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A. Effects of Abnormal Cerebral Perfusion

 

 

 

 

 

 

Bleeding

1

 

Paralysis

Irreversible

 

Ischemia

Dys-

 

 

damage

 

 

 

 

 

 

O2

K+

function

 

10 – 20 s

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

4 – 6 s

3 – 5 min

Disorders

 

 

ATP

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Cell death

 

 

Na+

Onset of anoxia

 

Depolarization

Ca2+

 

 

 

Cl

Glutamate

Thromboxan

 

Flow:

 

Vasoconstriction

 

Blood

H2O

 

 

Necrosis

 

Nerve cell

 

 

 

 

 

 

Brain tissue

 

Lesion of cells

 

 

 

 

 

 

 

Cerebral

 

 

 

 

 

at margin of

 

 

 

 

Inflammation

 

ischemic region

 

Cell swelling

 

 

 

Intracranial

 

 

 

 

 

 

pressure

 

10.32

B. Vascular Occlusion as Cause of Ischemia

 

 

 

 

 

 

 

 

Hemiparesis,

 

 

 

 

 

 

hemianesthesia,

 

Plate

 

 

 

 

 

apraxia,

 

 

 

 

 

 

apathy

 

 

 

 

 

 

 

 

 

 

 

Hemianesthesia,

 

 

Anterior

 

hemiparesis,

 

 

cerebral a.

 

conjugate deviation,

 

Internal

 

 

visual field defect,

 

Medial

 

aphasia, apraxia,

 

carotis a.

 

 

cerebral a.

 

hemineglect

 

 

 

 

Posterior

Anterior

Basal ganglia

Hypokinesia

 

communi-

Internal capsule

Hemiparesis

 

cating a.

choroid a.

Optic tract

Hemianopsia

 

 

 

 

 

Posterior

Thalamus

Hemianesthesia

 

 

cerebral a.

 

 

 

 

 

 

Hemianopsia

 

a.

Branches

III, VII, XII,

 

 

Basilar

 

 

of basilar a.

Parkinson’s dis., hemiparesis

 

 

 

 

Mid-brain

V, VI, VII, hypacusis, ataxia,

 

 

 

nystagmus, Horner’s syndrome

 

 

 

Tetraplegia,

 

 

 

Pons

pseudobulbar paralysis

 

 

V, X,

 

 

 

 

 

 

 

 

nystagmus, Horner’s syndrome,

 

 

 

hemiataxia, hiccough,

 

 

 

hemianästhesia, ageusis,

 

 

 

hypakusis

 

 

 

Medulla

XII,

 

361

 

oblongata

hemiparesis, Hemihypesthesia

 

 

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme

All rights reserved. Usage subject to terms and conditions of license.

Further Reading

General Physiology

Berne RM, Levy MN. Physiology. 4th ed. St. Louis: Mosby Inc.; 1998

Despopoulos A, Silbernagl S. Color Atlas of Physiology. 4th ed. Stuttgart–New York: Thieme; 1991

Guyton AC, Hall JE. Textbook of Medical Physiology. 9th ed. Philadelphia: W.B. Saunders Company; 1996

Johnson LR. Essential Medical Physiology. 2nd ed. Philadelphia–New York: Lippincott–Rav- en Publishers; 1998

Rhoades RA, Tanner GA. Medical Physiology. Boston–New York: Little, Brown and Company; 1995

West JB. Physiological Basis of Medical Practice. 12th ed. Baltimore: Williams & Wilkins; 1990

General Pathophysiology

Bennett JC, Plum F. Cecil Textbook of Medicine. 20th ed. Philadelphia: Saunders; 1996

Cotran R, Kumar V, Robbins SL. Pathologic Basis of Disease. 5th ed. Philadelphia: Saunders; 1994

Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL. Harrison’s Principles of Internal Medicine. 14th ed. New York: McGraw-Hill; 1998 McCance KL, Huether SE. Pathophysiology, The Biologic Basis for Disease in Adults and Children. 2nd ed. St. Louis: Mosby-Year Book;

1994

McPhee SJ, Lingappa VR, Ganong WF, Lange JD. Pathophysiology of Disease, An Introduction to Clinical Medicine. 2nd ed. Stamford (Connecticut): Appleton & Lange; 1997

Single Topics of Pathophysiology

and Physiology

Cell Physiology

Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. Molecular Biology of The Cell. 3rd ed. New York: Garland; 1994

