Botkin’s Disease

Botkin’s disease, or so-called epidemic or infectious hepatitis, is an acute viral disease affecting hepatic cells and bile ducts.

The prominent German scientist Virchow believing it to be due to obstruction of the common bile duct with mucus during inflammatory processes in the duodenum, the disease was called catarrhal jaundice.

But in 1880 the prominent Russian scientist S. Botkin having advanced the idea of an infectious origin of this disease, proved his suggestions by such facts as the involvement in this pathologic process not only of the liver but also of the nervous system, the kidneys, the enlargement of the spleen, etc.

But it was not before 1940 that the term “Botkin’s disease” was introduced into medicine due to the efforts of the well-known physician M. Konchalovsky.

Botkin’s disease occurs in epidemic form. This disease more commonly affects children, adults as well as elderly persons suffering from it frequently too.

Botkin’s disease is known to be due to a filterable virus present in the blood, liver and found in stool and urine. The virus is infective only for man. As this virus cannot be seen under a usual microscope, it is revealed only by an electronic one. Being highly infective the virus survives in water, food, and on hands for days and weeks.

1. Выпишите из текста эквиваленты следующих значений:

1) закупорка общего желчного протока;

2) благодаря усилиям;

3) а также пожилые люди;

4) клетки печени;

5) выживают в воде и пище;

6) увеличение селезенки;

7) острое вирусное заболевание;

8) воспалительный процесс

III. Class Assignments

1. Translate the following words with the same root:

obstruction, obstruct, obstructive;

survive, survival, survivor;

suggest, suggestive, suggestion;

contribute, contribution, contributory, contributor

2. Give the words of the close meaning:

to put forward, origin, whole, at the same time, to stay alive, in a wrong way, some time later, rather old, quite easily

3. Choose the sentences with Absolute Participle Construction:

1) Gastric and duodenal ulcer having proved results from disturbances in the central nervous system, the corticovisceral theory of the pathogenesis of ulcer was developed.

2) Being followed by erosion of the affected area of the stomach, spastic contractions of vessels result in trophic disturbances of this origin.

3) The patient having survived the operation well, the danger of peritonitis was eliminated.

4. Define functions of the Infinitive. Translate the sentences:

1) The prominent Russian scientist S. Botkin was the first to advance the idea of an infectious origin of hepatitis.

2) The patient was known to have been operated on for gangrenous appendicitis a year before his admission to this hospital.

3) The physician did not expect the tissues of the spleen and gallbladder to become involved simultaneously with the liver.

4) The patient had to follow a strict diet to prevent the recurrence of the bile duct obstruction and jaundice.

5. Read the words and translate the sentences:

1) incubation

Incubation period is the time during which pathogenic microorganisms grow in the body.

2) prodromal

Prodromal period is the time when the characteristic symptoms of an infectious disease have not appeared yet, but the patient feels a general malaise.

3) parenterally

All intramuscular and intravenous injections are given parenterally, i.e. directly into the body but not orally.

4) serum

Serum is the watery fluid which remains after blood has coagulated.

6. Answer the following questions:

1) What do pathogenic microorganisms do in the human body during the period of incubation?

2) What does the term “parenterally” mean?

3) What is the watery fluid which remains after blood coagulation called?

7. 1) Read the following text. 2) Entitle it. 3) Answer the question: How does infection spread in this disease? 4) Put 10 questions to cover all the text:

Text

In hepatitis the source of virus is a sick person who may spread the infection by personal contact from the last days of the incubation period during the entire course of the disease. But the infection is particularly virulent in the prodromal period and in the first week of the disease. The patient’s blood being highly infective, even a small dose of 0.1 ml may be dangerous for a person.

In case of Virus A hepatitis infection enters the body through the mouth when eating infected food or drinking water. In case of Virus B hepatitis infection enters parenterally during transfusion of blood, plasma and serum, prophylactic vaccinations or is due to inadequately sterilized instruments.

Epidemic (Virus A) hepatitis most commonly occurs late in autumn, early in winter, or in spring. The incubation period lasts from 14 days to 50 days, but in Virus B hepatitis it is from 2 to 6-8 months.

Botkin’s disease causes inflammatory changes and degeneration of hepatic cells and damage to the bile ducts due to which bile enters the lymph flow and subsequently the blood. The tissues of the spleen, gallbladder and the nervous and endocrine systems become involved simultaneously with the liver.

IV. Home Assignments

1. Напишите известные вам сочетания слов “blood” и “heart” с другими словами (не менее 5 на каждое слово).

2. Замените вы деленное слово близким по значению:

1) In our country prophylactic vaccination is carried out against a number of infectious diseases (preventive, supportive).

2) Before making a blood transfusion the blood group is to be determined (to be obtained, to be established).

3) Jaundice may result from the impairment of the common bile duct (to be due to, to result in).

4) The pain was stated to radiate to the left arm and shoulder (to spread to, to lead to).

5) The temperature was known to have risen suddenly at the onset of the attack (to have decreased, to have elevated).

6) The incidence of this disease varies in different age groups (changes, exchanges).

3. Составьте из двух предложений одно, пользуясь данными в скобках союзами и глаголами в нужном времени:

1) The infection will not appear. (if) The instruments … adequately (to remove, to sterilize, to eliminate).

2) Certain viruses will be destroyed. (as soon as) The temperature of the substance … to 100° C (to elevate, to exclude, to support).

3) Bile will enter the lymph flow. (after) The degeneration of the hepatic cells and damage to the bile ducts … (to diminish, to support, to occur).

4. Переведите предложения, используя самостоятельный причастный оборот (письменно):

1) Так как была первая неделя гепатита, то инфекция была особенно заразна.

2) Когда была сделана срочная операция по поводу гангренозного аппендицита, у больного были сняты все болезненные симптомы.

3) Когда обильное желудочное кровотечение было остановлено, была устранена опасность для жизни больного.

5. Запомните произношение следующих слов. Найдите их перевод в правой колонке:

cholecystitis – брюшина

intrahepatic – холецистит, воспаление желчного пузыря

extrahepatic – химиотерапия

hypochondrium – лекарственная терапия

umbilical – внутрипеченочный

peritoneum – пупочный

chemotherapy – подреберная область

drug therapy – внепеченочный

6. Выучите следующие слова:

constipation (n) – запор

irritation (n) – раздражение

approximately (adv) – примерно, приблизительно

emergency (n) – неотложный случай; (a) срочный, неотложный

7. 1) Прочтите текст “Acute Cholecystitis”. 2) Найдите и переведите предложения: (а) с самостоятельным причастным оборотом; (b) со сложным подлежащим. 3) Выпишите слова с суффиксами “-ity”, “-ize”, “-ness”, “-ency”. 4) Назовите все симптомы острого холецистита. 5) Выпишите английские эквивалента следующих словосочетаний:

сильная боль, боль усиливается, у совершенно здоровых людей, тяжелое течение, чрезвычайно опасно для жизни