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434
Metals in Medicine, Volume 2
Nature.2013, 496 (7446), 504–507.
Lancet North Am. Ed. 2015, 385 (9966), 453–465.
BMC Syst. Biol. 2018, 12 (1),
1–3.
Schemes. J. Microbiol. Immunol. Infec. 2013, 46 (4), 271–281.
Lancet Infect. Dis. 2017, 17 (3), E70–E78.
J. Med. V ir ol.
2016, 88 (7), 1137–1151.
N. Engl. J. Med.
2019, 381 (21), 2009–2019.
J.
Infect. Dis. 2018, 217 (5), 742–753.
Nat. Biotechnol. 2006, 24 (9),
1151–1161.
Outcome and Guidelines on Statistical Analysis and Reporting. J. Natl. Cancer Inst.
2007, 99 (2), 147–157.
Breast Cancer Res.
2006, 8 (5), 1–7.
Weight Cytokeratin Expression Patterns. J. Pathol. 2001, 195 (4), 415–421.
Nat. Rev. Cancer 2001, 1 (1),
46–54.
Proc. Natl. Acad. Sci.
2003, 100 (7), 3983–398.
https://t.me/med1917
Role of Gold Nanoparticles as Novel Agents for Cancer Diagnosis and Therapy
435
Cancer Res. 2005, 65 (13),
5506–5511.
Stem Cells. Nature 2001, 414 (6859), 105–111.
Tumor Biol. 2005, 26 (4), 173–185.
Signals. Curr. Opin. Genet. Dev. 2001, 11 (1), 54–59.
Gene Expression Patterns During Carcinogenesis and Metastasis. Int. J. Cancer 2006,
119 (2), 251–263.
in Cancer. Nat. Rev. Cancer. 2004, 4 (11), 839–849.
N. Engl. J.
Med. 2006, 354 (3), 270–282.
Endocr. Relat. Cancer 2006, 13 (2), 617–628.
J. Steroid
Biochem. Mol. Biol. 2006, 102 (1–5), 89–96.
Nature 2002, 420 (6917), 860–867.
Cell Cycle
2007, 6 (16), 2010–2018.
https://t.me/med1917
https://t.me/med1917
Index
A
Anticancer activity, 261–262
blood, 131
brain, 131
breast, 127
cervical, 127
colon, 130
liver, 128
lung, 128
oral, 130–131
ovarian, 129–130
pancreatic, 132
prostate, 129
skin, 129
Anticancerous drugs, 62–63
sustain, 63
targeted, 64–65
Antidiabetic action
α-amylase, 124–125
anti-dyslipidemic, 124
antihyperglycemic, 123
anti-oxidative, 125–126
develop insulin sensitivity, 125
glucose biosensors, 123–124
α-glucosidase, 124–125
B
application
antimicrobial, 307–310
bioimaging, 302–304
cancer therapy, 298–300
drug delivery, 300–302
gene delivery, 310–312
tissue engineering, 304–306
historical perspective, 293
methods, 293–294
synthesis, 294–297
Blood brain barrier (BBB), 82
Blood iron balance, 327
hemoglobin, 336–337
liver, 333–335
macrophages, 335–336
treatment
sample selection, 342
statistical analysis, 342–343
study design, 341–342
therapy, 342
Breast cancer (BC), 102–103
C
Cancer therapy, 39
anticancerous drugs, 62–63
sustain, 63
targeted, 64–65
bioactive compound, 65–67
chemistry, 45–47
nanocomposite, 58–62
possible mechanisms, 52–55
synthesis, 48–52
treatment, 55
bio-imaging, 56–58
biosensors, 55–56
uses, 43–45
Carbon paste electrode (CPE), 108
Chemical bath deposition (CDB), 107
Chronic lymphocytic leukemia (CLL), 105
Constant potential amperometry (CPA), 108
D
Disease diagnosis, 81
https://t.me/med1917
438 Index
analytes, 105–108
cancer, 101–102
breast cancer (BC), 102–103
cervical cancer, 104
leukemia cells, 105
oral cancer, 103–104
nanoparticles, 90–91
methods, 91–94
morphology, 95–96
properties, 95
oxide, 96–98
toxicity, 108–109
compounds, 88–90
Drug delivery system (DDS), 162–164
Dynamic light scattering (DLS), 179
F
G
Gold nanoparticle, 174
application, 192–194
cancer treatment, 190–192
challenge, 194–196
drug delivery systems, 183–186
green methodologies, 175–179
optical imaging systems, 187–189
properties, 181–183
scope, 194–196
Gold nanoparticles, 393
analysis
microarray data, 415–416
string analysis, 423–429
applications, 402–404
biological techniques
biomolecule components, 397
green synthesis, 398–399
microorganism, 398
plant-based constituents, 398
cancer therapy, 408–412
chemical techniques
additional, 397
turkevich method, 396
diagnostics, 406–408
passive targeting strategies, 399
active, 401–402
targeting, 401
treatments, 405–406
Gold nanoparticles (AuNPs), 147
applications
biosensing, 152–153
diagnostics, 156
drug delivery system (DDS), 162–164
gene delivery, 161–162
therapy, 159
biosensing
colorimetric sensing, 153–154
electrochemical, 154–155
(SERS), 155–156
diagnostics
properties, 150–151
synthesis, 149–150
therapy
photoacoustic imaging (PAI), 157–158
raman imaging, 156
Gold-based nanoparticles, 1
applications, 3
drug delivery, 4–7
photodynamic, 12–15
photothermal therapy, 7–12
https://t.me/med1917
