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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5430_Библиотеки_им_академика_М_И_Перельмана
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64
Metals in Medicine, Volume 2
-
127
the ZnO NP-based drug delivery provides synergistic cytotoxicity to cancer
128
promyelocytic leukemia HL-60 cell colonic adenocarcinoma COLO205
line.
127
cells aids in the cytotoxic action both in vitro and in vivo.
124
-
overexpressed integrin v3 receptors.
113
-
129
Porphyrin-
cells.
130
131
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Zinc Oxide Nanoformulations for Cancer Therapy
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resistance time
132
-
(MDA-MB-231).
133
134
cell lines.
135
136
2.7 ZnO NANOPARTICLES AS A CARRIER OF ANTICANCEROUS
BIOACTIVE COMPOUND
using plants and their bioactive compounds as antitumor agents to treat
agents into the ZnO NPs has gained more attention as antitumor agents.
process.
5,137,138
properties.
42,139,140
Besides, phytoconstituent-loaded ZnO NPs have been
studied against numerous cell lines (Fig. 2.6)
63,141,142
and the most established
-
death.
143–142
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Metals in Medicine, Volume 2
145
Zhang et al. investigated the root
cancer cells and discovered that the spherical-shaped EF-ZnO NPs possessed
an increased ROS production, decreased mitochondrial membrane potential,
42
cancer cell lines are
• Laurus nobilis (A549),
146
• Hibiscus sabdariffa (MCF-7, HeLa, Hep-2),
147
• Aloe vera (MCF-7, HeLa, Hep-2),
147
• Lavandula vera
148
• Melia azedarach (DU-145, Calu-6)
149
• Indigofera tinctoria (DU-145, Calu-6)
149
• Mangifera indica (A549),
150
FIGURE 2.6 Phytogenic ZnO NPs against various cell lines.
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• Rubia cordifolia L. ( MG-63 human)
151
• Costus pictus D. Don (MDA-MB-231)
152
• Abutilon indicum (MDA-MB-231),
153
• Clerodendrum infortunatum and Clerodendrum inerme
(MDA-MB-231),
153
• Morus nigra (AGS),
154
Punica granatum L (MCF-7),
155
Tamarindus indica L (MCF-7),
155
Rambutan (HepG2)
156
), seeds (Pongamia
pinnata (MCF-7),
157
Ricinus communis (MDA-MB-231)
158
plants (Sargassum (PC3),
159
Gracilaria edulis (HepG2)
160
2.8 CONCLUSION
-
-
-
as the challenges in controlling their stability, crystalline structure, and rate
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Metals in Medicine, Volume 2
CONFLICT OF INTEREST
None
ACKNOWLEDGMENTS
KEYWORDS
• zinc oxide nanoparticles
• stability
• cancer
• drug delivery
• diagnosis
• cancer
• malignancy
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