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- •Dedication
- •Contributors
- •Foreword
- •Preface
- •Contents
- •Indications/Contraindications
- •Surgery
- •Conclusions
- •Complications
- •Results
- •Indications/Contraindications
- •Surgery
- •Technique
- •Complications
- •Results
- •Conclusions
- •Indications
- •Contraindications
- •Conclusions
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Acknowledgments
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Indications
- •Contraindications
- •Results
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Complications
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Acknowledgments
- •Introduction
- •Indications/Contraindications
- •Surgery
- •Conclusions
- •Complications
- •Results
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Conclusions
- •Introduction
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Anatomy
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Indications/Contraindications

mesh.
FIGURE12-20Vaginalwallclosedtransversely.

POSTOPERATIVEMANAGEMENT
PatientsareadmittedforobservationandmonitoringtheFoleycatheter
drainagefor2days.Anormaldietmaybeimmediatelyresumed.Patients
aredischargedwhenadequatelyambulatorywithoutassistanceandpain
reliefisobtainedwithoralmedication.Patientsmayshower48hours
aftertheoperation.
Patientsshouldadheretostrictactivity.Activitylimitationsinclude
nothingpervaginaorrectumfor6weeks;seatedposition/sittingshould
berestrictedto15minutesonapillowformealsfor14days.Thereisno
scientificevidencetosupportthisrecommendation,butemphasizesthe
needtoreduceanyforcesontheperineumandtherepairedrectovaginal
septum.Theauthorencouragestheuseofthepreferredpositionduring
thedayisinareclinerchairorlateraldecubituspositioningonacouch.
Noexerciseorvigorousactivityisallowedfor6weeks.Examination
underanesthesiaisperformed6–12weeksafterthesurgerytoassessthe
statusoftherepair.

RESULTS
Pyeetal.reportedthefirstcaseofsuccessfulrepairofarecurrent
rectovaginalfistulaviaatransvaginalapproachwithlayeredrepairand
insertionofbioprostheticinterpositionmesh(porcineintestinal
submucosa).Thefistularesultedfromtheexcisionofatumorofthe
rectovaginalseptum.Fecaldiversionwasperformedwhentheinitial
repairofthefistulafailed.Subsequentrepairwasperformedwith
bioprostheticmeshviaatransvaginalapproach.Nearlysimultaneously,
anadditionalreportgeneratedwaspublishedbyMooreetal.who
reportedtheuseofbiologicmeshinsertionforaninitialrepairof
rectovaginalfistulaviaatransvaginalapproach.Inthisreport,the
authorsrevealedthenecessityforinnovationastheydescribetwocases
whereininadequatetissuewaspresenttoachieveamultilayeredclosure.
Inbothpatients,fistulasresultedfromobstetricinjuries.Thesetwo
patientsunderwentprimaryrepairofthefistulaswithbiologicmesh
interpositionduringlayeredrepair.Asuccessfulhealingofthefistulas
resulted.Theauthorcitedapriorexperienceoftheirpracticeusing
humancadavericdermalallograftmeshforrectocelerepair.
Ellisreportedaseriesofpatientsundergoingabiologicgraftinsertion
fortherepairofrectovaginalfistulausingbothbiologicmeshandplugs.
Themeshwasinsertedviaatransperinealapproachdissectinginthe
intersphinctericplaneandrepairofthefistulainvolvedanterior
levatorplasty.About27patientsunderwentrepairwithahealingrateof
81%.Theauthorreportedthatinitiallythemeshwasofferedonlyto
patientswhohadhadtwopriorfailedrepairs,andinthissubsetgroupof
14patients,4recurredindicatingahealingrateof71%.Asaresultofthis
experience,Ellisstatesthatpatientswerethenofferedmeshattheinitial
attemptatrepairwithhealingoccurringin12of13patients(92%).
Applicabilityoftheseresultstothepresentdiscussionisunclear,given
thatEllis’operativeapproachwastransperinealandhistechniqueadded
levatorplasty,whichverywellmaybeasignificanttechnicalfeature
resultingincontributingtothishighsuccessrate.Inanycase,Ellis’
reportindicatesfewcomplicationsoccurring.
Schwandersubsequentlyreportedaseriesof21patientswithrecurrent
fistulas(meanof2.3priorrepairs),whounderwentrepairwithinsertion
ofporcinedermalgraftsviaatransvaginalapproach.Thecauseof
rectovaginalfistulaformationinthecohortrepresentedthespectrumof
potentialetiologies—Crohn’sdiseaserelated,iatrogenic,postirradiation,
postobstetric,andidiopathic.Technicaldetailsincludedcomplete
fistulectomy,formalendorectaladvancementflaprepair,andinsertionof
thebiologicmeshinterposedbetweenthelayeredrepairs.Successful

