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- •Contents
- •Contributors
- •1.6 Mixed Disorders
- •1.7 Isolated Symptoms
- •1.7.1 Snoring
- •1.7.2 Catathrenia
- •1.8 Summary
- •References
- •1.1 Introduction
- •1.2 Obstructive Sleep Apnea
- •1.2.1 Obstructive Sleep Apnea, Adult
- •1.2.2 Obstructive Sleep Apnea, Pediatric
- •1.3 Central Sleep Apnea
- •1.3.5 Primary Central Sleep Apnea
- •1.5 Sleep-Related Hypoxemia Disorder
- •2.7 Summary
- •References
- •3: Health Consequences of Obstructive Sleep Apnea
- •3.1 Cardiovascular Consequences
- •3.1.1 Chronic Heart Failure
- •3.1.2 Systemic Hypertension
- •3.1.3 Coronary Heart Disease
- •3.1.4 Arrhythmias
- •3.1.5 Cerebrovascular Disease
- •3.2 Respiratory Consequences
- •3.2.1 Asthma
- •3.2.3 Pulmonary Embolism
- •3.2.4 Pulmonary Hypertension
- •3.3.1 Diabetes Mellitus
- •3.3.2 Metabolic Syndrome
- •3.3.3 Sexual Dysfunction
- •3.4 Gastrointestinal Consequences
- •3.4.2 Nonalcoholic Fatty Liver Disease
- •3.5 Obstetric Outcomes
- •3.5.2 Gestational Diabetes
- •3.5.4 Maternal Surgical Complications
- •3.6 Perinatal Outcomes
- •3.6.1 Impaired Fetal Growth
- •3.6.2 Preterm Birth
- •3.6.4 Stillbirth
- •3.6.5 NICU Admission
- •3.7 Perioperative Outcomes
- •3.8 Accident-Related Consequences
- •3.9 Cancer-Related Outcomes
- •3.10 Survival Outcomes
- •3.10.1 Overall Mortality
- •3.10.2 Cardiovascular Death
- •3.10.4 Perioperative Mortality
- •References
- •4.1 Patient Case
- •4.2 Introduction
- •4.3 History
- •4.4.1 Oxygen
- •4.4.2 Vascular
- •4.4.3 Endocrine
- •4.6.1 Attention & Executive Function
- •4.6.4 Visual-Spatial
- •4.7 Summary
- •References
- •5.1 Introduction
- •5.2 Obesity
- •5.3 Hypertension
- •5.4 Diabetes Mellitus
- •5.5 Fatty Liver Disease
- •5.6 Conclusions
- •References
- •6.1 Background
- •6.2 History Taking
- •6.3 Physical Examination
- •6.4 Conclusion
- •References
- •Further Reading
- •7.1 Background
- •7.2.2 Screening Tools
- •7.2.3 Diagnostic Tests
- •7.2.7 Clinical Guidelines
- •7.3 Home Sleep Apnea Test (HSAT)
- •7.3.1 Advantages
- •7.3.2 Disadvantages
- •7.3.3 Patient Selection
- •7.3.4 Data Obtained
- •7.3.8 Recommended Follow-Up
- •7.3.9 Clinical Outcomes
- •7.4 Polysomnography (PSG)
- •7.4.1 Patient Selection
- •7.4.4 Follow-Up
- •7.5 Conclusions
- •Further Reading
- •8.1 Introduction
- •8.4 CBCT and OSA
- •8.5.1 CPAP
- •8.5.2 Oral Appliances
- •8.5.3 Maxillomandibular Advancement
- •8.6 Upper Airway Stimulation
- •8.7 Summary
- •References
- •9.1.1.1 Cranial Base Lengthening
- •9.1.1.2 Cranial Base Flexion
- •9.1.5.3 Tongue Growth
- •References
- •10.2.1.1 Cranial Base
- •10.2.1.2 Facial Height
- •10.2.1.4 Pharyngeal Airway Space
- •10.2.1.6 Hyoid Bone Position
- •10.3.1 Maxillary Expansion
- •10.3.1.4 RME for OSA
- •References
- •11.2 Pathophysiology
- •11.3 Clinical Exam
- •11.5 Treatment
