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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_953_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Dedication
- •Contributors
- •Foreword
- •Preface
- •Contents
- •Indications/Contraindications
- •Surgery
- •Conclusions
- •Complications
- •Results
- •Indications/Contraindications
- •Surgery
- •Technique
- •Complications
- •Results
- •Conclusions
- •Indications
- •Contraindications
- •Conclusions
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Acknowledgments
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Indications
- •Contraindications
- •Results
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Complications
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Acknowledgments
- •Introduction
- •Indications/Contraindications
- •Surgery
- •Conclusions
- •Complications
- •Results
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Conclusions
- •Introduction
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Anatomy
- •Complications
- •Results
- •Conclusions
- •Indications/Contraindications
- •Surgery
- •Complications
- •Results
- •Conclusions
- •Introduction
- •Indications/Contraindications

Theauthorsprefertousea3–5×2–4cmdiamond-shapedislandflap
comprisingfullthicknessskinandsubcutaneousfat.Theflapoutlineis
firstmarkedonthenonscarredbuttockskin(Figs.6-9and6-10AandB).
Theflapiselevatedusingdiathermy,aimingtoensurethattheedges
slopeoutlaterallyinthesubcutaneoustissuetogiveabroaderbase;this
actionreducestheriskoftheflapbeingdevascularized,whenitis
advancedintotheanalcanal.
p.33
p.34
FIGURE6-9Probeinfistulatract(schematic).
FIGURE6-10Incisionfordiamond-shapedanocutaneous
advancementflap:(A)actualviewand(B)schematic.
Theinternalopeningofthefistulaisexcised,includingasmallamount
oftheinternalsphinctersurroundingtheinternalopening,butthedistal
sphincterisnotdivided.Theinternalopeningisclosedwitha
longitudinallineofinterruptedabsorbablemonofilamentsutures.The

externalcomponentofthetract,extendingfromtheexternalopeningto
theexternalsphincter,isalsoexcised.Thescartissuebetweenthe
internalandtheexternalopeningsisalsoroutinelyincised,andif
feasible,excised;or,alternatively,curetted.
Itisveryimportanttodisconnecttheleadingedgeoftheflapfromthe
subcutaneoustissuesattachedtothesphinctertogivemobility.Oncethe
flapismobile,itisadvancedintotheanalcanal(Figs.6-11AandB)and
usedtocovertheinternalopening.Itisusuallynecessarytorotatethe
flapfromthecontralateralsidetocoveramidlinedefectbecauseof
ipsilateralscarring.Theflapissuturedinsituusinginterrupted2/0–3/0
absorbablebraidedsutures(polyglactin)(Fig.6-12AandB).Thebuttock
defect,outsidetheadvancedflap,isalsoclosedusing2/0braided
absorbablesuturesinalinearfashion.Braidedabsorbablesuturesare
usedforpatients’comfort.
p.34
p.35
FIGURE6-11Flapbeingadvancedtocovertheinternal
opening:(A)actualviewand(B)schematic.
FIGURE6-12Suturedanocutaneousadvancementflap:
(A)actualviewand(B)schematic.
Asmalldrain,suchasasmalldePezzerormushroomtipcatheter,is
placedintolargertractsviatheexternalopening.
Note:OthersprefertouseabroadbasedU-shapedinverted

anocutaneousflap.Theapexoftheflapshouldbe2–2.5cminwidthand
sitedjustproximaltotheinternalopening.Itismarkedoutsothatthe
baseisapproximatelytwicethewidthoftheapex.Thebasecanbe
releasedfrom(asahouseflap)orleftattachedtothebuttockasa
“tongue.”Proximally,theflapshouldencompassthesuperficialfibersof
thelowerinternalsphincter.Thelengthshouldbesuchthatitallowsa
tension-freeclosure.Thedistalpartoftheflapwillincludetheskinand
subcutaneousfatoftheperianalregion.Furtheradvancementcanbe
gained,ifrequired,byexcisingBurrow’strianglesofskinfromthe
adjacentbase.Adisadvantageoftheseflapsisthattheyhavelimited
lengthofmobilitywhencomparedwiththeislandflapsthatcanbe
mobilizedabovetheanorectaljunctionwhenneeded,forexample,
followingafailedrectaladvancementflapforarecurrent
suprasphinctericfistula.
Theuseofalocalanestheticisavoidedinflaprepairstohelpprevent
flapedemaand/orischemia.Temporarydivertingstomasareonly
fashionedifthepatienthascomplexunresolvedsepsisortherehavebeen
multiplepreviousattemptsatrepair.