Lodish H, Baltimore D, Berk A, Zipursky SL, Matsudaira P, Darnell J. Molecular Cell Biology. 3rd ed. New York: Freeman and Company – Scientific American Books Inc.; 1995

Blood and Immunology

Kuby J. Immunology. 2nd ed. New York: Freeman and Company; 1994

Respiration and Acid–Base Balance

Crystal RG, West JB, Barnes PJ, Weibel ER. The Lung: Scientific Foundations. 2nd ed. Philadelphia: Lippincott-Raven; 1996

Halperin ML, Goldstein MB. Fluid, Electrolyte and Acid-Base Physiology. A Problem-based Approach. 2nd ed. Philadelphia: Saunders; 1994

West JB. Respiratory Physiology: The Essentials. 5th ed. Baltimore: Williams & Wilkins; 1995

Kidney and Electrolytes

Halperin ML, Goldstein MB. Fluid, Electrolyte and Acid-Base Physiology. A Problem-based Approach. 2nd ed. Philadelphia: Saunders; 1994

Seldin DW, Giebisch G (eds). The Kidney: Physiology and Pathophysiology. 2nd ed. New York: Raven Press; 1992

Massry SG, Glassock RJ. Textbook of Nephrology. Vol.1. 3rd ed. Baltimore: Williams & Wilkins; 1995

Stomach, Intestine, Liver

Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter D, Shafritz DA. The Liver, Biology and Pathobiology. 3rd ed. New York: Raven Press; 1994

362

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme

All rights reserved. Usage subject to terms and conditions of license.

Johnson LR, ed. Physiology of the Gastrointestinal Tract. Vol.1 and 2. 3rd ed. New York: Raven Press; 1994

Misiewicz JJ, Forbes A, Price AB, Shorvon PJ, Triger DR, Tytgat GNJ. Atlas of Clinical Gastroenterology. 2nd ed. St. Lewis, MO: Wolfe Publishing (Mosby Year Book Europe); 1994 Netter FH. The Ciba Collection of Medical Illustrations. Vol. 3: Digestive System, Parts

I–III. Ciba Pharmaceutical Co.; 1964 Sleisenger MH, Fordtran JS. Gastrointestinal

Disease. Vol.1 and 2. 5th ed. Philadelphia: Saunders; 1993

Heart and Circulation

Goldman MJ. Principles of Clinical Electrocardiography. 12th ed. Los Altos/Ca: Lange Medical Publications; 1986

Katz AM. Physiology of the Heart. 2nd ed. New York: Raven Press; 1992

Levine HJ. Clinical Cardiovascular Physiology. New York: Grune & Stratton; 1976

Lilly LS, ed. Pathophysiology of Heart Disease. Malvern/Pa: Lea & Febiger; 1993

Ross G. Pathophysiology of the Heart. New York: Masson Publishing USA; 1982

Schlant RC, Alexander RW. The Heart, Arteries and Veins. 8th ed. New York: McGraw-Hill; 1994

van der Werf T. Cardiovascular Pathophysiology. Oxford University Press; 1980

Hormones

Felig P, Baxter JD, Frohman LA. Endocrinology and Metabolism. 3rd ed. New York: McGraw-Hill; 1995

Greenspan FS, Strewler GJ. Basic & Clinical Endocrinology. 5th ed. Stamford (Connecticut): Appleton & Lange; 1997

Griffin JE, Ojeda SR. Textbook of Endocrine Physiology. 3rd ed. Oxford Univ. Press; 1996 Wilson JD, Foster DW. Williams Textbook of Endocrinology. 9th ed. Philadelphia: Saun-

ders; 1998

Neuromuscular and Sensory System

Adams RD, Victor M. Principles of Neurology. 6th ed. New York: McGraw-Hill; 1997

Frazer A, Molinoff PB, Winokur A. Biological Basis of Brain Function and Disease. 2nd ed. New York: Raven Press 1993

Kandel ER, Schwartz JH, Jessell TM, eds. Principles of Neural Science. 3rd ed. Stamford (Connecticut): Appleton & Lange; 1992

Kaplan IH, Sadock BJ (eds). Comprehensive Textbook of Psychiatry. Vol.1. 6th ed. (30th anniversary). Baltimore:Williams&Wilkins; 1995

Rosenberg RN, Prusiner SB (ed), Dimauro S, Barchi RL. The Molecular and Genetic Basis of Neurological Disease. 2nd ed. Boston: Butterworth-Heinemann; 1997

