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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_953_Библиотеки_им_академика_М_И_Перельмана.pdf
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mesh.
FIGURE12-20Vaginalwallclosedtransversely.
POSTOPERATIVEMANAGEMENT
PatientsareadmittedforobservationandmonitoringtheFoleycatheter drainagefor2days.Anormaldietmaybeimmediatelyresumed.Patients aredischargedwhenadequatelyambulatorywithoutassistanceandpain reliefisobtainedwithoralmedication.Patientsmayshower48hours aftertheoperation.
Patientsshouldadheretostrictactivity.Activitylimitationsinclude nothingpervaginaorrectumfor6weeks;seatedposition/sittingshould berestrictedto15minutesonapillowformealsfor14days.Thereisno scientificevidencetosupportthisrecommendation,butemphasizesthe needtoreduceanyforcesontheperineumandtherepairedrectovaginal septum.Theauthorencouragestheuseofthepreferredpositionduring thedayisinareclinerchairorlateraldecubituspositioningonacouch. Noexerciseorvigorousactivityisallowedfor6weeks.Examination underanesthesiaisperformed6–12weeksafterthesurgerytoassessthe statusoftherepair.

RESULTS

Pyeetal.reportedthefirstcaseofsuccessfulrepairofarecurrent rectovaginalfistulaviaatransvaginalapproachwithlayeredrepairand insertionofbioprostheticinterpositionmesh(porcineintestinal submucosa).Thefistularesultedfromtheexcisionofatumorofthe rectovaginalseptum.Fecaldiversionwasperformedwhentheinitial repairofthefistulafailed.Subsequentrepairwasperformedwith bioprostheticmeshviaatransvaginalapproach.Nearlysimultaneously, anadditionalreportgeneratedwaspublishedbyMooreetal.who reportedtheuseofbiologicmeshinsertionforaninitialrepairof rectovaginalfistulaviaatransvaginalapproach.Inthisreport,the authorsrevealedthenecessityforinnovationastheydescribetwocases whereininadequatetissuewaspresenttoachieveamultilayeredclosure. Inbothpatients,fistulasresultedfromobstetricinjuries.Thesetwo patientsunderwentprimaryrepairofthefistulaswithbiologicmesh interpositionduringlayeredrepair.Asuccessfulhealingofthefistulas resulted.Theauthorcitedapriorexperienceoftheirpracticeusing humancadavericdermalallograftmeshforrectocelerepair.
Ellisreportedaseriesofpatientsundergoingabiologicgraftinsertion fortherepairofrectovaginalfistulausingbothbiologicmeshandplugs. Themeshwasinsertedviaatransperinealapproachdissectinginthe intersphinctericplaneandrepairofthefistulainvolvedanterior levatorplasty.About27patientsunderwentrepairwithahealingrateof 81%.Theauthorreportedthatinitiallythemeshwasofferedonlyto patientswhohadhadtwopriorfailedrepairs,andinthissubsetgroupof 14patients,4recurredindicatingahealingrateof71%.Asaresultofthis experience,Ellisstatesthatpatientswerethenofferedmeshattheinitial attemptatrepairwithhealingoccurringin12of13patients(92%). Applicabilityoftheseresultstothepresentdiscussionisunclear,given thatEllis’operativeapproachwastransperinealandhistechniqueadded levatorplasty,whichverywellmaybeasignificanttechnicalfeature resultingincontributingtothishighsuccessrate.Inanycase,Ellis’ reportindicatesfewcomplicationsoccurring.
Schwandersubsequentlyreportedaseriesof21patientswithrecurrent fistulas(meanof2.3priorrepairs),whounderwentrepairwithinsertion ofporcinedermalgraftsviaatransvaginalapproach.Thecauseof rectovaginalfistulaformationinthecohortrepresentedthespectrumof potentialetiologies—Crohn’sdiseaserelated,iatrogenic,postirradiation, postobstetric,andidiopathic.Technicaldetailsincludedcomplete fistulectomy,formalendorectaladvancementflaprepair,andinsertionof thebiologicmeshinterposedbetweenthelayeredrepairs.Successful
healingoccurredin71%ofthepatients.Theauthorsreportedthat38%of patientshaddivertingstomasinplacepriortotherepair.Fourpatients experiencedcomplications—twourinaryinfections,onedehiscenceofthe rectaladvancementflap,andonepatientsufferedfromvaginal “soreness.”Dyspareuniawasnotdiscussed.
Inaseparatepublication,thesamegroupreportedonrectovaginal fistularepairinpatientsspecificallywithCrohn’sdisease.Thecohort includedpatientsundergoingeithertransvaginalbiologicmeshinsertion, orbiologicfistulapluginsertion.Inthemeshgroup,fistulassuccessfully healedin4of6(66%)patients.