POSTOPERATIVEMANAGEMENT
Oralanalgesicsusuallysufficewiththeendorectaladvancementflapas
postoperativediscomfortisminimal,becausethereisnoperinealwound.
Patientsareadvisedtoshowergently.Sitzbathsareavoided,particularly
ifananocutaneousflaphasbeenraised,topreventtheflapdonorsite
becomingmacerated.Thewoundshouldbedriedthoroughlyusinga
hairdryerandadrydressingisappliedonlytoseparatethebuttocks.The
patientcanhaveanormaldietbutstoolsoftenersaregiven.Low-dose
metronidazoleiscontinuedinthepostoperativeperiodfor5days.
p.35
p.36
Thepatientsarereviewedinthesurgeon’soffice4–6weeks
postdischarge.Theyareadvisedtoavoidvigorousexerciseduringthis
period.Patientsarealsoadvisednottobeconcernedifthereisapartial
dehiscenceoftheflapdonorsitewound(thiscanoccurinupto50%of
thepatients).Onanaverage,ittakesabout6weeksfortheperineal
woundtohealcompletely.Inourexperience,patientstendtocheckthe
appearancewithamirrorregularlyandneedreassuranceaboutthe
appearance,particularlyduringthefirstcoupleofweeks.

COMPLICATIONS
Specifictothefistularepair,thecomplicationsinclude:
failure/recurrence.Itisimportanttoreevaluatepatientstoassessthe
outcomeassuccessratesdecreasewithtime.Recurrenceappearstobe
causedbothbyfailureofthetreatmentandbyrecurrentpatientdisease
flapbreakdown
sphinctercompromiseandincontinence(attributedtooverstretchingof
theanalsphinctersbytheself-retainingretractor,disruptionofthe
sphinctercomplexbyinclusionoftheinternalsphincterfibers,and
sensorydisruptionwithadvancementofrectalmucosadistally)
anorectalsepsis
hematomaformation
iatrogenicfistulaformation,includingrectovaginalfistulaewithanterior
flaprepairs
ectropion(MAFs)

RESULTS
Successratesrelatingtothedifferenttypesoffistularepairvarywidelyin
thepublishedliterature.Therehavebeenfewrandomizedcontrolled
trials(RCTs)andmostofthestudiesofthetreatmentofanalfistulaeare
smallandheterogeneouswithrespecttothetypeoffistulaincluded,the
surgicaltechnique,andthelengthofthefollow-up,makingcomparison
difficult.
SimpleAppositionalClosure
Theliteratureincludesonlyafewstudiesreportingexcisionandclosure
oftheinternalopeningalone,withouttheuseofaflapprocedure.In
2004,ThomsonandFowlerreportedtheirexperiencewith44patientsof
directappositionalclosureoftheinternalopeningwithouttheuseofa
flap.Twenty-sixfistulaein28patientsappearedhealedat2–5months;
withlongerfollow-ups,therepairfailedin41%ofthepatients.
Athanasiadisetal.usingathree-layeredclosure,reportedaseriesof90
patientshavingatotalof106operations,andafollow-uptimeofbetween
6monthsand6years(median2.6years).Theriskofrecurrencewas18%
(19fistulae),withthepredominantcauseoffailurebeingsutureline
dehiscence.Followingrepair,94%ofthepatientswerecontinentand6%
sufferedminimaldisorderedcontinence.
Transanal/EndorectalAdvancementFlaps
Awiderangeofsuccesswiththistypeofflaphasbeenreportedinthe
literature,rangingfrom37%to93%.Morerecentstudieswithlarger
patientnumbersandlongerfollow-upssuggestthatsuccessisgenerally
intheorderof60–70%.Alargesingle-surgeonexperiencefromthe
ClevelandClinic,Ohioreportedtheresultsofrectaladvancementflap
repairsin75patients,31ofwhomsufferedCrohn’sdisease.Theywere
followedupforameanof7±3years,andprimaryhealingoccurredin
72%ofpatients.Functionalresultsfollowingtheendorectaladvancement
flaprepairappeargood,althoughmildtomoderateincontinencehas
beenreportedinupto7–38%,associatedwithadecreaseinbothresting
andsqueezepressuresonpostoperativemanometry.
Higherrecurrenceratesfollowingendoanaladvancementflapsare
associatedwithundrainedsepsis,Crohn’sdisease,rectovaginalfistulae,
andpriorrepair;inaddition,thesuccessratedecreaseswithtime.An
RCTcomparingMAFwithfull-thicknessflapshasshownalowerrateof
recurrencewiththelatter(40%comparedwith10%;P<0.05).

