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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5430_Библиотеки_им_академика_М_И_Перельмана
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204
Metals in Medicine, Volume 2
Approach. J. Radiat. Res. Appl. Sci. 2022, 15 (4), 100473.
Biomater. Adv. 2022, 142, 213155.
Appl. Surf. Sci. 2021, 552,
149428.
Colloids Surf. B Biointerfaces 2022,
211, 112295.
Biomedicines 2022, 10
Appl. Sci. 2020, 10 (11).
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Metals in Medicine, Volume 2: Metallic Nanoparticles for Biomedical Applications.
Sonali Sundram, Rishabha Malviya, and GSN Koteswara Rao
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)
Silver and Gold Nanoparticles for Tissue
Engineering Application
ARTI A. BAGADA and PRIYA V. PATEL
Department of Pharmaceutical Sciences, Saurashtra University, Rajkot,
Gujarat, India
CHAPTER 7
ABSTRACT
mechatronics, and medical physiology to create biological constructs that
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value. Silver nanoparticles (SNPs) and gold nanoparticles (GNPs) have taken
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ibility , noncytotoxicity, consistency, high disparity , and inertness. NPs made
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Metals in Medicine, Volume 2
7.1 INTRODUCTION OF SILVER AND GOLD NANOPARTICLES
Engineering, mechatronics, and healthcare physiology are combined in
1,2
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3,4
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engineering, nanotechnology can resolve this issue.
4,5
million nanometers can be produced.
6
Nanomaterials stand out due to their ability to acquire essential chemical
and physical attributes that enhance their capabilities and increase their
7
been used in the biomedical sector,
8,9
10–12
gene delivery, photothermal cellular cell
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14,15
Further-
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17
bioink ingredients, antibacterial, and pharmacologically active agent carriers
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Silver and Gold Nanoparticles for Tissue Engineering Application
207
Metal nanoparticles (MNPs) have distinctive qualities that keep moti-
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20
21
potential and greater plane section. GNPs are large, nontoxic particles that
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compatibility and optical characteristics. Since they are easily transported
agents.
22
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ment.
23
When compared to solid silver, SNPs have distinctive biological,
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tering and optical habits patterns.
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26
In the antimicro-
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paints, cosmetics, and colloidal coating. GNPs are prime candidates to
used in biomedical applications. In numerous pharmacy applications and
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etc.
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Metals in Medicine, Volume 2
FIGURE 7.1
7.2 SILVER AND GOLD NANOPARTICLES APPLICATION IN TISSUE
ENGINEERING
demonstrated by GNPs have led to intriguing biomedical applications as
29,30
31,32
33,34
34
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Silver and Gold Nanoparticles for Tissue Engineering Application
209
FIGURE 7.2
According to one study , the human adipose-derived stem cell (ADSC) role
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meters (nm),
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ters (nm).
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36,37
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replacement.
38–40
40
41,42
43
extracellular environment and cytoplasm, upregulating osteogenic genes
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Metals in Medicine, Volume 2
45
(HA-NP), GNP, chitosan NP (CNP), chitosan hydroxyapatite NP (CHN),
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Additionally connected to GNPs amount, dimensions,
and structure is this capacity .
47,48
33
In one study, a polydopamine (PDA)-coated GNPs-based nanoprobe
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50
and, alkaline phosphatase (ALP).
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by Biocompatible ceramic-based glass and SNPs.
52
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Silver and Gold Nanoparticles for Tissue Engineering Application
211
TABLE 7.1
Types of NPs Influences on TE References
GNPs
osteoblast parent cell line in bone.
31,32
GNP-loaded
43
GNPs
nm dimensions.
33
PDA-coated GNPs-
based nanoprobe
49
Hydroxy ethyl
cellulose SNPs
50
SNPs-based hydrogel
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ylene glycol diacrylate
antibacterial properties that increase the expression
51
SNP composites-based
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tive glass ceramic.
both improved.
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17
Natural polymers
ECM, and they have excellent durability , nontoxicity, nonthrombogenic, and
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Within the type-2 connective tissue matrix comprising GNP composites,
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materials include a higher modulus, distinctive magnitude, and elevated anti-
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Metals in Medicine, Volume 2
GNPs can also be cross-linked using gelatin hydrogels that are photocurable
(Gel).
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hydrogel as per the dosing schedule.
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both injectable and conductive.
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ADSC osteogenesis.
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bioprinting incorporates autoaccumulation using biomaterials and cells to
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human dental pulp to disassociate into osteoblasts.
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Synthetic polymers such as poly(ethylene glycol), poly(lactic-co-glycolic
acid) (PLGA), poly(vinyl alcohol), poly(2-hydroxyethyl methacrylate), and
others
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have good mechanical qualities, improved environmental speci-
bioactivity.
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homogeneous distribution and a controllable concentration.
43
60
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61
According to one study, cardiac
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Silver and Gold Nanoparticles for Tissue Engineering Application
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62
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vascular connective tissue among these GNP structures can strengthen the
63–65
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microporous nanostructures.
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bacteria.
17
It has undoubtedly brought attention to the ever-increasing need
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particular application.
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lular biomolecules or the cell membrane, and the oxidative stress action by
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It has been demonstrated that SNPs, an outstanding antimicrobial agent,
negative bacterial species that are susceptible to vancomycin. In microbial
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