Finally,aseriespublishedin2014reportedontheuseofacollagen cross-linkedmeshin12patients;10patientsunderwentinsertionviaa transperinealapproach,whereas2hadatransvaginalapproach.A healingrateof64%wasnoted.Theauthorsusedthisparticularmesh becauseoftheoreticaladvantageofgreaterdurabilityandlongerinterval todegradationasaresultofthecross-linkedcollagenfeature.The authorsfeltthatthislongerintervaltodegradationmayhaveservedthe purposeasabarrierbetweenthelayersofrepairbetterthanothermesh graftsthatdegradefaster.Again,thisstudydiffersinthat10of12 patientsunderwentatransperinealapproachasopposedtoa transvaginalapproachandtheimpactofadifferentmethodofexposure forlayeredrepairandmeshinsertionremainsunclear.
Itisdifficulttoascertaintheutilityandimpactofbioprostheticmesh ontheoutcomesoftransvaginalapproachtorectovaginalfistularepair, giventhedifferencesintechniquesandheterogeneityofthecaseseries publishedtodate.Thevariabilityofoutcomesofsurgeryforrectovaginal fistulaingeneralmakesthepotentialbenefitofrepairaugmentationwith interpositionmeshcompellingandworthyoffurtherinterestand continuedstudytodeterminetheindicationsforitspotentialuseand safetyforthisindication.Thistechniquehasyettobestudiedadequately, butthisisnotuniquetotheliteratureingeneralregardingthetopicof surgeryforrectovaginalfistula.Overall,thecurrentstatusofthe literatureformanagementofrectovaginalfistulasremainswantingasthe heterogeneityofthecondition,variationinanatomicaldefects,multitude ofcauses,andthenumerousdescribedtechniquesforrepairmakethis topicespeciallychallengingtoinvestigate.Itisarguablethatfew conditionsareingreaterneedforwell-designed,multi-institutional prospectivestudiestoprovidebetterevidenceonwhichtobaseour treatmenttoalleviatethesufferingofthisgroupofpatients.
RECOMMENDEDREFERENCESAND READINGS
AdelwoA,EllerkmannR,RosenblattP.Rectovaginalfistularepairusingadisposablebiopsy
punch.FemalePelvicMedReconstrSurg2014;20:52–55. ByrnesJN,SchmittJJ,FaustichBM,etal.Outcomesofrectovaginalfistularepair.FemalePelvic
MedReconstrSurg2017;23:124–30. CorteH,MaggioriL,TretonX,LefevreJH,FerronM,PanisY.Rectovaginalfistula:whatisthe
optimalstrategy?Ananalysisof79patientsundergoing286procedures.AnnSurg
2015;262:855–61. El-GazzazG,HullT,MignanelliE,HammelJ,GurlandB,ZutshiM.Analysisoffunctionand
predictorsoffailureinwomenundergoingrepairofCrohn’srelatedrectovaginalfistula.J
GastrointSurg2010;14:824–9. El-GazzazG,HullT,MignanelliE,ZutshiM.Obstetricandcryptoglandularrectovaginalfistulas:
long-termsurgicaloutcomes;qualityoflife;andsexualfunction.JGastrointSurg
2010;14:1758–63. EllisCN.Outcomesafterrepairofrectovaginalfistulasusingbioprosthetics.DisColonRectum
2008;51:1084–8. GazalaMA,WexnerSD.Managementofrectovaginalfistulasandpatientoutcome.ExpertRev
GastroenterolHepatol2017;11:461–71. GottgensKW,SmeetsRR,StassenLP,BeetsG,BreukinkSO.Thedisappointingqualityof
publishedstudiesonoperativetechniquesforrectovaginalfistulas:ablueprintfora
prospectivemulti-institutionalstudy.DisColonRectum2014;57:888–98. LowryAC,ThorsonAG,RothenbergerDA,GoldbergSM.Repairofsimplerectovaginalfistulas.
Influenceofpreviousrepairs.DisColonRectum1988;31:676–8. MacRaeHM,McLeodRS,CohenZ,SternH,ReznickR.Treatmentofrectovaginalfistulasthat
hasfailedpreviousrepairattempts.DisColonRectum1995;38:921–5. NarangR,HullT,PerrinsS,GarciaJS,WexnerSD.Shouldimmunomodulationtherapyalterthe
surgicalmanagementinpatientswithrectovaginalfistulaandCrohn’sdisease?DisColon
Rectum2016;59:670–6. PintoRA,PetersonTV,ShawkiS,DavilaGW,WexnerSD.Aretherepredictorsofoutcome
followingrectovaginalfistularepair.DisColonRectum2010;53:1240–7. PyeP,DadaT,DuthieG,PhillipsK.Surgisismesh:anovelapproachtorepairofarecurrent
rectovaginalfistula.DisColonRectum2004;47:1554–6. SchwanderO,FuerstA,KunstrichK,SchererR.Innovativetechniquefortheclosureof
rectovaginalfistulausingSurgisismesh.TechColoproctol2009;13:135–40.
Chapter13
RectovaginalFistula: TransvaginalApproach withoutMesh
AliceFrontaliandYvesPanis
Despitemanysurgicaloptions,managementofrectovaginalfistula(RVF) stillremainsasurgicalchallengewithahighfailurerate,whateverthe surgicaloptionchosen.
ThischapterdescribesthetreatmentofRVFbytransvaginalapproach withoutamesh.Althoughthistechniqueisnotthemostusedinthis indication,itcanbeproposedasaconservativeprocedure,asan alternativetotransanalapproach,beforemoreaggressiveoperations suchastemporarystomaandgraciloplastyareundertaken.