Variousstudieshaveinvestigatedwhetheraflaprepairincombination
withanothertechnique(includingfibringlue,bioprostheticfistulaplug,
orLIFTprocedure)isbetterthanaflaprepairalone,withmixedresults.
p.36
p.37
FewRCTshavebeenperformedcomparingsurgicaltechniques.A
meta-analysisofthreeRCTscomparingMAFwithafistulaplug,failedto
showanadvantageofeithertechniqueorasignificantdifferencein
complicationrate,pre-andpostoperativecontinencelevelsorqualityof
life.OnesmallRCTcomparingMAFwiththeLIFTprocedurefailedto
showasignificantdifferenceinrecurrenceorpre-andpostoperative
continencelevels,althoughtheLIFTprocedurewasassociatedwitha
highersatisfactionrate,lowerpostoperativepainandshortertimeto
resumingnormalactivities.
AnocutaneousAdvancementFlaps
Theauthorspublishedtheirresultsusingthistechniquein16patients
withcomplex,recurrent,orchronicsuprasphinctericfistulaein2005.
Afterameanperiodoffollow-upof20(range1.5–43)months,complete
healingwasseenin15(94%)patients.Atemporarydefunctioningstoma
wasformedintwopatients.Only11patients(almost70%)reported
improvedincontinence,2patientsreportednochangeintheirlevelof
incontinence,and3patients(19%)reportedworseincontinence.
Otherpublishedstudiesreportcompletehealingratesof46–100%in
non-inflammatoryboweldisease(IBD)patients.Oneofthelargest
studiesbyNelsonetal.includedpatientswithbothIBDandnon–IBDrelatedfistulatracts.Seventy-threedermalislandflapsusingateardrop
incisionwereperformedin65patients.Theyreportedapatientfailure
rateof20%andaprocedurefailurerateof23%afterameanfollow-upof
28.4(range4–63)months.

CONCLUSIONS
Despitefamiliaritywithtechniqueandexpertise,allcolorectalsurgeons
areawareofthechallengescomplexfistuladiseaseposeandthe
frustrationoffailureandrecurrence.Nottheleast,otherwisehealthy
youngpatientswithcomplexfistulaefindthediseasefrustratingand
oftendifficulttocomprehendintermsoftheneedforstagedrepairsand
potentialneedformultipleprocedures.Goodresultsaredependentonan
understandingoftheanatomyofthepathologicalcondition,controlof
sepsispriortoaflaprepair,andattentiontodetailtoensureatensionfree,well-vascularizedflap.

ACKNOWLEDGMENTS
TheauthorswouldliketothankProfessorA.Eyersforhiskind
permissiontousehisEndorectalAdvancementFlapvideointhis
publication.

RECOMMENDEDREFERENCESAND
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