healingoccurredin71%ofthepatients.Theauthorsreportedthat38%of
patientshaddivertingstomasinplacepriortotherepair.Fourpatients
experiencedcomplications—twourinaryinfections,onedehiscenceofthe
rectaladvancementflap,andonepatientsufferedfromvaginal
“soreness.”Dyspareuniawasnotdiscussed.
Inaseparatepublication,thesamegroupreportedonrectovaginal
fistularepairinpatientsspecificallywithCrohn’sdisease.Thecohort
includedpatientsundergoingeithertransvaginalbiologicmeshinsertion,
orbiologicfistulapluginsertion.Inthemeshgroup,fistulassuccessfully
healedin4of6(66%)patients.
Finally,aseriespublishedin2014reportedontheuseofacollagen
cross-linkedmeshin12patients;10patientsunderwentinsertionviaa
transperinealapproach,whereas2hadatransvaginalapproach.A
healingrateof64%wasnoted.Theauthorsusedthisparticularmesh
becauseoftheoreticaladvantageofgreaterdurabilityandlongerinterval
todegradationasaresultofthecross-linkedcollagenfeature.The
authorsfeltthatthislongerintervaltodegradationmayhaveservedthe
purposeasabarrierbetweenthelayersofrepairbetterthanothermesh
graftsthatdegradefaster.Again,thisstudydiffersinthat10of12
patientsunderwentatransperinealapproachasopposedtoa
transvaginalapproachandtheimpactofadifferentmethodofexposure
forlayeredrepairandmeshinsertionremainsunclear.
Itisdifficulttoascertaintheutilityandimpactofbioprostheticmesh
ontheoutcomesoftransvaginalapproachtorectovaginalfistularepair,
giventhedifferencesintechniquesandheterogeneityofthecaseseries
publishedtodate.Thevariabilityofoutcomesofsurgeryforrectovaginal
fistulaingeneralmakesthepotentialbenefitofrepairaugmentationwith
interpositionmeshcompellingandworthyoffurtherinterestand
continuedstudytodeterminetheindicationsforitspotentialuseand
safetyforthisindication.Thistechniquehasyettobestudiedadequately,
butthisisnotuniquetotheliteratureingeneralregardingthetopicof
surgeryforrectovaginalfistula.Overall,thecurrentstatusofthe
literatureformanagementofrectovaginalfistulasremainswantingasthe
heterogeneityofthecondition,variationinanatomicaldefects,multitude
ofcauses,andthenumerousdescribedtechniquesforrepairmakethis
topicespeciallychallengingtoinvestigate.Itisarguablethatfew
conditionsareingreaterneedforwell-designed,multi-institutional
prospectivestudiestoprovidebetterevidenceonwhichtobaseour
treatmenttoalleviatethesufferingofthisgroupofpatients.