Pathobiochemistry

Scriver C, Beaudet AL, Sly W, Valle D (eds). The Metabolic and Molecular Basis of Inherited Disease. Vol.1 – 3. 7th ed. New York: McGraw-Hill; 1995

Pathology, Anatomy and Histology

Cotran R, Kumar V, Robbins SL. Pathologic Basis of Disease. 5th ed. Philadelphia: Saunders; 1994

Frick H, Leonhardt H, Starck D. Human Anatomy 2, Vol.1 and 2. Stuttgart–New York: Thieme; 1991

Kahle W, Leonhardt H, Platzer W. Color Atlas/ Text of Human Anatomy, Locomotor System, Vol.1–3. 4th ed. Stuttgart–New York: Thieme; 1992

Williams PL, Warwick R, Dyson M, Bannister LH. Gray’s Anatomy. 37th ed. New York: Churchill Livingstone; 1989

Pharmacology

Goodman LS, Gilman A (eds). The Pharmaco-

logical Basis of Therapeutics. 9th ed. New

York: McGraw-Hill; 1996

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme

All rights reserved. Usage subject to terms and conditions of license.

References

363

Medical Dictionaries

Smith AD, Datta SP, Howard Smith G, Campbell PN, Bentley R, McKenzie HA. Oxford Dictionary of Biochemistry and Molecular Biology. Oxford: Oxford University Press; 1997

References

Journals

Annual Review of Physiology. Annual Review Inc. Palo Alto, California/USA

Nature Medicine. Nature America Inc., New York/USA

Nature. Macmillan Magazines, London/UK NIPS (News in Physiological Sciences). Schultz

SG, ed. Houston, Texas/USA

Physiological Reviews. The American Physiological Society, Bethesda, Maryland/USA Reviews of Physiology, Biochemistry and Pharmacology. Springer Verlag: Berlin – Heidel-

berg – New York

Science. American Association for the Advancement of Science, New York/USA

364

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme

All rights reserved. Usage subject to terms and conditions of license.

Index (Including Abbreviations)

 

A

acetylsalicylic acid, 20

acute respiratory failure,

 

 

 

 

hemostasis, 64

232

 

 

 

eicosanoids, 296

acute-phase proteins, 50

 

A1, A2 receptors, 6, 216

pancreatitis, 158

acute-phase response, 20,

 

a wave, electroretino-

ACh (receptors)

48, 50

 

 

gramm, 324

see acetylcholine

acyl-CoA-cholesterol-acyl

 

a wave, central venous

achalasia, 138

transferase, 246

 

 

pressure, 198, 202

achlorhydria, 38

Adams-Stokes attack, 188

 

ABCR (ATP-binding carrier),

gastritis, 142

adaptation, 4

 

 

retina, 324

malabsorption, 152

ADDC (antibody dependent

 

abducens nerve, 358ff

achromatopsia, 326

cell-mediated cyto-

 

abetalipoproteinemia,

acid aminoaciduria, 96

toxicity), 52

 

154, 247

acid base metabolism

Addiction, 354f

 

abnormal distribution, 76

see acidosis, alkalosis

Addison’s disease, 266, 270f

 

ABO blood group mis-

acid lipase, 244

circulatory shock, 230

 

 

matches, hemostasis, 64

acidosis (see as well H+), 88ff

adenine phosphoribosyl

 

ABO incompatibility, 52

Addison’s disease, 270

transferase, 250

 

abortion, 56, 296

cardiac rhythm, 188

adenoma, 256, 262

 

ABP (androgen binding

circulatory shock, 232

adenosine deaminase, 58

 

 

protein), 272

coronary heart

adenosine, acute renal

 

abscess

disease, 220

failure, 108

 

 

tissue repair, 50f

diarrhea, 150

coronary circulation,

 

 

brain, 338, 342, 358

hyperthermia, 22

216, 220

 

 

pancreatitis, 160

hypoxia, 84

peptic ulcer, 144

 

absences, 338

kidney, 106, 110

signal transmission, 6

 

absorption, gastro-

liver failure, 174

adenylcyclase, acidosis, 90

 

 

intestinal, 134

phosphate, 130

calcium, 128

 

ACAT (Acyl-CoA-Cholesterin-

potassium, 124

opiate receptor, 354

 

 

Acyltransferase), 164, 246

tumors, 16

signal transmission, 6f

 

