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Metals in Medicine, Volume 2
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Metals in Medicine, Volume 2: Metallic Nanoparticles for Biomedical Applications.
Sonali Sundram, Rishabha Malviya, and GSN Koteswara Rao
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)
Green Synthesis of Gold Nanoparticles
and Their Biomedical Applications
ANNIKA DURVE GUPTA
1
and SONALI ZANKAR PATIL
2
1
Department of Biotechnology, B. K. Birla College (Autonomous), Kalyan,
Maharashtra, India
2
Department of Bioanalytical Sciences, B. K. Birla College (Autonomous),
Kalyan, Maharashtra, India
CHAPTER 5
ABSTRACT
produced during chemical synthesis, biogenic gold nanoparticles are
biomedical applications like biosensing, bioimaging, cancer therapy, and
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Metals in Medicine, Volume 2
biomedical research applications.
5.1 INTRODUCTION
develop and are the most developed technology, include nanoparticles. Due
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tions, including nanospheres, nanorods, nanocubes, nanobipyramids,
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1
antibodies,
2
and proteins
3
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systems.
4
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and redox behavior, resulting in audible signals.
5,6
7
and targeting
agents
8
).
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Green Synthesis of Gold Nanoparticles and Their Biomedical Applications
149
FIGURE 5.1
5.2 SYNTHESIS OF GOLD NANOPARTICLES
9
10
11
al.
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thiolate ligands, they may experience irreversible aggregation. In order to
aggregation
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15
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Metals in Medicine, Volume 2
FIGURE 5.2
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18
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made a break-
including the gold: thiol ratio, the reduction temperature, and the reaction
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In contrast to most other AuNPs, these alkanethiol-
5.3 PROPERTIES OF GOLD NANOPARTICLES
19
related to
20
AuNPs are an essential tool in bionanotech-
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Green Synthesis of Gold Nanoparticles and Their Biomedical Applications
151
500 and 550 nm.
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inter-particle plasmons.
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TABLE 5.1
Properties Application area
Colorimetric sensing
and photothermal therapy
Redox activity
Electrochemical sensing and electronic devices
Sensing and imaging
Fluorescence quenching
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5.4 FUNCTIONALIZATION OF AUNPS
AuNPs (citrates, thiols, or other adsorption ligands) can be replaced by thiols
by a place ligand exchange procedure to produce mixed monolayer-protected
AuNPs.
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Metals in Medicine, Volume 2
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Additionally, place exchange procedure can produce combined
place ligand exchange. Since molecules can connect to AuNPs by a variety
31
electrostatic interac-
tions,
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hydrophobic interactions,
33
and noncovalent conjugation, it is easier
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FIGURE 5.3
5.5 APPLICATIONS OF AUNPS IN BIOMEDICAL
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compounds such as analytes, proteins, toxins, nucleotides, and saccharides
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Green Synthesis of Gold Nanoparticles and Their Biomedical Applications
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metal ions, alkali earth metal and alkaline ions, and molecules such as small
organic molecules, oligonucleotides, anions, and proteins.
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promoted as potential colorimetric sensor options.
37
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numerous experiments to date.
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disease diagnosis and treatment because they serve as diagnostic markers.
Using a colormetric method, the produced compound is used to selectively
determine glucose.
39
Based on H2O2-induced AuNP association via cascade
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Fn-AuNPs to accomplish this. According to Nirala et al.
40
the constructed
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A colorimetric sensor can be used
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