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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5430_Библиотеки_им_академика_М_И_Перельмана
.pdf
374
Metals in Medicine, Volume 2
12.3 APPLICATIONS OF PALLADIUM IN PHOTOTHERMAL
THERAPY OF CANCER
27,28
medicine.
12
and stability, Pd collora,
29
Pd-Ag,
30
PdAu,
31
PdPt,
32
and Pd-SiO
2
33
-
dium NPs,
34
Pd-PPy-NPs,
35
Pd-RGD peptide NPs,
36
NS,
37
38
Due to their exceptional photothermal characteristics, Pd-based NMs are
-
-
NMs have strong catalytic activity and can assist in the development or
https://t.me/med1917
Utilization of Palladium in Photothermal Therapy of Cancer
375
39
-
40
It is notable
synthetic approaches.
41,42
throughout the past 20 years.
43
-
absorption.
44
-
28
Pd-NSs
-
3
29
Pd corolla demonstrates
-
cellular absorption,
33
30–32
45
Pd-GSH exhibits extended blood
27,46
https://t.me/med1917
376
Metals in Medicine, Volume 2
-
tured.
31
Pd-Au-PEG has demonstrated comparatively prolonged blood circulation
cm
2
47
-
48
-
-
34
applications.
35
-
36
Pd-COS-RGD NPs
chitosan oligosaccharide (COS), and the concentration in the tumor location
that adding H
2
-
2
) to
49
https://t.me/med1917
Utilization of Palladium in Photothermal Therapy of Cancer
377
2
2
depletion
50
2
in situ
treat tumor hypoxia.
51
Based on Pd-Pt nanoplates,
32
a PSs Pd-Pt nanosystem (Pd-Pt-PEG-Ce
6
6
.
Additionally, Pd-Pt nanoplates might cause endogenous hydrogen peroxide
(H
2
O
2
2
2
concentra-
6
2
Pd-Ag-mSiO
2
-Ce
6
NPs.
52
2
-Ce
6
6
53
6
-
cancer impact.
38
6
(Pd-Ce
6
treatment, by improving their singlet oxygen (1O
2
) production and photo-
thermal conversion.
-
pores.
54
by H-Pd nanostructures. Strangely, H-Pd-NSs may yield PSs that resemble
1O
2
H
2
O
2
to produce O
2
2
. As a result,
-
combining Pd and indocyanine green (ICG) to generate Pd-Cs-HSA-ICG.
55
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378
Metals in Medicine, Volume 2
-
chemotherapeutic agents. Numerous studies have suggested that the syner-
56,57
-
58
coupled through common amide coupling processes to create a versatile
nanocomposite (Pd-Au-PEG-Pt).
59
In cancer cells, physiological reductants
hydrophilic and cytotoxic Pt (II). Due to the substantial tumor accumulation,
-
2012.
60
combined cancer treatment have also been described.
61
Additionally, nano-
62
63
Both
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Utilization of Palladium in Photothermal Therapy of Cancer
379
37
chemotherapy, Wu and colleagues most recently created a Pd-NSs hydrogel
64
rheumatoid arthritis, a chronic condition brought on by an autoimmune
-
65
Additionally, it may be possible
-
radiosensitive.
66
-
67,68
2
concentra-
2
import and endogenous O
2
generation have
69
among them as a prospective contender because it can reduce tumor hypoxia
https://t.me/med1917
380
Metals in Medicine, Volume 2
70
O
2
2
O
2
. More
-
robust X-ray absorption, and large tumor accumulation. For combination
investigated.
71
Pd-NSs has been reported.
72,73
131
I
By enhancing the host immune system, cancer immunotherapy has created
-
been investigated, such as immune checkpoint blockade treatment, chimeric
cytokine therapy .
74
-
antitumor immunity to prevent tumor spread or recurrence.
75
some encouraging outcomes.
54,76
Combining immunoadjuvants, immune
77
immunoadjuvant CpG oligodeoxynucleotides.
78
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Utilization of Palladium in Photothermal Therapy of Cancer
381
-
therapy.
2
) can be used therapeutically as a viable cancer
therapy technique in clinical practice.
79
redox activities or cell signaling processes, H
2
can selectively hunt ROS,
particularly hydroxide (•OH) and nitrite peroxide (ONOO
) radicals.
80
H
2
membranes in contrast to chemotherapy medicines. H
2
2
2
H
2
2
in H
2
2
2
are crucial.
2
admin-
istration and regulated H
2
microenvironment or external laser irradiation are both made possible by
2
2
into
as H
2
81
x
x
improves the PdH
x
activity in the NIR range, enabling their use in biological
2
,
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382
Metals in Medicine, Volume 2
82
2
released H
2
can control the excessive ROS levels in normal cells. PdH0.2
H
2
6
, He et. al.,
high H
2
2
release capability
and strong tumor targeting behavior.
83
Despite the
-
84
85
catalysis.
86
87
Pro-5-FU and F-Pd NWs
implanted intratumorally, the palladium devices might trigger the release
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Utilization of Palladium in Photothermal Therapy of Cancer
383
88
Addition-
89
-
panobinostat.
12.4 CONCLUSION AND FUTURE CHALLENGES
domains among these innovative NMs. Pd-based NMs are superior and very
-
thermal parameters and biocompatibility. As previously indicated, Pd-based
NMs, such as Pd-Au, Pd-NP, Pd-NS, and Pd-Pt NSs, have undergone
-
microenvironment and hence increase anticancer actions seems exciting.
microscopic lesions.
https://t.me/med1917
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