ACE inhibitors, 210

ventilation, 66ff, 82

ADH (antidiuretic hormone),

 

acenocumarol, 64

acinar cells, 158, 162

260f

 

acetaldehyde, 172

acohol dehydrogenase, 354

adrenocortical hor-

 

acetaldehyde dehydrogenase,

acquired immunodeficiency

mones, 266, 270

 

 

addiction, 354

syndrome see AIDS

circulatory shock,

 

acetic acid, diabetes

acromegaly, 262f, 286

226, 232

 

 

mellitus, 288

ACTH, 264 ff

fever, 20

 

acetone see ketone bodies

diabetes mellitus, 286

hepatorenal syndrome,

 

acetylcholine, 332f

hypertension, 212

118

 

 

breathing regulation, 82

signal transmission, 6

hypothalamus, 334

 

 

cholelithiasis, 166

actin-myosin, 224

magnesium, 126

 

 

coronary circulation, 216

action potential, heart, 180ff,

nephritis, 106

 

 

esophagus, 136ff

188, 126

nephrotic syndrome, 104

 

 

neuromuscular

action potential,

renal hypertension, 114

 

 

transmission, 304

nerves, 302ff

signal transmission, 6f

 

 

peptic ulcer, 144

activin, 274

urinary concentra-

 

 

signal transmission, 6f

acute myeloid leukemia, 30

tion, 98ff

 

acetylcholinesterase,

acute pancreatitis

urolithiasis, 120

 

300, 304

see pancreatitis

vomiting, 140

 

acetyl-CoA-cholesterol-

acute renal failure, 108f,

water balance, 122

365

 

acetyl transferase, 164

230ff, 250

adhesion, 156

 

 

 

 

 

 

 

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme

All rights reserved. Usage subject to terms and conditions of license.

ad

am

Index

366

adhesion molecules,

AIDS (aquired immune

alexia, 326

atherosclerosis, 238

deficiency syndrome), 58

alkaline phosphatase, 132

eicosanoids, 296

AIDS, gastritis, 142

alkalosis (see as well

inflammation, 48ff

malabsorption, 154

H+), 86ff

tumors, 16

AIDS-related complex, 58

breathing regulation, 82

adiposity see obesity

ailment, 320

calcium, 128

adiuretin see ADH

airways, 76, 80, 90

Cushing’s disease, 268

ADP, 60, 64, 216

akanthocytes, 168

hypoxia, 84

adrenal medulla

akinesia (see Parkinson’s

insulin, 288

(see autonomic nervous

disease), 312f

liver failure, 174

system) 332f

heart, 222

nephrotic syndrome, 104

adrenaline see epinephrine

akinetopsia, 326

phosphate, 130

adrenals, 266ff, 332f

ALA (see aminolevulinate)

potassium, 124

lipoprotein, 246

alanine-glyoxylate amino-

sleep disorders, 340

adrenergic

transferase, 242

vomiting, 140

see (nor)epinephrine

albumin, copper, 252

alkaptonuria, 242

adrenocortical hormones,

edemas, 234

allergens, 45, 48, 52

266ff, 342 (see cortisol,

hypothyroidism, 284

allergies, 52ff

aldosterone, testosterone)

