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Metals in Medicine, Volume 2
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Metals in Medicine, Volume 2: Metallic Nanoparticles for Biomedical Applications.
Sonali Sundram, Rishabha Malviya, and GSN Koteswara Rao
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)
Zinc Oxide Nanocarriers for Therapeutic
Applications
DINESH KUMAR SHARMA
1
, GURUDUTTA PATTNAIK
1
,
SRIKANTA MOHARANA
2
, and AMULYARATNA BEHERA
1
1
School of Pharmacy and Life Sciences, Centurion University of
Technology and Management, Odisha, India
2
School of Applied Sciences, Centurion University of Technology and
Management, Odisha, India
CHAPTER 4
ABSTRACT
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hormone levels, and the neurological and lymphatic systems. Based on
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Metals in Medicine, Volume 2
4.1 INTRODUCTION
using them in various domains around us.
1
Nanoparticles (NPs) can be made
metal NPs (like Ag and Au NPs), metal oxide NPs (ZnO), carbon NPs,
substances, synthetic NPs exhibit unique physicochemical characteristics
2
E. coli, Streptococcus,
and Staphylococcus.
3
in many important body organs, including the brain, muscles, and bones.
4
It
in the body.
5
metabolism, protein digestion, and blood coagulation. Same as elemental Zn,
damage.
6
uses in tissue engineering, drug delivery systems (DDSs), and bioimaging, as
4.2 MECHANISM OF ACTION OF ZNO-NPS
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Zinc Oxide Nanocarriers for Therapeutic Applications
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7
ZnO nanoparticles are mostly
used in biomedicine due to their capability to produce ROS (reactive
cells is exceeded.
8
semiconductor characteristics. For crystalline ZnO, the band gap, or space,
-
and hydroxyl
radicals.
7,9
initiating redox-cycling cascades.
10
necrosis and apoptosis.
11,12
ROS-induced DNA damage triggers the apopto-
13
As a result, apoptosomes are created,
14
Apoptosis and cell death result
11,14
4.3 THERAPEUTIC APPLICATIONS OF ZNO NANOCARRIERS
-
(Fig. 4.1).
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Metals in Medicine, Volume 2
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tivity, glucose disposal, and Zn status.
15
Wahba et al.
16
as evidenced by improvements in ultrastructural and structural characteristics
16
them in other investigations.
17,18
FIGURE 4.2
FIGURE 4.1
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Zinc Oxide Nanocarriers for Therapeutic Applications
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in blood glucose levels.
19
ZnO-NPs may be able to increase glucose tolerance
character in maintaining blood glucose homeostasis. Although the underlying
the damage, like a decrease in pancreatic islet cell quantity and organ density.
20
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21
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