- •11.6 Summary
- •References
- •12.1 Introduction
- •12.5 Mask Options
- •12.6.1 Dry Mouth
- •12.6.2 Tangled Tubing
- •12.6.3 Condensation
- •12.6.4 Headgear Problems
- •12.6.6 Ramp
- •12.6.7 Cleaning Equipment
- •12.6.8 Skin Irritation
- •12.6.9 Nasal Congestion
- •12.6.10 Aerophagia
- •12.7 Cleaning Equipment
- •12.7.1 Travel Options
- •References
- •13: Oral Appliance Therapy
- •13.1 Introduction
- •13.2 Terminology
- •13.3.2 Device Designs
- •13.4 Methodology
- •13.7.2 Device Design
- •13.7.5 Non-anatomical Traits
- •13.7.6 Disease Severity
- •13.7.7 Supine Dependency
- •13.12.3 Adherence
- •13.12.4 Mean Disease Alleviation
- •13.13 Long-Term Outcomes
- •13.16 Guidelines
- •References
- •14.1 Introduction
- •14.2 Positional Therapy
- •14.2.1 Weight Loss
- •14.2.2 Nasal EPAP Therapy
- •14.2.3 Oral Pressure Therapy
- •14.2.4 Hypoglossal Nerve Stimulation
- •References
- •15.1 Introduction: Background Information
- •15.4 Preoperative Assessment
- •15.4.1 Physical Examination
- •15.4.2 Polysomnography
- •15.4.3 Clinical History
- •15.5 Preoperative Consent
- •15.6 Preoperative Assessment
- •15.6.1 Surgical Setting
- •15.8 Instrumentation
- •15.8.1 Tonsillectomy
- •15.8.2 Adenoidectomy
- •15.9 Postoperative Management
- •15.9.1 Pain
- •15.9.2 Diet
- •15.9.3 Follow-Up
- •15.10 Expected Outcomes by Population
- •15.10.1 General Population
- •15.10.2 Complex Children
- •15.10.2.1 Obese Children
- •15.10.2.2 Down Syndrome
- •15.10.2.3 Craniofacial Syndromes
- •15.10.2.4 Synchronous Airway Lesion
- •15.11.3 Cardiovascular Parameters
- •15.13 Conclusion
- •References
- •Further Reading
- •16.1 Introduction
- •16.3.1 Anatomic Factors
- •16.8 Summary
- •References
- •17: Palatal Surgery for OSA Patients
- •17.1 Introduction
- •17.2.2 Nasopharyngeal Endoscopy
- •17.2.3 Cephalometrics
- •17.3.1.1 Success Rate of UPPP
- •17.3.1.2 Limitations of UPPP
- •17.3.1.3 Impact of UPPP
- •17.3.1.4 Complications of UPPP
- •17.3.2.2 Z-Palatopharyngoplasty
- •17.3.2.3 Expansion Sphincter Pharyngoplasty
- •References
- •18: Hypopharyngeal Surgery for OSA Patients
- •18.1 Introduction
- •18.2 Historical Perspective
- •18.3 Patient Selection
- •18.4 Physical Exam
- •18.5 Imaging I
- •18.5.1 Imaging
- •18.6 Drug-Induced Sedated Endoscopy
- •18.7 Treatment Algorithm
- •18.8 Procedures
- •18.8.1 Transoral Robotic Surgery
- •18.8.2 Radiofrequency Ablation (RFA)
- •18.8.3 Genioglossus Advancement
- •18.8.4 Tongue Base Suspension
- •18.8.5 Hyoid Suspension
- •18.8.7 Hypoglossal Nerve Stimulators
- •18.9 Future Directions
- •References
- •Suggested Reading
- •19.1.1 Imaging
- •19.2.1.1 Pierre Robin Sequence
- •19.2.1.2 Craniofacial Microsomia
- •19.2.2.1 Crouzon’s Syndrome
- •19.2.2.2 Apert Syndrome
- •19.2.3.1 Treacher Collins Syndrome
- •19.2.3.2 Goldenhar Syndrome
- •19.3 Surgical Correction
- •Bibliography
