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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5430_Библиотеки_им_академика_М_И_Перельмана
.pdf
134
Metals in Medicine, Volume 2
brought on by released Zn
.
58
59
generated ZnO nanoparticles
plants Sonneratia apetala
than silver nanoparticles.
-
et al.
60
S. aureus
E. coli
61
4.4 DRUG DELIVERY
interactions, including ligand–receptor recognition, and hydrophobic and
62
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Zinc Oxide Nanocarriers for Therapeutic Applications
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described by Cai et al. in 2016,
63
-
have over-expressed CD44 and release the medication by rupturing the
the acidic intracellular compartments. Due to enhanced cellular absorption,
non-targeted ZnOQD-DOX.
in 2017,
64
oxide core serves as a drug storage reservoir. A549 cancer cells internal-
ROS production mediated by ZnO. Dine et al. in 2018,
65
reported employing
-
methoxy ethoxy) ethyl methacrylate (MEO2MA) serving as the shell. Here,
the drug could be contained by the polymeric shell and released in response
under heating circumstances.
For targeted cancer therapy, Yang et al. in 2019,
66
created arginine–
-
-
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a pH-responsive drug release. Chen et al. in 2020,
67
created a ZnO quantum
dots (QD) capped, pH-responsive, mesoporous silica nanoparticles (MSN)-
68,69
in 2019 and
-
-
70
-
by actively targeting the target cells or organs, it aids in drug delivery and
tissues and organs.
4.5 HEALTH RISKS OF ZNO NANOPARTICLES
Studies conducted in recent years have suggested that ZnO nanoparticles
may be used as both medicinal agents and gene carriers. Several published
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Zinc Oxide Nanocarriers for Therapeutic Applications
137
71
Zinc oxide
raised their concentration and caused lung toxicity.
72
Additionally , ZnO-NPs
causing oxidative stress that is depending on concentration.
73
74
Hong et al. in 2014,
75
76
investigated
demonstrated that exposure to ZnONPs resulted in apoptosis and oxidative
Hosseini et al. in 2019,
77
78
-
as sperm abnormalities, sperm motility, and sperm counts. Additionally,
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Metals in Medicine, Volume 2
Guo et al. in 2020,
79
Using their ability to dissolve into Zn
, ZnONPs disrupted cholinergic neuro-
by ZnONPs either by enhancing acetylcholine synthesis or transport or by
AChE activity is reduced. According to scientists, long-term inhalation
disease.
polymeric layers. Additionally, actively directing the nanoparticles to the
4.6 CONCLUSION
-
neurological system, and hematological indices can all be impacted by ZnO
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Zinc Oxide Nanocarriers for Therapeutic Applications
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-
KEYWORDS
• zinc oxide
• nanoparticles
• antidiabetic
• anticancer
• antibacterial
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