RECOMMENDEDREFERENCESAND
READINGS
AdelwoA,EllerkmannR,RosenblattP.Rectovaginalfistularepairusingadisposablebiopsy
punch.FemalePelvicMedReconstrSurg2014;20:52–55.
ByrnesJN,SchmittJJ,FaustichBM,etal.Outcomesofrectovaginalfistularepair.FemalePelvic
MedReconstrSurg2017;23:124–30.
CorteH,MaggioriL,TretonX,LefevreJH,FerronM,PanisY.Rectovaginalfistula:whatisthe
optimalstrategy?Ananalysisof79patientsundergoing286procedures.AnnSurg
2015;262:855–61.
El-GazzazG,HullT,MignanelliE,HammelJ,GurlandB,ZutshiM.Analysisoffunctionand
predictorsoffailureinwomenundergoingrepairofCrohn’srelatedrectovaginalfistula.J
GastrointSurg2010;14:824–9.
El-GazzazG,HullT,MignanelliE,ZutshiM.Obstetricandcryptoglandularrectovaginalfistulas:
long-termsurgicaloutcomes;qualityoflife;andsexualfunction.JGastrointSurg
2010;14:1758–63.
EllisCN.Outcomesafterrepairofrectovaginalfistulasusingbioprosthetics.DisColonRectum
2008;51:1084–8.
GazalaMA,WexnerSD.Managementofrectovaginalfistulasandpatientoutcome.ExpertRev
GastroenterolHepatol2017;11:461–71.
GottgensKW,SmeetsRR,StassenLP,BeetsG,BreukinkSO.Thedisappointingqualityof
publishedstudiesonoperativetechniquesforrectovaginalfistulas:ablueprintfora
prospectivemulti-institutionalstudy.DisColonRectum2014;57:888–98.
LowryAC,ThorsonAG,RothenbergerDA,GoldbergSM.Repairofsimplerectovaginalfistulas.
Influenceofpreviousrepairs.DisColonRectum1988;31:676–8.
MacRaeHM,McLeodRS,CohenZ,SternH,ReznickR.Treatmentofrectovaginalfistulasthat
hasfailedpreviousrepairattempts.DisColonRectum1995;38:921–5.
NarangR,HullT,PerrinsS,GarciaJS,WexnerSD.Shouldimmunomodulationtherapyalterthe
surgicalmanagementinpatientswithrectovaginalfistulaandCrohn’sdisease?DisColon
Rectum2016;59:670–6.
PintoRA,PetersonTV,ShawkiS,DavilaGW,WexnerSD.Aretherepredictorsofoutcome
followingrectovaginalfistularepair.DisColonRectum2010;53:1240–7.
PyeP,DadaT,DuthieG,PhillipsK.Surgisismesh:anovelapproachtorepairofarecurrent
rectovaginalfistula.DisColonRectum2004;47:1554–6.
SchwanderO,FuerstA,KunstrichK,SchererR.Innovativetechniquefortheclosureof
rectovaginalfistulausingSurgisismesh.TechColoproctol2009;13:135–40.

Chapter13
RectovaginalFistula:
TransvaginalApproach
withoutMesh
AliceFrontaliandYvesPanis
Despitemanysurgicaloptions,managementofrectovaginalfistula(RVF)
stillremainsasurgicalchallengewithahighfailurerate,whateverthe
surgicaloptionchosen.
ThischapterdescribesthetreatmentofRVFbytransvaginalapproach
withoutamesh.Althoughthistechniqueisnotthemostusedinthis
indication,itcanbeproposedasaconservativeprocedure,asan
alternativetotransanalapproach,beforemoreaggressiveoperations
suchastemporarystomaandgraciloplastyareundertaken.
INDICATIONS/CONTRAINDICATIONS
Indications
RVFisadevastatingandaweakconditionthatnegativelyaffectsthe
woman’squalityoflife.However,notallRVFrequireasurgical
treatment.Onlysymptomaticpatientsareconsideredforsurgical
treatment.Womenwithsmallfistulasandminimalsymptomsshouldbe
discussed,atleastinitially,formedicaltreatmentonly.Itisparticularly
trueinpatientswithRVFcomplicatingCrohn’sdiseaseforwhomsurgical
treatmentcanbeworsethanmedicaltreatmentonly.Furthermore,in
patientswithCrohn’sdisease,surgicaltreatmentofsymptomaticRVF
shouldbediscussedonlyaftercontrolofthediseasebymedicaltherapy,
includingwithanti-TNFdrugs.
Thus,thetransvaginalapproachwithoutameshcanbeproposedin
symptomaticpatientsforwhomaminorlocaltreatmentisdiscussed.In
ourexperience,aswellasinmanyothercenters,this“minor”local