- •20.1 Introduction
- •20.4.2 Surgical Technique (DOME)
- •20.4.4 Consolidation Phase
- •20.6 Discussion
- •References
- •21.3.3 Maxillomandibular Setback
- •References
- •22.1 Introduction
- •22.3 Results
- •22.3.1 Success Rate
- •22.4 Cases
- •22.5 Discussion
- •22.6 Conclusion
- •References
- •23.1 Patient Evaluation
- •23.1.1 Patient Concerns
- •23.1.4 Facial Evaluation
- •23.1.5 Lateral View
- •23.1.6 Oral Examination
- •23.1.7 Periodontal Evaluation
- •23.1.8 Tongue Assessment
- •23.1.9 Temporomandibular Joint
- •23.1.10 The Nose
- •23.1.11 Oropharyngeal Airway Assessment
- •23.2 Radiographic Evaluation
- •23.2.2 Lateral Cephalometric Radiograph
- •23.2.5 Cephalometric Analysis
- •23.3 Dental Model Analysis
- •23.3.1 Arch Length Measurements
- •23.3.2 Tooth Size Analysis
- •23.3.3 Tooth Position
- •23.3.4 Arch Width Analysis
- •23.3.6 Cuspid-Molar Position
- •23.3.7 Tooth Arch Symmetry
- •23.3.10 Ankylosed Teeth
- •23.4 Summary
- •References
- •24.1 TMJ Articular Disc Displacement
- •24.3 Reactive Arthritis (ReA)
- •24.5 Trauma
- •24.6 TMJ Ankylosis
- •24.7 Other End-Stage TMJ Conditions
- •24.8 Summary
- •References
- •25.1 Background
- •25.2 Treatment Planning Maxillary Surgery
- •25.2.1 Bone Anatomy
- •25.2.2 Vascular Anatomy
- •25.5 Adjunct Procedures
- •25.6 Complications
- •References
- •26: Mandibular Surgical Procedures
- •26.1 Genioplasty Procedures
- •26.2 Osseous Genioplasty
- •26.2.1 Anteroposterior Augmentation
- •26.2.2 Surgical Procedure
- •26.2.3 Anteroposterior Reduction
- •26.2.4 Vertical Augmentation (Downgraft)
- •26.2.5 Vertical Reduction
- •26.3 Alloplastic Augmentations
- •26.3.1 Surgical Procedure
- •26.4 Genioplasty Complications
- •26.5 Mandibular Subapical Procedures
- •26.5.3 Possible Complications
- •26.6 Mandibular Body Surgery
- •26.7.1 Nonunion or Malunion
- •26.7.3 Infections
- •26.7.4 Periodontal Defects
- •26.7.5 Nerve Damage
- •26.8 Mandibular Ramus Surgery
- •26.9 Vertical Ramus Osteotomy
- •26.11.1 Early Relapse
- •26.11.2 Condylar Sag
- •26.11.4 Unfavorable Splits or Fractures
- •26.11.6 Periodontal Defects
- •26.11.8 Nerve Injury
- •26.11.9 Infections
- •26.11.10 Nonunion
- •26.11.11 Bleeding Problems
- •References
- •27.1 Occlusal Plane Alteration
- •27.1.1 History
- •27.2 Corrected Frankfort Horizontal Plane
- •27.3 High Occlusal Plane (HOP) Facial Type
- •27.3.6 MRI Evaluation
- •27.3.7 TMJ Disc Displacement
- •27.3.9 Reactive Arthritis
- •27.3.11 Other End-Stage TMJ Pathologies
- •27.6 Summary
- •References
- •28: Maxillomandibular Advancement
- •28.1.1 Symptoms
- •28.1.3.1 Noninvasive Treatments
- •28.1.3.2 Surgical Interventions
- •28.4.1 Preoperative Medical Assessment
- •28.5 Procedure
- •28.5.1.2 Plates Vs. Screws
- •28.7 Post-MMA Follow-Up Care
- •28.8 Conclusion
- •References
- •29.2.1 CASS Adoption Widespread
