nih.gov/
medlineplus/radiationemergencies.html.

S U M M A R Y

CHAPTER 16 Radioisotopes and Radiation Protection
339
• Isotopes are atoms that have the same number of pro­tons within the nucleus but have different numbers of neutrons.
• Some nuclei of isotopes have too many neutrons or too many protons for stability.
• Radioactive isotopes spontaneously undergo changes or transformations to rectify their unstable arrangement.
• Rapidly dividing cells that are well oxygenated are very radiosensitive.
• When cells are radiosensitive, cancerous growths or tumors can be either eliminated, or at least controlled, by irradiation of the area containing the growth.
• Therapeutic isotopes generally have relatively long half-lives compared with diagnostically employed isotopes.
• Fast electrons are beta radiation.
• Gamma rays and x-ray photons differ only in their point of origin.
• Iodine-125 decays with a half-life of 59.4 days by a process called electron capture.
• The most practical radiation protection to follow for patients having therapeutic prostate seed implants is use of the concepts of distance and time.
• When iodine-131 is being administered to treat a hospitalized patient for thyroid cancer, a large, up to
2.5 cm or 1-inch-thick, movable lead shield can be positioned between the patient and any attending personnel for protection.
• Residual unused nonreturned radioisotopes, as well as radioactively contaminated items, must be held in a secure, shielded, and posted storage area for a pe­riod of 10 half-lives of the isotope before being able to be discarded in ordinary trash. Proper record keeping is to be kept of storage and disposal.
• Diagnostic techniques in nuclear medicine typically make use of short-lived radioisotopes as radioactive tracers.
• Technetium-99m is the most common radioisotope used in nuclear medicine.
• Positron emission tomography (PET) makes use of annihilation radiation events.
• When matter–antimatter annihilation occurs, a posi­tron and an electron interact destructively and disap­pear. Their respective masses are converted into en­ergy that will be carried off by two photons emerging
from the annihilation site in opposite directions, each with an energy of 511 keV.
• A neutrino is a particle that has almost negligible mass and no electric charge but carries away any ex­cess energy from the nucleus of the atom in processes such as beta and positron decay.
• Fluorine-18 is the most important isotope used for PET scanning.
• PET is an important imaging modality because it can examine metabolic processes within the body.
• Fluorodeoxyglucose (FDG) is a radioactive tracer that is taken up or metabolized by cancerous cells and that reveals their location through positron emission decay and subsequent generation of oppo­sitely traveling annihilation photons.
• A PET-computed tomography (CT) scanner can de­tect the presence of regions of abnormally high glu­cose metabolism, thus providing evidence of cancer metastasis to other body areas, and at the same time can obtain detailed information about the location and size of these lesions or growths.
• Positron emitters result in the production of high­energy radiation, and for this reason the design of a PET-CT imaging suite involves significant radiation safety concerns.
• Radioimmunotherapy (RIT) is a specific treatment protocol for cancer by cytotoxic radioisotopes conju­gated to specialized immune system antibodies.
• Monoclonal antibodies are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
• Organs of the human body that are part of the im­mune system include organs such as the liver, thymus gland, bone marrow, lymph nodes, spleen, and tonsils.
• Radioimmunotherapy (RIT) is a combination of ra­diation therapy and immunotherapy, and the success of RIT depends on the selective accumulation of cy­totoxic radioisotopes at the affected areas.
• One of the most intriguing advantages of RIT over external x-ray beam therapy is the ability to attack not only the primary tumor but also lesions systemi­cally metastasizing or spreading.
• Most hospitals have elaborate crisis plans for han­dling emergency situations involving radioactive contamination.
340
CHAPTER 16 Radioisotopes and Radiation Protection
• A radioactive dispersal device, or “dirty bomb,” is a radioactive source mixed with conventional explo­sives, the actual long-term health effects of which will most likely be minimal.
• If radioactive material from a dirty bomb remains in a small area, only a few people may be seriously affected.
• Conversely, if enough explosives are used to spread the radioactive material over a broad area, radioac­tivity will be diluted and may not be much higher than background levels.
• If a dirty bomb were to explode with the same force as the explosion at Chernobyl, the actual number of radiation injuries could be quite small.
• The United States currently has emergency responders who are prepared and equipped to monitor and assess personnel exposure on-site in an emergency situation.
• After an explosion of a dirty bomb, externally contami­nated individuals can be decontaminated by removal of contaminated clothing and immersion in a shower.
• Geiger–Müller (GM) detectors may be used by
• During an emergency situation, individuals engaged
• If surface contamination is suspected, emergency
• Handling of patients with internal contamination