treatmentcanbeeitherthroughatransvaginalapproachwithoutmeshor
throughanalternativesuchastransanalflaprepair.Ifitfails,the
authors’policyistoproposeasecondstepwithsimilarminorlocal
treatmentbutassociatedwithatemporarystoma.Ifthisrepeatattempt
withdiversionfails,amoreaggressiveproceduresuchasatransperineal
approachwithgracilismuscleorMartiusflapinterpositionisdiscussed.
ContraindicationsofMinorLocalTreatmentSuchas
TransvaginalApproach
ActiveCrohn’sdiseasewithpersistentrectalmucosainflammation
RVFcomplicatingpelvicmalignancy
Radiation-inducedRVF
Severefecalincontinenceforwhichadefinitivestomaisprobablythe
bestoption
HighRVFforwhichanabdominalapproachforrepairisthebestoption.

PREOPERATIVEPLANNING
Afterclinicalexamination,confirmingtheexistenceofanRVFlocatedon
thelowerpartofthevaginaandtherectum,forwhichatransvaginal
repairispossibleandindicated,preoperativeassessmentwithendoscopy
and/orimagingdependsontheetiologyoftheRVF.
IncaseofpostoperativeorobstetricalRVF,forwhichnootherlesionis
associated,nootherimagingisrequired.Fistulographyand/orMRIis
notnecessarytoproveRVFbecauseexaminationundergeneral
anesthesiaatthetimeofRVFrepairissufficient.
p.93
p.94
InpatientswithRVFcomplicatingactiveCrohn’sdisease,colonoscopy
andsmallbowelevaluationisindicated.Furthermore,perianalMRIis
alsoindicatedbecauseoftheriskoftheassociatedcomplexperineal
fistulainpatientswithCrohn’sdisease.

SURGERY
Thepatientsreceivemechanicalbowelpreparationthedaybefore
operationwithanadditionalprophylacticenemarepeatedonthe
morningoftheoperation.
Duringtheoperation,followingtheguidelines,allthepatientsreceive
perioperativeintravenousantibioticprophylaxis.
Therearethetwotechniquesoftransvaginalrepairwithoutmesh:
DirectRVFclosure
Vaginaladvancementflap
Positioning
Allproceduresareperformedundergeneralanesthesiawiththepatient
inlithotomyposition;theperineumisdraped,andthebladderis
catheterized.
ThepresenceoftheRVFisconfirmedwithaninitialexaminationwith
theidentificationofbothvaginalandrectalorifices,usingifnecessaryan
injectionofbluemethylenethroughtheanusand/orcatheterizationwith
aprobe.However,mostofthetime,theRVFiseasilyconfirmed.
Forthebestexposureofthevaginafortransvaginalrepair,weusean
analdilatatorsuchasaPrattrectalspeculuminsertedintothevagina.
Alternatively,astandardvaginalspeculumcanbeused.
TechniqueofDirectRVFClosure
ThetechniqueisclosetowhatwasdescribedbyBurkeetal.forpouchvaginalfistulaafterilealpouch-analanastomosisforulcerativecolitis.
AvaginalincisionismadeattheleveloftheRVFalongthemidline
longitudinalaxisoftheposteriorvaginalwall.Thevaginalwallisthen
dissectedfromtherectum(Fig.13-1).Theinternalrectalopeningisthen
excisedandthedefecttransverselyclosedwithinterrupted3/0Vicryl
suture(Ethicon).Thevaginalwallisthenlongitudinallyclosedwith
interrupted2/0Vicrylsuture.Ahemostaticgauze(Algosteril,Brothier,
Nanterre,France)isplacedintothevaginafor24hours.

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