- •29.2.2 Overall CASS Accuracy
- •29.2.2.1 Soft-Tissue Prediction Simulators
- •29.2.3 Cost
- •29.4.1 Overall CASS Process
- •29.4.1.1 Step 1: Patient Referral
- •29.4.1.7 Step 7: Procedure
- •29.4.4 Case 3
- •29.5 Conclusion
- •References
- •30.1 Introduction
- •30.2 Preoperative Considerations
- •30.2.1 Surgical Facility
- •30.2.2 Medical Clearance
- •30.2.3 Anesthesia Considerations
- •30.3 Inpatient Postoperative Management
- •30.3.1 Immediate Postoperative Course
- •30.3.2 Acute Pain Management
- •30.3.5 DVT Prophylaxis
- •30.3.6 Nutrition
- •30.3.7 Antibiotics
- •30.4.1 Follow-Up Regimen
- •30.4.2 Postoperative Occlusal Guidance
- •30.5 Conclusion
- •References
- •31.1 Paradigm
- •31.2 Preoperative
- •31.3 Acute Post-surgical
- •31.4 Long-Term Post-surgical
- •References

24
372
L. Wolford
. Fig. 24.11 A low-grade ReA may actually cause bone deposition
around the condyle and fossa (white arrows), with slow destruction
of the articular disc (green arrow). ReA that stimulates bone deposition can result in bony ankylosis
resorption; and articular disc may be in position but
surrounded by a pannus (reactive tissue) that eventually
destroys the disc but also is the cause of condylar and
articular eminence resorption (. Fig. 24.12). In more
severe cases, particularly in JIA patients, the condylar
stump may function forward beneath the remaining
articular eminence.
fascia and muscle aps, dermal grafts, rib grafts, sternoclavicular grafts, and vertical sliding ramus osteotomy.
However, the disease process that created the original
TMJ pathology can attack the autogenous tissues used
in the TMJ reconstruction causing failure of the grafts.
Performing orthognathic surgery only for MMA with or
without CCWR will have a high failure rate relative to
skeletal and occlusal stability, pain, and maintenance of
the oropharyngeal airway.
24.5 Trauma
Traumatic injuries to the mandible may create facial
deformities leading to OSA, particularly involving
untreated displaced bilateral or unilateral subcondylar fractures. Patients may present with: (1) mandible
retruded with deviation toward the affected side if
unilateral; (2) pain and jaw dysfunction; (3) decient
growth on the affected side(s) in growing patients; (4)
Class II skeletal and occlusal relationships with anterior open bite; and (5) unilateral cases, premature contact of the posterior occlusion on the affected side with
anterior and contralateral open bite. Imaging features
could include the following: (1) evidence of subcondylar
fractures; (2) condyles malpositioned downward, forward, and medial to the fossa; and (3) decreased vertical
ramus/condyle length.
MRI will also show the disc position and condition.
The disc may be displaced with the condyle, or the disc
can remain in the fossa with only the condyle displaced
(.
Fig.24.13).