G E N E R A L D I S C U S S I O N Q U E S T I O N S

1. Why do isotopes that have too many neutrons or too
many protons spontaneously undergo changes or transformations?
2. What causes cancerous growths or tumors to be
eliminated or controlled by irradiation?
3. What difference exists between gamma rays and
x-ray photons?
4. What are the best radiation safety practices to follow
for patients having therapeutic prostate seed implants?
5. While caring for a hospitalized patient receiving
iodine-131 therapy for cancer, what can hospital per­sonnel do to minimize occupational exposure?
6. What radiation safety concerns are associated with the
design of a PET/CT imaging suite, and how is radia­tion protection provided to meet these concerns?
7. What is a radioactive dispersal device, or “dirty
bomb,” and what are the possible consequences if such a device is detonated?
8. If a wound contains radioactive material, what
9. What dose level may an individual engaged in life-
10. If surface contamination is suspected, what should
11. What is radioimmunotherapy?
12. Where does the development of all cells of the immune
13. Upon what does the success of radioimmunotherapy
14. What professional individuals are usually involved
15. For what groups of patients is radioimmunother-
trained emergency personnel to monitor contamina­tion levels.
in non-lifesaving activities are to work under a dose limit of 50 mSv per event, whereas those persons performing lifesaving activities have a dose limit of 250 mSv.
personnel should protect themselves by wearing gowns, masks, and gloves while working with the patient.
varies depending on the clinical and radiologic form of contamination. Strategies may include dilution and blocking absorption in the gastrointestinal tract. Potassium iodide can be administered to block fur­ther uptake of radioactive iodine in the thyroid gland.
should be done to decontaminate the wound?
saving activities during a radiation emergency receive?
medical personnel wear when working with a con­taminated patient?
system begin?
depend?
in radioimmunotherapy procedures?
apy an important choice?

