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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5430_Библиотеки_им_академика_М_И_Перельмана
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Contributors
V eronica A.
Research, Mysuru, Karnataka, India
V etcher A. A.
Shreyas Adiga
Usha Adiga
Anushka Agrawal
Research, Mysuru, Karnataka, India
Shishonin A. Y .
Erdi Can Aytar
Gasparuan B. A.
Arti A. Bagada
Kanthesh M. Basalingappa
Research, Mysuru, Karnataka, India
Amulyaratna Behera
Odisha, India
Roja Rani Budha
Alper Durmaz
Poovi Ganesan
Mrunal R. Genge
https://t.me/med1917
xii Contributors
Annika Durve Gupta
Gobianand K.
İbrahimMizanKahyaoğlu
SelcanKarakuş
Shah Alam Khan
Sathish Kumar Konidala
Zhukov K. V.
Rishabha Malviya
Uttar Pradesh, India
Dhanalekshmi Unnikrishnan Meenakshi
Srikanta Moharana
Wanis Nafo
South Korea
Selvasudha Nandakumar
Bharath Singh Padya
Priya V. Patel
Tanishka C. Patil
Sonali Zankar Patil
Gurudutta Pattnaik
India
Kiran D. Pawar
https://t.me/med1917
Contributors xiii
Mythreyi R.
Research, Mysuru, Karnataka, India
Tirthal Rai
GSN Koteswara Rao
Lekshmi Salim
Dinesh Kumar Sharma
Odisha, India
Rishav Sharma
Noida, Uttar Pradesh, India
Joseph Pushpa Sweety
Desy T . M.
Mangalore, India
Gopenath T . S.
Mysuru, Karnataka, India
https://t.me/med1917
Abbreviations
AgNPs silver nanoparticles
AgO silver oxide
Al
2
O
3
aluminum oxide
ALP alkaline phosphatase
BMP-2 bone morphogenetic protein 2
CDDP cis-diamminedichlo-platinum
CeO2 selenium oxide
CLEM correlative light and electron microscopy
Co cobalt
CP calcium phosphate
CSNCPs core-shell nanocomposites
CuO copper oxide
DNA deoxyribonucleic acid
DOX doxorubicin
ECL electro-chemilumeinescenc
ECM extracellular matrix
EIS electro-chemical impedance spectroscopy
GO graphene oxide
GOx glucose oxidase
HA hydroxyapatite
HDPE high density polyethylene
HRP horseradish peroxidase
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xvi Abbreviations
ICG inert gas condensation
Lox lactate oxidase
Mg magnesium
MgO magnesium Oxide
MRI magnetic resonance imaging
NaOH sodium hydroxide
Nb niobium
NiO nickel oxide
NK natural killer
Nm nanometer
NP nanoparticle
ORR oxygen releasing reactions
Pd palladium
PdNP palladium nanoparticle
PEC photoelectron-chemical chemistry
PEG polyethylene glycol
PLGA poly(l-lactide-co-glycolide acid)
Pt platinum
PtNP platinum nanoparticle
QDs quantum dots
ROS reactive oxygen species
ssDNA single-stranded DNA
2
titanium oxide
ZrO
2
https://t.me/med1917
Foreword
drugs, the recent trend in drug discovery can be applied to the development
-
modern biological and medical research. Metals in Medicine Volumes 1 and
2
metallurgical engineering, chemistry, pharmaceutical sciences, and drug
—Prof. Roop Krishen Khar
Director, B. S. Anangpuria Educational Institutes
Ballabgarh Sohna Road, Alampur, Faridabad, India
Director, Formulators Koncept Pvt. Ltd.
Director, Unicure India Ltd.
Former Dean & HOD, Jamia Hamdard, New Delhi, India
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Preface
Metal in Medicine, Volume 1,-
Metals in Medicine, Volume 2: Metallic Nanoparticles for Biomedical Appli-
cations
students in medicinal inorganic chemistry , bioinor ganic chemistry, biochem-
istry, pharmacology, biophysics, biology, and bioengineering. It serves as a
chemistry, medicinal chemistry, and drug discovery.
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Metals in Medicine, Volume 2: Metallic Nanoparticles for Biomedical Applications.
Sonali Sundram, Rishabha Malviya, and GSN Koteswara Rao
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)
Gold-based Nanoparticles and Their
Applications in Cancer Therapy
WANIS NAFO
1,2
1
Department of Mechanical System Engineering, Jeonbuk National
University, Jeonju-si, Republic of South Korea
2
School of Mathematical and Statistical Sciences, University of Galway,
Galway, Ireland
CHAPTER 1
ABSTRACT
-
ments in cancer treatment modalities (surgical intervention, radiation,
and chemotherapy). Although popular, these modalities are nonetheless
-
-
-
-
in anticancer therapy. Lastly, this chapter discusses the overall toxicity and
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2
Metals in Medicine, Volume 2
1.1 INTRODUCTION
to more than 20 million by 2040.
1,2
1,3
Although still highly debatable, errors in DNA
4,5
-
6
Nevertheless,
several treatment modalities are being improved and developed to limit the
on the tumor type, progression stage, and anatomical location. Currently, the
most common modalities are surgical intervention, chemotherapy, radiation,
7
-
triggers apoptosis, eventually causing cell death.
8
Although these modalities
-
therapeutic strategies that can replace or complement conventional therapies.
During the last decade, substantial advancements have been made in the
https://t.me/med1917
Gold-based Nanoparticles and Their Applications in Cancer Therapy
3
patterns, reduced cytotoxicity, monodispersity, and selective interactions
1
-
(EPR) mechanism:
9
vessels that have reduced lymphatic drainage, irregular epithelium, and
10
gold-based nanoparticles (AuNPs) thanks to their versatile properties and
characteristics that enable them to be used in applications related to cancer
therapy, medical imaging, biochemistry, and drugs-targeted delivery.
1
Such
characteristics include biocompatibility, and unique optical properties.
1,11,12
13
therapies, drug delivery, immunotherapy, targeted and gene therapies, thera-
14–17
Furthermore, the
in anticancer therapy. Moreover, this chapter sheds the light on the overall
legislative regulations.
1.2 CANCER THERAPY AND AUNPS MEDICINAL APPLICATIONS
-
quency ablation, and combined therapy.
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