24.4.1 Implications fortheOSA Patient
The most predictable treatment for OSA patients with
the TMJs affected by CT/AI diseases includes the following: (1) bilateral reconstruction of the TMJs and
CCWR and advancement of the mandible with customtted total joint prostheses (. Fig. 24.8); (2) coronoidectomies if the ramus is signicantly advanced or
vertically lengthened with the prostheses; (3) autogenous fat graft harvested form the abdomen or buttock,
packed around the prosthesis in the articulation area
[76–79]; (4) maxillary osteotomies for advancement with
CCWR; and (5) additional adjunctive procedures indicated (i.e., genioplasty, rhinoplasty, turbinectomies, and
septoplasty) [8, 34–59]. Other techniques that have been
advocated for TMJ reconstruction for this patient population include using autogenous tissues such as temporal
24.5.1 Implications fortheOSA Patient
At the initial presentation of the trauma, the options
for treating subcondylar fractures are open reduction,
closed reduction, or no treatment. The amount of displacement and the condition of the fracture(s) will dictate the necessary treatment to x the problem. When
identied early, fractures may be best treated by open
reduction for signicantly displaced segments or closed
reduction for minimally displaced segments to achieve
a symmetric face and stable occlusion. If the condyle
is minimally to moderately displaced, still salvageable
along with its articular disc but already healed, then it is
possible that orthognathic surgery could realign the jaw
structures properly, and if the disc is displaced, it can be
repositioned with a Mitek anchor (.
Fig.24.2) [24–33].

MRI Evaluation forPatients withTMJ Disorders andObstructive Sleep Apnea
373
24
a
c
b
. Fig. 24.12 a Sagittal view of the joint with JIA. There is signi-
cant loss of the vertical height of the condyle and commonly “mushrooming” (increased AP dimension of the residual condyle). The
articular disc is commonly in position but surrounded by a reactive
pannus (thin gray tissue surrounding the disc). b This is the same
image but with the mushroomed condylar head and disc outlined.
The gray tissue surrounding the disc is responsible for destruction of
the joint. Notice also that the articular eminence has signicantly
resorbed as well. c Coronal views show the signicant condylar
resorption and transverse narrowness of the residual condylar elements classic with JIA

24
ab
374
L. Wolford
. Fig. 24.13 a Sagittal view of a left mandibular subcondylar frac-
ture with the condyle displaced anteromedial to the ramus. The articular disc (green arrows) is anteriorly displaced relative to the fossa
but posteriorly displaced relative to the condylar head. C condyle, E
If the condyle is severely deformed and nonsalvageable,
then the most predictable method for reconstruction
of the TMJ is using custom-tted total joint prostheses (. Fig.24.8) [8, 34–59], TMJ fat grafts [76–79], and
repositioning of the mandible, if there is an associated
mandibular malalignment. Other treatment options for
TMJ reconstruction following removal of the displaced
condyles are rib grafts, sternoclavicular grafts, vertical
ramus osteotomies, etc., but these outcomes are far less
predictable.
OSA patients that have subcondylar fractures with
malunion and malalignment and a retruded mandible
will have the best outcome predictability with TMJ
reconstruction and mandibular advancement with
custom- tted total joint prostheses and MMA with
CCWR if also indicated.
articular eminence, F fossa. b Coronal view illustrates the medial displacement of the condylar head c. The disc (green arrows) is laterally
displaced relative to the condylar head
radiographic characteristics of TMJ ankylosis, particularly when occurring in children, include the following:
(1) decreased jaw mobility and function; (2) decreased
growth on the involved side(s); (3) retruded mandible;
(4) facial asymmetry if unilateral involvement with the
mandible shifted toward the ipsilateral side; (5) Class
II occlusion; (6) radiographic evidence of heterotopic
bone around the TMJ(s); (7) decreased vertical height
of the ramus and posterior maxilla; and (8) decreased
oropharyngeal airway [80].
MRI may demonstrate evidence of brous or bony
ankylosis between the condyle and the fossa or heterotopic bone surrounding the joint (. Fig.24.14) appearing as a dense black mass. In the early stages of the
process, the disc may be identiable with or without displacement and there may be evidence of inammation
particularly when the etiology is related to an inammatory or infectious process. Areas of calcication and
24.6 TMJ Ankylosis
osteophytes may be seen. As the disease progressed, the
disc and joint space may not be visualized.