R E V I E W Q U E S T I O N S

1. Well-oxygenated rapidly dividing cells are:
A. Very insensitive and are not damaged by
radiation
B. Very sensitive to damage by radiation C. Moderately sensitive to damage by radiation D. Somewhat sensitive to damage by radiation
2. Iodine-125 decays with a half-life of 59.4 days by a
process called:
A. Attenuation B. Electron capture C. Pair production D. Photodisintegration
CHAPTER 16 Radioisotopes and Radiation Protection
341
3. Which of the following steps should be taken for ex-
ternal decontamination from radioactive materials?
1. Removal of contaminated clothing
2. Immersion of contaminated person in a shower
3. Monitoring of the contaminated individual
with a Geiger–Müller detector
A. 1 and 2 only B. 1 and 3 only C. 2 and 3 only D. 1, 2, and 3
4. What dose level may an individual who is engaged in
non-lifesaving activities during a radiation emer­gency safely receive?
A. 10 mSv per event B. 30 mSv per event C. 50 mSv per event D. 250 mSv per event
5. The clothing of individuals that has been contami-
nated should be:
A. Aired out on a clothesline to decontaminate B. Burned immediately C. Placed in plastic containers and set aside for later
evaluation
D. Shaken out and put back on
6. All of the following statements are true except:
A. In dealing with patients with acute radiation syn-
drome (ARS), some estimate of the amount of exposure they have received helps predict the clinical course of the syndrome.
B. If beta-emitting radioactive material settles on a
patient’s skin, the dose is very deep and skin grafts will not be very successful.
C. Gamma-emitting radioactive materials can
produce a deep dose that may interfere with healing.
D. Current strategy for an ARS patient is to admin-
ister drugs that stimulate any remaining bone marrow.
7. Some of the strategies used to treat internal radiation
contamination include:
1. Dilution (forcing fluids)
2. Blocking absorption in the gastrointestinal tract
(administration of emetics, charcoal, laxatives)
3. Administration of potassium iodide to block further uptake in the thyroid if the radionu­clide is iodine and no more than a few hours have elapsed since the contamination
A. 1 only B. 2 only
C. 3 only D. 1, 2, and 3
8. A well-designed PET/CT facility should be arranged
so that there are no areas of full occupancy imme­diately adjacent to a:
A. High-energy radiation source B. Low-energy radiation source C. Patient waiting area D. Public corridor
9. Which of the following are almost impossible to
detect?
A. X-rays B. Gamma rays C. Positrons D. Neutrinos
10. Patients receiving iodine-125 should significantly
limit durations of close contact (,30 cm or 1 foot) with small children and pregnant women for a period of:
A. Six days after the implant procedure B. Six weeks after the implant procedure C. Six months after the implant procedure D. Six years after the implant procedure
11. Antibodies that are made by identical immune cells
that are all clones of a unique parent cell are known as:
A. Antigen antibodies B. Conjugated antibodies C. Monoclonal antibodies D. Pathogen antibodies
12. Organs of the human body such as the liver, thymus
gland, bone marrow, lymph nodes, spleen, and ton­sils are part of the:
A. Circulatory system B. Endocrine system C. Immune system D. Reproductive system
13. Radioimmunotherapy (RIT) is a combination of:
1. Immunotherapy
2. Chemotherapy
3. Radiation therapy
A. 1 and 2 only B. 1 and 3 only C. 2 and 3 only D. 1, 2, and 3
14. One of the most intriguing advantages of radioim-
munotherapy over external x-ray beam radiother­apy is the ability to attack:
A. Not only the primary tumor but also lesions
systemically metastasizing or spreading
342
CHAPTER 16 Radioisotopes and Radiation Protection
B. Only the primary tumor cells C. Only lesions systemically metastasizing or
spreading
D. Only the primary tumor cells and all the non-
cancerous cells surrounding the primary tumor
15. The success of radioimmunotherapy depends on the:
A. Energy of the diagnostic x-ray beam employed
B. Malignancies that present in free-floating cells C. Selective accumulation of cytotoxic radioiso-
topes at affected areas
D. Tumor’s molecular characteristics
A P P E N D I X
A
Relationships Between Systems of Units
As has been shown throughout this textbook, various quantities are necessary for describing physical pro­cesses. Well-known examples of such quantities are length, mass, force, energy, and time. If one also includes electric charge, then virtually all of the fundamental characteristics of nature can be found to be included within combinations of these physical quantities or, more precisely, the units associated with them. The pur­pose of this appendix is to tabulate quantities and units, including those that pertain to ionizing radiation that may be encountered by the student. It should be empha­sized that a concerted effort has long been under way to just have one system of units in place throughout the world, namely the Systeme International, or SI. There are strong pockets of resistance to this, especially in the United States, which is firmly wedded to the English system. However, in official areas such as radiation pro­tection regulations and registry and licensing examina­tions, SI units have become the norm, and they have been used in this text as much as possible.
Three basic systems of physical units have been in existence for a long time and are familiar to varying degrees, depending on what part of the world one lives in and perhaps one’s field of work. They are the English system, the CGS (centimeter-gram-second) system, and the MKS (meter-kilogram-second) or SI system. The following tables specify for each important physical quantity the corresponding associated fundamental unit in each of the three systems and the relationship among these units when possible. Boxes demonstrating calculations for conversions among units and for equiv­alent and effective radiation dose are also provided.
English System
Quantity Unit
Length Foot, inch Force (weight) Pound (lb) Mass Slug (an object of mass 1 slug
weighs 32 lb on the surface
of the Earth) Energy Foot-pound Power Horsepower (hp) Pressure Lb/in Time Second Electric charge Coulomb Temperature Degrees Fahrenheit (°F) Absorbed dose No specific unit Exposure Roentgen
CGS System
Quantity Unit
Length Centimeter (cm) Force (weight) Dyne (1 gm-cm/sec2) Mass Gram (g) Energy Erg (1 gm-cm2/sec2) Power Ergs per second Pressure Barye (Ba) (1 Ba 5 1 dyne/cm2) Time Second Electric charge Statcoulomb or ESU (ESU means
Temperature Degrees Centigrade (Celsius) (°C) Absorbed dose Rad (1 rad 5 100 ergs/gram) Equivalent dose Rem
2
electrostatic unit of charge)
343
344
APPENDIX A Relationships Between Systems of Units
MKS (SI) System
Quantity Unit
Length Meter (m) Force (weight) Newton (1 N 5 1 kg-m/sec2) Mass Kilogram (kg) Energy Joule (1 J 5 1 kg-m2/sec2) Power Watt (1 W 5 1 joule/sec) Pressure N/m
2
Time Second Electric charge Coulomb (C) Temperature Degrees Centigrade (ºC)
(Celsius), degrees Kelvin (K) Absorbed dose Gray (Gy) (1 Gy 5 1 J/kg) Equivalent dose Sievert (Sv)
Relationships Among Units
Quantity Unit Conversions
Length 1 m 5 100 cm 5 39.37 inches;
2.54 cm 5 1 inch Force (weight) 1 N 5 0.225 lb 5 105 dynes Mass 1 kg 5 1000 g; 1 slug 5 14.6 kg Energy 1 J 5 107 ergs 5 0.738 ft-lb Power 1 W 5 0.738 ft-lb/sec; 1 hp 5
550 ft-lb/sec 5 746 W 5 0.746 kW
Pressure 1 N/m2 5 1.45(10)24 lb/in2 510 Ba;
1 atmosphere 5 14.7 lb/in2 5
1.013(10)5 N/m Time 1 second 5 1/3600 hour 5
approximately 1/100,000 day
Electric charge 1 ESU 5 1 statcoulomb 5
3.34(10) Temperature TF 5 9/5TC 1 32, TK 5 TC 1 273 Exposure 1 coulomb/kg 5 1/2.58(10)24 C/kg
per R 5 3876 R (a very large
exposure) Absorbed dose 1 Gy 5 100 rad, 1 cGy 5 1 rad Equivalent dose 1 Sv 5 100 rem, 10 mSv 5 1 rem
1 mSv 5 0.1 rem 5 100 mrem
210
2
C
Determining and Expressing Effective Dose (EfD) in Rem
Example: The WR for x-radiation is 1 (see Table 4.2), and the WT for the gonads is 0.20 (see Table 4.3). If the gonads receive an absorbed dose (D) of 10 cGy from exposure to x-radiation, what is the EfD in rem? Answer:
EfD 5 D 3 WR 3 W
T
5 10 3 1 3 0.20 5 2 rem 5 2/100 5 0.02 Sv 5 20 mSv
Traditional and SI Equivalents
1 roentgen (R) equals 2.58 3 1024 C/kg of air 1 milliroentgen (mR)
equals
1 rad equals 100 erg/g
1 millirad equals 1023 rad 1 rem equals
1 millirem equals
1
1000
R or 1023 R
1
100
J/kg
1
100
Gy
1 cGy
1
100
J/kg (for x-radiation,
Q 5 1)
1
100
Sv 1 cSv 10 mSv
1
1000
rem
A P P E N D I X
B
Image Gently Pledge and Image Wisely Pledge
Pledges begin on January 1 of each year and expire on December 31 of the same year. It is up to the radiogra­pher to renew the pledges each year.

