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254
Metals in Medicine, Volume 2


         





      

75,76

         -
       
        






77,78


        
       

       
           
        


          

79,80,81
Several morpho-
          


•         


• 
https://t.me/med1917
Impact of Metallic Nanoparticles for Tissue Engineering and Regenerative Medicine
255
• 
      

•       


• 
       

      

       
       


-

are better suited to encourage axon elongation.
82


 

impact on several bodily metabolic processes that either directly or indirectly

reactivity, translocation into cells, biocompatibility, medical imaging capa-


83


in side a porous degradable matrix that acts as an ECM.
      

• Serve as osteogenesis stimuli.
• A bacterial-killing impact.
• 
-

https://t.me/med1917
256
Metals in Medicine, Volume 2
 
       
          
       


an interconnected porosity structure, and acceptable mechanical properties,
  
     


-

      
   

84–86


       
-

      
     
          
87

-
       


76
        


-

and have a positive impact on both osteogenesis and angiogenesis. Si ions


   

https://t.me/med1917
Impact of Metallic Nanoparticles for Tissue Engineering and Regenerative Medicine
257
bone repair and regeneration in clinical settings.
88,89
It is also observed
          



demonstrated.
90,91

Wound healing is still a hotly debated topic in modern medicine given the
   -
         
    

-
     
clinical concern.
92,93

• 
• 
• 
-
        
       
       
94
Due
 -
      
therapy.
95,96
           
       
         
   
      

    
97
For instance,
E. coli
      
 
   
https://t.me/med1917
258
Metals in Medicine, Volume 2

Candida albicans

98,99
     

  
   


       


100,101

Ag are represented in Figure 8.4.
FIGURE 8.4 
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8.3 SILVER NANOPARTICLES

FIGURE 8.5 
https://t.me/med1917
260
Metals in Medicine, Volume 2


Due to uses in biomedicine, AgNPs are receiving more and more attention.


         
        

are largely dependent on their physicochemical qualities. As a result, AgNP
       
      

• 
• 
• XPS - X-ray photoelectron spectroscopy
• DLS - Dynamic light scattering
• 
• SEM - Scanning electron microscopy
• 
• 
• 
     
    


are key components in determining their cytotoxicity .
102–104
AgNPs have been

    
AgNPs have biological and medicinal uses such as antimicrobial, antibiotic,
     


      


         
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       
or positive and methicillin-resistant methicillin-resistant Staphylococcus
aureus (MRSA) strains by the silver nanocrystalline chlorhexidine (AgCHX)
complex.
104,105






antibacterial clothing, and implantable devices coatings.
106
  
    
       
    -
        
in bacterial proteins, disrupt their metabolic response, and cause cell death.
According to Gurunathan et al.,
108
probiotics, AgNPs, or AgNP mixtures
      -
organisms such as Pseudomonas aeruginosa, Shigella flexneri, S. aureus,
and Streptococci. When compared to either AgNPs or antimicrobials alone,

-




          
     
  
       
      
traditional chemotherapy, and nanotechnology may hold the key.
109,110



   

decreased metabolic activity , and cell viability , and enhanced oxidative stress
that resulted in DNA damage by damaging the mitochondria and producing
https://t.me/med1917
262
Metals in Medicine, Volume 2
        

104,111
According to a




arrested cells, apoptosis is induced.
112–114

    


     
  -
     



inorganic, and polymer materials, to enhance the optical properties.
115,116




       
117
  

-


2
O
2
concentration could be made

         

         
biological applications like optical labeling.
118,119

          
         
https://t.me/med1917
Impact of Metallic Nanoparticles for Tissue Engineering and Regenerative Medicine
263
techniques, including physical, chemical, and biological ones, have been
        
methods that combine chemical, physical, and biological techniques (Fig.
   
 
        


 
120




the precursor salt.
121
FIGURE 8.6 

          
      
 

        
        
https://t.me/med1917