TMJ bony ankylosis can occur bilateral or unilateral,
usually develops as a result of trauma, inammation,
sepsis, and/or systemic diseases, resulting in severely lim-
24.6.1 Implications fortheOSA Patient
ited jaw function as well as oral hygiene and nutritional
problems. When this condition occurs during the growing
years, it can severely affect jaw growth and development
as well as contribute to OSA.In unilateral ankylosis, the
other condyle will continue to grow but may be retarded
in its true growth potential. The common clinical and
The most predictable treatment for the OSA patient
with ankylosis includes the following: (1) release of the
ankylosed joint, condylectomy, removal of the heterotopic and reactive bone with thorough debridement of
the TMJ and adjacent areas; (2) coronoidectomies if the

MRI Evaluation forPatients withTMJ Disorders andObstructive Sleep Apnea
375
24
a
c
b
. Fig. 24.14 a MRI sagittal view of TMJ ankylosis. “C” identies
the condylar head. The bony mass outlined by the green arrows surrounds the condyle. AC auditory canal. b Coronal view shows bony
continuity of the condyle and fossa. c Sagittal view of another case
ramus is signicantly advanced or vertically lengthened
with the prosthesis, or if coronoid hyperplasia developed
which is a risk, particularly with ankylosis at an early
age; (3) reconstruct the TMJs and advance the mandible
with a custom-tted total joint prosthesis (. Fig.24.8);
(4) autogenous fat graft (harvested from the abdomen
or buttock) packed around the prosthesis in the TMJ
articulation area; (5) maxillary osteotomies for MMA
with CCWR; and (6) adjunctive procedures indicated
with a large dense bony mass surrounding the condyle associated
with ankylosing spondylitis. The condyle is not identiable. AC auditory canal
such as genioplasty, turbinectomies, nasoseptoplasty,
and rhinoplasty [80–83].
Other techniques that have been advocated for
reconstruction of TMJ ankylosis include using autogenous tissues such as temporal fascia and muscle aps,
dermis- fat grafts, rib grafts, sternoclavicular grafts, vertical sliding osteotomy, and gap arthroplasty. The total
joint prosthesis with a fat graft packed around it is a
superior technique.

376
L. Wolford
24
24.7 Other End-Stage TMJ Conditions
Other TMJ end-stage conditions that can contribute to
OSA include (1) congenital deformities (i.e., hemifacial
microsomia, Treacher-Collins syndrome); (2) multiply
operated joints; (3) failed TMJ alloplastic implants; and
(4) failed autogenous tissue used for TMJ reconstruction.
MRI evaluation of these conditions may not be particularly helpful for diagnosis and treatment planning
as signicant distortion and interference may render
the MRI unreadable and nondiagnostic. CBCT and CT
scans would be the imaging of choice for initial evaluation of these conditions.
OSA patients with these TMJ pathologies may benet
from TMJ reconstruction and mandibular advancement
with custom-tted total joint prosthesis (. Fig. 24.8),
placement of fat grafts around the articulating part of
the prostheses, as well as concomitant maxillary osteotomies for MMA with CCWR, and other indicated
adjunctive procedures to achieve the best outcome
results relative to function, stability, esthetics, and elimination of pain.
Studies show good outcomes with these treatment
protocols. However, the quality of results decreases as
the number of previous TMJ surgeries increases, particularly in reference to pain relief and jaw function. When
the TMJ concepts total joint prostheses system is used
as the rst or second TMJ surgery, the success rate is
very good relative to jaw function, stability, facial balance, and pain relief. After two or more previous TMJ
surgeries, the decrease or elimination of pain and jaw
function is far less predictable [8, 34–59, 76–87].