nephrotic syndrome, 104

circulatory shock, 230

adrenocortical insufficiency,

alcohol (ism), addiction, 354

gastrointestinal tract, 134

270

cerebellum, 316

histamine, 294

adrenogenital syndrome,

consciousness, 342

allodynia, 320

264f, 274

EEG, 336

allopurinol, 168

hypertension, 210ff

epilepsy, 338

Alport’s syndrome, 242

adult respiratory distress

esophagus, 138

altitude, 82, 86

syndrome, 232

gastritis, 142

coronary heart disease,

advanced glycation end

gout, 250

218

products, 290f,

hypoglycemia, 292

pulmonary hypertension,

322ff, 348

liver failure, 168ff, 252

214

adventitia, 238

magnesium balance, 126

aluminium, 130ff

adynamia, 124

malabsorption, 154

alveoli, 66ff

affinity, renal transport, 94ff

memory, 346

alveolitis, 54

afibrinogenemia, 62

motor unit, 306

Alzheimer’s disease, 54ff

afterpotentials, 226

olfaction, 330

apotic cell death, 12

agammaglobulinemia, 58

pain, 320

memory, 346

aganglionosis, 156

pancreatitis, 158ff

olfaction, 330

AGE see advanced glycation

peptic ulcer, 146

amacrine cells, 324

end products

phosphate balance, 130

Amadori, 290

age-1, 18

tissue repair, 51

Amanita phalloides, 168

ageusia, 330, 360

vomiting, 140

amaurosis, 326

aggrecan, 172

aldosereductase, 290

amenorrhea, 276f

aggressiveness

aldosterone (see mineral-

androgens, 272

androgen, 272

corticoids), 266f

Cushing’s disease, 268

aging, 18f

alkalosis, 86

obesity, 26

atherosclerosis, 236

Bartter’s syndrome, 98

prolactin, 260

deafness, 328

circulatory shock, 232

somatotropin, 262

dementia, 348

diabetes mellitus, 288

amines, 110, 174

diabetes mellitus, 290

glomerulonephritis, 102ff

amino acids, 242f

emphysema, 78

hepatorenal syndrome,

cerebellum, 316

hyperthermia, 24

118

diabetes mellitus, 290

olfaction, 330

hypertension, 210ff

gastrointestinal tract,

somatotropin, 262

pregnancy, 116

134, 154

agnosia, 326

signal transmission, 7

hepatorenal syndrome,

agranulocytosis, 58

taste, 330

118

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme

All rights reserved. Usage subject to terms and conditions of license.

hormones, 258

androstenedione, 264,

prolactin, 260

insulin, 288, 292

274, 278

signal transmission, 6f

liver failure, 174

anemia, 30ff, 40

angiotensinogen, 114, 268

renal excretion, 94ff,

Addison’s disease, 270

angiotrophic mediators, 324

110, 116

blood pressure, 206

anhidrosis, 360

somatotropin, 262

cobalamine, 34

anion exchangers, 96

aminoaciduria, renal

coronary heart dis-

anismus, 156

excretion, 94ff

ease, 218

ankle edema, 234

γ-aminobutyrate see GABA

diffusion abnormalities, 70

ankylosing spondylitis, 56

γ-aminobutyric acid see

gastrectomy, 148

ankyrin, 40

GABA

heme synthesis, 254

anlage, 274

α-amino-β-ketoadipate,

hypothyroidism, 284

anopsia, 326

heme synthesis, 254

hypoxia, 84

anorectal inhibitory reflexes

aminolevulinate, 254

icterus, 168

constipation, 156

aminolevulinate syn-

malabsorption, 154

anorexia nervosa, 26, 334

thase, 254

portal hypertension, 170

anosmia, 330

aminolevulinatedehydro-

renal disease, 102, 110

anoxia see hypoxia

genase, 254

tumors, 16

ANP see atriopeptin

δ-aminolevulinic acid,

anergy, 45, 56

antacids, 146, 150

36, 254

anesthesia, 342f

anterior cerebral artery, 360

aminopterin, 34

anemias, 36

anterior commissure, 342

ammonia, 92, 174, 342

sensory system, 318

anterior pituitary, 350

amnesia, 346ff

pain, 320

anterior temporal lobes, 348

amniotic fluid, 64

stroke, 360

anterolateral tract, 318

AMP, 250

anesthetics, neuromuscular

antibiotics, deafness, 328

AMPA receptor, 338

transmission, 304

gastritis, 142

amphetamines, 312, 350ff

anesthetics, taste, 330

malabsorption, 154

amplitude, blood pressure,

aneurysm, 212, 238f, 360

peptic ulcer, 146

206

ANF (atrial natriuretic factor)