INDICATIONS/CONTRAINDICATIONS

Indications
RVFisadevastatingandaweakconditionthatnegativelyaffectsthe woman’squalityoflife.However,notallRVFrequireasurgical treatment.Onlysymptomaticpatientsareconsideredforsurgical treatment.Womenwithsmallfistulasandminimalsymptomsshouldbe discussed,atleastinitially,formedicaltreatmentonly.Itisparticularly trueinpatientswithRVFcomplicatingCrohn’sdiseaseforwhomsurgical treatmentcanbeworsethanmedicaltreatmentonly.Furthermore,in patientswithCrohn’sdisease,surgicaltreatmentofsymptomaticRVF shouldbediscussedonlyaftercontrolofthediseasebymedicaltherapy, includingwithanti-TNFdrugs.
Thus,thetransvaginalapproachwithoutameshcanbeproposedin symptomaticpatientsforwhomaminorlocaltreatmentisdiscussed.In ourexperience,aswellasinmanyothercenters,this“minor”local
treatmentcanbeeitherthroughatransvaginalapproachwithoutmeshor throughanalternativesuchastransanalflaprepair.Ifitfails,the authors’policyistoproposeasecondstepwithsimilarminorlocal treatmentbutassociatedwithatemporarystoma.Ifthisrepeatattempt withdiversionfails,amoreaggressiveproceduresuchasatransperineal approachwithgracilismuscleorMartiusflapinterpositionisdiscussed.
ContraindicationsofMinorLocalTreatmentSuchas TransvaginalApproach
ActiveCrohn’sdiseasewithpersistentrectalmucosainflammation RVFcomplicatingpelvicmalignancy Radiation-inducedRVF Severefecalincontinenceforwhichadefinitivestomaisprobablythe
bestoption HighRVFforwhichanabdominalapproachforrepairisthebestoption.
PREOPERATIVEPLANNING
Afterclinicalexamination,confirmingtheexistenceofanRVFlocatedon thelowerpartofthevaginaandtherectum,forwhichatransvaginal repairispossibleandindicated,preoperativeassessmentwithendoscopy and/orimagingdependsontheetiologyoftheRVF.
IncaseofpostoperativeorobstetricalRVF,forwhichnootherlesionis associated,nootherimagingisrequired.Fistulographyand/orMRIis notnecessarytoproveRVFbecauseexaminationundergeneral anesthesiaatthetimeofRVFrepairissufficient.
p.93
p.94
InpatientswithRVFcomplicatingactiveCrohn’sdisease,colonoscopy andsmallbowelevaluationisindicated.Furthermore,perianalMRIis alsoindicatedbecauseoftheriskoftheassociatedcomplexperineal fistulainpatientswithCrohn’sdisease.

SURGERY

Thepatientsreceivemechanicalbowelpreparationthedaybefore operationwithanadditionalprophylacticenemarepeatedonthe morningoftheoperation.
Duringtheoperation,followingtheguidelines,allthepatientsreceive perioperativeintravenousantibioticprophylaxis.
Therearethetwotechniquesoftransvaginalrepairwithoutmesh:
DirectRVFclosure Vaginaladvancementflap
Positioning
Allproceduresareperformedundergeneralanesthesiawiththepatient inlithotomyposition;theperineumisdraped,andthebladderis catheterized.
ThepresenceoftheRVFisconfirmedwithaninitialexaminationwith theidentificationofbothvaginalandrectalorifices,usingifnecessaryan injectionofbluemethylenethroughtheanusand/orcatheterizationwith aprobe.However,mostofthetime,theRVFiseasilyconfirmed.
Forthebestexposureofthevaginafortransvaginalrepair,weusean analdilatatorsuchasaPrattrectalspeculuminsertedintothevagina. Alternatively,astandardvaginalspeculumcanbeused.
TechniqueofDirectRVFClosure
ThetechniqueisclosetowhatwasdescribedbyBurkeetal.forpouch­vaginalfistulaafterilealpouch-analanastomosisforulcerativecolitis.
AvaginalincisionismadeattheleveloftheRVFalongthemidline longitudinalaxisoftheposteriorvaginalwall.Thevaginalwallisthen dissectedfromtherectum(Fig.13-1).Theinternalrectalopeningisthen excisedandthedefecttransverselyclosedwithinterrupted3/0Vicryl suture(Ethicon).Thevaginalwallisthenlongitudinallyclosedwith interrupted2/0Vicrylsuture.Ahemostaticgauze(Algosteril,Brothier, Nanterre,France)isplacedintothevaginafor24hours.