24.8 Summary
Healthy and stable TMJs are necessary for quality treatment outcomes in orthognathic surgery for the OSA
patients. If TMJ pathology is preexisting, orthognathic
surgery results may be unsatisfactory relative to function, esthetics, skeletal, and occlusal stability as well as
pain. The oral and maxillofacial surgeon should be suspicious of possible TMJ problems in the OSA patient
with the following conditions: (1) Class II high occlusal
plane angle facial morphology with retruded mandible;
(2) progressively worsening Class II occlusal and jaw
relationship; (3) facial asymmetry, particularly with progressive worsening; (4) anterior open bite and/or lateral
open bite; (5) patients reporting headaches, TMJ pain,
myofascial pain, history of clicking and popping of the
TMJs, and/or ear symptoms; and (6) history of CT/AI
diseases, other joint problems, facial trauma, etc. The
surgeon should not ignore these symptoms. With one or
more of these symptoms, OSA patients should be evaluated for possible TMJ pathology. An MRI of the TMJs
can aid in the identication of the specic TMJ pathology and progression of the disease process and indicate
the surgical procedures necessary to maximize the treatment outcomes. Failure to recognize and treat these conditions can result in signicant relapse, increased pain,
decrease of the oropharyngeal airway, and a greater
complexity of subsequent treatment.
During the past three decades, major advancements
have been made in TMJ diagnostics and the development of surgical procedures to treat and rehabilitate the
pathological, dysfunctional, and painful TMJ.Research
has clearly demonstrated that TMJ and orthognathic
surgery can be safely and predictably performed at the
same operation, but it does necessitate the correct diagnosis and treatment plan, as well as requires the surgeon to have expertise in both TMJ and orthognathic
surgery. The surgical procedures can be separated into
two or more surgical stages, but the TMJ surgery should
be done rst. With the correct diagnosis and treatment plan, combined TMJ and orthognathic surgical
approaches provide complete and comprehensive management of OSA patients with coexisting TMJ pathology and dentofacial deformities.
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381
Maxillary Surgical Procedures
forCorrection ofObstructive
Sleep Apnea
WillR.Allen andMattJ.Madsen
Contents
25.1 Background – 382
25.2 Treatment Planning Maxillary Surgery – 382
25.2.1 Bone Anatomy – 383
25.2.2 Vascular Anatomy – 383
25.3 Lefort IOsteotomy Including Modications – 384
25
25.4 Surgically Assisted Rapid Palatal Expansion (SARPE) – 388
25.5 Adjunct Procedures – 389
25.6 Complications – 390
References – 391
© Springer Nature Switzerland AG 2021
K. B. Kim et al. (eds.), Management of Obstructive Sleep Apnea, https://doi.org/10.1007/978-3-030-54146-0_25

382
W. R. Allen and M. J. Madsen
25
25.1 Background
Obstructive sleep apnea (OSA) is a sleep disorder that
affects approximately 5–15% of the adult general population [1]. It is characterized by repetitive intermittent
complete or partial breathing obstruction during sleep
due to collapse of the airway. This interrupted respiration affects sleep pattern due to continuous arousals
which often leads to daytime sleepiness and contribute
to a host of medical comorbidities. These obstructions
lead to decreased oxygen saturation and increased partial pressure of blood CO2 levels. This affects patient
well-being and has been documented to be associated
with a host of medical comorbidities including hypertension [2–6], cardiovascular disease [4], heart failure
[4–6] metabolic syndrome [3, 4, 6], and stroke [5, 6].
Obstructive sleep apnea is commonly observed in
patients with obesity [6], large neck circumference, male
sex, maxillary or mandibular deciency [7, 8], long
upper airway length [8–13], narrow nasal passage [14],
maxillary constriction [14], and a narrow pharynx [15].
A more detailed discussion of the anatomy, physical
ndings, and diagnosis is described in detail elsewhere in
this text.