antibodies, 48ff

amygdala, 330, 346

see atriopeptin

Cushing’s disease, 268

amylase, 152

angina pectoris, 218ff

female sex hormones, 274

α-amylase, 134

aortic stenosis, 198

gastrointestinal tract, 134

β-amyloid precursor, 348

aortic regurgitation, 200

neuromuscular trans-

amyloidosis, 102, 170

coronary heart disease, 218

mission, 304

amyotrophic lateral sclerosis,

mitral regurgitation, 196

tumors, 16

12, 306

somatotropin, 262

antibody-dependent cell-

anabolics, 274

vasculitis, 240

mediated cytotoxicity, 52

anaemia see anemia

angiogenesis, 16

anticoagulants, 64

anaerobic glycolysis,

angioneurotic edema, 294

anticonvulsives, 342

30, 88, 216

angioplasty, 220

antidiuresis, 100f, 122

tumor cells, 16

angiostatin, 16

Antidiuretic Hormone

anal fissure, 156

angiotensin (I, II), 122f

see ADH

analgesia, 320

acute renal failure, 108

antigen-presenting

analgesic asthma, 296

adrenocortical hormones,

cells, 44ff

analgesics, 354

266ff

antigens, 42ff

anaphase, 2

antidiuretic hormone, 260

gastrointestinal tract, 134

anaphylactic shock, 52, 230

Bartter’s syndrome, 98

obstructive lung disease,

anaphylaxins, 50

circulatory shock, 232

76

anaphylaxis, 52f, 234

edemas, 234

antigravity muscles, 310

Andersen, 244

glomerular disease, 102ff

antimineralocorticoid, 276

androgen (see testosterone),

hepatorenal syndrome,

anti-Müller hormone, 278

272f

118

α2-antiplasmin, 62

androgen-binding protein,

hypertension, 208ff

antipsychotics, 314

272

pregnancy, 116

antipyretics, 20

am

an

Index

367

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme

All rights reserved. Usage subject to terms and conditions of license.

an

at

Index

368

antithrombin III, 60, 220

ARC see AIDS related complex

asphyxia, 294

α1-antitrypsin, 60, 78, 174

arcuate fasciculus, 344

aspiration, 140

antrum, 148, 160

arcuate nucleus, 26

aspirin, 146, 296

anuria, 108f, 158

ARDS (acute respiratory

association tracts, 318

anxiety, 340, 346

distress syndrome), 232

associations, 352

aorta, aneurysm, 64,

area 22, aphasias, 344

astereognosis, 318

230, 238

area 28, memory, 346

asthma, 52f

atherosclerosis, 236ff

area 39, aphasias, 344

distribution ab-

cardiac cycle, 178

area 40, aphasias, 344

normalities, 72

circulatory shunts, 204

area 44, aphasias, 344

eicosanoids, 296

hypertension, 212

area postrema, 140, 356

heart failure, 226

aortic coarctation, 114, 210

area preoptica, 20

obstructivelung disease,76

aortic regurgitation, 200f

areflexia, 310

pulmonary hypertension,

aortic stenosis, 198f,

arginine, 86, 88, 96

214

218, 222

arrectores pilorum, 332

signal transmission, 6

AP-1, 7

arrhythmia, 186f

astigmatism, 322

apathy, 22, 174, 360

aortic stenosis, 198

astrocytes, 356

APC see antigen

Ca2+, 128

asynthesia, 326

presenting cells

circulatory shock, 230

asystole, 24, 186ff

aphagia, 334

coronary heart disease,

ataxia, 318

aphasias, 344f

220, 222

Alzheimer’s disease, 348

aphemia, 344

heart failure, 226

cerebellum, 316

apheresis, 247

hemochromatoses, 252

multiple sclerosis, 302

aphthous ulcers, 154

hyperthermia, 22ff

atelectasis, 74

aplasia, 4, 256

magnesium balance, 126

distribution ab-

aplastic anemia, 12, 30ff

arterioles, hypertension, 208

normalities, 72

apnea, 24, 340

arteriosclerosis

hyperoxia, 84

Apo a (lipoprotein), 236

see atherosclerosis

tumors, 16

Apo-1 see CD 95 (FAS/Apo-1)