IMAGE GENTLY PLEDGE

Yes, I want to image gently. Recognizing that every member of the health care team plays a vital role in caring for the patient and wants to provide the best care, I pledge:
• To make the image gently message a priority in staff communications this year
This certificate is completed online by the individual (named here) who has pledged to “image gently.” In doing so, he/she pledges:
to make the image gently message a priority in staff communications this year to review the protocol recommendations and, where necessary, implement adjustments to practice processes to respect and listen to suggestions from every member of the imaging team on ways to ensure changes are made to communicate openly with parents
The Alliance for Radiation Safety in Pediatric Imaging thanks those who commit to the goal to “image gently” in the imaging of children. Spread the word in your department, practice, hospital or clinic.
• To review the protocol recommendations and, where necessary, implement adjustments to our processes
• To respect and listen to suggestions from every mem­ber of the imaging team on ways to ensure changes are made
• To communicate openly with parents
Thank you for committing to the goal to image gently when you image or treat children. Spread the word in your department, practice, hospital, or clinic. Take the pledge at https://radsociety.wufoo.com/forms/
image-gently-pledge/
Name/Practice Address Date
The Image Gently Campaign is a message from the Alliance for Radiation Safety in Pediatric Imaging.
This certificate is not an accreditation document from the Image Gently campaign. It is a sign of the voluntary pledge taken by the named individual.
Visit the website at www.imagegently.org for more information
From The Image Gently Alliance, www.imagegently.org.
345
346
APPENDIX B Image Gently Pledge and Image Wisely Pledge

IMAGE WISELY PLEDGE

Pledge for Imaging Professionals

Yes, I want to image wisely. I wish to optimize the use of radiation in imaging patients and thereby pledge:
1. To put my patients’ safety, health, and welfare first by optimizing imaging examinations to use only the ra­diation necessary to produce diagnostic-quality images
2. To convey the principles of the Image Wisely program to the imaging team in order to ensure that my facility optimizes its use of radiation when imaging patients
3. To communicate optimal patient imaging strategies to referring physicians and to be available for consultation
4. To routinely review imaging protocols to ensure that the least radiation necessary to acquire a diagnostic­quality image is used for each examination
5. To monitor examination radiation dose indices to en­able comparison to established diagnostic reference levels
Take the pledge at http://www.imagewisely.org/Pledge/
Imaging-Professionals-Pledge