First-line treatment for OSA is nonsurgical medical
management with continuous positive airway pressure
(CPAP). This treatment modality is poorly tolerated by
some patients which necessitates other avenues including surgical intervention. Patients with a Respiratory
Disturbance Index (RDI) of greater than 20 episodes
per hour, oxygen saturation less than 90%, hypertension,
arrhythmia, anatomical abnormalities of the upper airway, or failure of medical management are candidates
for surgical intervention.
Surgical management has traditionally been divided
into two phases. Phase 1 focuses on correction of aberrant nasal, palatal, tongue, and septum anatomy.
Therapy includes nasal septoplasty, turbinectomy,
tongue advancement, palate reduction including UPPP,
and hyoid myotomy. Phase 2 therapy includes skeletal
correction, most often in the form of maxillomandibular advancement.
For patients with failed surgical intervention via
phase 1 therapies or nonsurgical therapy, maxillomandibular advancement (MMA) often with counterclockwise rotation of the mandible has become the surgery of
choice. This surgery consists of advancing the maxilla
with a LeFort I osteotomy and the mandible with a
bilateral sagittal split osteotomy of the mandible (BSSO)
as much as 10 millimeters. Often, surgical correction
involves rotating the occlusal plane in a counterclockwise (CCW) fashion. MMA results in a decrease in lateral pharyngeal wall tension, which is a determinate
factor in increasing the airway size which improves a
patient’s apnea hypopnea index (AHI) [16–18], O
satu-
2
ration [16, 18], and ESS score [16–18] following CCW
advancement. This CCW rotation has been shown to
improve OSA in patients by reducing the apnea hypopnea index (AHI) [7, 12, 17–24], improve Epworth
Sleepiness Scale [16, 17, 20, 21], improve oxygen saturation [7, 16, 19], increase airway diameter [11, 12, 15, 20,
25–28], decrease airway length [11, 12] which improves
clinical symptoms and overall quality of life.
Traditional approaches have focused on bimaxillary
surgery or single mandibular surgery, specically mandibular advancement to improve retrolingual airway
space. However, recent studies have sought to understand the role of improving OSA via maxillary orthognathic surgery procedures. Orthopedic procedures such
as rapid maxillary expansion (RME) [29–35] in children
and surgical assisted rapid palatal expansion (SARPE)
[14, 36–39] or segmental Lefort surgery in adults demonstrate improvements in OSA. The mechanism by
which AHI is improved is likely due to widening of the
nasal oor which widens the nasal cavity [29, 30, 33].
This decreases the nasal resistance to airow reducing
obligate mouth breathing which has been shown to be a
contributing factor to abnormal dentofacial development [40]. Additionally, a pathologically constricted
maxillary arch does not allow for a normal tongue posture contributing to a posterior and inferior tongue
position [41]. Normalizing maxillary arch width and
increasing the horizontal dimension of the dentoalveolar framework, allows the tongue enough space within
the dentoalveolar process. This new tongue posture
improves pharyngeal airway [35] and even improves the
airway dimension in the lower airway near the epiglottis
[14]. In addition to tongue position, correction and widening of the skeletal landmarks, the surrounding soft
tissue anatomy of the airway responds in kind. Maxillary
advancement pulls the velum and velopharyngeal muscles forward which results in less tension [7, 19, 27].
The greatest perceived benet to maxillomandibular
advancement or advancement of the maxilla or mandible in single jaw surgery is to decrease airway resistance.
As described in Pouiseuilles’s law, ∆P=8μLQ/πr4 where
P is pressure difference at ends of the airway, L=length
airway, Q=volume of air which passes per given time,
μ= dynamic viscosity, r = airway radius. In short, the
resistance of a tube is proportional to the fourth power
of its radius. As we surgically increase the radius of the
airway, resistance greatly decreases. This chapter will
discuss maxillary procedures for the OSA patient.
25.2 Treatment Planning Maxillary Surgery
Prior to surgery, an accurate and comprehensive examination should be performed to determine the patient’s
diagnosis. Clinical records for orthognathic surgery con-
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