arteriovenous fistulae, 204

atheroma see atherosclerosis

ApoA, lipoprotein, 246

arteriovenous O2 differ-

atherosclerosis, 236ff

ApoB, lipoprotein, 238, 246f

ence, 70, 84, 194, 216

aneurysm, 238

ApoC, lipoprotein, 247

arteriovenous shunt, 66

aortic regurgitation, 200

ApoE, lipoprotein, 246f, 348

arthritis, aortic regurgi-

constipation, 156

apolipoproteins, 246f,

tation, 200

coronary heart disease,

236, 348

chronic renal failure, 110

216ff

apomorphine, 140

gout, 250

Cushing’s disease, 268

apoptosis, 12ff

phosphate balance, 130

estrogens, 276

acidosis, 90

arthrosis deformans, 262

glomeruli, 102

immune defense, 45

Arthus’ phenomenon, 54

hypertension, 210, 212

nerve cells, 300

ASAT (aspartate aminotrans-

hypothyroidism, 284

Parkinson’s disease, 312

ferase), 222

lipidoses, 244

hyperkinesias, 314

asbestos, 48, 74

lipoproteins, 247

apotransferrin, 38

Ascaris, 156

obesity, 26

appetite, 26, 284, 292

ascending reticular activating

Parkinson’s disease, 312

apraxia, 360

system, 340ff

athetosis, 314

APRT (adenine phosphori-

ascites, 170ff, 234

athletes, 186, 206

bosyl transferase), 250

circulatory shock, 230

atopic dermatitis, 52

aquaporins, 100, 260

esophagus, 136

atopic individual, 296

aqueduct, 356

pancreatitis, 160

ATP, coronary circulation, 216

aqueous humor, 322

pericarditis, 228

erythrocytes, 30

arachidonic acid, 7, 48, 296f

salt balance, 122

esophagus, 136

arachnoid villi, 356

ascorbic acid, 252

hemolytic anemias, 40

ARAS (ascending reticular

aspartate aminotrans-

hypoxia, 84

activating system), 340ff

ferase, 222

tissue repair, 50

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ATP-binding carrier,

hypoglycemia, 292

basal ganglia, 312f

blindness, 324

multiple sclerosis, 302

aphasias, 344

atransferrinemia, 252

myastheny, 304ff

depression, 350

atresia, 140

automatic bladder, 332

kernicterus, 356

atria, 178ff

autonomic nervous

memory, 346

antidiuretic hormone, 260

system, 332f

stroke, 360

cardiac rhythm, 186

diabetes mellitus, 290

basal metabolism, 282

circulatory shunts, 204

hypothyroidism, 284

basal nucleus of Meynert,

mitral stenosis, 194

autonomy, heart, 180

348

pericarditis, 228

AV fistula, 206

basement membrane, 102ff

right heart valve

AV node see atrioventricular

basilar artery, 360

defects, 202

node

basilar membrane, 328

salt balance, 122

AVD02 see arteriovenous

basophil granulocytes, 48

thromboembolism, 240

O2 difference

Cushing’s disease, 268

atrial fibrillation, 186f

AVP see ADH

histamine, 294

hyperthyroidism, 282

awakening, 340

peptic ulcer, 146

valve defects, 194, 202

axillary hair, 272, 276

bathmotropism, 182f, 332f

atrial flutter, 186

axon, 302, 306

bax, 12

atrial gallop, 220

axonal transport, 300

Bc12, 12ff

atrial natriuretic factor

A-β-lipoproteinemia, 247

beard, 272

see atriopeptin

 

Becker’s dystrophy, 308

atrial pressure, 198

B

Becker’s myotonia, 306

atrial septal defect, 194

behavior, 352ff

atrial tachycardia, 186

 

benzbromarone, 250

atrial natriuretic factor, 92

B cells, pancreas, 286, 292

Bernard-Soulier syn-

atriopeptin, 122f

B lymphocytes, 42ff, 58f

drome, 64

adrenocortical hormones,

B12 see vitamin B12

beta cells, 286, 292

266

B7 protein, 45

betaine, 110

chronic renal failure, 112

Babinski’s sign, 310

b-FGF, 348

circulatory shock, 232

bacteria (microorganisms),

BFU-E, 32

hypertension, 210

autoimmune diseases, 56

bicarbonate, 86ff, see HCO3

salt balance, 122

cholelithiasis, 164, 166

biglycan, 172

signal transmission, 6

circulatory shock, 230

biguanides, 154

atrioventricular node, 180

CSF, 356

bile, 134f, 164ff

atrium see atria

fever, 20

cell growth, 2

atrophy, 4

gastritis, 152

copper, 252

atropin, 82

immune defense, 42ff

cystic fibrosis, 162

auditory association

inflammation, 48ff

diarrhea, 150ff

cortex, 344

intestine, 134, 150, 156

esophagus, 138

auditory cortex, 344

liver failure, 118, 174

gastritis, 142

auscultatory gap, 206

nephritis, 106

heme synthesis, 254

autoantibodies, 52ff, 56f

obstructive lung disease,

lipoprotein, 247

autocrine, 256

76

pancreatitis, 158

autoimmune diseases,

pain, 320

thyroid hormones, 282

48, 56f

peptic ulcer, 146

vomiting, 140

adrenocortical hormones,

valve defect, 194

Wilson’s disease, 252

266

balance, 316, 330

bilharziasis, 54, 234

androgens, 272

balloon dilation, 194

bilirubin, 168ff

antidiuretic hormone, 260

barbiturates, 82, 230, 260

cholelithiasis, 164

cell death, 12

Barlow’s syndrome, 196

circulatory shock, 232

diabetes mellitus, 286

barrel chest, 76ff

CSF, 356

esophagus, 138

Bartter’s syndrome, 98f,

erythrocyte, 30

gastritis, 142

126, 296

gastrointestinal tract, 134

hyperthyroidism, 280

basal forebrain, 346

Billroth, 148

at

bi

Index

369

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All rights reserved. Usage subject to terms and conditions of license.