Index 439
biocompatibility, 24–25
toxicity, 25–27
synthesis
biological, 22–24
chemical, 20–22
physical methods, 17–20
H
Human cells
ex vivo studies, 356–357
in vivo studies, 357–358
I
applications, 251–252
biological
biocompatibility, 245–246
delivery, 247
targeting, 246–247
bone tissue, 255–257
bottom–up
biological, 266–268
chemical synthesis, 265–266
cardiac tissue, 252–253
characteristics, 241
delivery
drug, 247
gene, 247
protein, 248
(LSPR)
spectroscop, 242–243
medicinal properties, 242
methods
bottom–up, 265
neural tissue, 253–255
physicochemical
high atomic number, 245
(LSPR), 242
radioactivity, 245
pros and cons, 274
silver nanoparticle
antibacterial property, 260–261
anticancer, 261–262
applications, 269
biomedical, 272–273
bone engineering, 269–270
characteristics, 259
mechanism, 260
methods, 262–263
optical, 262
K
(KEGG), 416
L
Labile iron pool (LIP), 331
(LSPR), 242
242–243
M
Metallic nanoparticles, 237
applications, 251–252
biological
biocompatibility, 245–246
delivery, 247
targeting, 246–247
bone tissue, 255–257
bottom–up
biological, 266–268
chemical synthesis, 265–266
cardiac tissue, 252–253
characteristics, 241
delivery
drug, 247
gene, 247
protein, 248
(LSPR)
https://t.me/med1917
440 Index
spectroscop, 242–243
medicinal properties, 242
methods
neural tissue, 253–255
physicochemical
high atomic number, 245
(LSPR), 242
radioactivity, 245
pros and cons, 274
silver nanoparticle
antibacterial property, 260–261
anticancer, 261–262
applications, 269
biomedical, 272–273
bone engineering, 269–270
characteristics, 259
mechanism, 260
methods, 262–263
optical, 262
106
N
hydrogen (NADH), 331
P
Palladium nanoparticles (Pd-NPs), 351
animal cells, 355
antitumor therapy, 364
clinical trials, 363–364
human cells
ex vivo studies, 356–357
in vivo studies, 357–358
models, 358–359
complex nanocarriers, 361–363
compounds, 360–361
plant models, 353–354
possible, 353
in vitro studies, 354–355
Peptide nucleic acid (PNA), 105
Photoacoustic imaging (PAI), 157–158
372
applications, 374
chemotherapy, 378–379
combined, 376–377
hydrogen therapy, 381–382
immunotherapy, 380–381
palladium, 374
prodrug activation, 382–383
radiotherapy, 379–380
preparation, 373
Polyethylene glycol (PEG), 84
Printed circuit boards (PCB), 107
R
Reactive oxygen species (ROS), 394
analysis
microarray data, 415–416
string analysis, 423–429
applications, 402–404
biological techniques
biomolecule components, 397
green synthesis, 398–399
microorganism, 398
plant-based constituents, 398
cancer therapy, 408–412
chemical techniques
additional, 397
turkevich method, 396
diagnostics, 406–408
passive targeting strategies, 399
active, 401–402
https://t.me/med1917
Index 441
targeting, 401
treatments, 405–406
S
Scanning electron microscopy (SEM), 93
Screen printed carbon electrode (SPCE), 179
Silver nanoparticle, 174
antibacterial property, 260–261
anticancer, 261–262
application, 192–194
applications, 269
biomedical, 272–273
bone engineering, 269–270
cancer treatment, 190–192
challenge, 194–196
characteristics, 259
drug delivery systems, 183–186
green methodologies, 175–179
mechanism, 260
methods, 262–263
optical, 262
optical imaging systems, 187–189
properties, 181–183
scope, 194–196
Single-photon emission computed
(SERS), 155–156
T
anticancer activity
blood, 131
brain, 131
breast, 127
cervical, 127
colon, 130
liver, 128
lung, 128
oral, 130–131
ovarian, 129–130
pancreatic, 132
prostate, 129
skin, 129
antidiabetic action
α-amylase, 124–125
anti-dyslipidemic, 124
antihyperglycemic, 123
anti-oxidative, 125–126
develop insulin sensitivity, 125
glucose biosensors, 123–124
α-glucosidase, 124–125
drug delivery, 134–136
health risks, 136–138
mechanism, 120–121
nanocarriers
antibacterial action, 132–133
anticancer activity, 126
bioimaging, 132
application
antimicrobial, 213–216
bimolecular detection, 218–220
electric properties, 212–213
stimulation, 216–217
bimolecular detection
electrical, 221–222
electrochemical, 222–223
optical, 220–221
challenges, 223
179
U
projection (UMAP), 421
V
photoacoustic imaging (PAI), 157–158
raman imaging, 156
https://t.me/med1917
442 Index
W
X
Z
Zinc, 85–86
compounds, 88–90
Zinc oxide nanoparticles (ZNO NP), 43
https://t.me/med1917
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