bi

br

Index

370

bipolar cells, 324

aortic valve defects, 198ff

tumors, 16

bipolar disorder, 350

autonomic nervous

Wilson’s disease, 252

bird fancier’s lung, 54

system, 332

bone conduction, 328

birth, 38, 204

breathing regulation, 82

bone marrow, 28ff

bisexual gonads, 278

circulatory shock, 230ff

cell growth, 2

bitemporal hemianopsia,

coronary heart disease,

immune defense, 42f, 50ff

262, 326

218ff

iron deficiency, 38

bladder, 332

edemas, 234

Lipidoses, 244

bleeding, 60ff

hepatorenal syndrome,

Botalli, 202

atherosclerosis, 238

118

botulinus toxin, 300, 304

cerebral, 310, 338,

histamine, 294

bow-legs, 132

342, 356ff

hypertension (see hyper-

BPG (bisphosphoglyc-

circulatory shock, 230ff

tension), 208ff

erate), 282, 290

erythrocyte, 32

hyperthermia, 22ff

bradycardia, 186ff

liver failure, 174

kidney, 92, 102f, 110, 114ff

aortic regurgitation, 200

malabsorption, 154

magnesium, 126

cerebral edema, 358

pancreatitis, 158

pain, 320

hyperthermia, 24

peptic ulcer, 146

pericarditis, 228

hypothyroidism, 284

portal hypertension, 170

portal hypertension, 170

obesity, 26

blind loop syndrome,

pregnancy, 116

bradykinin, 294ff

gastrectomy, 148

salt balance, 122

coronary circulation, 216

malabsorption, 152

thyroid hormones, 282ff

edemas, 234

blind sight, pupillary

blood transfusions,

hemostasis, 60

sphincter, 326

40, 52, 252

hepatorenal syn-

blind-loop syndrome

blood vessels see vasodila-

drome, 118

cobalamine, 34

tion, vasoconstriction

inflammation, 48

blindness, 322ff

blood viscosity, 208,

pain, 320

diabetes mellitus, 290

232, 290

pancreatitis, 158

stroke, 360

blood volume, 86, 176f

urinary concentration, 100

vasculitis, 240

blood brain barrier,

brain, 298ff

blister, 24

300, 356f

cell growth, 4

blood, 28ff

breathing regulation, 82

circulation, 176, 230

blood cells, 28

vomiting, 140

glycogen storage diseases,

blood clotting, 28, 60ff

bloodlettings, 252

244

bradykinin, 294

blot breathing, 82

heart failure, 226

chronic renal failure, 110

blue bloaters, 78

hemostasis, 64

diabetes mellitus, 290

body image, 318

hyperoxia, 84

liver failure, 174

body temperature

salt balance, 122

malabsorption, 154

see temperature

brain stem, 350

pain, 320

bombesin, 144

brain tumor, 16, 212

pancreatitis, 158

bone, 132f

branched-chain, amino

portal hypertension, 170

acid-base, 86ff

acids, 242

tumors, 16

aging, 18

brancher enzyme, 244

blood flow, 176ff

androgens, 272

breast-feeding, 38, 152

brain, 24, 236, 360f

calcium, 128

breathing see respiration

coronary circulation, 216

Cushing’s disease, 268

breathing regulation, 82f

kidney, 102f

eicosanoids, 296

Broca’s aphasia, 344f, 360

malabsorption, 154

female sex hormones, 276

bronchi, 76ff

peptic ulcer, 146

gout, 250

alkalosis, 90

schizophrenia, 352

kidney, 96

autonomic nervous

blood pressure, 206ff

magnesium, 126

system, 332

acidosis, 90

phosphate, 130

cystic fibrosis, 162

adrenocortical hormones,

somatotropin, 262

distribution ab-

266ff

thyroid hormones, 282ff

normalities, 72

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